Advanced Photon Counting

Advanced Photon Counting

Author: Peter Kapusta

Publisher: Springer

Published: 2015-04-23

Total Pages: 370

ISBN-13: 3319156365

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This volume focuses on Time-Correlated Single Photon Counting (TCSPC), a powerful tool allowing luminescence lifetime measurements to be made with high temporal resolution, even on single molecules. Combining spectrum and lifetime provides a “fingerprint” for identifying such molecules in the presence of a background. Used together with confocal detection, this permits single-molecule spectroscopy and microscopy in addition to ensemble measurements, opening up an enormous range of hot life science applications such as fluorescence lifetime imaging (FLIM) and measurement of Förster Resonant Energy Transfer (FRET) for the investigation of protein folding and interaction. Several technology-related chapters present both the basics and current state-of-the-art, in particular of TCSPC electronics, photon detectors and lasers. The remaining chapters cover a broad range of applications and methodologies for experiments and data analysis, including the life sciences, defect centers in diamonds, super-resolution microscopy, and optical tomography. The chapters detailing new options arising from the combination of classic TCSPC and fluorescence lifetime with methods based on intensity fluctuation represent a particularly unique highlight.


Book Synopsis Advanced Photon Counting by : Peter Kapusta

Download or read book Advanced Photon Counting written by Peter Kapusta and published by Springer. This book was released on 2015-04-23 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on Time-Correlated Single Photon Counting (TCSPC), a powerful tool allowing luminescence lifetime measurements to be made with high temporal resolution, even on single molecules. Combining spectrum and lifetime provides a “fingerprint” for identifying such molecules in the presence of a background. Used together with confocal detection, this permits single-molecule spectroscopy and microscopy in addition to ensemble measurements, opening up an enormous range of hot life science applications such as fluorescence lifetime imaging (FLIM) and measurement of Förster Resonant Energy Transfer (FRET) for the investigation of protein folding and interaction. Several technology-related chapters present both the basics and current state-of-the-art, in particular of TCSPC electronics, photon detectors and lasers. The remaining chapters cover a broad range of applications and methodologies for experiments and data analysis, including the life sciences, defect centers in diamonds, super-resolution microscopy, and optical tomography. The chapters detailing new options arising from the combination of classic TCSPC and fluorescence lifetime with methods based on intensity fluctuation represent a particularly unique highlight.

Photon-Counting Image Sensors

Photon-Counting Image Sensors

Author: Eric R. Fossum

Publisher: MDPI

Published: 2018-07-06

Total Pages: 379

ISBN-13: 3038423742

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This book is a printed edition of the Special Issue "Photon-Counting Image Sensors" that was published in Sensors


Book Synopsis Photon-Counting Image Sensors by : Eric R. Fossum

Download or read book Photon-Counting Image Sensors written by Eric R. Fossum and published by MDPI. This book was released on 2018-07-06 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Photon-Counting Image Sensors" that was published in Sensors

Spectral, Photon Counting Computed Tomography

Spectral, Photon Counting Computed Tomography

Author: Katsuyuki Taguchi

Publisher: CRC Press

Published: 2020-07-14

Total Pages: 446

ISBN-13: 0429942001

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Spectral, Photon Counting Computed Tomography is a comprehensive cover of the latest developments in the most prevalent imaging modality (x-ray computed tomography (CT)) in its latest incarnation: Spectral, Dual-Energy, and Photon Counting CT. Disadvantages of the conventional single-energy technique used by CT technology are that different materials cannot be distinguished and that the noise is larger. To address these problems, a novel spectral CT concept has been proposed. Spectral Dual-Energy CT (DE-CT) acquires two sets of spectral data, and Spectral Photon Counting CT (PC-CT) detects energy of x-ray photons to reveal additional material information of objects by using novel energy-sensitive, photon-counting detectors. The K-edge imaging may be a gateway for functional or molecular CT. The book covers detectors and electronics, image reconstruction methods, image quality assessments, a simulation tool, nanoparticle contrast agents, and clinical applications for spectral CT.


Book Synopsis Spectral, Photon Counting Computed Tomography by : Katsuyuki Taguchi

Download or read book Spectral, Photon Counting Computed Tomography written by Katsuyuki Taguchi and published by CRC Press. This book was released on 2020-07-14 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spectral, Photon Counting Computed Tomography is a comprehensive cover of the latest developments in the most prevalent imaging modality (x-ray computed tomography (CT)) in its latest incarnation: Spectral, Dual-Energy, and Photon Counting CT. Disadvantages of the conventional single-energy technique used by CT technology are that different materials cannot be distinguished and that the noise is larger. To address these problems, a novel spectral CT concept has been proposed. Spectral Dual-Energy CT (DE-CT) acquires two sets of spectral data, and Spectral Photon Counting CT (PC-CT) detects energy of x-ray photons to reveal additional material information of objects by using novel energy-sensitive, photon-counting detectors. The K-edge imaging may be a gateway for functional or molecular CT. The book covers detectors and electronics, image reconstruction methods, image quality assessments, a simulation tool, nanoparticle contrast agents, and clinical applications for spectral CT.

