Off Target

Off Target

Author: Eve Smith

Publisher: Orenda Books

Published: 2021-12-17

Total Pages: 363

ISBN-13: 1914585038

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When a one-night stand leads to a long-desired pregnancy, Susan will do anything to ensure her husband won't find out ... including the unthinkable. But when something horrendous is unleashed around the globe, her secret isn't the only thing that is no longer safe... –––––––––––––––––––––––– A longed-for baby An unthinkable decision A deadly mistake In an all-too-possible near future, when genetic engineering has become the norm for humans, not just crops, parents are prepared to take incalculable risks to ensure that their babies are perfect ... altering genes that may cause illness, and more... Susan has been trying for a baby for years, and when an impulsive one-night stand makes her dream come true, she'll do anything to keep her daughter and ensure her husband doesn't find out ... including the unthinkable. She believes her secret is safe. For now. But as governments embark on a perilous genetic arms race and children around the globe start experiencing a host of distressing symptoms – even taking their own lives – something truly horrendous is unleashed. Because those children have only one thing in common, and people are starting to ask questions... Bestselling author of The Waiting Rooms, Eve Smith returns with an authentic, startlingly thought-provoking, disturbing blockbuster of a thriller that provides a chilling glimpse of a future that's just one modification away... –––––––––––––––––––––––– Praise for The Waiting Rooms 'Combines the excitement of a medical thriller À la Michael Crichton with sensitive characterisation and social insight in a timely debut novel all the more remarkable for being conceived and written before the current pandemic' Guardian 'STUNNING and terrifying ... The Waiting Rooms wrenches your heart in every way possible, but written with such humanity and emotion' Miranda Dickinson 'Chillingly close to reality, this gripping thriller brims with authenticity ... a captivating, accomplished and timely debut from an author to watch' Adam Hamdy 'Engrossing and eye-opening, with heart-stopping plot twists ... a stunning medical thriller set in a terrifying possible future' Foreword Reviews 'A touching, gut-wrenching story of family mystery and tragedy ... a thriller that punches on two fronts – heart AND mind' The Sun 'Gripping and disturbing ... the medical research is convincing, the scenarios plausible, and the story is emotionally engaging. This is an incredible debut!' Gill Paul 'If the themes are dark and topical, the writing is exquisite. Breath held, I got to the finale with my heart in my mouth. Eve Smith weaves a complex and clever tale, merging countries and timelines; the result is a superb and satisfying novel' Louise Beech 'Margaret Atwood is one of my all-time writing heroes and The Handmaid's Tale is probably the best book I've ever read. Eve Smith and The Waiting Rooms really do challenge that long-held crown...' Random Things through My Letterbox 'Thoroughly engaging ... an eye-opening read’ Crime Fiction Lover ‘A novel of our times’ Trip Fiction ‘Haunting, honest and horrifying in its reality … An epic and thrilling read’ Book Literati


Book Synopsis Off Target by : Eve Smith

Download or read book Off Target written by Eve Smith and published by Orenda Books. This book was released on 2021-12-17 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: When a one-night stand leads to a long-desired pregnancy, Susan will do anything to ensure her husband won't find out ... including the unthinkable. But when something horrendous is unleashed around the globe, her secret isn't the only thing that is no longer safe... –––––––––––––––––––––––– A longed-for baby An unthinkable decision A deadly mistake In an all-too-possible near future, when genetic engineering has become the norm for humans, not just crops, parents are prepared to take incalculable risks to ensure that their babies are perfect ... altering genes that may cause illness, and more... Susan has been trying for a baby for years, and when an impulsive one-night stand makes her dream come true, she'll do anything to keep her daughter and ensure her husband doesn't find out ... including the unthinkable. She believes her secret is safe. For now. But as governments embark on a perilous genetic arms race and children around the globe start experiencing a host of distressing symptoms – even taking their own lives – something truly horrendous is unleashed. Because those children have only one thing in common, and people are starting to ask questions... Bestselling author of The Waiting Rooms, Eve Smith returns with an authentic, startlingly thought-provoking, disturbing blockbuster of a thriller that provides a chilling glimpse of a future that's just one modification away... –––––––––––––––––––––––– Praise for The Waiting Rooms 'Combines the excitement of a medical thriller À la Michael Crichton with sensitive characterisation and social insight in a timely debut novel all the more remarkable for being conceived and written before the current pandemic' Guardian 'STUNNING and terrifying ... The Waiting Rooms wrenches your heart in every way possible, but written with such humanity and emotion' Miranda Dickinson 'Chillingly close to reality, this gripping thriller brims with authenticity ... a captivating, accomplished and timely debut from an author to watch' Adam Hamdy 'Engrossing and eye-opening, with heart-stopping plot twists ... a stunning medical thriller set in a terrifying possible future' Foreword Reviews 'A touching, gut-wrenching story of family mystery and tragedy ... a thriller that punches on two fronts – heart AND mind' The Sun 'Gripping and disturbing ... the medical research is convincing, the scenarios plausible, and the story is emotionally engaging. This is an incredible debut!' Gill Paul 'If the themes are dark and topical, the writing is exquisite. Breath held, I got to the finale with my heart in my mouth. Eve Smith weaves a complex and clever tale, merging countries and timelines; the result is a superb and satisfying novel' Louise Beech 'Margaret Atwood is one of my all-time writing heroes and The Handmaid's Tale is probably the best book I've ever read. Eve Smith and The Waiting Rooms really do challenge that long-held crown...' Random Things through My Letterbox 'Thoroughly engaging ... an eye-opening read’ Crime Fiction Lover ‘A novel of our times’ Trip Fiction ‘Haunting, honest and horrifying in its reality … An epic and thrilling read’ Book Literati

