Pharmacology of Potassium Channels

Pharmacology of Potassium Channels

Author: Nikita Gamper

Publisher: Springer Nature

Published: 2021-09-27

Total Pages: 546

ISBN-13: 3030840522

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The aim of the present book is to comprehensively review current advances in understanding of genetics, structural biology, pharmacology of potassium channels and their roles in disease as well as to identify current gaps in knowledge. The ultimate goal is to provide a scientific foundation for better understanding of modulatory mechanisms and pharmacology of potassium channels and to use this understanding to drive future drug discovery. This book will be a must-have for academic and industrial scientists interested in physiology, pharmacology, pathology and structure-functional relationships of ion channels. The book will also be helpful for lecturers and students in the college and university classrooms, as well as for anyone interested in the state-of-the art in modern cell biology, physiology and pharmacology.


Book Synopsis Pharmacology of Potassium Channels by : Nikita Gamper

Download or read book Pharmacology of Potassium Channels written by Nikita Gamper and published by Springer Nature. This book was released on 2021-09-27 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of the present book is to comprehensively review current advances in understanding of genetics, structural biology, pharmacology of potassium channels and their roles in disease as well as to identify current gaps in knowledge. The ultimate goal is to provide a scientific foundation for better understanding of modulatory mechanisms and pharmacology of potassium channels and to use this understanding to drive future drug discovery. This book will be a must-have for academic and industrial scientists interested in physiology, pharmacology, pathology and structure-functional relationships of ion channels. The book will also be helpful for lecturers and students in the college and university classrooms, as well as for anyone interested in the state-of-the art in modern cell biology, physiology and pharmacology.

Frontiers in Pharmacology of Neurotransmitters

Frontiers in Pharmacology of Neurotransmitters

Author: Puneet Kumar

Publisher: Springer Nature

Published: 2020-10-29

Total Pages: 729

ISBN-13: 9811535566

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Numerous phenomenal advances have been made towards understanding the role of neurotransmitters in the pathophysiology of neurological disorders, and these have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of such disorders. This book provides a comprehensive and detailed explanation of brain neurotransmitters and their receptors and associated channels. It includes a basic introduction, and also discusses the functions and recent advances and their pharmacology, highlighting the role of various computer aided drug design (CADD) strategies for the development of therapeutic ligands to modulate these receptors/ion channels. Written in an easy-to-read style, it is intended for neuroscience and pharmaceutical students and researchers working in the area of brain neurotransmitters.


Book Synopsis Frontiers in Pharmacology of Neurotransmitters by : Puneet Kumar

Download or read book Frontiers in Pharmacology of Neurotransmitters written by Puneet Kumar and published by Springer Nature. This book was released on 2020-10-29 with total page 729 pages. Available in PDF, EPUB and Kindle. Book excerpt: Numerous phenomenal advances have been made towards understanding the role of neurotransmitters in the pathophysiology of neurological disorders, and these have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of such disorders. This book provides a comprehensive and detailed explanation of brain neurotransmitters and their receptors and associated channels. It includes a basic introduction, and also discusses the functions and recent advances and their pharmacology, highlighting the role of various computer aided drug design (CADD) strategies for the development of therapeutic ligands to modulate these receptors/ion channels. Written in an easy-to-read style, it is intended for neuroscience and pharmaceutical students and researchers working in the area of brain neurotransmitters.

Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters

Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters

Author: M. Morad

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 586

ISBN-13: 9401139903

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Knowledge of cardiac ion channels and transporters has advanced remarkably in the last two decades with the development of patch-clamp and molecular biological techniques. This textbook offers a comprehensive overview of structures and functions of ion channels and transporters in the heart. Readers are first introduced to the molecular biology and electrophysiology of all the important ion channels. After discussing their developmental changes, the pharmacology and pathophysiology of clinically-relevant ion channels are reviewed. Molecular aspects of the cardiac excitation-contraction coupling and intracellular Ca2+ regulation by ion transporters are also described. The book will be useful to electrophysiologists, cardiac physiologists and pharmacologists, and molecular biologists interested in ion channels at all levels. For research specialists, the book will provide a perspective of the field. The book can be used as a reference source for working scientists in the fields of ion channels, biophysics, cardiac electrophysiology, and pharmacology. It is aimed at graduate and medical students, designed for use as a textbook for graduate and medical courses.