Time-correlated single photon counting

Time-correlated single photon counting

Author: Desmond O'Connor

Publisher: Academic Press

Published: 2012-12-02

Total Pages: 299

ISBN-13: 0323141447

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Time-correlated Single Photon Counting has been written in the hope that by relating the authors' experiences with a variety of different single photon counting systems, they may provide a useful service to users and potential users of this formidably sensitive technique. Of all the techniques available to obtain information on the rates of depopulation of excited electronic singlet states of molecular species, monitoring of fluorescence provides, in principle, the simplest and most direct measure of concentration. This volume comprises eight chapters, with the first focusing on the time dependence and applications of fluorescence. Succeeding chapters go on to discuss basic principles of the single photon counting lifetime measurement; light sources; photomultipliers; electronics; data analysis; nanosecond time-resolved emission spectroscopy; time dependence of fluorescence anisotropy. This book will be of interest to practitioners in the field of chemistry.


Book Synopsis Time-correlated single photon counting by : Desmond O'Connor

Download or read book Time-correlated single photon counting written by Desmond O'Connor and published by Academic Press. This book was released on 2012-12-02 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: Time-correlated Single Photon Counting has been written in the hope that by relating the authors' experiences with a variety of different single photon counting systems, they may provide a useful service to users and potential users of this formidably sensitive technique. Of all the techniques available to obtain information on the rates of depopulation of excited electronic singlet states of molecular species, monitoring of fluorescence provides, in principle, the simplest and most direct measure of concentration. This volume comprises eight chapters, with the first focusing on the time dependence and applications of fluorescence. Succeeding chapters go on to discuss basic principles of the single photon counting lifetime measurement; light sources; photomultipliers; electronics; data analysis; nanosecond time-resolved emission spectroscopy; time dependence of fluorescence anisotropy. This book will be of interest to practitioners in the field of chemistry.

Advanced Time-Correlated Single Photon Counting Techniques

Advanced Time-Correlated Single Photon Counting Techniques

Author: Wolfgang Becker

Publisher: Springer Science & Business Media

Published: 2005-12-19

Total Pages: 414

ISBN-13: 3540288821

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In 1984 Desmond O’Connor and David Phillips published their comprehensive book „Time-correlated Single Photon Counting“. At that time time-correlated s- gle photon counting, or TCSPC, was used primarily to record fluorescence decay functions of dye solutions in cuvettes. From the beginning, TCSPC was an am- ingly sensitive and accurate technique with excellent time-resolution. However, acquisition times were relatively slow due to the low repetition rate of the light sources and the limited speed of the electronics of the 70s and early 80s. Moreover, TCSPC was intrinsically one-dimensional, i.e. limited to the recording of the wa- form of a periodic light signal. Even with these limitations, it was a wonderful te- nique. More than 20 years have elapsed, and electronics and laser techniques have made impressive progress. The number of transistors on a single chip has approximately doubled every 18 months, resulting in a more than 1,000-fold increase in compl- ity and speed. The repetition rate and power of pulsed light sources have increased by about the same factor.


Book Synopsis Advanced Time-Correlated Single Photon Counting Techniques by : Wolfgang Becker

Download or read book Advanced Time-Correlated Single Photon Counting Techniques written by Wolfgang Becker and published by Springer Science & Business Media. This book was released on 2005-12-19 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1984 Desmond O’Connor and David Phillips published their comprehensive book „Time-correlated Single Photon Counting“. At that time time-correlated s- gle photon counting, or TCSPC, was used primarily to record fluorescence decay functions of dye solutions in cuvettes. From the beginning, TCSPC was an am- ingly sensitive and accurate technique with excellent time-resolution. However, acquisition times were relatively slow due to the low repetition rate of the light sources and the limited speed of the electronics of the 70s and early 80s. Moreover, TCSPC was intrinsically one-dimensional, i.e. limited to the recording of the wa- form of a periodic light signal. Even with these limitations, it was a wonderful te- nique. More than 20 years have elapsed, and electronics and laser techniques have made impressive progress. The number of transistors on a single chip has approximately doubled every 18 months, resulting in a more than 1,000-fold increase in compl- ity and speed. The repetition rate and power of pulsed light sources have increased by about the same factor.

