Non-invasive Mechanical Ventilation in Critical Care, Anesthesiology and Palliative Care

Non-invasive Mechanical Ventilation in Critical Care, Anesthesiology and Palliative Care

Author: Giuseppe Servillo

Publisher: Springer Nature

Published: 2023-11-12

Total Pages: 179

ISBN-13: 3031365100

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This book provides an easy, modern and practical way for physicians to approach the world of noninvasive mechanical ventilation (NIMV). Noninvasive ventilation is well-established and increasingly used in routine clinical practice. However, some concepts and techniques of NIMV may be difficult to grasp for students or for healthcare professionals with less experience. The book is subdivided into 7 sections covering different aspects of clinical applications of NIMV. From modes of ventilation to the proper moment to start noninvasive ventilation; from critical care applications of NIVM (pre-, intra- and post-hospitalization as well as in emergency medicine), to the use outside of ICUs. Its purpose is also considered in several different diseases and settings, including the experience during Covid-19 pandemic and at the end of life. The book addresses anesthesiologists, critical care, emergency care, palliative care, primary care physicians using noninvasive ventilation and will represent an invaluable tool for a better understanding of this technique.


Book Synopsis Non-invasive Mechanical Ventilation in Critical Care, Anesthesiology and Palliative Care by : Giuseppe Servillo

Download or read book Non-invasive Mechanical Ventilation in Critical Care, Anesthesiology and Palliative Care written by Giuseppe Servillo and published by Springer Nature. This book was released on 2023-11-12 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an easy, modern and practical way for physicians to approach the world of noninvasive mechanical ventilation (NIMV). Noninvasive ventilation is well-established and increasingly used in routine clinical practice. However, some concepts and techniques of NIMV may be difficult to grasp for students or for healthcare professionals with less experience. The book is subdivided into 7 sections covering different aspects of clinical applications of NIMV. From modes of ventilation to the proper moment to start noninvasive ventilation; from critical care applications of NIVM (pre-, intra- and post-hospitalization as well as in emergency medicine), to the use outside of ICUs. Its purpose is also considered in several different diseases and settings, including the experience during Covid-19 pandemic and at the end of life. The book addresses anesthesiologists, critical care, emergency care, palliative care, primary care physicians using noninvasive ventilation and will represent an invaluable tool for a better understanding of this technique.


Noninvasive Ventilation in Sleep Medicine and Pulmonary Critical Care

Noninvasive Ventilation in Sleep Medicine and Pulmonary Critical Care

Author: Antonio M. Esquinas

Publisher: Springer Nature

Published: 2020-05-28

Total Pages: 530

ISBN-13: 3030429989

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This book is an introduction to a comprehensive analysis of recent advances and clinical research in noninvasive mechanical ventilation (NIV) in Pulmonary, Critical Care, and Sleep Medicine. The objective of the book is to increase the knowledge and understanding of the reader in the best clinical practice in three main sections. A selected international group of experts in the field of noninvasive ventilation formed a panel to provide an update on the recent literature in the application and efficient utilization of NIV in Pulmonary, Critical Care, and Sleep Medicine. Each particular section will discuss the application of NIV in different disease process. The authors summarized the main results of the recent trials, clinical and technological advances, expert opinions, and practical guidelines. Chapters, summarized by expert committee, provide a “deep and exhaustive critical analysis and summary” of the recent advances in the field of NIV, presented as key points and/recommendations for the best clinical practice from articles published in the last decade. The content of the book will serve as a resource and a tool to the practicing physicians toward NIV. Main objective is to increase their proficiency in management of different pathophysiological aspects of the respiratory system. In this line, the book offers to the readers, who are seeking the latest recommendations, the future research directions in noninvasive mechanical ventilation. Table of contents describe and analyze, the items trend setters in noninvasive ventilation, organized in three main sections, “pulmonary”, “critical care” and “sleep medicine”, using the primary keyword related with term “noninvasive mechanical ventilation” as search term associated with “secondary keywords” studies from a period of 2018 to 2019. This searching methodology and analysis define this unique book to the approach in noninvasive mechanical ventilation for best clinical practice, research, clinical study designs and critical analysis, how noninvasive ventilation is current and trending. Based on this form of conception of book updated, editors and authors consider that this book opens a new and original vision for adequate knowledge and deep updated based on key publications in the period under review, very useful for clinical practice, studies designs and potential new trends in the use of noninvasive ventilation. As such, it is a unique update book resource in noninvasive ventilation in pulmonary, critical care and sleep medicine that may influence current clinical practice and future studies. With ultimate goal is better care and outcome for our patients.