Book Synopsis Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters by : M. Morad

Download or read book Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters written by M. Morad and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge of cardiac ion channels and transporters has advanced remarkably in the last two decades with the development of patch-clamp and molecular biological techniques. This textbook offers a comprehensive overview of structures and functions of ion channels and transporters in the heart. Readers are first introduced to the molecular biology and electrophysiology of all the important ion channels. After discussing their developmental changes, the pharmacology and pathophysiology of clinically-relevant ion channels are reviewed. Molecular aspects of the cardiac excitation-contraction coupling and intracellular Ca2+ regulation by ion transporters are also described. The book will be useful to electrophysiologists, cardiac physiologists and pharmacologists, and molecular biologists interested in ion channels at all levels. For research specialists, the book will provide a perspective of the field. The book can be used as a reference source for working scientists in the fields of ion channels, biophysics, cardiac electrophysiology, and pharmacology. It is aimed at graduate and medical students, designed for use as a textbook for graduate and medical courses.

Voltage-Gated Ion Channels as Drug Targets

Voltage-Gated Ion Channels as Drug Targets

Author: David J. Triggle

Publisher: John Wiley & Sons

Published: 2006-08-21

Total Pages: 492

ISBN-13: 3527607749

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Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology. After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section each on calcium, sodium and potassium channels. Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion channel drug development. For medicinal and pharmaceutical chemists, biochemists, molecular biologists and those working in the pharmaceutical industry.


Book Synopsis Voltage-Gated Ion Channels as Drug Targets by : David J. Triggle

Download or read book Voltage-Gated Ion Channels as Drug Targets written by David J. Triggle and published by John Wiley & Sons. This book was released on 2006-08-21 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology. After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section each on calcium, sodium and potassium channels. Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion channel drug development. For medicinal and pharmaceutical chemists, biochemists, molecular biologists and those working in the pharmaceutical industry.

Ion Channel Pharmacology

Ion Channel Pharmacology

Author: Bernat Soria

Publisher:

Published: 1998

Total Pages: 498

ISBN-13:

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The improved understanding of ion channel structure, achieved through the use of molecular biology techniques, has opened the way for the development of new drugs targeted at specific types of ion channels. This book provides a comprehensive, single-volume overview of the effects of different drugs and toxins on ionic channels. The first part of the book deals with the development of ion channels, while subsequent chapters detail the electrophysiological properties and pharmacology of eight different types of ion channels, including intracellular, cyclic nucleotide-gated, and receptor operated channels. Drug effects in various cell types, along with the potential use of channels in therapeutics, are discussed for each channel type. Comprehensive and up-to-date, Ion Channel Pharmacology is an essential reference for every investigator in this fast-growing area of research.


Book Synopsis Ion Channel Pharmacology by : Bernat Soria

Download or read book Ion Channel Pharmacology written by Bernat Soria and published by . This book was released on 1998 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: The improved understanding of ion channel structure, achieved through the use of molecular biology techniques, has opened the way for the development of new drugs targeted at specific types of ion channels. This book provides a comprehensive, single-volume overview of the effects of different drugs and toxins on ionic channels. The first part of the book deals with the development of ion channels, while subsequent chapters detail the electrophysiological properties and pharmacology of eight different types of ion channels, including intracellular, cyclic nucleotide-gated, and receptor operated channels. Drug effects in various cell types, along with the potential use of channels in therapeutics, are discussed for each channel type. Comprehensive and up-to-date, Ion Channel Pharmacology is an essential reference for every investigator in this fast-growing area of research.

Potassium Channels And Their Modulators

Potassium Channels And Their Modulators

Author: John M Evans

Publisher: CRC Press

Published: 2003-09-02

Total Pages: 521

ISBN-13: 0203304411

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Potassium ions K+ ions are vital in physiological processes, particularly with regard to the cardiovascular system. Modulators influence the channels through which these ions flow and the research into modulator drugs of these channels is the subject of rapidly-advancing research. This work is intended to be of use as a tool for those working in the pharmaceutical industry. Early chapters concentrate on the synthesis and structure-activity relationships of potassium channel modulators. These are followed by discussion on the application of these drugs to different target organs, such as the cardiovascular system and the airways. The book concludes with a broad overview of clinical experience and future prospects.; The authors show how potassium channel activators and potassium channel blockers each have a role to play as therapeutic agents for many disorders, including asthma and respiratory tract disorders, diseases of the central nervous system such as epilepsy, and vascular diseases such as angina, peripheral vascular disease and high blood pressure. This book should therefore also be of interest to those researching into this wide range of diseases.


Book Synopsis Potassium Channels And Their Modulators by : John M Evans

Download or read book Potassium Channels And Their Modulators written by John M Evans and published by CRC Press. This book was released on 2003-09-02 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: Potassium ions K+ ions are vital in physiological processes, particularly with regard to the cardiovascular system. Modulators influence the channels through which these ions flow and the research into modulator drugs of these channels is the subject of rapidly-advancing research. This work is intended to be of use as a tool for those working in the pharmaceutical industry. Early chapters concentrate on the synthesis and structure-activity relationships of potassium channel modulators. These are followed by discussion on the application of these drugs to different target organs, such as the cardiovascular system and the airways. The book concludes with a broad overview of clinical experience and future prospects.; The authors show how potassium channel activators and potassium channel blockers each have a role to play as therapeutic agents for many disorders, including asthma and respiratory tract disorders, diseases of the central nervous system such as epilepsy, and vascular diseases such as angina, peripheral vascular disease and high blood pressure. This book should therefore also be of interest to those researching into this wide range of diseases.

