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Novel Calcium-Binding Proteins

Author: Claus W. Heizmann

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 606

ISBN-13: 364276150X

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A wide variety of hormones, neurotransmitters and growth factors exert their cellular effects by reacting first with membrane receptors resulting in an increase of intracellular calcium and the cellular response. The calcium signal in the cell is mediated by the high-affinity calcium binding proteins (characterized by the EF-hand structural element), and by the calcium and phospholipid dependent proteins. Many of these have been discovered most recently. Their purification, distribution, protein and gene structures as well as their physiological roles are discussed. The book is of interest to biochemists and molecular biologists as well as to clinicians and the pharmaceutical industry who can apply the results in this field.

Book Synopsis Novel Calcium-Binding Proteins by : Claus W. Heizmann

Download or read book Novel Calcium-Binding Proteins written by Claus W. Heizmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: A wide variety of hormones, neurotransmitters and growth factors exert their cellular effects by reacting first with membrane receptors resulting in an increase of intracellular calcium and the cellular response. The calcium signal in the cell is mediated by the high-affinity calcium binding proteins (characterized by the EF-hand structural element), and by the calcium and phospholipid dependent proteins. Many of these have been discovered most recently. Their purification, distribution, protein and gene structures as well as their physiological roles are discussed. The book is of interest to biochemists and molecular biologists as well as to clinicians and the pharmaceutical industry who can apply the results in this field.

Novel Calcium-Binding Proteins

Author: Claus W Heizmann

Publisher:

Published: 1991-03-28

Total Pages: 640

ISBN-13: 9783642761515

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Book Synopsis Novel Calcium-Binding Proteins by : Claus W Heizmann

Download or read book Novel Calcium-Binding Proteins written by Claus W Heizmann and published by . This book was released on 1991-03-28 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Calcium-Binding Proteins of the EF-Hand Superfamily

Author: Claus W. Heizmann

Publisher: Humana Press

Published: 2019-02-02

Total Pages: 779

ISBN-13: 9781493990290

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This detailed volume explores protocols for studying the many facets of Ca2+-imaging, Ca2+-signaling, and Ca2+-binding along with background information on the principles and application of these techniques. The content of the book delves into 48 chapters including subjects such as data analysis and modern technologies to study calcium-binding and signaling in cells, the superfamily of calcium-binding proteins characterized by the EF-hand structural motif, as well as their use as diagnostic and prognostic biomarkers in Laboratory Medicine and novel therapeutic drug targets. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Calcium-Binding Proteins of the EF-Hand Superfamily: From Basics to Medical Applications presents state-of-the-art, lab-based methods and easy-to-follow protocols for daily use, making it interesting for basic and medical researchers, cell- and molecular biologists, clinicians, clinical chemists, and the diagnostic industry.

Book Synopsis Calcium-Binding Proteins of the EF-Hand Superfamily by : Claus W. Heizmann

Download or read book Calcium-Binding Proteins of the EF-Hand Superfamily written by Claus W. Heizmann and published by Humana Press. This book was released on 2019-02-02 with total page 779 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume explores protocols for studying the many facets of Ca2+-imaging, Ca2+-signaling, and Ca2+-binding along with background information on the principles and application of these techniques. The content of the book delves into 48 chapters including subjects such as data analysis and modern technologies to study calcium-binding and signaling in cells, the superfamily of calcium-binding proteins characterized by the EF-hand structural motif, as well as their use as diagnostic and prognostic biomarkers in Laboratory Medicine and novel therapeutic drug targets. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Calcium-Binding Proteins of the EF-Hand Superfamily: From Basics to Medical Applications presents state-of-the-art, lab-based methods and easy-to-follow protocols for daily use, making it interesting for basic and medical researchers, cell- and molecular biologists, clinicians, clinical chemists, and the diagnostic industry.

Calcium-binding Proteins in Health and Disease

Author: Anthony W. Norman

Publisher:

Published: 1987

Total Pages: 629

ISBN-13:

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Book Synopsis Calcium-binding Proteins in Health and Disease by : Anthony W. Norman

Download or read book Calcium-binding Proteins in Health and Disease written by Anthony W. Norman and published by . This book was released on 1987 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Calcium-binding Proteins in Normal and Transformed Cells

Author: C. W. Heizmann

Publisher:

Published: 1994

Total Pages: 102

ISBN-13:

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Book Synopsis Calcium-binding Proteins in Normal and Transformed Cells by : C. W. Heizmann

Download or read book Calcium-binding Proteins in Normal and Transformed Cells written by C. W. Heizmann and published by . This book was released on 1994 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Calcium-Binding Protein Protocols