Off Target

Off Target

Author: Jill Ammon Vanderwood

Publisher: Human Rights Watch

Published: 2019-01-28

Total Pages: 134

ISBN-13:

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What would you do if your friend showed you a gun?You are new in town and it's your first day at a new school. Your neighbor, Trevor introduces you to a group of three boys and two girls. Right away you notice that Eric, one of the guys in the group, is being bullied at school. When you go to Eric's house with your new friends, he shows the group a fully loaded handgun that is left in his mother's nightstand. You are faced with some hard choices when someone suggests that Eric should take the gun to school.___________________________________________What should you do? It's time to choose a path: If you're worried that Eric will take the gun to school-continue on page 7.If you decide to take the gun to prevent anyone from being hurt-continue on page 9.If you leave the house with the others and plan to come back for target practice the next day-continue on page 10.____________________________________________Off Target is the first book in The Path You Choose series. You, the reader determine the outcome by the choices you make. Once you read one story, go back and choose a different story. There are thirteen possible endings in this book.What path will you choose


Book Synopsis Off Target by : Jill Ammon Vanderwood

Download or read book Off Target written by Jill Ammon Vanderwood and published by Human Rights Watch. This book was released on 2019-01-28 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: What would you do if your friend showed you a gun?You are new in town and it's your first day at a new school. Your neighbor, Trevor introduces you to a group of three boys and two girls. Right away you notice that Eric, one of the guys in the group, is being bullied at school. When you go to Eric's house with your new friends, he shows the group a fully loaded handgun that is left in his mother's nightstand. You are faced with some hard choices when someone suggests that Eric should take the gun to school.___________________________________________What should you do? It's time to choose a path: If you're worried that Eric will take the gun to school-continue on page 7.If you decide to take the gun to prevent anyone from being hurt-continue on page 9.If you leave the house with the others and plan to come back for target practice the next day-continue on page 10.____________________________________________Off Target is the first book in The Path You Choose series. You, the reader determine the outcome by the choices you make. Once you read one story, go back and choose a different story. There are thirteen possible endings in this book.What path will you choose