Book Synopsis Noninvasive Ventilation in Sleep Medicine and Pulmonary Critical Care by : Antonio M. Esquinas

Download or read book Noninvasive Ventilation in Sleep Medicine and Pulmonary Critical Care written by Antonio M. Esquinas and published by Springer Nature. This book was released on 2020-05-28 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an introduction to a comprehensive analysis of recent advances and clinical research in noninvasive mechanical ventilation (NIV) in Pulmonary, Critical Care, and Sleep Medicine. The objective of the book is to increase the knowledge and understanding of the reader in the best clinical practice in three main sections. A selected international group of experts in the field of noninvasive ventilation formed a panel to provide an update on the recent literature in the application and efficient utilization of NIV in Pulmonary, Critical Care, and Sleep Medicine. Each particular section will discuss the application of NIV in different disease process. The authors summarized the main results of the recent trials, clinical and technological advances, expert opinions, and practical guidelines. Chapters, summarized by expert committee, provide a “deep and exhaustive critical analysis and summary” of the recent advances in the field of NIV, presented as key points and/recommendations for the best clinical practice from articles published in the last decade. The content of the book will serve as a resource and a tool to the practicing physicians toward NIV. Main objective is to increase their proficiency in management of different pathophysiological aspects of the respiratory system. In this line, the book offers to the readers, who are seeking the latest recommendations, the future research directions in noninvasive mechanical ventilation. Table of contents describe and analyze, the items trend setters in noninvasive ventilation, organized in three main sections, “pulmonary”, “critical care” and “sleep medicine”, using the primary keyword related with term “noninvasive mechanical ventilation” as search term associated with “secondary keywords” studies from a period of 2018 to 2019. This searching methodology and analysis define this unique book to the approach in noninvasive mechanical ventilation for best clinical practice, research, clinical study designs and critical analysis, how noninvasive ventilation is current and trending. Based on this form of conception of book updated, editors and authors consider that this book opens a new and original vision for adequate knowledge and deep updated based on key publications in the period under review, very useful for clinical practice, studies designs and potential new trends in the use of noninvasive ventilation. As such, it is a unique update book resource in noninvasive ventilation in pulmonary, critical care and sleep medicine that may influence current clinical practice and future studies. With ultimate goal is better care and outcome for our patients.


Noninvasive Mechanical Ventilation and Difficult Weaning in Critical Care

Noninvasive Mechanical Ventilation and Difficult Weaning in Critical Care

Author: Antonio M. Esquinas

Publisher: Springer

Published: 2016-01-04

Total Pages: 466

ISBN-13: 3319042599

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This book establishes the indications for the use of NIV in the context of weaning from invasive mechanical ventilation. It provides a comprehensive overview of key topics relevant for correct practical application, including NIV and weaning principles, important aspects of patient care before and after weaning, and pediatric and neonatology weaning. Finally, the book summarizes international guidelines and new perspectives of NIV during weaning. With contributions by international experts in the field on noninvasive mechanical ventilation, the book will serve as a valuable guide for critical care physicians, respiratory physiotherapists, and pulmonologists.


Book Synopsis Noninvasive Mechanical Ventilation and Difficult Weaning in Critical Care by : Antonio M. Esquinas

Download or read book Noninvasive Mechanical Ventilation and Difficult Weaning in Critical Care written by Antonio M. Esquinas and published by Springer. This book was released on 2016-01-04 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book establishes the indications for the use of NIV in the context of weaning from invasive mechanical ventilation. It provides a comprehensive overview of key topics relevant for correct practical application, including NIV and weaning principles, important aspects of patient care before and after weaning, and pediatric and neonatology weaning. Finally, the book summarizes international guidelines and new perspectives of NIV during weaning. With contributions by international experts in the field on noninvasive mechanical ventilation, the book will serve as a valuable guide for critical care physicians, respiratory physiotherapists, and pulmonologists.


