Pancreatic Islet Biology

Pancreatic Islet Biology

Author: Anandwardhan A. Hardikar

Publisher: Springer

Published: 2016-10-25

Total Pages: 324

ISBN-13: 3319453076

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This comprehensive volume discusses in vitro laboratory development of insulin-producing cells. It encompasses multiple aspects of islet biology—from embryonic development and stem cell differentiation to clinical studies in islet transplantation, regulation of islet beta-cell regeneration, pancreatic progenitors, mathematical modelling of islet development, epigenetic regulation, and much more. The chapter authors represent leading laboratories from around the world who contribute their international perspectives and global expertise. Collectively, they provide the reader with a concise yet detailed knowledge of processes and current developments in islet regenerative biology. Pancreatic Islet Biology, part of the Stem Cell Biology and Regenerative Medicine series, is essential reading for researchers and clinicians in stem cells or endocrinology, especially those focusing on diabetes.


Book Synopsis Pancreatic Islet Biology by : Anandwardhan A. Hardikar

Download or read book Pancreatic Islet Biology written by Anandwardhan A. Hardikar and published by Springer. This book was released on 2016-10-25 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive volume discusses in vitro laboratory development of insulin-producing cells. It encompasses multiple aspects of islet biology—from embryonic development and stem cell differentiation to clinical studies in islet transplantation, regulation of islet beta-cell regeneration, pancreatic progenitors, mathematical modelling of islet development, epigenetic regulation, and much more. The chapter authors represent leading laboratories from around the world who contribute their international perspectives and global expertise. Collectively, they provide the reader with a concise yet detailed knowledge of processes and current developments in islet regenerative biology. Pancreatic Islet Biology, part of the Stem Cell Biology and Regenerative Medicine series, is essential reading for researchers and clinicians in stem cells or endocrinology, especially those focusing on diabetes.

Pancreatic Islet Isolation

Pancreatic Islet Isolation

Author: Miriam Ramírez-Domínguez

Publisher: Springer

Published: 2016-09-01

Total Pages: 123

ISBN-13: 3319398245

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Pancreatic islets make up the endocrine pancreas and they contain the only source of insulin in the body, beta cells. Hence, access to high quality preparations of pancreatic islets is fundamental for in vitro studies and to test pre-clinical applications in animal models in vivo. Access to healthy human islets is also crucial to improve transplantation procedures for diabetes. Given the susceptibility of pancreatic islets to the enzymatic digestion and mechanical stress required to obtain them, the isolation of islets is often considered as the delicate “work of a craftsman”. This book, which is aimed at beginners and experts alike, is a survey of the current state-of–the-art in this field and it centres on the challenges, pitfalls and peculiarities of pancreatic islet isolation in the different species used in pre-clinical and clinical applications. It explores the similarities and differences between human islets and those from other relevant species (rodents, pigs and non-human primates), and how these influence islet isolation. The ultimate goal of this book is to improve the outcome of islet isolation and transplantation in pre-clinical and clinical applications.


Book Synopsis Pancreatic Islet Isolation by : Miriam Ramírez-Domínguez

Download or read book Pancreatic Islet Isolation written by Miriam Ramírez-Domínguez and published by Springer. This book was released on 2016-09-01 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pancreatic islets make up the endocrine pancreas and they contain the only source of insulin in the body, beta cells. Hence, access to high quality preparations of pancreatic islets is fundamental for in vitro studies and to test pre-clinical applications in animal models in vivo. Access to healthy human islets is also crucial to improve transplantation procedures for diabetes. Given the susceptibility of pancreatic islets to the enzymatic digestion and mechanical stress required to obtain them, the isolation of islets is often considered as the delicate “work of a craftsman”. This book, which is aimed at beginners and experts alike, is a survey of the current state-of–the-art in this field and it centres on the challenges, pitfalls and peculiarities of pancreatic islet isolation in the different species used in pre-clinical and clinical applications. It explores the similarities and differences between human islets and those from other relevant species (rodents, pigs and non-human primates), and how these influence islet isolation. The ultimate goal of this book is to improve the outcome of islet isolation and transplantation in pre-clinical and clinical applications.

