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Novel Therapeutic Approaches to the Treatment of Parkinson’s Disease

Author: Corey R. Hopkins

Publisher: Springer

Published: 2016-06-23

Total Pages: 158

ISBN-13: 3319399268

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Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Book Synopsis Novel Therapeutic Approaches to the Treatment of Parkinson’s Disease by : Corey R. Hopkins

Download or read book Novel Therapeutic Approaches to the Treatment of Parkinson’s Disease written by Corey R. Hopkins and published by Springer. This book was released on 2016-06-23 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Diagnosis and Treatment of Parkinson’s Disease — State of the Art

Author: Horst Przuntek

Publisher: Springer Science & Business Media

Published: 2013-12-01

Total Pages: 222

ISBN-13: 3709163609

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Expert clinicians and basic scientists with a special interest in Parkinson’s disease review the current state of science and clinical therapeutics of the disease. Therefore these articles represent an authorative review of the current state of knowledge regarding preclinical course and symptomatology, subtypes with their impact on the pathology, genetic alterations, novel mechanisms of neuronal cell death, diagnostic tools and old and novel therapeutic approaches with respect to neuroprotection and neuroregeneration in Parkinson’s disease. Particular emphasis has been placed on a novel antiparkinsonian drug called budipine with various modes of action also influencing altered non dopaminergic systems in Parkinson’s disease. It is evident, that many questions on the cause, course and treatment of Parkinson’s disease are still unanswered and therefore the ideal way to treat a parkinsonian patient remains to be defined.

Book Synopsis Diagnosis and Treatment of Parkinson’s Disease — State of the Art by : Horst Przuntek

Download or read book Diagnosis and Treatment of Parkinson’s Disease — State of the Art written by Horst Przuntek and published by Springer Science & Business Media. This book was released on 2013-12-01 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert clinicians and basic scientists with a special interest in Parkinson’s disease review the current state of science and clinical therapeutics of the disease. Therefore these articles represent an authorative review of the current state of knowledge regarding preclinical course and symptomatology, subtypes with their impact on the pathology, genetic alterations, novel mechanisms of neuronal cell death, diagnostic tools and old and novel therapeutic approaches with respect to neuroprotection and neuroregeneration in Parkinson’s disease. Particular emphasis has been placed on a novel antiparkinsonian drug called budipine with various modes of action also influencing altered non dopaminergic systems in Parkinson’s disease. It is evident, that many questions on the cause, course and treatment of Parkinson’s disease are still unanswered and therefore the ideal way to treat a parkinsonian patient remains to be defined.

Novel Therapeutic Strategies for the Treatment of Parkinson's Disease

Author: Stephen J. Crocker

Publisher:

Published: 2000

Total Pages: 0

ISBN-13:

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Book Synopsis Novel Therapeutic Strategies for the Treatment of Parkinson's Disease by : Stephen J. Crocker

Download or read book Novel Therapeutic Strategies for the Treatment of Parkinson's Disease written by Stephen J. Crocker and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Novel Therapeutic Approaches Targeting Oxidative Stress

Author: Pawan Kumar Maurya

Publisher: Academic Press

Published: 2022-02-18

Total Pages: 294

ISBN-13: 032390906X

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Novel Therapeutic Approaches Targeting Oxidative Stress investigates the role of oxidative stress in disease and explores the latest methods and approaches to targeting oxidative stress for treatment and diagnosis. The book begins with an introduction to oxidative stress and its significance. Subsequent sections cover biochemical methods for detecting free radicals and novel therapeutic approaches for targeting oxidative stress in a number of different diseases. This includes age-related illnesses, neuropsychiatric disorders such as schizophrenia and bipolar disorder, and neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. Novel approaches for targeting oxidative stress in cancer and cardiovascular diseases are also explored. The book then moves on to discuss advances in drug delivery systems and detecting oxidative stress biomarkers using biosensors. It concludes with case studies that illustrate the targeting of oxidative stress and future perspectives. Explores oxidative stress in a variety of diseases, including neurological disorders, cardiovascular diseases, age-related diseases, and cancer Covers a range of therapeutic approaches to target oxidative stress Includes chapters on the application of novel drug delivery systems and diagnostic biosensors to oxidative stress Features case studies illustrating the targeting of oxidative stress

Book Synopsis Novel Therapeutic Approaches Targeting Oxidative Stress by : Pawan Kumar Maurya

Download or read book Novel Therapeutic Approaches Targeting Oxidative Stress written by Pawan Kumar Maurya and published by Academic Press. This book was released on 2022-02-18 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel Therapeutic Approaches Targeting Oxidative Stress investigates the role of oxidative stress in disease and explores the latest methods and approaches to targeting oxidative stress for treatment and diagnosis. The book begins with an introduction to oxidative stress and its significance. Subsequent sections cover biochemical methods for detecting free radicals and novel therapeutic approaches for targeting oxidative stress in a number of different diseases. This includes age-related illnesses, neuropsychiatric disorders such as schizophrenia and bipolar disorder, and neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. Novel approaches for targeting oxidative stress in cancer and cardiovascular diseases are also explored. The book then moves on to discuss advances in drug delivery systems and detecting oxidative stress biomarkers using biosensors. It concludes with case studies that illustrate the targeting of oxidative stress and future perspectives. Explores oxidative stress in a variety of diseases, including neurological disorders, cardiovascular diseases, age-related diseases, and cancer Covers a range of therapeutic approaches to target oxidative stress Includes chapters on the application of novel drug delivery systems and diagnostic biosensors to oxidative stress Features case studies illustrating the targeting of oxidative stress