Mechanical Ventilation in Critically Ill Cancer Patients

Mechanical Ventilation in Critically Ill Cancer Patients

Author: Antonio M. Esquinas

Publisher: Springer

Published: 2018-02-07

Total Pages: 368

ISBN-13: 331949256X

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This book aims to equip the reader to make optimal decisions on the use of mechanical ventilatory support in critically ill cancer patients with acute respiratory failure (ARF) and to implement the different strategies effectively. Detailed information is provided on the rationale for invasive and non-invasive ventilation, the different modes of ventilation, indications and contraindications, prognostic factors, and outcomes. The role of postoperative mechanical ventilation following various forms of surgery is extensively addressed, and key aspects of withdrawal from ventilatory support are discussed. Attention is also devoted to mechanical ventilation in the palliative care context. The concluding part of the book focuses on healthcare resource utilization and organizational support in cancer critical care. ARF is the most common reason for hospital and intensive care admission among oncological patients, and there is growing evidence that outcome following mechanical ventilation is improving. Readers will find this book to be an invaluable aid when selecting and executing a strategy for management of ARF in individual cancer patients.


Book Synopsis Mechanical Ventilation in Critically Ill Cancer Patients by : Antonio M. Esquinas

Download or read book Mechanical Ventilation in Critically Ill Cancer Patients written by Antonio M. Esquinas and published by Springer. This book was released on 2018-02-07 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to equip the reader to make optimal decisions on the use of mechanical ventilatory support in critically ill cancer patients with acute respiratory failure (ARF) and to implement the different strategies effectively. Detailed information is provided on the rationale for invasive and non-invasive ventilation, the different modes of ventilation, indications and contraindications, prognostic factors, and outcomes. The role of postoperative mechanical ventilation following various forms of surgery is extensively addressed, and key aspects of withdrawal from ventilatory support are discussed. Attention is also devoted to mechanical ventilation in the palliative care context. The concluding part of the book focuses on healthcare resource utilization and organizational support in cancer critical care. ARF is the most common reason for hospital and intensive care admission among oncological patients, and there is growing evidence that outcome following mechanical ventilation is improving. Readers will find this book to be an invaluable aid when selecting and executing a strategy for management of ARF in individual cancer patients.


Noninvasive Mechanical Ventilation

Noninvasive Mechanical Ventilation

Author: Antonio M. Esquinas

Publisher: Springer Nature

Published: 2023-08-28

Total Pages: 826

ISBN-13: 3031289633

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The 3rd and updated edition of this book represents a new and unique scientific reference for the medical community on how to understand rationale and applications of noninvasive mechanical ventilation (NIMV). Its aim is to establish the indications of NIMV in critically ill patients in weaning from invasive MV. Nowadays, there is a growing evidence-based medicine that recommends use of NIMV in patients after extubation or in difficult weaning patients also affected by comorbidities. This book has been conceived with the vision or providing the best resources for everyone working in ICUs even if belonging to different specialties (intensive care, anesthesiology, pneumology, emergency medicine, etc.). Considering the enormous increase of literature on this topic, authors have selected major key topics related to NIMV, excluding those with low rate of interest, have updated previous topics and have introduced new items collecting them in a practical book analyzing major key topics for a correct practical applications. A new gaze has been devoted to emergency medicine and prehospital applications and technical developments (new ventilation modes: neurology adaptive modes, average support mode and to the development of synchronization and patient-ventilator interaction result). A section dedicated to sleep medicine - due to the new interesting studies on NIV-CPAP adaptation studies, clinical impacts of CPAP devices and ventilatory modes representing an essentials development for a new adequate analysis - is now included. A part devoted to clinical indications based on the observation of new clinical indications in anesthesiology and pneumology in NIV as complementary technique for procedures like bronchoscopy, pre-oxygenation and difficult endotracheal intubations is also now foreseen.


