Obesity, Diabetes and Inflammation

Obesity, Diabetes and Inflammation

Author: Dimiter Avtanski

Publisher: Springer Nature

Published: 2023-09-26

Total Pages: 236

ISBN-13: 3031397215

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Obesity is a worldwide epidemic that affects half a billion people. It has been estimated that, if current trends continue, by 2050, 60% of men and 50% of women worldwide will be obese. Hypertrophy and hyperplasia of white adipose tissue caused by overweight and obesity lead to a chronic inflammatory state, which results in impaired insulin sensitivity and the development of diabetes. Currently, the number of people affected by diabetes globally exceeds 400 million (rising more rapidly in low- and middle-income countries). In 2019, diabetes was the ninth leading cause of mortality, with an estimated 1.5 million direct deaths. This book provides a comprehensive overview of the relationship between inflammation, obesity, and diabetes. It focuses on the pathogenesis and biological mechanisms of obesity, the interaction between adipose tissue and the immune system, the role of genetic and environmental factors, the progression of cardiovascular complications, and the association of obesity and inflammation with type 1 and type 2 diabetes, as well as gestational diabetes. This volume also includes practical recommendations for preventing and managing these conditions using both lifestyle modifications and pharmacological interventions. Written by experts in the field, Obesity, Diabetes and Inflammation: Molecular Mechanisms and Clinical Management addresses the role of inflammation in both obesity and diabetes, its effect on vascular and non-vascular pathologies, oxidative stress, genetics, and epigenetics. This text aims to be a valuable resource for researchers, clinicians, and students of medicine at all levels.


Book Synopsis Obesity, Diabetes and Inflammation by : Dimiter Avtanski

Download or read book Obesity, Diabetes and Inflammation written by Dimiter Avtanski and published by Springer Nature. This book was released on 2023-09-26 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Obesity is a worldwide epidemic that affects half a billion people. It has been estimated that, if current trends continue, by 2050, 60% of men and 50% of women worldwide will be obese. Hypertrophy and hyperplasia of white adipose tissue caused by overweight and obesity lead to a chronic inflammatory state, which results in impaired insulin sensitivity and the development of diabetes. Currently, the number of people affected by diabetes globally exceeds 400 million (rising more rapidly in low- and middle-income countries). In 2019, diabetes was the ninth leading cause of mortality, with an estimated 1.5 million direct deaths. This book provides a comprehensive overview of the relationship between inflammation, obesity, and diabetes. It focuses on the pathogenesis and biological mechanisms of obesity, the interaction between adipose tissue and the immune system, the role of genetic and environmental factors, the progression of cardiovascular complications, and the association of obesity and inflammation with type 1 and type 2 diabetes, as well as gestational diabetes. This volume also includes practical recommendations for preventing and managing these conditions using both lifestyle modifications and pharmacological interventions. Written by experts in the field, Obesity, Diabetes and Inflammation: Molecular Mechanisms and Clinical Management addresses the role of inflammation in both obesity and diabetes, its effect on vascular and non-vascular pathologies, oxidative stress, genetics, and epigenetics. This text aims to be a valuable resource for researchers, clinicians, and students of medicine at all levels.


Oxidative Stress and Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome

Oxidative Stress and Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome

Author: Helmut Sies

Publisher: CRC Press

Published: 2007-07-27

Total Pages: 346

ISBN-13: 142004379X

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Characterized by obesity, insulin resistance, dyslipidemia, and hypertension, metabolic syndrome is associated with the risks of type 2 diabetes mellitus and cardiovascular disease. Obesity, which increases the incidence of atherosclerotic cardiovascular disease and subsequently leads to increased stress and inflammation, appears to play a central


Book Synopsis Oxidative Stress and Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome by : Helmut Sies

Download or read book Oxidative Stress and Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome written by Helmut Sies and published by CRC Press. This book was released on 2007-07-27 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Characterized by obesity, insulin resistance, dyslipidemia, and hypertension, metabolic syndrome is associated with the risks of type 2 diabetes mellitus and cardiovascular disease. Obesity, which increases the incidence of atherosclerotic cardiovascular disease and subsequently leads to increased stress and inflammation, appears to play a central