The Waiting Rooms

The Waiting Rooms

Author: Eve Smith

Publisher: Orenda Books

Published: 2020-04-09

Total Pages: 400

ISBN-13: 1913193276

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Swinging from South Africa to England: one woman's hunt for her birth mother in an all-too-believable near future in which an antibiotic crisis has decimated the population. A prescient, thrilling debut. 'Combines the excitement of a medical thriller à la Michael Crichton with sensitive characterisation and social insight in a timely debut novel all the more remarkable for being conceived and written before the current pandemic' Guardian 'STUNNING and terrifying ... The Waiting Rooms wrenches your heart in every way possible, but written with such humanity and emotion' Miranda Dickinson 'Chillingly close to reality, this gripping thriller brims with authenticity ... a captivating, accomplished and timely debut from an author to watch' Adam Hamdy ________________ Decades of spiralling drug resistance have unleashed a global antibiotic crisis. Ordinary infections are untreatable, and a scratch from a pet can kill. A sacrifice is required to keep the majority safe: no one over seventy is allowed new antibiotics. The elderly are sent to hospitals nicknamed 'The Waiting Rooms' ... hospitals where no one ever gets well. Twenty years after the crisis takes hold, Kate begins a search for her birth mother, armed only with her name and her age. As Kate unearths disturbing facts about her mother's past, she puts her family in danger and risks losing everything. Because Kate is not the only secret that her mother is hiding. Someone else is looking for her, too. Sweeping from an all-too-real modern Britain to a pre-crisis South Africa, The Waiting Rooms is epic in scope, richly populated with unforgettable characters, and a tense, haunting vision of a future that is only a few mutations away. ________________ 'Engrossing and eye-opening, with heart-stopping plot twists ... a stunning medical thriller set in a terrifying possible future' Foreword Reviews 'A touching, gut-wrenching story of family mystery and tragedy ... a thriller that punches on two fronts – heart AND mind' The Sun 'Gripping and disturbing ... the medical research is convincing, the scenarios plausible, and the story is emotionally engaging. This is an incredible debut!' Gill Paul 'If the themes are dark and topical, the writing is exquisite. Breath held, I got to the finale with my heart in my mouth. Eve Smith weaves a complex and clever tale, merging countries and timelines; the result is a superb and satisfying novel' Louise Beech 'Margaret Atwood is one of my all-time writing heroes and The Handmaid's Tale is probably the best book I've ever read. Eve Smith and The Waiting Rooms really do challenge that long-held crown...' Random Things through My Letterbox 'Thoroughly engaging ... an eye-opening read' Crime Fiction Lover 'A novel of our times' Trip Fiction 'Haunting, honest and horrifying in its reality ... An epic and thrilling read' Book Literati 'Stunning dystopian debut. A prescient and alarming tale that seems just a whisper from reality' Suzy Apsley ' The Waiting Rooms will certainly distract us from the real world for a few hours and this is the immeasurable value of fiction. It gives hope that, as in Eve Smith's fictitious world, the possibility of a happy ending still exists' Die Burger ' The Waiting Rooms is a seriously impressive debut, a novel that is intuitive and chilling, one that will resonate with all in this current climate' Swirl & Thread


Book Synopsis The Waiting Rooms by : Eve Smith

Download or read book The Waiting Rooms written by Eve Smith and published by Orenda Books. This book was released on 2020-04-09 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Swinging from South Africa to England: one woman's hunt for her birth mother in an all-too-believable near future in which an antibiotic crisis has decimated the population. A prescient, thrilling debut. 'Combines the excitement of a medical thriller à la Michael Crichton with sensitive characterisation and social insight in a timely debut novel all the more remarkable for being conceived and written before the current pandemic' Guardian 'STUNNING and terrifying ... The Waiting Rooms wrenches your heart in every way possible, but written with such humanity and emotion' Miranda Dickinson 'Chillingly close to reality, this gripping thriller brims with authenticity ... a captivating, accomplished and timely debut from an author to watch' Adam Hamdy ________________ Decades of spiralling drug resistance have unleashed a global antibiotic crisis. Ordinary infections are untreatable, and a scratch from a pet can kill. A sacrifice is required to keep the majority safe: no one over seventy is allowed new antibiotics. The elderly are sent to hospitals nicknamed 'The Waiting Rooms' ... hospitals where no one ever gets well. Twenty years after the crisis takes hold, Kate begins a search for her birth mother, armed only with her name and her age. As Kate unearths disturbing facts about her mother's past, she puts her family in danger and risks losing everything. Because Kate is not the only secret that her mother is hiding. Someone else is looking for her, too. Sweeping from an all-too-real modern Britain to a pre-crisis South Africa, The Waiting Rooms is epic in scope, richly populated with unforgettable characters, and a tense, haunting vision of a future that is only a few mutations away. ________________ 'Engrossing and eye-opening, with heart-stopping plot twists ... a stunning medical thriller set in a terrifying possible future' Foreword Reviews 'A touching, gut-wrenching story of family mystery and tragedy ... a thriller that punches on two fronts – heart AND mind' The Sun 'Gripping and disturbing ... the medical research is convincing, the scenarios plausible, and the story is emotionally engaging. This is an incredible debut!' Gill Paul 'If the themes are dark and topical, the writing is exquisite. Breath held, I got to the finale with my heart in my mouth. Eve Smith weaves a complex and clever tale, merging countries and timelines; the result is a superb and satisfying novel' Louise Beech 'Margaret Atwood is one of my all-time writing heroes and The Handmaid's Tale is probably the best book I've ever read. Eve Smith and The Waiting Rooms really do challenge that long-held crown...' Random Things through My Letterbox 'Thoroughly engaging ... an eye-opening read' Crime Fiction Lover 'A novel of our times' Trip Fiction 'Haunting, honest and horrifying in its reality ... An epic and thrilling read' Book Literati 'Stunning dystopian debut. A prescient and alarming tale that seems just a whisper from reality' Suzy Apsley ' The Waiting Rooms will certainly distract us from the real world for a few hours and this is the immeasurable value of fiction. It gives hope that, as in Eve Smith's fictitious world, the possibility of a happy ending still exists' Die Burger ' The Waiting Rooms is a seriously impressive debut, a novel that is intuitive and chilling, one that will resonate with all in this current climate' Swirl & Thread

