Virtual Screening

Virtual Screening

Author: Christoph Sotriffer

Publisher: John Wiley & Sons

Published: 2011-03-31

Total Pages: 774

ISBN-13: 3527633340

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Drug discovery is all about finding small molecules that interact in a desired way with larger molecules, namely proteins and other macromolecules in the human body. If the three-dimensional structures of both the small and large molecule are known, their interaction can be tested by computer simulation with a reasonable degree of accuracy. Alternatively, if active ligands are already available, molecular similarity searches can be used to find new molecules. This virtual screening can even be applied to compounds that have yet to be synthesized, as opposed to "real" screening that requires cost- and labor-intensive laboratory testing with previously synthesized drug compounds. Unique in its focus on the end user, this is a real "how to" book that does not presuppose prior experience in virtual screening or a background in computational chemistry. It is both a desktop reference and practical guide to virtual screening applications in drug discovery, offering a comprehensive and up-to-date overview. Clearly divided into four major sections, the first provides a detailed description of the methods required for and applied in virtual screening, while the second discusses the most important challenges in order to improve the impact and success of this technique. The third and fourth, practical parts contain practical guidelines and several case studies covering the most important scenarios for new drug discovery, accompanied by general guidelines for the entire workflow of virtual screening studies. Throughout the text, medicinal chemists from academia, as well as from large and small pharmaceutical companies report on their experience and pass on priceless practical advice on how to make best use of these powerful methods.


Book Synopsis Virtual Screening by : Christoph Sotriffer

Download or read book Virtual Screening written by Christoph Sotriffer and published by John Wiley & Sons. This book was released on 2011-03-31 with total page 774 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug discovery is all about finding small molecules that interact in a desired way with larger molecules, namely proteins and other macromolecules in the human body. If the three-dimensional structures of both the small and large molecule are known, their interaction can be tested by computer simulation with a reasonable degree of accuracy. Alternatively, if active ligands are already available, molecular similarity searches can be used to find new molecules. This virtual screening can even be applied to compounds that have yet to be synthesized, as opposed to "real" screening that requires cost- and labor-intensive laboratory testing with previously synthesized drug compounds. Unique in its focus on the end user, this is a real "how to" book that does not presuppose prior experience in virtual screening or a background in computational chemistry. It is both a desktop reference and practical guide to virtual screening applications in drug discovery, offering a comprehensive and up-to-date overview. Clearly divided into four major sections, the first provides a detailed description of the methods required for and applied in virtual screening, while the second discusses the most important challenges in order to improve the impact and success of this technique. The third and fourth, practical parts contain practical guidelines and several case studies covering the most important scenarios for new drug discovery, accompanied by general guidelines for the entire workflow of virtual screening studies. Throughout the text, medicinal chemists from academia, as well as from large and small pharmaceutical companies report on their experience and pass on priceless practical advice on how to make best use of these powerful methods.


Inside Cultures

Inside Cultures

Author: William Balée

Publisher: Routledge

Published: 2021-08-17

Total Pages: 278

ISBN-13: 1000411338

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This concise, contemporary option for instructors of cultural anthropology breaks away from the traditional structure of introductory textbooks. Emphasizing the interaction between humans and their environment, the tension between human universals and cultural variation, and the impacts of colonialism on traditional cultures, Inside Cultures shows students how cultural anthropology can help us understand the complex, globalized world around us. This third edition: contains brand new material on many subjects, including anthropological approaches to anti-racism social movements in the Global North during 2020; includes findings in anthropological research regarding the Covid-19 pandemic, and its relation to other recent global events and conditions; updates the organization and presentation of cultural universals and cultural variations; presents updated and enhanced discussions of anthropological studies of humankind and the environment, with expanded analysis of industrial agriculture in the age of globalization; includes more illustrations and updates to existing illustrations, sidebars, and guideposts throughout the volume; is written in clear, supple prose that delights readers while informing on content of one of the important courses in a liberal arts education, one that effectively bridges humanities and the sciences.