Book Synopsis Noninvasive Mechanical Ventilation by : Antonio M. Esquinas

Download or read book Noninvasive Mechanical Ventilation written by Antonio M. Esquinas and published by Springer Nature. This book was released on 2023-08-28 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 3rd and updated edition of this book represents a new and unique scientific reference for the medical community on how to understand rationale and applications of noninvasive mechanical ventilation (NIMV). Its aim is to establish the indications of NIMV in critically ill patients in weaning from invasive MV. Nowadays, there is a growing evidence-based medicine that recommends use of NIMV in patients after extubation or in difficult weaning patients also affected by comorbidities. This book has been conceived with the vision or providing the best resources for everyone working in ICUs even if belonging to different specialties (intensive care, anesthesiology, pneumology, emergency medicine, etc.). Considering the enormous increase of literature on this topic, authors have selected major key topics related to NIMV, excluding those with low rate of interest, have updated previous topics and have introduced new items collecting them in a practical book analyzing major key topics for a correct practical applications. A new gaze has been devoted to emergency medicine and prehospital applications and technical developments (new ventilation modes: neurology adaptive modes, average support mode and to the development of synchronization and patient-ventilator interaction result). A section dedicated to sleep medicine - due to the new interesting studies on NIV-CPAP adaptation studies, clinical impacts of CPAP devices and ventilatory modes representing an essentials development for a new adequate analysis - is now included. A part devoted to clinical indications based on the observation of new clinical indications in anesthesiology and pneumology in NIV as complementary technique for procedures like bronchoscopy, pre-oxygenation and difficult endotracheal intubations is also now foreseen.


Noninvasive Ventilation Outside Intensive Care Unit

Noninvasive Ventilation Outside Intensive Care Unit

Author: Antonio M. Esquinas

Publisher: Springer Nature

Published: 2023-12-28

Total Pages: 445

ISBN-13: 3031377966

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This book aims to highlight the importance of the development of health conditions and demand for the application of noninvasive mechanical ventilation (NIMV) outside the intensive care units (ICUs); the diversification of possible scenarios outside the ICUs; the need to establish references that consolidate this phenomenon and the healthcare organizations models. In the last decades the extension of the use of NIMV outside of the ICUs has led to the generation of protocols and to the creation of new in-hospital care models. In this field, the main determining factors are a better knowledge of technique, technological advancement, better monitoring capacity, the creation of multidisciplinary teams adequately trained in their application, and social and health events that have overloaded ICUs. All these elements have promoted the creation of these NIMV units outside ICUs. This new reality entails the need for clarification of concepts, recommendations, and analysis of how to plan NIMV. Although the literature that clearly determine the indications and aids on the use of NIMV is considerable, this volume, pointing out the diversity of different healthcare models to define how to organize NIMV outside the ICUs, shed a light and bring a clear benefit to the scientific community involved. The book is structured in eleven main sections analyzing the epidemiology and trends for NIMV healthcare models and determining factors for these models outside ICUs. The originality of the work, its clear clinical-practical impact and the multidisciplinary approach given by all healthcare professionals involved (intensivists, pneumologists, internal medicine and emergency medicine specialists, geriatricians, chest respiratory therapists, etc.) is very relevant for the thoroughness of the book.


Book Synopsis Noninvasive Ventilation Outside Intensive Care Unit by : Antonio M. Esquinas

Download or read book Noninvasive Ventilation Outside Intensive Care Unit written by Antonio M. Esquinas and published by Springer Nature. This book was released on 2023-12-28 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to highlight the importance of the development of health conditions and demand for the application of noninvasive mechanical ventilation (NIMV) outside the intensive care units (ICUs); the diversification of possible scenarios outside the ICUs; the need to establish references that consolidate this phenomenon and the healthcare organizations models. In the last decades the extension of the use of NIMV outside of the ICUs has led to the generation of protocols and to the creation of new in-hospital care models. In this field, the main determining factors are a better knowledge of technique, technological advancement, better monitoring capacity, the creation of multidisciplinary teams adequately trained in their application, and social and health events that have overloaded ICUs. All these elements have promoted the creation of these NIMV units outside ICUs. This new reality entails the need for clarification of concepts, recommendations, and analysis of how to plan NIMV. Although the literature that clearly determine the indications and aids on the use of NIMV is considerable, this volume, pointing out the diversity of different healthcare models to define how to organize NIMV outside the ICUs, shed a light and bring a clear benefit to the scientific community involved. The book is structured in eleven main sections analyzing the epidemiology and trends for NIMV healthcare models and determining factors for these models outside ICUs. The originality of the work, its clear clinical-practical impact and the multidisciplinary approach given by all healthcare professionals involved (intensivists, pneumologists, internal medicine and emergency medicine specialists, geriatricians, chest respiratory therapists, etc.) is very relevant for the thoroughness of the book.


