Parasite Neuromusculature and Its Utility as a Drug Target

Parasite Neuromusculature and Its Utility as a Drug Target

Author: Aaron G. Maule

Publisher: Cambridge University Press

Published: 2006-10-19

Total Pages: 208

ISBN-13: 9780521691789

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Nerve and muscle systems in helminth parasites interact in a highly co-ordinated manner to control movements associated with alimentation, reproduction, locomotion and attachment. All metazoan parasites rely on some or all of these activities for their survival. For a long time it has been known that neuromuscular function in parasites is susceptible to chemotherapeutic attack, and that compromising this aspect of parasite biology is sufficient to cure many parasite infections. This volume outlines the latest research in this area, showing why this system is so amenable to drug intervention and outlining potential targets for new treatments. Written by experts in the field, this volume will be invaluable to anyone interested in the molecular biology, physiology and biochemistry of parasites as well as those looking to exploit these for the creation of new treatments.


Book Synopsis Parasite Neuromusculature and Its Utility as a Drug Target by : Aaron G. Maule

Download or read book Parasite Neuromusculature and Its Utility as a Drug Target written by Aaron G. Maule and published by Cambridge University Press. This book was released on 2006-10-19 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nerve and muscle systems in helminth parasites interact in a highly co-ordinated manner to control movements associated with alimentation, reproduction, locomotion and attachment. All metazoan parasites rely on some or all of these activities for their survival. For a long time it has been known that neuromuscular function in parasites is susceptible to chemotherapeutic attack, and that compromising this aspect of parasite biology is sufficient to cure many parasite infections. This volume outlines the latest research in this area, showing why this system is so amenable to drug intervention and outlining potential targets for new treatments. Written by experts in the field, this volume will be invaluable to anyone interested in the molecular biology, physiology and biochemistry of parasites as well as those looking to exploit these for the creation of new treatments.

Neuropeptide Systems as Targets for Parasite and Pest Control

Neuropeptide Systems as Targets for Parasite and Pest Control

Author: Timothy G. Geary

Publisher: Springer Science & Business Media

Published: 2011-01-13

Total Pages: 246

ISBN-13: 1441969020

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The need to continually discover new agents for the control or treatment of invertebrate pests and pathogens is undeniable. Agriculture, both animal and plant, succeeds only to the extent that arthropod and helminth consumers, vectors and pathogens can be kept at bay. Humans and their companion animals are also plagued by invertebrate parasites. The deployment of chemical agents for these purposes inevitably elicits the selection of resistant populations of the targets of control, necessitating a regular introduction of new kinds of molecules. Experience in other areas of chemotherapy has shown that a thorough understanding of the biology of disease is an essential platform upon which to build a discovery program. Unfortunately, investment of research resources into understanding the basic physiology of invertebrates as a strategy to illuminate new molecular targets for pesticide and parasiticide discovery has been scarce, and the pace of introduction of new molecules for these indications has been slowed as a result. An exciting and so far unexploited area to explore in this regard is invertebrate neuropeptide physiology. This book was assembled to focus attention on this promising field by compiling a comprehensive review of recent research on neuropeptides in arthropods and helminths, with contributions from many of the leading laboratories working on these systems.


Book Synopsis Neuropeptide Systems as Targets for Parasite and Pest Control by : Timothy G. Geary

Download or read book Neuropeptide Systems as Targets for Parasite and Pest Control written by Timothy G. Geary and published by Springer Science & Business Media. This book was released on 2011-01-13 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: The need to continually discover new agents for the control or treatment of invertebrate pests and pathogens is undeniable. Agriculture, both animal and plant, succeeds only to the extent that arthropod and helminth consumers, vectors and pathogens can be kept at bay. Humans and their companion animals are also plagued by invertebrate parasites. The deployment of chemical agents for these purposes inevitably elicits the selection of resistant populations of the targets of control, necessitating a regular introduction of new kinds of molecules. Experience in other areas of chemotherapy has shown that a thorough understanding of the biology of disease is an essential platform upon which to build a discovery program. Unfortunately, investment of research resources into understanding the basic physiology of invertebrates as a strategy to illuminate new molecular targets for pesticide and parasiticide discovery has been scarce, and the pace of introduction of new molecules for these indications has been slowed as a result. An exciting and so far unexploited area to explore in this regard is invertebrate neuropeptide physiology. This book was assembled to focus attention on this promising field by compiling a comprehensive review of recent research on neuropeptides in arthropods and helminths, with contributions from many of the leading laboratories working on these systems.