Obesity-induced inflammation and insulin resistance

Obesity-induced inflammation and insulin resistance

Author: Tsuguhito Ota

Publisher: Frontiers Media SA

Published: 2015-03-26

Total Pages: 121

ISBN-13: 2889194280

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Immune response and metabolic regulation are highly integrated and this interface maintains a central homeostatic system, dysfunction of which can cause obesity-associated metabolic disorder such as type 2 diabetes, fatty liver disease and cardiovascular disease. Insulin resistance is an underlying basis for the pathogenesis of these metabolic diseases. Overnutrition or obesity activates the innate immune system with subsequent recruitment of immune cells such as macrophages and T cells, which contributes to the development of insulin resistance. In particular, a significant advance in our understanding of obesity-associated inflammation and insulin resistance has been recognition of the critical role of adipose tissue macrophages (ATMs). ATMs are a prominent source of proinflammatory cytokines, such as TNF-a and IL-6, that can block insulin action in adipose tissue, skeletal muscle, and liver autocrine/paracrine signaling and cause systemic insulin resistance via endocrine signaling, providing a potential link between inflammation and insulin resistance. All articles in this topic highlight the interconnection between obesity, inflammation, and insulin resistance in all its diversity to the mechanisms of obesity-induced inflammation and role of immune system in the pathogenesis of insulin resistance and diabetes.


Book Synopsis Obesity-induced inflammation and insulin resistance by : Tsuguhito Ota

Download or read book Obesity-induced inflammation and insulin resistance written by Tsuguhito Ota and published by Frontiers Media SA. This book was released on 2015-03-26 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immune response and metabolic regulation are highly integrated and this interface maintains a central homeostatic system, dysfunction of which can cause obesity-associated metabolic disorder such as type 2 diabetes, fatty liver disease and cardiovascular disease. Insulin resistance is an underlying basis for the pathogenesis of these metabolic diseases. Overnutrition or obesity activates the innate immune system with subsequent recruitment of immune cells such as macrophages and T cells, which contributes to the development of insulin resistance. In particular, a significant advance in our understanding of obesity-associated inflammation and insulin resistance has been recognition of the critical role of adipose tissue macrophages (ATMs). ATMs are a prominent source of proinflammatory cytokines, such as TNF-a and IL-6, that can block insulin action in adipose tissue, skeletal muscle, and liver autocrine/paracrine signaling and cause systemic insulin resistance via endocrine signaling, providing a potential link between inflammation and insulin resistance. All articles in this topic highlight the interconnection between obesity, inflammation, and insulin resistance in all its diversity to the mechanisms of obesity-induced inflammation and role of immune system in the pathogenesis of insulin resistance and diabetes.


Meta-Inflammation and Obesity

Meta-Inflammation and Obesity

Author: Asija Začiragić

Publisher: Bentham Science Publishers

Published: 2020-10-29

Total Pages: 224

ISBN-13: 9811479631

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For decades, scientific efforts have been made to understand obesity and related diseases such as type 2 diabetes and neurodegeneration, and their link with meta-inflammation. Adipose tissue is, at present, viewed as an endocrine organ with important biological effects on metabolism and inflammation, with a possible role in the pathogenesis of obesity-associated metabolic and inflammatory diseases. Chronic systemic low-grade inflammation has gained significant attention as the key player in the pathophysiology of obesity- and aging-associated diseases. Keeping view of this trend, Meta-Inflammation and Obesity offers readers state-of-the-art knowledge on this subject. Chapters cover special topics such as gender differences in obesity-related type 2 diabetes as the consequence of inflammatory response, insights into metabolic changes caused by excessive adipose tissue (which lead to abnormal brain metabolism, neuroinflammation, cognitive decline, development of type 3 diabetes), and the importance of inflammaging in the aging process. Graduate, postgraduate and Ph. D. candidates in medicine, pharmacy, and students of applied medicine, health care professionals as well as scientists involved in adipose tissue research, meta-inflammation analysis, obesity-related medical specialties will find this book a useful reference on the link between inflammation and obesity.