Scratch-Off Hidden Pictures Dinosaur Puzzles

Scratch-Off Hidden Pictures Dinosaur Puzzles

Author: Highlights

Publisher: Highlights Press

Published: 2022-05-03

Total Pages: 65

ISBN-13: 1644726742

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Puzzle, scratch, and draw! The perfect gift for paleontology fans and dinosaur enthusiasts, this 64-page activity book offers a unique experience—combining the thrill of scratch art with Hidden Pictures puzzles, as well as mazes, doodle pages, jokes and more. Kids ages 6-9 will love to find over 350 hidden objects and express their artistic talents in the scratch-off pages with bursts of color beneath. Highlights’ beloved Hidden Pictures puzzles have been transformed into scratch-off books, with room for kids to add their own creative touches. Reveal playful dinosaur-themed scenes bursting with color while also solving Hidden Pictures puzzles, giggling at the kid-friendly “punny” humor and tackling other dinosaur-themed activities. Scratching off the scene is easy, thanks to the included wooden stylus. The spiral binding means pages lie flat for easier scratching, doodling and drawing, even on the go. Scratch-off activity books are great for birthdays, holidays, just-for-fun or even family game night! Plus, solving puzzles is a great way for kids to build skills like concentration and visual perception, all while having fun. Winner, Mom's Choice Award Gold National Parenting Product Award National Parenting Seal of Approval


Book Synopsis Scratch-Off Hidden Pictures Dinosaur Puzzles by : Highlights

Download or read book Scratch-Off Hidden Pictures Dinosaur Puzzles written by Highlights and published by Highlights Press. This book was released on 2022-05-03 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt: Puzzle, scratch, and draw! The perfect gift for paleontology fans and dinosaur enthusiasts, this 64-page activity book offers a unique experience—combining the thrill of scratch art with Hidden Pictures puzzles, as well as mazes, doodle pages, jokes and more. Kids ages 6-9 will love to find over 350 hidden objects and express their artistic talents in the scratch-off pages with bursts of color beneath. Highlights’ beloved Hidden Pictures puzzles have been transformed into scratch-off books, with room for kids to add their own creative touches. Reveal playful dinosaur-themed scenes bursting with color while also solving Hidden Pictures puzzles, giggling at the kid-friendly “punny” humor and tackling other dinosaur-themed activities. Scratching off the scene is easy, thanks to the included wooden stylus. The spiral binding means pages lie flat for easier scratching, doodling and drawing, even on the go. Scratch-off activity books are great for birthdays, holidays, just-for-fun or even family game night! Plus, solving puzzles is a great way for kids to build skills like concentration and visual perception, all while having fun. Winner, Mom's Choice Award Gold National Parenting Product Award National Parenting Seal of Approval