Antimicrobial Drug Resistance

Antimicrobial Drug Resistance

Author: Douglas L. Mayers

Publisher: Springer

Published: 2017-06-19

Total Pages: 773

ISBN-13: 3319467182

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The two volumes included in Antimicrobial Drug Resistance, Second Edition is an updated, comprehensive and multidisciplinary reference covering the area of antimicrobial drug resistance in bacteria, fungi, viruses, and parasites from basic science, clinical, and epidemiological perspectives. This newly revised compendium reviews the most current research and development on drug resistance while still providing the information in the accessible format of the first edition. The first volume, Antimicrobial Drug Resistance: Mechanisms of Drug Resistance, is dedicated to the biological basis of drug resistance and effective avenues for drug development. With the emergence of more drug-resistant organisms, the approach to dealing with the drug resistance problem must include the research of different aspects of the mechanisms of bacterial resistance and the dissemination of resistance genes as well as research utilizing new genomic information. These approaches will permit the design of novel strategies to develop new antibiotics and preserve the effectiveness of those currently available. The second volume, Antimicrobial Drug Resistance: Clinical and Epidemiological Aspects, is devoted to the clinical aspects of drug resistance. Although there is evidence that restricted use of a specific antibiotic can be followed by a decrease in drug resistance to that agent, drug resistance control is not easily achieved. Thus, the infectious diseases physician requires input from the clinical microbiologist, antimicrobial stewardship personnel, and infection control specialist to make informed choices for the effective management of various strains of drug-resistant pathogens in individual patients. This 2-volume set is an important reference for students in microbiology, infectious diseases physicians, medical students, basic scientists, drug development researchers, microbiologists, epidemiologists, and public health practitioners.


Book Synopsis Antimicrobial Drug Resistance by : Douglas L. Mayers

Download or read book Antimicrobial Drug Resistance written by Douglas L. Mayers and published by Springer. This book was released on 2017-06-19 with total page 773 pages. Available in PDF, EPUB and Kindle. Book excerpt: The two volumes included in Antimicrobial Drug Resistance, Second Edition is an updated, comprehensive and multidisciplinary reference covering the area of antimicrobial drug resistance in bacteria, fungi, viruses, and parasites from basic science, clinical, and epidemiological perspectives. This newly revised compendium reviews the most current research and development on drug resistance while still providing the information in the accessible format of the first edition. The first volume, Antimicrobial Drug Resistance: Mechanisms of Drug Resistance, is dedicated to the biological basis of drug resistance and effective avenues for drug development. With the emergence of more drug-resistant organisms, the approach to dealing with the drug resistance problem must include the research of different aspects of the mechanisms of bacterial resistance and the dissemination of resistance genes as well as research utilizing new genomic information. These approaches will permit the design of novel strategies to develop new antibiotics and preserve the effectiveness of those currently available. The second volume, Antimicrobial Drug Resistance: Clinical and Epidemiological Aspects, is devoted to the clinical aspects of drug resistance. Although there is evidence that restricted use of a specific antibiotic can be followed by a decrease in drug resistance to that agent, drug resistance control is not easily achieved. Thus, the infectious diseases physician requires input from the clinical microbiologist, antimicrobial stewardship personnel, and infection control specialist to make informed choices for the effective management of various strains of drug-resistant pathogens in individual patients. This 2-volume set is an important reference for students in microbiology, infectious diseases physicians, medical students, basic scientists, drug development researchers, microbiologists, epidemiologists, and public health practitioners.

Drosophila

Drosophila

Author: Christian Dahmann

Publisher: Humana

Published: 2016-10-12

Total Pages: 0

ISBN-13: 9781493963690

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This second edition volume expands on the previous edition by presenting updated protocols for several of the techniques described in the first edition of Drosophila: Methods and Protocols and current methods that cover recent breakthroughs in Drosophila research. The book begins with a description of FlyBase--a database of genes and genomes--followed by the presentation of systems for versatile gene expression in the fly. The first few chapters in this book detail gene knockdown and editing, including CRISPR-Cas9 and protein knockdown. The next few chapters are devoted to methods describing live imaging of different tissues and organs, followed by chapters on how to quantify image data and how to probe tissue mechanics by laser ablation. The next two chapters provide methods for analyzing transcription followed by protocols to study growth, metabolism, ageing, and behavior in Drosophila. This volume concludes with chapters on electrophysiological recordings and methods to establish cell lines. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Drosophila: Methods and Protocols, Second Edition is a valuable source of hands-on protocols and reviews for molecular, cell, and developmental biologists using Drosophila as model systems in their work.