Author: Hans J. Vogel

Publisher: Springer Science & Business Media

Published: 2008-02-04

Total Pages: 346

ISBN-13: 1592591833

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Calcium plays an important role in a wide variety of biological processes. This divalent metal ion can bind to a large number of proteins; by doing so it modifies their biological activity or their stability. Because of its distinct che- cal properties calcium is uniquely suited to act as an on–off switch or as a light dimmer of biological activities. The two books entitled Calcium-Binding Protein Protocols (Volumes I and II) focus on modern experimental analyses and methodologies for the study of calcium-binding proteins. Both extracel- lar and intracellular calcium-binding proteins are discussed in detail. H- ever, proteins involved in calcium handling (e. g. , calcium pumps and calcium channels), fall outside of the scope of these two volumes. Also, calcium-bi- ing proteins involved in bone deposition will not be discussed, as this specific topic has been addressed previously. The focus of these two books is on studies of the calcium-binding proteins and their behavior in vitro and in vivo. The primary emphasis is on protein chemistry and biophysical methods. Many of the methods described will also be applicable to proteins that do not bind calcium. Calcium-Binding Protein Protocols is divided into three main sections. The section entitled Introduction and Reviews provides information on the role of calcium in intracellular secondary messenger activation mechanisms. Mo- over, unique aspects of calcium chemistry and the utilization of calcium in dairy proteins, as well as calcium-binding proteins involved in blood clotting, are addressed.

Book Synopsis Calcium-Binding Protein Protocols by : Hans J. Vogel

Download or read book Calcium-Binding Protein Protocols written by Hans J. Vogel and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium plays an important role in a wide variety of biological processes. This divalent metal ion can bind to a large number of proteins; by doing so it modifies their biological activity or their stability. Because of its distinct che- cal properties calcium is uniquely suited to act as an on–off switch or as a light dimmer of biological activities. The two books entitled Calcium-Binding Protein Protocols (Volumes I and II) focus on modern experimental analyses and methodologies for the study of calcium-binding proteins. Both extracel- lar and intracellular calcium-binding proteins are discussed in detail. H- ever, proteins involved in calcium handling (e. g. , calcium pumps and calcium channels), fall outside of the scope of these two volumes. Also, calcium-bi- ing proteins involved in bone deposition will not be discussed, as this specific topic has been addressed previously. The focus of these two books is on studies of the calcium-binding proteins and their behavior in vitro and in vivo. The primary emphasis is on protein chemistry and biophysical methods. Many of the methods described will also be applicable to proteins that do not bind calcium. Calcium-Binding Protein Protocols is divided into three main sections. The section entitled Introduction and Reviews provides information on the role of calcium in intracellular secondary messenger activation mechanisms. Mo- over, unique aspects of calcium chemistry and the utilization of calcium in dairy proteins, as well as calcium-binding proteins involved in blood clotting, are addressed.

Calcium Binding Proteins

Author: Eugene Permyakov

Publisher: John Wiley & Sons

Published: 2011-03-21

Total Pages: 456

ISBN-13: 1118099540

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Calcium Binding Proteins explains the unique and highly diverse functions of calcium in biology, which are realized by calcium binding proteins. The structures and physical characteristics of these calcium binding proteins are described, as well as their functions and general patterns of their evolution. Techniques that underlie the description of proteins are discussed, including NMR, circular dichroism, optical rotatory dispersion spectroscopy, calorimetry,and crystallography. The book discusses the patterns of bochmical phenomena such as calcium homeostasis, mineralization, and cell signaling that involve specific proteins. It summarizes ongoing research and presents general hypotheses that help to focus future research, and also provides a conceptual framework and a description of the underlying techniques that permits someone entering the field to become conversant.

Book Synopsis Calcium Binding Proteins by : Eugene Permyakov

Download or read book Calcium Binding Proteins written by Eugene Permyakov and published by John Wiley & Sons. This book was released on 2011-03-21 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium Binding Proteins explains the unique and highly diverse functions of calcium in biology, which are realized by calcium binding proteins. The structures and physical characteristics of these calcium binding proteins are described, as well as their functions and general patterns of their evolution. Techniques that underlie the description of proteins are discussed, including NMR, circular dichroism, optical rotatory dispersion spectroscopy, calorimetry,and crystallography. The book discusses the patterns of bochmical phenomena such as calcium homeostasis, mineralization, and cell signaling that involve specific proteins. It summarizes ongoing research and presents general hypotheses that help to focus future research, and also provides a conceptual framework and a description of the underlying techniques that permits someone entering the field to become conversant.