Islet Biology and Metabolism

Islet Biology and Metabolism

Author: Melkam A Kebede

Publisher: Mdpi AG

Published: 2022-01-11

Total Pages: 206

ISBN-13: 9783036527376

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This Special Issue of Metabolites, entitled "Islet Biology and Metabolism" is dedicated to islet research and the impact of islet function in metabolic health and disease. Specific topics include, but are not limited to, islet hormone processing and secretion, islet transplant research, novel proteins of the insulin secretory pathway, as well as islet drug targets for the management of T1D and T2D.


Book Synopsis Islet Biology and Metabolism by : Melkam A Kebede

Download or read book Islet Biology and Metabolism written by Melkam A Kebede and published by Mdpi AG. This book was released on 2022-01-11 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Special Issue of Metabolites, entitled "Islet Biology and Metabolism" is dedicated to islet research and the impact of islet function in metabolic health and disease. Specific topics include, but are not limited to, islet hormone processing and secretion, islet transplant research, novel proteins of the insulin secretory pathway, as well as islet drug targets for the management of T1D and T2D.

Pancreatic Beta Cell in Health and Disease

Pancreatic Beta Cell in Health and Disease

Author: Susumu Seino

Publisher: Springer Science & Business Media

Published: 2008-04-08

Total Pages: 475

ISBN-13: 4431754520

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The beta cells of the pancreatic islets of Langerhans are the only cells in the body that produce and secrete insulin. This metabolic hormone plays a central role in the maintenance of glucose homeostasis. This book provides a comprehensive review of the beta cell in health and disease. The book’s primary aim is to encourage investigators to become actively involved in diabetes research and the search for new approaches to prevent and treat diabetes.


Book Synopsis Pancreatic Beta Cell in Health and Disease by : Susumu Seino

Download or read book Pancreatic Beta Cell in Health and Disease written by Susumu Seino and published by Springer Science & Business Media. This book was released on 2008-04-08 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: The beta cells of the pancreatic islets of Langerhans are the only cells in the body that produce and secrete insulin. This metabolic hormone plays a central role in the maintenance of glucose homeostasis. This book provides a comprehensive review of the beta cell in health and disease. The book’s primary aim is to encourage investigators to become actively involved in diabetes research and the search for new approaches to prevent and treat diabetes.

The Biology of the Pancreatic Cell

The Biology of the Pancreatic Cell

Author: S.L. Howell

Publisher: Elsevier

Published: 1999-04-15

Total Pages: 354

ISBN-13: 9780080877143

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As a result of the key advances made more than 30 years ago, specifically the ability to isolate islets of Langerhans from the pancreas, the ability to measure insulin accurately by immunoasay, and the development of microchemical techniques for studying cells and their components, many research volumes, symposium reports, and original papers have been produced. This explosion of interest has probably had at least three stimuli: 1. the inherent scientific interest in understanding secretion of the pancreatic ß-cell 2. the ß-cells relevance to a very common disease 3. the availability of funding from specific sources related to diabetes research, for instance, Juvenile Diabetes Foundation International and the British Diabetic Association. As a result of all this activity, detailed scientific literature including research reviews are readily available. Surprisingly enough, there are relatively few attempts to summarize this great bulk of knowledge in a way that is accessible to the newcomer to this field and this book is intended to bridge this gap.


Book Synopsis The Biology of the Pancreatic Cell by : S.L. Howell

Download or read book The Biology of the Pancreatic Cell written by S.L. Howell and published by Elsevier. This book was released on 1999-04-15 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a result of the key advances made more than 30 years ago, specifically the ability to isolate islets of Langerhans from the pancreas, the ability to measure insulin accurately by immunoasay, and the development of microchemical techniques for studying cells and their components, many research volumes, symposium reports, and original papers have been produced. This explosion of interest has probably had at least three stimuli: 1. the inherent scientific interest in understanding secretion of the pancreatic ß-cell 2. the ß-cells relevance to a very common disease 3. the availability of funding from specific sources related to diabetes research, for instance, Juvenile Diabetes Foundation International and the British Diabetic Association. As a result of all this activity, detailed scientific literature including research reviews are readily available. Surprisingly enough, there are relatively few attempts to summarize this great bulk of knowledge in a way that is accessible to the newcomer to this field and this book is intended to bridge this gap.