Book Synopsis Inside Cultures by : William Balée

Download or read book Inside Cultures written by William Balée and published by Routledge. This book was released on 2021-08-17 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise, contemporary option for instructors of cultural anthropology breaks away from the traditional structure of introductory textbooks. Emphasizing the interaction between humans and their environment, the tension between human universals and cultural variation, and the impacts of colonialism on traditional cultures, Inside Cultures shows students how cultural anthropology can help us understand the complex, globalized world around us. This third edition: contains brand new material on many subjects, including anthropological approaches to anti-racism social movements in the Global North during 2020; includes findings in anthropological research regarding the Covid-19 pandemic, and its relation to other recent global events and conditions; updates the organization and presentation of cultural universals and cultural variations; presents updated and enhanced discussions of anthropological studies of humankind and the environment, with expanded analysis of industrial agriculture in the age of globalization; includes more illustrations and updates to existing illustrations, sidebars, and guideposts throughout the volume; is written in clear, supple prose that delights readers while informing on content of one of the important courses in a liberal arts education, one that effectively bridges humanities and the sciences.


The Millennial Generation and National Defense

The Millennial Generation and National Defense

Author: Morten G. Ender

Publisher: Springer

Published: 2013-12-02

Total Pages: 258

ISBN-13: 1137392320

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This study captures the attitudes and values of the youth generation of college students in the USA toward the military, war, national defence, and foreign policy matters. Providing a unique insight into civilian and military Millenials, the authors explore the impact of 9/11 and the level of tolerance within the military.


Book Synopsis The Millennial Generation and National Defense by : Morten G. Ender

Download or read book The Millennial Generation and National Defense written by Morten G. Ender and published by Springer. This book was released on 2013-12-02 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study captures the attitudes and values of the youth generation of college students in the USA toward the military, war, national defence, and foreign policy matters. Providing a unique insight into civilian and military Millenials, the authors explore the impact of 9/11 and the level of tolerance within the military.


Abstracts of Papers

Abstracts of Papers

Author: American Chemical Society

Publisher:

Published: 1988

Total Pages: 1066

ISBN-13:

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Book Synopsis Abstracts of Papers by : American Chemical Society

Download or read book Abstracts of Papers written by American Chemical Society and published by . This book was released on 1988 with total page 1066 pages. Available in PDF, EPUB and Kindle. Book excerpt:


New Directions in Media and Politics

New Directions in Media and Politics

Author: Travis N. Ridout

Publisher: Routledge

Published: 2013

Total Pages: 282

ISBN-13: 0415537320

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The field of media and politics is quickly changing as society transforms and new technologies develop continuously. Academic research in the area is rapidly breaking new ground to keep pace with the prolific media developments. This innovative, up-to-date text moves beyond rudimentary concepts and definitions to consider the exciting scholarly research that addresses the monumental recent changes in the media system of the United States and the world. This carefully crafted volume addresses the big questions that academic researchers are asking, exposing students to the rigorous scholarship in the field but making it readily understandable by undergraduate students. Each chapter starts with a "big question" about the impact of the news media, provides an overview of the more general topic, and then answers that question by appealing to the best, most-up-to-date research in the field. The volume as a whole is held together by an exploration of the rapidly changing media environment and the influence these changes have on individual political behavior and governments as a whole. New Directions in Media and Politics will make an ideal book for courses as it digs deeper into the questions that standard textbooks only hint at-and presents scholarly evidence to support the arguments made.


Book Synopsis New Directions in Media and Politics by : Travis N. Ridout

Download or read book New Directions in Media and Politics written by Travis N. Ridout and published by Routledge. This book was released on 2013 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of media and politics is quickly changing as society transforms and new technologies develop continuously. Academic research in the area is rapidly breaking new ground to keep pace with the prolific media developments. This innovative, up-to-date text moves beyond rudimentary concepts and definitions to consider the exciting scholarly research that addresses the monumental recent changes in the media system of the United States and the world. This carefully crafted volume addresses the big questions that academic researchers are asking, exposing students to the rigorous scholarship in the field but making it readily understandable by undergraduate students. Each chapter starts with a "big question" about the impact of the news media, provides an overview of the more general topic, and then answers that question by appealing to the best, most-up-to-date research in the field. The volume as a whole is held together by an exploration of the rapidly changing media environment and the influence these changes have on individual political behavior and governments as a whole. New Directions in Media and Politics will make an ideal book for courses as it digs deeper into the questions that standard textbooks only hint at-and presents scholarly evidence to support the arguments made.