Calcium-Binding Protein Protocols

Author: Hans J. Vogel

Publisher: Springer Science & Business Media

Published: 2008-02-05

Total Pages: 415

ISBN-13: 1592591841

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Book Synopsis Calcium-Binding Protein Protocols by : Hans J. Vogel

Download or read book Calcium-Binding Protein Protocols written by Hans J. Vogel and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium plays an important role in a wide variety of biological processes. This divalent metal ion can bind to a large number of proteins; by doing so it modifies their biological activity or their stability. Because of its distinct che- cal properties calcium is uniquely suited to act as an on–off switch or as a light dimmer of biological activities. The two books entitled Calcium-Binding Protein Protocols (Volumes I and II) focus on modern experimental analyses and methodologies for the study of calcium-binding proteins. Both extracel- lar and intracellular calcium-binding proteins are discussed in detail. H- ever, proteins involved in calcium handling (e. g. , calcium pumps and calcium channels), fall outside of the scope of these two volumes. Also, calcium-bi- ing proteins involved in bone deposition will not be discussed, as this specific topic has been addressed previously. The focus of these two books is on studies of the calcium-binding proteins and their behavior in vitro and in vivo. The primary emphasis is on protein chemistry and biophysical methods. Many of the methods described will also be applicable to proteins that do not bind calcium. Calcium-Binding Protein Protocols is divided into three main sections. The section entitled Introduction and Reviews provides information on the role of calcium in intracellular secondary messenger activation mechanisms. Mo- over, unique aspects of calcium chemistry and the utilization of calcium in dairy proteins, as well as calcium-binding proteins involved in blood clotting, are addressed.

Calcium and Calcium Binding Proteins

Author: Charles Gerday

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 265

ISBN-13: 3642730426

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The idea of Professors Bolis and Gilles to gather together for a 3 days' meeting in the splendid environment of Crans-Montana in Switzerland a limited number of people around the subject of calcium and calcium bind ing proteins seemed at first particularly attractive, and when they asked me to take charge of the scientific organization of the symposium, I accepted with enthusiasm. It rapidly became clear that the major problem would be the selection of the topics, since it was impossible to cover completely and in depth such a broad and dynamic area of research. In our view, one imperative was to associate as intimately as possible the structural and the functional aspects of the areas covered. Apart from one whole day focused on the fascinating roles played by calmodulin in cellular activities, the other sessions were devoted to calmodulin-related calcium binding proteins in muscle and non muscle tissues and to some selected biological systems such as mitochondria, secretory cells or sarcoplasmic reticulum in which calcium also plays a crucial role. The presentations were made by leading investigators in their field. Some of them do not, however, appear in the present volume, for which there are two reasons: first, some of the contributions were somewhat outside the scope of the book; second, three speakers, for valid reasons, simply found no opportunity to write a manuscript in the allotted time.

Book Synopsis Calcium and Calcium Binding Proteins by : Charles Gerday

Download or read book Calcium and Calcium Binding Proteins written by Charles Gerday and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: The idea of Professors Bolis and Gilles to gather together for a 3 days' meeting in the splendid environment of Crans-Montana in Switzerland a limited number of people around the subject of calcium and calcium bind ing proteins seemed at first particularly attractive, and when they asked me to take charge of the scientific organization of the symposium, I accepted with enthusiasm. It rapidly became clear that the major problem would be the selection of the topics, since it was impossible to cover completely and in depth such a broad and dynamic area of research. In our view, one imperative was to associate as intimately as possible the structural and the functional aspects of the areas covered. Apart from one whole day focused on the fascinating roles played by calmodulin in cellular activities, the other sessions were devoted to calmodulin-related calcium binding proteins in muscle and non muscle tissues and to some selected biological systems such as mitochondria, secretory cells or sarcoplasmic reticulum in which calcium also plays a crucial role. The presentations were made by leading investigators in their field. Some of them do not, however, appear in the present volume, for which there are two reasons: first, some of the contributions were somewhat outside the scope of the book; second, three speakers, for valid reasons, simply found no opportunity to write a manuscript in the allotted time.

Calcium Regulation by Calcium-Binding Proteins in Neurodegenerative Disorders

Author: Claus W. Heizmann

Publisher: Springer Science & Business Media

Published: 2013-06-29

Total Pages: 167

ISBN-13: 3662216892

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This book summarizes the recent advances in the knowledge of the structure and physiological functions of the calcium-binding proteins in the central nervous system, describes their cellular distribution and developmental appearance, and discusses their possible association with neurodegenerative disorders and their use as diagnostic tools. This is the first book describing the structure, localization, and functions of calcium-binding proteins in the central nervous system and their involvement in neurodegenerative disorders. It is of great value to neurobiologists, clinicians, pharmacologists, biochemists and molecular biologists.

Book Synopsis Calcium Regulation by Calcium-Binding Proteins in Neurodegenerative Disorders by : Claus W. Heizmann

Download or read book Calcium Regulation by Calcium-Binding Proteins in Neurodegenerative Disorders written by Claus W. Heizmann and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the recent advances in the knowledge of the structure and physiological functions of the calcium-binding proteins in the central nervous system, describes their cellular distribution and developmental appearance, and discusses their possible association with neurodegenerative disorders and their use as diagnostic tools. This is the first book describing the structure, localization, and functions of calcium-binding proteins in the central nervous system and their involvement in neurodegenerative disorders. It is of great value to neurobiologists, clinicians, pharmacologists, biochemists and molecular biologists.