Uncovering the Mechanism of Action of a Novel Therapeutic Compound for the Treatment of Parkinson's Disease

Author: Rachel Mary Hughes

Publisher:

Published: 2022

Total Pages: 0

ISBN-13:

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Book Synopsis Uncovering the Mechanism of Action of a Novel Therapeutic Compound for the Treatment of Parkinson's Disease by : Rachel Mary Hughes

Download or read book Uncovering the Mechanism of Action of a Novel Therapeutic Compound for the Treatment of Parkinson's Disease written by Rachel Mary Hughes and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Deprenyl - Past and Future

Author: Wilfried Kuhn

Publisher:

Published: 2014-01-15

Total Pages: 130

ISBN-13: 9783709174951

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Book Synopsis Deprenyl - Past and Future by : Wilfried Kuhn

Download or read book Deprenyl - Past and Future written by Wilfried Kuhn and published by . This book was released on 2014-01-15 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Novel Therapeutic Approaches for the Treatment of Ocular Disease, Volume I

Author: Kyriaki Thermos

Publisher: Frontiers Media SA

Published: 2022-07-27

Total Pages: 180

ISBN-13: 2889766284

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Book Synopsis Novel Therapeutic Approaches for the Treatment of Ocular Disease, Volume I by : Kyriaki Thermos

Download or read book Novel Therapeutic Approaches for the Treatment of Ocular Disease, Volume I written by Kyriaki Thermos and published by Frontiers Media SA. This book was released on 2022-07-27 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Breakthroughs in Parkinsons Therapy

Author: Karen Brach

Publisher: Independently Published

Published: 2024-03-20

Total Pages: 0

ISBN-13:

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Breakthroughs in Parkinson's Therapy: Neurodegenerative Insights and Treatment Strategies" emerges as an essential guide for countless individuals navigating the complexities of Parkinson's disease (PD), offering a beacon of hope through innovative therapy options and groundbreaking research insights.At the heart of this transformative work is an exploration of the latest advancements in Parkinson's therapy, including cutting-edge neurodegenerative insights and treatment strategies that have shown significant promise in altering the disease's trajectory. Despite these advances, there remains a critical gap in awareness and application among healthcare professionals, leaving many patients without access to potentially life-changing treatments. Designed with both individuals living with Parkinson's and their healthcare providers in mind, this book delves deep into the scientific underpinnings of novel therapeutic approaches. It presents a comprehensive overview of the current research landscape, exploring the mechanisms through which these new treatments exert their effects on the brain and offering a clear protocol for those interested in integrating these strategies into their care regimen. The urgency for neurologists, general practitioners, and Parkinson's specialists to familiarize themselves with these emerging therapies cannot be overstated. With Parkinson's disease continuing to challenge those it affects, the introduction of immediate, accessible, and innovative treatment options represents a pivotal shift towards improving the quality of life for many. Following the legacy of pioneers who have pushed the boundaries of Parkinson's research and treatment, "Breakthroughs in Parkinson's Therapy" not only sheds light on their groundbreaking work but also calls upon the medical community to embrace and further investigate these novel strategies. It underscores the necessity for ongoing research and funding to bring these therapies from the fringes of experimental medicine to the forefront of mainstream clinical practice. In a landscape yearning for hope and substantive progress, this book stands as a testament to the resilience of those affected by Parkinson's and the relentless pursuit of a future where managing and overcoming this neurodegenerative disease is within reach.

Book Synopsis Breakthroughs in Parkinsons Therapy by : Karen Brach

Download or read book Breakthroughs in Parkinsons Therapy written by Karen Brach and published by Independently Published. This book was released on 2024-03-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breakthroughs in Parkinson's Therapy: Neurodegenerative Insights and Treatment Strategies" emerges as an essential guide for countless individuals navigating the complexities of Parkinson's disease (PD), offering a beacon of hope through innovative therapy options and groundbreaking research insights.At the heart of this transformative work is an exploration of the latest advancements in Parkinson's therapy, including cutting-edge neurodegenerative insights and treatment strategies that have shown significant promise in altering the disease's trajectory. Despite these advances, there remains a critical gap in awareness and application among healthcare professionals, leaving many patients without access to potentially life-changing treatments. Designed with both individuals living with Parkinson's and their healthcare providers in mind, this book delves deep into the scientific underpinnings of novel therapeutic approaches. It presents a comprehensive overview of the current research landscape, exploring the mechanisms through which these new treatments exert their effects on the brain and offering a clear protocol for those interested in integrating these strategies into their care regimen. The urgency for neurologists, general practitioners, and Parkinson's specialists to familiarize themselves with these emerging therapies cannot be overstated. With Parkinson's disease continuing to challenge those it affects, the introduction of immediate, accessible, and innovative treatment options represents a pivotal shift towards improving the quality of life for many. Following the legacy of pioneers who have pushed the boundaries of Parkinson's research and treatment, "Breakthroughs in Parkinson's Therapy" not only sheds light on their groundbreaking work but also calls upon the medical community to embrace and further investigate these novel strategies. It underscores the necessity for ongoing research and funding to bring these therapies from the fringes of experimental medicine to the forefront of mainstream clinical practice. In a landscape yearning for hope and substantive progress, this book stands as a testament to the resilience of those affected by Parkinson's and the relentless pursuit of a future where managing and overcoming this neurodegenerative disease is within reach.