Book Synopsis Drosophila by : Christian Dahmann

Download or read book Drosophila written by Christian Dahmann and published by Humana. This book was released on 2016-10-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition volume expands on the previous edition by presenting updated protocols for several of the techniques described in the first edition of Drosophila: Methods and Protocols and current methods that cover recent breakthroughs in Drosophila research. The book begins with a description of FlyBase--a database of genes and genomes--followed by the presentation of systems for versatile gene expression in the fly. The first few chapters in this book detail gene knockdown and editing, including CRISPR-Cas9 and protein knockdown. The next few chapters are devoted to methods describing live imaging of different tissues and organs, followed by chapters on how to quantify image data and how to probe tissue mechanics by laser ablation. The next two chapters provide methods for analyzing transcription followed by protocols to study growth, metabolism, ageing, and behavior in Drosophila. This volume concludes with chapters on electrophysiological recordings and methods to establish cell lines. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Drosophila: Methods and Protocols, Second Edition is a valuable source of hands-on protocols and reviews for molecular, cell, and developmental biologists using Drosophila as model systems in their work.

Neonatal Formulary

Neonatal Formulary

Author: Sean Ainsworth

Publisher: Oxford University Press, USA

Published: 2020-04-09

Total Pages: 993

ISBN-13: 0198840780

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Neonatal Formulary advises on the safe use of medications in the pregnant or breastfeeding woman and her baby. It covers the period from conception through pregnancy and beyond with effects of administration of medicines to both mother and baby.


Book Synopsis Neonatal Formulary by : Sean Ainsworth

Download or read book Neonatal Formulary written by Sean Ainsworth and published by Oxford University Press, USA. This book was released on 2020-04-09 with total page 993 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neonatal Formulary advises on the safe use of medications in the pregnant or breastfeeding woman and her baby. It covers the period from conception through pregnancy and beyond with effects of administration of medicines to both mother and baby.

Peptidomics

Peptidomics

Author: Mikhail Soloviev

Publisher: John Wiley & Sons

Published: 2007-12-21

Total Pages: 432

ISBN-13: 0470196491

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The definitive guide to peptidomics- a hands-on lab reference The first truly comprehensive book about peptidomics for protein and peptide analysis, this reference provides a detailed description of the hows and whys of peptidomics and how the techniques have evolved. With chapters contributed by leading experts, it covers naturally occurring peptides, peptidomics methods and new developments, and the peptidomics approach to biomarker discovery. Explaining both the principles and the applications, Peptidomics: Methods and Applications: * Features examples of applications in diverse fields, including pharmaceutical science, toxicity biomarkers, and neuroscience * Details the successful peptidomic analyses of biological material ranging from plants to mammals * Describes a cross section of analytical techniques, including traditional methodologies, emerging trends, and new techniques for high throughput approaches An enlightening reference for experienced professionals, this book is sufficiently detailed to serve as a step-by-step guide for beginning researchers and an excellent resource for students taking biotechnology and proteomics courses. It is an invaluable reference for protein chemists and biochemists, professionals and researchers in drug and biopharmaceutical development, analytical and bioanalytical chemists, toxicologists, and others.