Potassium Channels

Potassium Channels

Author: Jonathan D. Lippiat

Publisher: Humana Press

Published: 2010-11-19

Total Pages: 0

ISBN-13: 9781617379406

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Due to the importance of potassium channels in cellular function, researchers have been challenged to develop tools and experimental procedures to probe the function and identify chemicals that modulate the behaviour of this super-family of ion channels. In Potassium Channels: Methods and Protocols, experts in the field present a range of experimental approaches that have been developed to investigate potassium channel structure, function, pharmacology, cell biology, gene expression, and their role in disease. Many of these techniques study potassium channels as cellular proteins as well as the resultant membrane biophysics. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters contain brief introductions to the subject, lists of the necessary materials and reagents, readily reproducible laboratory protocols, and a Notes section, which highlights tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Potassium Channels: Methods and Protocols provides a wide range of approaches in order to aid current research projects and inspire new investigations.


Book Synopsis Potassium Channels by : Jonathan D. Lippiat

Download or read book Potassium Channels written by Jonathan D. Lippiat and published by Humana Press. This book was released on 2010-11-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to the importance of potassium channels in cellular function, researchers have been challenged to develop tools and experimental procedures to probe the function and identify chemicals that modulate the behaviour of this super-family of ion channels. In Potassium Channels: Methods and Protocols, experts in the field present a range of experimental approaches that have been developed to investigate potassium channel structure, function, pharmacology, cell biology, gene expression, and their role in disease. Many of these techniques study potassium channels as cellular proteins as well as the resultant membrane biophysics. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters contain brief introductions to the subject, lists of the necessary materials and reagents, readily reproducible laboratory protocols, and a Notes section, which highlights tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Potassium Channels: Methods and Protocols provides a wide range of approaches in order to aid current research projects and inspire new investigations.

Jasper's Basic Mechanisms of the Epilepsies

Jasper's Basic Mechanisms of the Epilepsies

Author: Jeffrey L. Noebels

Publisher: OUP USA

Published: 2012-06-29

Total Pages: 1258

ISBN-13: 0199746540

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Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.


Book Synopsis Jasper's Basic Mechanisms of the Epilepsies by : Jeffrey L. Noebels

Download or read book Jasper's Basic Mechanisms of the Epilepsies written by Jeffrey L. Noebels and published by OUP USA. This book was released on 2012-06-29 with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.

Handbook of Ion Channels

Handbook of Ion Channels

Author: Jie Zheng

Publisher: CRC Press

Published: 2015-02-25

Total Pages: 682

ISBN-13: 1466551429

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The New Benchmark for Understanding the Latest Developments of Ion ChannelsIon channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of ce


Book Synopsis Handbook of Ion Channels by : Jie Zheng

Download or read book Handbook of Ion Channels written by Jie Zheng and published by CRC Press. This book was released on 2015-02-25 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: The New Benchmark for Understanding the Latest Developments of Ion ChannelsIon channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of ce

Potassium Channel Modulators

Potassium Channel Modulators

Author: AH Weston

Publisher: Wiley-Blackwell

Published: 1993-01-18

Total Pages: 528

ISBN-13: 9780632030446

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Modulation of potassium channels plays a very important part in nerve cell function in the autonomic nervous system. Compounds are now in development which can open or close potassium channels and will have numerous therapeutic applications. The major areas of clinical relevance will be hypertension, asthma and irritable bladder syndrome. The book describes the pharmacology of the channels and strategies for the design of drugs which exploit them. It consists of 17 chapters by international experts in the field which are written at a high level and will be of interest to pharmacologists and those in related clinical research disciplines


Book Synopsis Potassium Channel Modulators by : AH Weston

Download or read book Potassium Channel Modulators written by AH Weston and published by Wiley-Blackwell. This book was released on 1993-01-18 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modulation of potassium channels plays a very important part in nerve cell function in the autonomic nervous system. Compounds are now in development which can open or close potassium channels and will have numerous therapeutic applications. The major areas of clinical relevance will be hypertension, asthma and irritable bladder syndrome. The book describes the pharmacology of the channels and strategies for the design of drugs which exploit them. It consists of 17 chapters by international experts in the field which are written at a high level and will be of interest to pharmacologists and those in related clinical research disciplines