Pulmonary Function Measurement in Noninvasive Ventilatory Support

Pulmonary Function Measurement in Noninvasive Ventilatory Support

Author: Antonio M. Esquinas

Publisher: Springer Nature

Published: 2021-08-20

Total Pages: 354

ISBN-13: 3030761975

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This book comprehensively addresses the use of pulmonary function measurement for the evaluation, screening and timing of noninvasive mechanical ventilation (NIMV) from hospital to home care. To do so, it describes three clinical stages of NIMV support: before NIV, to detect early markers and determine whether NIV is appropriate; during NIV, to evaluate NIV response; and in long-term NIV support. Additionally, it assesses a range of complementary health care organizations (pulmonary function labs, pneumology wards, semi-intensive care units and home mechanical ventilation programs), techniques (chest physiotherapy/airway secretions, etc.) and applications. In closing, the book offers practical recommendations on how noninvasive ventilation and lung function measurement can improve outcomes and quality of life, making it a valuable resource for all specialists, e.g. intensivists and pneumologists, as well as anesthesiologists and therapists.


Book Synopsis Pulmonary Function Measurement in Noninvasive Ventilatory Support by : Antonio M. Esquinas

Download or read book Pulmonary Function Measurement in Noninvasive Ventilatory Support written by Antonio M. Esquinas and published by Springer Nature. This book was released on 2021-08-20 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively addresses the use of pulmonary function measurement for the evaluation, screening and timing of noninvasive mechanical ventilation (NIMV) from hospital to home care. To do so, it describes three clinical stages of NIMV support: before NIV, to detect early markers and determine whether NIV is appropriate; during NIV, to evaluate NIV response; and in long-term NIV support. Additionally, it assesses a range of complementary health care organizations (pulmonary function labs, pneumology wards, semi-intensive care units and home mechanical ventilation programs), techniques (chest physiotherapy/airway secretions, etc.) and applications. In closing, the book offers practical recommendations on how noninvasive ventilation and lung function measurement can improve outcomes and quality of life, making it a valuable resource for all specialists, e.g. intensivists and pneumologists, as well as anesthesiologists and therapists.


Mechanical Ventilation in the Critically Ill Obese Patient

Mechanical Ventilation in the Critically Ill Obese Patient

Author: Antonio M. Esquinas

Publisher: Springer

Published: 2017-12-20

Total Pages: 315

ISBN-13: 3319492535

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This book is the first to describe a practical evidence-based approach to the management of critically ill obese patients with various medical or postoperative respiratory problems in the intensive care unit. In brief, the book aims to identify the best strategy and present clinical recommendations for different circumstances, to establish indications for and contraindications to noninvasive and invasive mechanical ventilation, and to offer clear guidance on weaning from mechanical ventilation and on respiratory care. Causes of acute respiratory failure in the obese patient are discussed, and advice is offered on the prevention and management of complications during mechanical ventilation and on moving and feeding critically ill obese patients. Long-term outcomes, ethical issues, and health care costs are also addressed. The multidisciplinary approach, with contributions from international experts in different specialties, ensures that the book will be of interest to a range of health professionals involved in critical care, including intensivists, anesthesiologists, and pulmonologists.