Book Synopsis Meta-Inflammation and Obesity by : Asija Začiragić

Download or read book Meta-Inflammation and Obesity written by Asija Začiragić and published by Bentham Science Publishers. This book was released on 2020-10-29 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: For decades, scientific efforts have been made to understand obesity and related diseases such as type 2 diabetes and neurodegeneration, and their link with meta-inflammation. Adipose tissue is, at present, viewed as an endocrine organ with important biological effects on metabolism and inflammation, with a possible role in the pathogenesis of obesity-associated metabolic and inflammatory diseases. Chronic systemic low-grade inflammation has gained significant attention as the key player in the pathophysiology of obesity- and aging-associated diseases. Keeping view of this trend, Meta-Inflammation and Obesity offers readers state-of-the-art knowledge on this subject. Chapters cover special topics such as gender differences in obesity-related type 2 diabetes as the consequence of inflammatory response, insights into metabolic changes caused by excessive adipose tissue (which lead to abnormal brain metabolism, neuroinflammation, cognitive decline, development of type 3 diabetes), and the importance of inflammaging in the aging process. Graduate, postgraduate and Ph. D. candidates in medicine, pharmacy, and students of applied medicine, health care professionals as well as scientists involved in adipose tissue research, meta-inflammation analysis, obesity-related medical specialties will find this book a useful reference on the link between inflammation and obesity.


Obesity and Diabetes: Implications for Brain-Immunometabolism

Obesity and Diabetes: Implications for Brain-Immunometabolism

Author: Joana M. Gaspar

Publisher: Frontiers Media SA

Published: 2020-03-16

Total Pages: 204

ISBN-13: 2889635856

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Book Synopsis Obesity and Diabetes: Implications for Brain-Immunometabolism by : Joana M. Gaspar

Download or read book Obesity and Diabetes: Implications for Brain-Immunometabolism written by Joana M. Gaspar and published by Frontiers Media SA. This book was released on 2020-03-16 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt:


Effects of Obesity-induced Inflammation on Diabetes Mellitus

Effects of Obesity-induced Inflammation on Diabetes Mellitus

Author: Edwin Josef Petrus Asseldonk

Publisher:

Published: 2016

Total Pages:

ISBN-13: 9789402803198

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Book Synopsis Effects of Obesity-induced Inflammation on Diabetes Mellitus by : Edwin Josef Petrus Asseldonk

Download or read book Effects of Obesity-induced Inflammation on Diabetes Mellitus written by Edwin Josef Petrus Asseldonk and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:


Adipose Tissue and Inflammation

Adipose Tissue and Inflammation

Author: Atif B. Awad

Publisher: CRC Press

Published: 2009-10-08

Total Pages: 0

ISBN-13: 9781420091304

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The American Obesity Association identifies obesity’s link to numerous medical conditions, including hypertension, type 2 diabetes, cardiovascular disease, several cancers, and a host of inflammatory disorders. Evidence indicates that inflammation has more than a corollary relation with obesity; that in fact, obesity itself manifests a low-grade, metabolically associated inflammation involving many of the same mediators associated with classic inflammation. Concurrent with our understanding, we have to recognize that more than a storage site for fat, adipose tissue itself is an essential endocrine organ that produces and secretes a host of hormones in response to varying physiologic and pathologic states. Bringing together the research and findings of leading experts from across the world, Adipose Tissue and Inflammation focuses on the contribution of adipose tissue to local and systemic inflammation. Demonstrating the endocrine like nature of adipose tissue, this book— Looks at the direct relation between adipokines and inflammation Examines the role of adipose secreted hormones as mediators of inflammation Details the inflammatory actions of adiponectin, leptin, and resistin Discusses insulin and dietary fatty acids as modulators of inflammation This book belongs to the groundbreaking CRC Press Series on Oxidative Stress and Disease. The series now includes more than two-dozen volumes that address the multiple ways that oxidative stress initiates and accelerates disease mechanisms. Most importantly, this book, like the series, offers invaluable information regarding nutritional and life style choices, and interventions that can be employed to prevent, control, and even ameliorate disease processes attributed to oxidative stress. While much of the information put forth on these pages is sobering, the authors also look at the anti-inflammatory properties of plant sterols and phytoestrogens and the role that antioxidants and polyphenols play in moderating adipose inflammation. Further research looks at the role of exercise and weight loss in reducing inflammation; and discusses pharmaceutical approaches to adipose tissue related-inflammation.