Antisense Drug Technology

Antisense Drug Technology

Author: Stanley T. Crooke

Publisher: CRC Press

Published: 2007-07-25

Total Pages: 858

ISBN-13: 0849387957

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Extensively revised and updated, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition reflects the logarithmic progress made in the past four years of oligonucleotide-based therapies, and, in particular, antisense therapeutics and research. Interpreting lessons learned from the clinical trials of first generation drugs, the book evaluates the technology as a whole and offers new directions and avenues of research and development. Divided into five parts, the book begins with a thorough introduction to the mechanism of antisense drug action including the RNase H mechanism, small RNA silencing pathways, and the potential therapeutics of splice switching oligonucleotides. Leading researchers demonstrate the basics of oligonucleotide therapeutics in part two by delineating medicinal chemistry, pharmacokinetics, and delivery routes such as liposomal formulations for nucleic acid delivery. Part three details hybridization based drugs and considers the dramatic advances represented by 2’ methoxyethyl chimeric antisense inhibitors and duplex RNA drugs. Other chemical classes of drugs and mechanisms of action are described in part four with further discussions on improving the second generation antisense drugs. The final part delves deeply into therapeutic applications. Contributing authors examine the potential of antisense drugs for the alleviation of cardiovascular diseases, metabolic diseases, inflammatory diseases, cancer, neurological disorders, and immune modulation. Presenting a highly detailed, lucid discussion of the remarkable advances in the field, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition provides the platform for researchers to continue to aggressively pursue the great opportunity represented by this exciting technology.


Book Synopsis Antisense Drug Technology by : Stanley T. Crooke

Download or read book Antisense Drug Technology written by Stanley T. Crooke and published by CRC Press. This book was released on 2007-07-25 with total page 858 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensively revised and updated, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition reflects the logarithmic progress made in the past four years of oligonucleotide-based therapies, and, in particular, antisense therapeutics and research. Interpreting lessons learned from the clinical trials of first generation drugs, the book evaluates the technology as a whole and offers new directions and avenues of research and development. Divided into five parts, the book begins with a thorough introduction to the mechanism of antisense drug action including the RNase H mechanism, small RNA silencing pathways, and the potential therapeutics of splice switching oligonucleotides. Leading researchers demonstrate the basics of oligonucleotide therapeutics in part two by delineating medicinal chemistry, pharmacokinetics, and delivery routes such as liposomal formulations for nucleic acid delivery. Part three details hybridization based drugs and considers the dramatic advances represented by 2’ methoxyethyl chimeric antisense inhibitors and duplex RNA drugs. Other chemical classes of drugs and mechanisms of action are described in part four with further discussions on improving the second generation antisense drugs. The final part delves deeply into therapeutic applications. Contributing authors examine the potential of antisense drugs for the alleviation of cardiovascular diseases, metabolic diseases, inflammatory diseases, cancer, neurological disorders, and immune modulation. Presenting a highly detailed, lucid discussion of the remarkable advances in the field, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition provides the platform for researchers to continue to aggressively pursue the great opportunity represented by this exciting technology.

PopularMMOs Presents Zombies' Day Off

PopularMMOs Presents Zombies' Day Off

Author: PopularMMOs

Publisher: HarperCollins

Published: 2020-10-27

Total Pages: 211

ISBN-13: 0063006537

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New York Times bestselling authors and YouTube sensations Pat and Jen from the beloved Minecraft-inspired channel PopularMMOs fall into a “fun-tastic” new world in their exhilarating third graphic novel adventure, Zombies’ Day Off. Pat and Jen are heroes! After defeating Evil Jen and closing all the portals to the underworld, they have nothing to worry about, no villains to defeat, and no adventures to go on. Awesome, right? Until a mysterious voice tells Jen that she has to go to the underworld to uncover a secret about her past. It is a quest she can only undertake alone. With Jen off to find out the truth and Pat desperate to find Jen, the heroes almost don’t notice that a sinister plot is afoot. There’s a new villain in town, and his team of ninja sailors are determined to take over the underworld and the real world. To defeat him, Pat and Jen might just have to do the unthinkable—team up with Evil Jen! But can Pat and Jen find each other and find a way to work with their nemesis to stop this sinister plot before it’s too late? Join the adventure in the third book of the New York Times bestselling graphic novel series from PopularMMOs, one of the most popular YouTubers in the world, with over 22 million subscribers and 14 billion views!