Pancreatic B Cell Biology in Health and Disease

Pancreatic B Cell Biology in Health and Disease

Author:

Publisher: Academic Press

Published: 2021-04-06

Total Pages: 416

ISBN-13: 0128237562

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Pancreatic B Cell Biology in Health and Disease, Volume 360 presents the latest release in this ongoing series on the novel and widely studied physiology of pancreatic cells in homeostasis and under pathogenic conditions. This new volume includes new chapters on a variety of topics, including Pancreatic Beta Cell Dysfunction in Type 1 Diabetes: The Role of Ifn, Sexual Hormones and Diabetes: The Impact in Pancreatic Beta Cell, Pancreatic Beta Cell Dysfunction in Monogenic Diabetes, The Role of MiRNAs In Beta Cell Function, Pancreatic Beta Cell: How Environmental Endocrine Disruptors Alter Its Function, Enteroviral Infections and Pancreatic Beta Cell Dysfunction, and more. Final sections cover Long Non-Coding Rna-Regulated Pathways in Pancreatic Beta Cell: Their Role in Diabetes and Pancreatic Beta Cell Biology in Health and Disease. Provides updated and extensive review articles that focus on different aspects of pancreatic cell biology Offers a wide range of perspectives for basic and translational research Includes original figures that help readers understand the complex pathways involved in cell function in homeostasis and under pathogenic conditions


Book Synopsis Pancreatic B Cell Biology in Health and Disease by :

Download or read book Pancreatic B Cell Biology in Health and Disease written by and published by Academic Press. This book was released on 2021-04-06 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pancreatic B Cell Biology in Health and Disease, Volume 360 presents the latest release in this ongoing series on the novel and widely studied physiology of pancreatic cells in homeostasis and under pathogenic conditions. This new volume includes new chapters on a variety of topics, including Pancreatic Beta Cell Dysfunction in Type 1 Diabetes: The Role of Ifn, Sexual Hormones and Diabetes: The Impact in Pancreatic Beta Cell, Pancreatic Beta Cell Dysfunction in Monogenic Diabetes, The Role of MiRNAs In Beta Cell Function, Pancreatic Beta Cell: How Environmental Endocrine Disruptors Alter Its Function, Enteroviral Infections and Pancreatic Beta Cell Dysfunction, and more. Final sections cover Long Non-Coding Rna-Regulated Pathways in Pancreatic Beta Cell: Their Role in Diabetes and Pancreatic Beta Cell Biology in Health and Disease. Provides updated and extensive review articles that focus on different aspects of pancreatic cell biology Offers a wide range of perspectives for basic and translational research Includes original figures that help readers understand the complex pathways involved in cell function in homeostasis and under pathogenic conditions

Pancreatic Islet Cell Regeneration and Growth

Pancreatic Islet Cell Regeneration and Growth

Author: Aaron I. Vinik

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 177

ISBN-13: 1461534488

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Aaron I. Vinik, M.D., Ph.D. I IEastem Virginia Medical School The Diabetes Institutes Norfolk, Virginia 23510 This symposium, held in June 1991, was a gathering of international scientists to exchange their views on current concepts of cell growth and differentiation. Each scientist was asked to present a topic of their research related to cell growth and regeneration and to participate in a round table conference elaborating on current knowledge and sharing their experiences. By furthering this promising area of endeavor, a means of understanding ontogeny of cell development and of providing insights into tumor biology would prevail. Of prime importance was the anticipation that new information from a better understanding of the normal evolution of the pancreatic islet would generate alternative approaches to curing diabetes. This forward serves as a short introduction to the concept of pancreatic islet regeneration and the models currently in use to study the process. DEVELOPMENTAL ORIGIN OF ISLETS DURING EMRYOGENESIS The developing pancreas appears as a protrusion from the dorsal surface of the l embryonic gut. The different islet cell types appear sequentially during development in vivo. It therefore seems reasonable to propose that coordinated growth is dependent upon specificity of growth factors.