Book Synopsis Adipose Tissue and Inflammation by : Atif B. Awad

Download or read book Adipose Tissue and Inflammation written by Atif B. Awad and published by CRC Press. This book was released on 2009-10-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The American Obesity Association identifies obesity’s link to numerous medical conditions, including hypertension, type 2 diabetes, cardiovascular disease, several cancers, and a host of inflammatory disorders. Evidence indicates that inflammation has more than a corollary relation with obesity; that in fact, obesity itself manifests a low-grade, metabolically associated inflammation involving many of the same mediators associated with classic inflammation. Concurrent with our understanding, we have to recognize that more than a storage site for fat, adipose tissue itself is an essential endocrine organ that produces and secretes a host of hormones in response to varying physiologic and pathologic states. Bringing together the research and findings of leading experts from across the world, Adipose Tissue and Inflammation focuses on the contribution of adipose tissue to local and systemic inflammation. Demonstrating the endocrine like nature of adipose tissue, this book— Looks at the direct relation between adipokines and inflammation Examines the role of adipose secreted hormones as mediators of inflammation Details the inflammatory actions of adiponectin, leptin, and resistin Discusses insulin and dietary fatty acids as modulators of inflammation This book belongs to the groundbreaking CRC Press Series on Oxidative Stress and Disease. The series now includes more than two-dozen volumes that address the multiple ways that oxidative stress initiates and accelerates disease mechanisms. Most importantly, this book, like the series, offers invaluable information regarding nutritional and life style choices, and interventions that can be employed to prevent, control, and even ameliorate disease processes attributed to oxidative stress. While much of the information put forth on these pages is sobering, the authors also look at the anti-inflammatory properties of plant sterols and phytoestrogens and the role that antioxidants and polyphenols play in moderating adipose inflammation. Further research looks at the role of exercise and weight loss in reducing inflammation; and discusses pharmaceutical approaches to adipose tissue related-inflammation.


ABC of Obesity

ABC of Obesity

Author: Naveed Sattar

Publisher: John Wiley & Sons

Published: 2009-04-08

Total Pages: 64

ISBN-13: 1444312707

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Obesity is a hugely expensive and increasing problem worldwide,leading to disability, reproductive problems, depression andaccelerated metabolic and vascular diseases in a large proportionof men, women and children. The ABC of Obesity is a newguide which will aid its effective management, addressing issuessuch as dieting, exercise, self esteem, drug treatment and surgery.Recent evidence is used to highlight frequent problems, successfultreatment options, and the most common causes. Written by leading experts, this is a widely accessible text andan indispensable guide for all general practitioners, juniordoctors, nurses, and other healthcare professionals who areinvolved in the treatment and research of this commoncondition.


Book Synopsis ABC of Obesity by : Naveed Sattar

Download or read book ABC of Obesity written by Naveed Sattar and published by John Wiley & Sons. This book was released on 2009-04-08 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: Obesity is a hugely expensive and increasing problem worldwide,leading to disability, reproductive problems, depression andaccelerated metabolic and vascular diseases in a large proportionof men, women and children. The ABC of Obesity is a newguide which will aid its effective management, addressing issuessuch as dieting, exercise, self esteem, drug treatment and surgery.Recent evidence is used to highlight frequent problems, successfultreatment options, and the most common causes. Written by leading experts, this is a widely accessible text andan indispensable guide for all general practitioners, juniordoctors, nurses, and other healthcare professionals who areinvolved in the treatment and research of this commoncondition.


After the Rain

After the Rain

Author: David Dobson

Publisher: Xlibris Corporation

Published: 2014-05-30

Total Pages: 153

ISBN-13: 1493196502

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At the age of 38, two doctors told him that he would not see 40. Now, at the age of 45, David Dobson is in perfect health, overcoming 5 major diseases and is now enjoying a healthy and active lifestyle. Mr. Dobsons lighthearted personality and sense of humor shows as he explains how after many years of living with diabetes, sarcoidosis, lupus, obesity, and arthritis, his health turned around in a very short period of time, and now no longer has to rely on any medications. It is his hope that the millions of people that are suffering from any or all of these same diseases will be able to overcome them as well and live a fruitful and happy life. Throughout his entire life, David Dobson has had the privilege of traveling throughout the entire world. David graduated from the University of Texas at Arlington with a bachelors degree in Architecture and Urban Design in 1987. David was a paratrooper in the Army, earning his jump wings on his 30th birthday. David Dobson is an architect currently living in San Diego, California.