Book Synopsis PopularMMOs Presents Zombies' Day Off by : PopularMMOs

Download or read book PopularMMOs Presents Zombies' Day Off written by PopularMMOs and published by HarperCollins. This book was released on 2020-10-27 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: New York Times bestselling authors and YouTube sensations Pat and Jen from the beloved Minecraft-inspired channel PopularMMOs fall into a “fun-tastic” new world in their exhilarating third graphic novel adventure, Zombies’ Day Off. Pat and Jen are heroes! After defeating Evil Jen and closing all the portals to the underworld, they have nothing to worry about, no villains to defeat, and no adventures to go on. Awesome, right? Until a mysterious voice tells Jen that she has to go to the underworld to uncover a secret about her past. It is a quest she can only undertake alone. With Jen off to find out the truth and Pat desperate to find Jen, the heroes almost don’t notice that a sinister plot is afoot. There’s a new villain in town, and his team of ninja sailors are determined to take over the underworld and the real world. To defeat him, Pat and Jen might just have to do the unthinkable—team up with Evil Jen! But can Pat and Jen find each other and find a way to work with their nemesis to stop this sinister plot before it’s too late? Join the adventure in the third book of the New York Times bestselling graphic novel series from PopularMMOs, one of the most popular YouTubers in the world, with over 22 million subscribers and 14 billion views!

Soft Target

Soft Target

Author: Zuhair Kashmeri

Publisher: James Lorimer & Company

Published: 2005-09-06

Total Pages: 204

ISBN-13: 9781550289046

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A provocative look at one of Canada's biggest tragedies On March 16, 2005, almost twenty years after one of the biggest mass murders in Canadian Aviation history, the Air-India Case concluded with a verdict that authors Zuhair Kashmeri and Brian McAndrew predicted sixteen years ago when Soft Target was first published: not guilty. In this second edition, the two offer a detailed foreword that brings readers up-to-date with some startling new information surrounding the twin bombings on June 23, 1985 in the air over the Atlantic, and on the ground in Japan, which left 331 people dead. They offer key details from the trial of Ripudaman Singh Malik and Ajaib Singh Bagri that took place in a specially-built Vancouver courtroom, leads that were not followed up, and more details of India's intelligence service's clandestine interference in Canada. They explain how their own prediction that justice would not be found because of a botched investigation came true, and that only a public inquiry will offer closure to the families of the victims.


Book Synopsis Soft Target by : Zuhair Kashmeri

Download or read book Soft Target written by Zuhair Kashmeri and published by James Lorimer & Company. This book was released on 2005-09-06 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: A provocative look at one of Canada's biggest tragedies On March 16, 2005, almost twenty years after one of the biggest mass murders in Canadian Aviation history, the Air-India Case concluded with a verdict that authors Zuhair Kashmeri and Brian McAndrew predicted sixteen years ago when Soft Target was first published: not guilty. In this second edition, the two offer a detailed foreword that brings readers up-to-date with some startling new information surrounding the twin bombings on June 23, 1985 in the air over the Atlantic, and on the ground in Japan, which left 331 people dead. They offer key details from the trial of Ripudaman Singh Malik and Ajaib Singh Bagri that took place in a specially-built Vancouver courtroom, leads that were not followed up, and more details of India's intelligence service's clandestine interference in Canada. They explain how their own prediction that justice would not be found because of a botched investigation came true, and that only a public inquiry will offer closure to the families of the victims.

Genome Editing and Engineering

Genome Editing and Engineering

Author: Krishnarao Appasani

Publisher: Cambridge University Press

Published: 2018-08-23

Total Pages: 535

ISBN-13: 1107170370

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A complete guide to endonuclease-based genomic engineering, from basic science to application in disease biology and clinical treatment.


Book Synopsis Genome Editing and Engineering by : Krishnarao Appasani

Download or read book Genome Editing and Engineering written by Krishnarao Appasani and published by Cambridge University Press. This book was released on 2018-08-23 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete guide to endonuclease-based genomic engineering, from basic science to application in disease biology and clinical treatment.

Genome Stability

Genome Stability

Author: Igor Kovalchuk

Publisher: Academic Press

Published: 2021-07-17

Total Pages: 762

ISBN-13: 0323856802

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Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability Contains applications of genome instability research and outcomes for human disease Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair


Book Synopsis Genome Stability by : Igor Kovalchuk

Download or read book Genome Stability written by Igor Kovalchuk and published by Academic Press. This book was released on 2021-07-17 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability Contains applications of genome instability research and outcomes for human disease Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair

Translational Medicine

Translational Medicine

Author: Joy A. Cavagnaro

Publisher: CRC Press

Published: 2021-11-26

Total Pages: 952

ISBN-13: 1000471853

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Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.


Book Synopsis Translational Medicine by : Joy A. Cavagnaro

Download or read book Translational Medicine written by Joy A. Cavagnaro and published by CRC Press. This book was released on 2021-11-26 with total page 952 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.