Book Synopsis Pancreatic Islet Cell Regeneration and Growth by : Aaron I. Vinik

Download or read book Pancreatic Islet Cell Regeneration and Growth written by Aaron I. Vinik and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aaron I. Vinik, M.D., Ph.D. I IEastem Virginia Medical School The Diabetes Institutes Norfolk, Virginia 23510 This symposium, held in June 1991, was a gathering of international scientists to exchange their views on current concepts of cell growth and differentiation. Each scientist was asked to present a topic of their research related to cell growth and regeneration and to participate in a round table conference elaborating on current knowledge and sharing their experiences. By furthering this promising area of endeavor, a means of understanding ontogeny of cell development and of providing insights into tumor biology would prevail. Of prime importance was the anticipation that new information from a better understanding of the normal evolution of the pancreatic islet would generate alternative approaches to curing diabetes. This forward serves as a short introduction to the concept of pancreatic islet regeneration and the models currently in use to study the process. DEVELOPMENTAL ORIGIN OF ISLETS DURING EMRYOGENESIS The developing pancreas appears as a protrusion from the dorsal surface of the l embryonic gut. The different islet cell types appear sequentially during development in vivo. It therefore seems reasonable to propose that coordinated growth is dependent upon specificity of growth factors.

Pancreatic Stem Cells

Pancreatic Stem Cells

Author: Juan Domínguez-Bendala

Publisher: Springer Science & Business Media

Published: 2009-06-18

Total Pages: 154

ISBN-13: 1607611325

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From the discovery of Pdx1, the first “master gene” of pancreatic development, to the most recent findings on the role of microRNAs in beta cell homeostasis, the last fifteen years have seen an unprecedented advance in our understanding of the precise development and organization of the many different cell types that make up the pancreas. It is now widely acknowledged that the therapeutic differentiation of stem cells into pancreatic cells is an ambitious endeavor that will not succeed without a thorough understanding of the molecular processes underlying the native development of the organ. This book, aimed at experts and students alike, offers a comprehensive review of the state of the art in both pancreatic development and regeneration. The many strategies to differentiate adult and embryonic stem cells into pancreatic beta cells are also discussed in the context of potential therapeutic interventions for type I diabetes.


Book Synopsis Pancreatic Stem Cells by : Juan Domínguez-Bendala

Download or read book Pancreatic Stem Cells written by Juan Domínguez-Bendala and published by Springer Science & Business Media. This book was released on 2009-06-18 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the discovery of Pdx1, the first “master gene” of pancreatic development, to the most recent findings on the role of microRNAs in beta cell homeostasis, the last fifteen years have seen an unprecedented advance in our understanding of the precise development and organization of the many different cell types that make up the pancreas. It is now widely acknowledged that the therapeutic differentiation of stem cells into pancreatic cells is an ambitious endeavor that will not succeed without a thorough understanding of the molecular processes underlying the native development of the organ. This book, aimed at experts and students alike, offers a comprehensive review of the state of the art in both pancreatic development and regeneration. The many strategies to differentiate adult and embryonic stem cells into pancreatic beta cells are also discussed in the context of potential therapeutic interventions for type I diabetes.

Molecular Biology of the Islets of Langerhans

Molecular Biology of the Islets of Langerhans

Author: Hiroshi Okamoto

Publisher: Cambridge University Press

Published: 1990-02-22

Total Pages: 362

ISBN-13: 0521362040

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The islets of Langerhans, the primary source of hormone production in the pancreas, have been the focus of research into the nature of diabetes for decades. In recent years, the molecular biology of this multiendocrine organ has been intensively investigated, with a corresponding increase in our understanding of the normal and pathological functioning of islet cells.


Book Synopsis Molecular Biology of the Islets of Langerhans by : Hiroshi Okamoto

Download or read book Molecular Biology of the Islets of Langerhans written by Hiroshi Okamoto and published by Cambridge University Press. This book was released on 1990-02-22 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: The islets of Langerhans, the primary source of hormone production in the pancreas, have been the focus of research into the nature of diabetes for decades. In recent years, the molecular biology of this multiendocrine organ has been intensively investigated, with a corresponding increase in our understanding of the normal and pathological functioning of islet cells.

BetaSys

BetaSys

Author: Bernhelm Booß-Bavnbek

Publisher: Springer Science & Business Media

Published: 2011-03-02

Total Pages: 558

ISBN-13: 144196956X

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BetaSys uses the example of regulated exocytosis in pancreatic β-cells, and its relevance to diabetes, to illustrate the major concepts of systems biology, its methods and applications.


Book Synopsis BetaSys by : Bernhelm Booß-Bavnbek

Download or read book BetaSys written by Bernhelm Booß-Bavnbek and published by Springer Science & Business Media. This book was released on 2011-03-02 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: BetaSys uses the example of regulated exocytosis in pancreatic β-cells, and its relevance to diabetes, to illustrate the major concepts of systems biology, its methods and applications.