Book Synopsis After the Rain by : David Dobson

Download or read book After the Rain written by David Dobson and published by Xlibris Corporation. This book was released on 2014-05-30 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the age of 38, two doctors told him that he would not see 40. Now, at the age of 45, David Dobson is in perfect health, overcoming 5 major diseases and is now enjoying a healthy and active lifestyle. Mr. Dobsons lighthearted personality and sense of humor shows as he explains how after many years of living with diabetes, sarcoidosis, lupus, obesity, and arthritis, his health turned around in a very short period of time, and now no longer has to rely on any medications. It is his hope that the millions of people that are suffering from any or all of these same diseases will be able to overcome them as well and live a fruitful and happy life. Throughout his entire life, David Dobson has had the privilege of traveling throughout the entire world. David graduated from the University of Texas at Arlington with a bachelors degree in Architecture and Urban Design in 1987. David was a paratrooper in the Army, earning his jump wings on his 30th birthday. David Dobson is an architect currently living in San Diego, California.


Pathophysiology of Obesity-Induced Health Complications

Pathophysiology of Obesity-Induced Health Complications

Author: Paramjit S. Tappia

Publisher: Springer Nature

Published: 2020-01-17

Total Pages: 348

ISBN-13: 3030353583

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​According to the World Health Organization, the epidemic of global obesity has nearly tripled since 1975. In 2016, more than 1.9 billion adults were overweight, over 650 million of which were obese. Being overweight and obese has been linked to a number of non-communicable, chronic diseases. Pathophysiology of Obesity-Induced Health Complications is a compilation of review articles dedicated to describe co-morbidities associated with obesity. The wide range that is covered is of significant interest to basic research scientists, clinicians and graduate students who are engaged in studying obesity-induced health complications. Furthermore, this book highlights the potential of novel approaches for the prevention and treatment of obesity and its related illnesses. Nineteen articles in this book are organized in four sections that are designed to provide an overview of obesity-induced health complications. The first section serves as an introductory section on the prevalence, causes, consequences, treatments and preventive approaches for obesity. Section two covers the metabolic disturbances and inflammation due to obesity. The third section is focused on neurological and visceral complications as a consequence of obesity. The final section covers strategies for the prevention of obesity-induced complications. The book illustrates that obesity can result in a diverse range of pathophysiological conditions that adversely affect health.


Book Synopsis Pathophysiology of Obesity-Induced Health Complications by : Paramjit S. Tappia

Download or read book Pathophysiology of Obesity-Induced Health Complications written by Paramjit S. Tappia and published by Springer Nature. This book was released on 2020-01-17 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​According to the World Health Organization, the epidemic of global obesity has nearly tripled since 1975. In 2016, more than 1.9 billion adults were overweight, over 650 million of which were obese. Being overweight and obese has been linked to a number of non-communicable, chronic diseases. Pathophysiology of Obesity-Induced Health Complications is a compilation of review articles dedicated to describe co-morbidities associated with obesity. The wide range that is covered is of significant interest to basic research scientists, clinicians and graduate students who are engaged in studying obesity-induced health complications. Furthermore, this book highlights the potential of novel approaches for the prevention and treatment of obesity and its related illnesses. Nineteen articles in this book are organized in four sections that are designed to provide an overview of obesity-induced health complications. The first section serves as an introductory section on the prevalence, causes, consequences, treatments and preventive approaches for obesity. Section two covers the metabolic disturbances and inflammation due to obesity. The third section is focused on neurological and visceral complications as a consequence of obesity. The final section covers strategies for the prevention of obesity-induced complications. The book illustrates that obesity can result in a diverse range of pathophysiological conditions that adversely affect health.