Radio Journalism in America

Radio Journalism in America

Author: Jim Cox

Publisher: McFarland

Published: 2013-04-06

Total Pages: 273

ISBN-13: 1476601194

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This history of radio news reporting recounts and assesses the contributions of radio toward keeping America informed since the 1920s. It identifies distinct periods and milestones in broadcast journalism and includes a biographical dictionary of important figures who brought news to the airwaves. Americans were dependent on radio for cheap entertainment during the Great Depression and for critical information during the Second World War, when no other medium could approach its speed and accessibility. Radio's diminished influence in the age of television beginning in the 1950s is studied, as the aural medium shifted from being at the core of many families' activities to more specialized applications, reaching narrowly defined listener bases. Many people turned elsewhere for the news. (And now even TV is challenged by yet newer media.) The introduction of technological marvels throughout the past hundred years has significantly altered what Americans hear and how, when, and where they hear it.


Book Synopsis Radio Journalism in America by : Jim Cox

Download or read book Radio Journalism in America written by Jim Cox and published by McFarland. This book was released on 2013-04-06 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This history of radio news reporting recounts and assesses the contributions of radio toward keeping America informed since the 1920s. It identifies distinct periods and milestones in broadcast journalism and includes a biographical dictionary of important figures who brought news to the airwaves. Americans were dependent on radio for cheap entertainment during the Great Depression and for critical information during the Second World War, when no other medium could approach its speed and accessibility. Radio's diminished influence in the age of television beginning in the 1950s is studied, as the aural medium shifted from being at the core of many families' activities to more specialized applications, reaching narrowly defined listener bases. Many people turned elsewhere for the news. (And now even TV is challenged by yet newer media.) The introduction of technological marvels throughout the past hundred years has significantly altered what Americans hear and how, when, and where they hear it.


No Longer Newsworthy

No Longer Newsworthy

Author: Christopher R. Martin

Publisher: ILR Press

Published: 2019-05-15

Total Pages: 271

ISBN-13: 1501735268

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Until the recent political shift pushed workers back into the media spotlight, the mainstream media had largely ignored this significant part of American society in favor of the moneyed "upscale" consumer for more than four decades. Christopher R. Martin now reveals why and how the media lost sight of the American working class and the effects of it doing so. The damning indictment of the mainstream media that flows through No Longer Newsworthy is a wakeup call about the critical role of the media in telling news stories about labor unions, workers, and working-class readers. As Martin charts the decline of labor reporting from the late 1960s onwards, he reveals the shift in news coverage as the mainstream media abandoned labor in favor of consumer and business interests. When newspapers, especially, wrote off working-class readers as useless for their business model, the American worker became invisible. In No Longer Newsworthy, Martin covers this shift in focus, the loss of political voice for the working class, and the emergence of a more conservative media in the form of Christian television, talk radio, Fox News, and conservative websites. Now, with our fractured society and news media, Martin offers the mainstream media recommendations for how to push back against right-wing media and once again embrace the working class as critical to its audience and its democratic function.


Book Synopsis No Longer Newsworthy by : Christopher R. Martin

Download or read book No Longer Newsworthy written by Christopher R. Martin and published by ILR Press. This book was released on 2019-05-15 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Until the recent political shift pushed workers back into the media spotlight, the mainstream media had largely ignored this significant part of American society in favor of the moneyed "upscale" consumer for more than four decades. Christopher R. Martin now reveals why and how the media lost sight of the American working class and the effects of it doing so. The damning indictment of the mainstream media that flows through No Longer Newsworthy is a wakeup call about the critical role of the media in telling news stories about labor unions, workers, and working-class readers. As Martin charts the decline of labor reporting from the late 1960s onwards, he reveals the shift in news coverage as the mainstream media abandoned labor in favor of consumer and business interests. When newspapers, especially, wrote off working-class readers as useless for their business model, the American worker became invisible. In No Longer Newsworthy, Martin covers this shift in focus, the loss of political voice for the working class, and the emergence of a more conservative media in the form of Christian television, talk radio, Fox News, and conservative websites. Now, with our fractured society and news media, Martin offers the mainstream media recommendations for how to push back against right-wing media and once again embrace the working class as critical to its audience and its democratic function.