Book Synopsis Mechanical Ventilation in the Critically Ill Obese Patient by : Antonio M. Esquinas

Download or read book Mechanical Ventilation in the Critically Ill Obese Patient written by Antonio M. Esquinas and published by Springer. This book was released on 2017-12-20 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first to describe a practical evidence-based approach to the management of critically ill obese patients with various medical or postoperative respiratory problems in the intensive care unit. In brief, the book aims to identify the best strategy and present clinical recommendations for different circumstances, to establish indications for and contraindications to noninvasive and invasive mechanical ventilation, and to offer clear guidance on weaning from mechanical ventilation and on respiratory care. Causes of acute respiratory failure in the obese patient are discussed, and advice is offered on the prevention and management of complications during mechanical ventilation and on moving and feeding critically ill obese patients. Long-term outcomes, ethical issues, and health care costs are also addressed. The multidisciplinary approach, with contributions from international experts in different specialties, ensures that the book will be of interest to a range of health professionals involved in critical care, including intensivists, anesthesiologists, and pulmonologists.


Noninvasive Mechanical Ventilation

Noninvasive Mechanical Ventilation

Author: ANTONIO ESQUINAS

Publisher: Springer Science & Business Media

Published: 2010-08-12

Total Pages: 388

ISBN-13: 3642113656

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Noninvasive mechanical ventilation is an effective technique for the management of patients with acute or chronic respiratory failure. This comprehensive and up-to-date book explores all aspects of the subject. The opening sections are devoted to theory and equipment, with detailed attention to the use of full-face masks or helmets, the range of available ventilators, and patient-ventilator interactions. Clinical applications are then considered in depth in a series of chapters that address the use of noninvasive mechanical ventilation in chronic settings and in critical care, both within and outside of intensive care units. Due attention is also paid to weaning from conventional mechanical ventilation, potential complications, intraoperative applications, and staff training. The closing chapters examine uses of noninvasive mechanical ventilation in neonatal and pediatric care. This book, written by internationally recognized experts, will be an invaluable guide for both clinicians and researchers.


Book Synopsis Noninvasive Mechanical Ventilation by : ANTONIO ESQUINAS

Download or read book Noninvasive Mechanical Ventilation written by ANTONIO ESQUINAS and published by Springer Science & Business Media. This book was released on 2010-08-12 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Noninvasive mechanical ventilation is an effective technique for the management of patients with acute or chronic respiratory failure. This comprehensive and up-to-date book explores all aspects of the subject. The opening sections are devoted to theory and equipment, with detailed attention to the use of full-face masks or helmets, the range of available ventilators, and patient-ventilator interactions. Clinical applications are then considered in depth in a series of chapters that address the use of noninvasive mechanical ventilation in chronic settings and in critical care, both within and outside of intensive care units. Due attention is also paid to weaning from conventional mechanical ventilation, potential complications, intraoperative applications, and staff training. The closing chapters examine uses of noninvasive mechanical ventilation in neonatal and pediatric care. This book, written by internationally recognized experts, will be an invaluable guide for both clinicians and researchers.


Noninvasive Mechanical Ventilation

Noninvasive Mechanical Ventilation

Author: Antonio M. Esquinas

Publisher: Springer

Published: 2015-12-03

Total Pages: 0

ISBN-13: 9783319216522

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The new edition presents updates regarding new clinical applications of noninvasive mechanical ventilation and discusses recent technical advances in this field. The opening sections are devoted to theory , equipment, with new chapters on clinical applications in emergency medicine, critical care and sleep medicine, with detailed attention to current studies on NIV-CPAP, innovative clinical implications of NIV-CPAP devices. Due attention is also paid to new ventilation modes and the development of synchronization and patient ventilator interaction results. The closing chapters examine clinical indication. Written by internationally recognized experts in the field, this book will be an invaluable guide for both clinicians and researchers.


Book Synopsis Noninvasive Mechanical Ventilation by : Antonio M. Esquinas

Download or read book Noninvasive Mechanical Ventilation written by Antonio M. Esquinas and published by Springer. This book was released on 2015-12-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition presents updates regarding new clinical applications of noninvasive mechanical ventilation and discusses recent technical advances in this field. The opening sections are devoted to theory , equipment, with new chapters on clinical applications in emergency medicine, critical care and sleep medicine, with detailed attention to current studies on NIV-CPAP, innovative clinical implications of NIV-CPAP devices. Due attention is also paid to new ventilation modes and the development of synchronization and patient ventilator interaction results. The closing chapters examine clinical indication. Written by internationally recognized experts in the field, this book will be an invaluable guide for both clinicians and researchers.