Approaches in the Treatment of Parkinson's Disease

Author: Tareq Al-maqtari

Publisher:

Published: 2012

Total Pages: 152

ISBN-13:

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Parkinson's disease (PD) is a hypokinetic movement disorder resulting from the progressive neurodegeneration of the dopaminergic nigrostriatal system in the brain and the resulting imbalance between dopamine and acetylcholine in the basal ganglia motor circuitry. Although drug-based therapy approaches have shown dramatic symptomatic improvement in patients, they do not halt the progressive nature of the disease and their long-term use is associated with distressing adverse side effects. Consequently, several studies have aimed at discovering effective non-pharmacological strategies to reduce or to eliminate the need for drugs and possibly to halt or to reverse the neurodegenerative process in PD. Surgical deep brain stimulation, neurotrophic factor delivery, gene therapy and cell replacement therapy are potential candidates. Here, we review the latest advancements in the aforementioned therapeutic strategies paying special attention to regenerative stem cell- (SC)-based approaches in combating PD. Although intracerebrally transplanted SC-derived cells can replace degenerated neurons in PD and simultaneously secrete neurotrophic factors that can partly protect the viable ones, potential tumorigenicity and low survivability of these cells hinder the advancement of this novel therapeutic approach. Hence, more investigations are needed to resolve the associated safety and efficacy concerns in order to make SC-based therapy a feasible therapy for PD patients.

Book Synopsis Approaches in the Treatment of Parkinson's Disease by : Tareq Al-maqtari

Download or read book Approaches in the Treatment of Parkinson's Disease written by Tareq Al-maqtari and published by . This book was released on 2012 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson's disease (PD) is a hypokinetic movement disorder resulting from the progressive neurodegeneration of the dopaminergic nigrostriatal system in the brain and the resulting imbalance between dopamine and acetylcholine in the basal ganglia motor circuitry. Although drug-based therapy approaches have shown dramatic symptomatic improvement in patients, they do not halt the progressive nature of the disease and their long-term use is associated with distressing adverse side effects. Consequently, several studies have aimed at discovering effective non-pharmacological strategies to reduce or to eliminate the need for drugs and possibly to halt or to reverse the neurodegenerative process in PD. Surgical deep brain stimulation, neurotrophic factor delivery, gene therapy and cell replacement therapy are potential candidates. Here, we review the latest advancements in the aforementioned therapeutic strategies paying special attention to regenerative stem cell- (SC)-based approaches in combating PD. Although intracerebrally transplanted SC-derived cells can replace degenerated neurons in PD and simultaneously secrete neurotrophic factors that can partly protect the viable ones, potential tumorigenicity and low survivability of these cells hinder the advancement of this novel therapeutic approach. Hence, more investigations are needed to resolve the associated safety and efficacy concerns in order to make SC-based therapy a feasible therapy for PD patients.

Parkinson's Disease

Author: Ronald F. Pfeiffer

Publisher: CRC Press

Published: 2004-12-28

Total Pages: 1088

ISBN-13: 9780849315909

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Recent research is leading to an ever-increasing range of investigative approaches whose aim is to achieve effective neuroprotective or neurorestorative treatment for individuals affected by Parkinson’s disease. New directions under investigation reach beyond traditional pharmacological approaches to venture into innovative surgical methods, gene therapy, stem cell therapy, and neurotransplantation. In this comprehensive volume, leading medical authorities provide state-of-the-art information on all aspects of Parkinson’s disease. They cover the historical background, neuropathological and neurophysiological characteristics, epidemiological aspects, clinical features, current treatment approaches, and potential therapeutic methods. Novel models are included to simplify more complex concepts.

Book Synopsis Parkinson's Disease by : Ronald F. Pfeiffer

Download or read book Parkinson's Disease written by Ronald F. Pfeiffer and published by CRC Press. This book was released on 2004-12-28 with total page 1088 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent research is leading to an ever-increasing range of investigative approaches whose aim is to achieve effective neuroprotective or neurorestorative treatment for individuals affected by Parkinson’s disease. New directions under investigation reach beyond traditional pharmacological approaches to venture into innovative surgical methods, gene therapy, stem cell therapy, and neurotransplantation. In this comprehensive volume, leading medical authorities provide state-of-the-art information on all aspects of Parkinson’s disease. They cover the historical background, neuropathological and neurophysiological characteristics, epidemiological aspects, clinical features, current treatment approaches, and potential therapeutic methods. Novel models are included to simplify more complex concepts.