Communicating for Success

Communicating for Success

Author: Cheryl M. Hamilton

Publisher: Routledge

Published: 2016-07-22

Total Pages: 1052

ISBN-13: 1315299976

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This text focuses student-learning on the key communication competencies recommended by the National Communication Association. With applied examples and a vibrant and engaging design, this text covers all the expected topics in an introductory course (foundations of communication, interpersonal communication, small group communication, and public speaking - plus a special appendix on interviewing). Scenarios begin each chapter with a problem to which students can relate and then solve as they learn about the concepts discussed in each chapter. A concentrated focus on careers in communication, highlighted in a two-page spread near the end of each chapter, brings home the relevance of communication outside the classroom and helps students learn more about how studying communication can help them throughout their lives. Additional emphasis on topics such as ethics, culture, gender, and technology is found throughout the text.


Book Synopsis Communicating for Success by : Cheryl M. Hamilton

Download or read book Communicating for Success written by Cheryl M. Hamilton and published by Routledge. This book was released on 2016-07-22 with total page 1052 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text focuses student-learning on the key communication competencies recommended by the National Communication Association. With applied examples and a vibrant and engaging design, this text covers all the expected topics in an introductory course (foundations of communication, interpersonal communication, small group communication, and public speaking - plus a special appendix on interviewing). Scenarios begin each chapter with a problem to which students can relate and then solve as they learn about the concepts discussed in each chapter. A concentrated focus on careers in communication, highlighted in a two-page spread near the end of each chapter, brings home the relevance of communication outside the classroom and helps students learn more about how studying communication can help them throughout their lives. Additional emphasis on topics such as ethics, culture, gender, and technology is found throughout the text.


Typing Politics

Typing Politics

Author: Richard Davis

Publisher: Oxford University Press

Published: 2009-05-26

Total Pages: 256

ISBN-13: 0199888337

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The power of political blogs in American politics is now evident to anyone who follows it. In Typing Politics, Richard Davis provides a comprehensive yet concise assessment of the growing role played by political blogs and their relationship with the mainstream media. Through a detailed content analysis of the most popular political blogs--Daily Kos, Instapundit, Michelle Malkin, and Wonkette--he shows the degree to which blogs influence the traditional news media. Specifically, he compares the content of these blogs to four leading newspapers noted for their political coverage: The Washington Post, The New York Times, The Wall Street Journal, and The Washington Times. He explains how political journalists at these papers use blogs to inform their reportage and analyzes general attitudes about the role of blogs in journalism. Drawing on a national survey of political blog readers, Davis concludes with a novel assessment of the blog audience. Compact, accessible, and well-researched, Typing Politics will be an invaluable contribution to the literature on a phenomenon that has reshaped the landscape of political communication.


Book Synopsis Typing Politics by : Richard Davis

Download or read book Typing Politics written by Richard Davis and published by Oxford University Press. This book was released on 2009-05-26 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: The power of political blogs in American politics is now evident to anyone who follows it. In Typing Politics, Richard Davis provides a comprehensive yet concise assessment of the growing role played by political blogs and their relationship with the mainstream media. Through a detailed content analysis of the most popular political blogs--Daily Kos, Instapundit, Michelle Malkin, and Wonkette--he shows the degree to which blogs influence the traditional news media. Specifically, he compares the content of these blogs to four leading newspapers noted for their political coverage: The Washington Post, The New York Times, The Wall Street Journal, and The Washington Times. He explains how political journalists at these papers use blogs to inform their reportage and analyzes general attitudes about the role of blogs in journalism. Drawing on a national survey of political blog readers, Davis concludes with a novel assessment of the blog audience. Compact, accessible, and well-researched, Typing Politics will be an invaluable contribution to the literature on a phenomenon that has reshaped the landscape of political communication.