Book Synopsis Peptidomics by : Mikhail Soloviev

Download or read book Peptidomics written by Mikhail Soloviev and published by John Wiley & Sons. This book was released on 2007-12-21 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive guide to peptidomics- a hands-on lab reference The first truly comprehensive book about peptidomics for protein and peptide analysis, this reference provides a detailed description of the hows and whys of peptidomics and how the techniques have evolved. With chapters contributed by leading experts, it covers naturally occurring peptides, peptidomics methods and new developments, and the peptidomics approach to biomarker discovery. Explaining both the principles and the applications, Peptidomics: Methods and Applications: * Features examples of applications in diverse fields, including pharmaceutical science, toxicity biomarkers, and neuroscience * Details the successful peptidomic analyses of biological material ranging from plants to mammals * Describes a cross section of analytical techniques, including traditional methodologies, emerging trends, and new techniques for high throughput approaches An enlightening reference for experienced professionals, this book is sufficiently detailed to serve as a step-by-step guide for beginning researchers and an excellent resource for students taking biotechnology and proteomics courses. It is an invaluable reference for protein chemists and biochemists, professionals and researchers in drug and biopharmaceutical development, analytical and bioanalytical chemists, toxicologists, and others.

Macrocyclic Lactones in Antiparasitic Therapy

Macrocyclic Lactones in Antiparasitic Therapy

Author: Robert S. Rew

Publisher: CABI

Published: 2002-01-01

Total Pages: 432

ISBN-13: 9780851996172

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"A previous book published in 1989 provided a comprehensive view of one of the macrocyclic lactones. The present book updates previous information and expands to provide new information generated on the entire class of compounds together with detailed coverage of the basic science of these drugs and their mode of action, as well as their clinical use in farm and companion animals and in humans. The contents include chemistry and mode of action, pharmacology, toxicology, ecology and efficacy, use in large and small animals and in humans, and resistance against macrocyclic lactones. The book will be of interest to those working within the areas of parasitology, pharmacology, and veterinary and human medicine."--BOOK JACKET.


Book Synopsis Macrocyclic Lactones in Antiparasitic Therapy by : Robert S. Rew

Download or read book Macrocyclic Lactones in Antiparasitic Therapy written by Robert S. Rew and published by CABI. This book was released on 2002-01-01 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: "A previous book published in 1989 provided a comprehensive view of one of the macrocyclic lactones. The present book updates previous information and expands to provide new information generated on the entire class of compounds together with detailed coverage of the basic science of these drugs and their mode of action, as well as their clinical use in farm and companion animals and in humans. The contents include chemistry and mode of action, pharmacology, toxicology, ecology and efficacy, use in large and small animals and in humans, and resistance against macrocyclic lactones. The book will be of interest to those working within the areas of parasitology, pharmacology, and veterinary and human medicine."--BOOK JACKET.

Algorithms in Bioinformatics

Algorithms in Bioinformatics

Author: Steven L. Salzberg

Publisher: Springer Science & Business Media

Published: 2009-08-28

Total Pages: 440

ISBN-13: 3642042406

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These proceedings contain papers from the 2009 Workshop on Algorithms in Bioinformatics (WABI), held at the University of Pennsylvania in Philadelphia, Pennsylvania during September 12–13, 2009. WABI 2009 was the ninth annual conference in this series, which focuses on novel algorithms that address imp- tantproblemsingenomics,molecularbiology,andevolution.Theconference- phasizes research that describes computationally e?cient algorithms and data structures that have been implemented and tested in simulations and on real data. WABI is sponsored by the European Association for Theoretical C- puter Science (EATCS) and the International Society for Computational Bi- ogy (ISCB). WABI 2009 was supported by the Penn Genome Frontiers Institute and the Penn Center for Bioinformatics at the University of Pennsylvania. For the 2009 conference, 90 full papers were submitted for review by the Program Committee, and from this strong ?eld of submissions, 34 papers were chosen for presentation at the conference and publication in the proceedings. The ?nal programcovered a wide range of topics including gene interaction n- works, molecular phylogeny, RNA and protein structure, and genome evolution.


Book Synopsis Algorithms in Bioinformatics by : Steven L. Salzberg

Download or read book Algorithms in Bioinformatics written by Steven L. Salzberg and published by Springer Science & Business Media. This book was released on 2009-08-28 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: These proceedings contain papers from the 2009 Workshop on Algorithms in Bioinformatics (WABI), held at the University of Pennsylvania in Philadelphia, Pennsylvania during September 12–13, 2009. WABI 2009 was the ninth annual conference in this series, which focuses on novel algorithms that address imp- tantproblemsingenomics,molecularbiology,andevolution.Theconference- phasizes research that describes computationally e?cient algorithms and data structures that have been implemented and tested in simulations and on real data. WABI is sponsored by the European Association for Theoretical C- puter Science (EATCS) and the International Society for Computational Bi- ogy (ISCB). WABI 2009 was supported by the Penn Genome Frontiers Institute and the Penn Center for Bioinformatics at the University of Pennsylvania. For the 2009 conference, 90 full papers were submitted for review by the Program Committee, and from this strong ?eld of submissions, 34 papers were chosen for presentation at the conference and publication in the proceedings. The ?nal programcovered a wide range of topics including gene interaction n- works, molecular phylogeny, RNA and protein structure, and genome evolution.