The Outrage Industry

The Outrage Industry

Author: Jeffrey M. Berry

Publisher: Oxford University Press

Published: 2013-12-03

Total Pages: 256

ISBN-13: 0199338655

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In early 2012, conservative radio host Rush Limbaugh claimed that Sandra Fluke, a Georgetown University law student who advocated for insurance coverage of contraceptives, "wants to be paid to have sex." Over the next few days, Limbaugh attacked Fluke personally, often in crude terms, while a powerful backlash grew, led by organizations such as the National Organization for Women. But perhaps what was most notable about the incident was that it wasn't unusual. From Limbaugh's venomous attacks on Fluke to liberal radio host Mike Malloy's suggestion that Bill O'Reilly "drink a vat of poison... and choke to death," over-the-top discourse in today's political opinion media is pervasive. Anyone who observes the skyrocketing number of incendiary political opinion shows on television and radio might conclude that political vitriol on the airwaves is fueled by the increasingly partisan American political system. But in The Outrage Industry Jeffrey M. Berry and Sarah Sobieraj show how the proliferation of outrage-the provocative, hyperbolic style of commentary delivered by hosts like Ed Schultz, Bill O'Reilly, and Sean Hannity- says more about regulatory, technological, and cultural changes, than it does about our political inclinations. Berry and Sobieraj tackle the mechanics of outrage rhetoric, exploring its various forms such as mockery, emotional display, fear mongering, audience flattery, and conspiracy theories. They then investigate the impact of outrage rhetoric-which stigmatizes cooperation and brands collaboration and compromise as weak-on a contemporary political landscape that features frequent straight-party voting in Congress. Outrage tactics have also facilitated the growth of the Tea Party, a movement which appeals to older, white conservatives and has dragged the GOP farther away from the demographically significant moderates whose favor it should be courting. Finally, The Outrage Industry examines how these shows sour our own political lives, exacerbating anxieties about political talk and collaboration in our own communities. Drawing from a rich base of evidence, this book forces all of us to consider the negative consequences that flow from our increasingly hyper-partisan political media.


Book Synopsis The Outrage Industry by : Jeffrey M. Berry

Download or read book The Outrage Industry written by Jeffrey M. Berry and published by Oxford University Press. This book was released on 2013-12-03 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: In early 2012, conservative radio host Rush Limbaugh claimed that Sandra Fluke, a Georgetown University law student who advocated for insurance coverage of contraceptives, "wants to be paid to have sex." Over the next few days, Limbaugh attacked Fluke personally, often in crude terms, while a powerful backlash grew, led by organizations such as the National Organization for Women. But perhaps what was most notable about the incident was that it wasn't unusual. From Limbaugh's venomous attacks on Fluke to liberal radio host Mike Malloy's suggestion that Bill O'Reilly "drink a vat of poison... and choke to death," over-the-top discourse in today's political opinion media is pervasive. Anyone who observes the skyrocketing number of incendiary political opinion shows on television and radio might conclude that political vitriol on the airwaves is fueled by the increasingly partisan American political system. But in The Outrage Industry Jeffrey M. Berry and Sarah Sobieraj show how the proliferation of outrage-the provocative, hyperbolic style of commentary delivered by hosts like Ed Schultz, Bill O'Reilly, and Sean Hannity- says more about regulatory, technological, and cultural changes, than it does about our political inclinations. Berry and Sobieraj tackle the mechanics of outrage rhetoric, exploring its various forms such as mockery, emotional display, fear mongering, audience flattery, and conspiracy theories. They then investigate the impact of outrage rhetoric-which stigmatizes cooperation and brands collaboration and compromise as weak-on a contemporary political landscape that features frequent straight-party voting in Congress. Outrage tactics have also facilitated the growth of the Tea Party, a movement which appeals to older, white conservatives and has dragged the GOP farther away from the demographically significant moderates whose favor it should be courting. Finally, The Outrage Industry examines how these shows sour our own political lives, exacerbating anxieties about political talk and collaboration in our own communities. Drawing from a rich base of evidence, this book forces all of us to consider the negative consequences that flow from our increasingly hyper-partisan political media.