Intestinal Failure

Intestinal Failure

Author: Jeremy M.D. Nightingale

Publisher: Springer Nature

Published: 2023-10-03

Total Pages: 953

ISBN-13: 3031222652

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This is the second and fully updated edition of the successful volume on intestinal failure in adults and children. The book provides a comprehensive coverage of all aspects of intestinal failure: from acute and chronic intestinal failure management and treatment, to outcomes, consequences and problems of treatment. In addition, 20 new chapters have been added, covering acute and chronic pancreatitis, critical care and abdominal pain among other topics. Each of the chapters contains a section with top tips on the topic, summarizing the essential take-home messages. Highly educational, this book is a must have for gastroenterologists but is of use for all members of a hospital nutrition support team including nurses, dietitians and pharmacists, whom it will serve as a practical guide for management of intestinal failure both in the hospital and in an outpatient setting. Written by a multidisciplinary author team, this book brings this important subject to a wide readership. With extensive referencing the book provides a detailed overview of the topic, discussing the latest research in the subject and how this relates to current clinical practice and potential future treatments.


Book Synopsis Intestinal Failure by : Jeremy M.D. Nightingale

Download or read book Intestinal Failure written by Jeremy M.D. Nightingale and published by Springer Nature. This book was released on 2023-10-03 with total page 953 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second and fully updated edition of the successful volume on intestinal failure in adults and children. The book provides a comprehensive coverage of all aspects of intestinal failure: from acute and chronic intestinal failure management and treatment, to outcomes, consequences and problems of treatment. In addition, 20 new chapters have been added, covering acute and chronic pancreatitis, critical care and abdominal pain among other topics. Each of the chapters contains a section with top tips on the topic, summarizing the essential take-home messages. Highly educational, this book is a must have for gastroenterologists but is of use for all members of a hospital nutrition support team including nurses, dietitians and pharmacists, whom it will serve as a practical guide for management of intestinal failure both in the hospital and in an outpatient setting. Written by a multidisciplinary author team, this book brings this important subject to a wide readership. With extensive referencing the book provides a detailed overview of the topic, discussing the latest research in the subject and how this relates to current clinical practice and potential future treatments.

Encyclopedia of Parasitology: A-M

Encyclopedia of Parasitology: A-M

Author: Heinz Mehlhorn

Publisher: Springer Science & Business Media

Published: 2007-11-28

Total Pages: 1577

ISBN-13: 3540489940

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Knowledge in the field of parasitology must be kept at a high level and up to date in order to fight a parasitosis as quickly and effectively as possible. The third edition of this, one of Springer’s renowned and authoritative Major Reference Works, contributes to these goals in several ways. First, the number of entries has been increased by about 30%. Secondly the content has been improved even more by adding additional tables and figures. Thirdly, the extensive linking between definitions and essays facilitates information within a minimum of time. More than 40 international contributors, who are well known specialists in their fields, give a comprehensive review of all parasites and therapeutic strategies in veterinarian and human parasitology.


Book Synopsis Encyclopedia of Parasitology: A-M by : Heinz Mehlhorn

Download or read book Encyclopedia of Parasitology: A-M written by Heinz Mehlhorn and published by Springer Science & Business Media. This book was released on 2007-11-28 with total page 1577 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge in the field of parasitology must be kept at a high level and up to date in order to fight a parasitosis as quickly and effectively as possible. The third edition of this, one of Springer’s renowned and authoritative Major Reference Works, contributes to these goals in several ways. First, the number of entries has been increased by about 30%. Secondly the content has been improved even more by adding additional tables and figures. Thirdly, the extensive linking between definitions and essays facilitates information within a minimum of time. More than 40 international contributors, who are well known specialists in their fields, give a comprehensive review of all parasites and therapeutic strategies in veterinarian and human parasitology.