Photon Counting

Photon Counting

Author: Nikolay Britun

Publisher: BoD – Books on Demand

Published: 2018-03-21

Total Pages: 298

ISBN-13: 953513907X

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Photon counting is a unified name for the techniques using single-photon detection for accumulative measurements of the light flux, normally occurring under extremely low-light conditions. Nowadays, this approach can be applied to the wide variety of the radiation wavelengths, starting from X-ray and deep ultraviolet transitions and ending with far-infrared part of the spectrum. As a special tribute to the photon counting, the studies of cosmic microwave background radiation in astronomy, the experiments with muon detection, and the large-scale fundamental experiments on the nature of matter should be noted. The book provides readers with an overview on the fundamentals and state-of-the-art applications of photon counting technique in the applied science and everyday life.


Book Synopsis Photon Counting by : Nikolay Britun

Download or read book Photon Counting written by Nikolay Britun and published by BoD – Books on Demand. This book was released on 2018-03-21 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photon counting is a unified name for the techniques using single-photon detection for accumulative measurements of the light flux, normally occurring under extremely low-light conditions. Nowadays, this approach can be applied to the wide variety of the radiation wavelengths, starting from X-ray and deep ultraviolet transitions and ending with far-infrared part of the spectrum. As a special tribute to the photon counting, the studies of cosmic microwave background radiation in astronomy, the experiments with muon detection, and the large-scale fundamental experiments on the nature of matter should be noted. The book provides readers with an overview on the fundamentals and state-of-the-art applications of photon counting technique in the applied science and everyday life.

Photon Counting Detectors for X-ray Imaging

Photon Counting Detectors for X-ray Imaging

Author: Hiroaki Hayashi

Publisher: Springer Nature

Published: 2021-02-15

Total Pages: 119

ISBN-13: 3030626806

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This book first provides readers with an introduction to the underlying physics and state-of-the-art application of photon counting detectors for X-ray imaging. The authors explain that a photon-counting imaging detector can realize quantitative analysis because the detector can derive X-ray attenuation information based on the analysis of intensity changes of individual X-ray. To realize this analysis, it is important to consider the physics of an object and detector material. In this book, the authors introduce a novel analytical procedure to create quantitative X-ray images for medical diagnosis.


Book Synopsis Photon Counting Detectors for X-ray Imaging by : Hiroaki Hayashi

Download or read book Photon Counting Detectors for X-ray Imaging written by Hiroaki Hayashi and published by Springer Nature. This book was released on 2021-02-15 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book first provides readers with an introduction to the underlying physics and state-of-the-art application of photon counting detectors for X-ray imaging. The authors explain that a photon-counting imaging detector can realize quantitative analysis because the detector can derive X-ray attenuation information based on the analysis of intensity changes of individual X-ray. To realize this analysis, it is important to consider the physics of an object and detector material. In this book, the authors introduce a novel analytical procedure to create quantitative X-ray images for medical diagnosis.

Radiation Detectors for Medical Imaging

Radiation Detectors for Medical Imaging

Author: Jan S. Iwanczyk

Publisher: CRC Press

Published: 2015-12-01

Total Pages: 335

ISBN-13: 149876682X

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Radiation Detectors for Medical Imaging discusses the current state of the art and future prospects of photon-counting detectors for medical imaging applications. Featuring contributions from leading experts and pioneers in their respective fields, this book: Describes x-ray spectral imaging detectors based on cadmium zinc telluride (CdZnTe) and cadmium telluride (CdTe) materials Presents novel computed tomography (CT) and x-ray clinical applications of photon-counting detectors Considers the future use of CT scanners as both an anatomical and a functional modality in areas typically reserved for nuclear medicine techniques Addresses pulse pileup, incomplete charge collection, and other phenomena that can degrade the spectral response of photon-counting detectors Examines silicon photomultipliers used in single-photon emission computed tomography (SPECT) and positron emission tomography (PET) systems Radiation Detectors for Medical Imaging explores cutting-edge technologies that play a vital role in the detection, diagnosis, and treatment of major human diseases, including heart disease and cancer—the top killers in developed countries.


Book Synopsis Radiation Detectors for Medical Imaging by : Jan S. Iwanczyk

Download or read book Radiation Detectors for Medical Imaging written by Jan S. Iwanczyk and published by CRC Press. This book was released on 2015-12-01 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiation Detectors for Medical Imaging discusses the current state of the art and future prospects of photon-counting detectors for medical imaging applications. Featuring contributions from leading experts and pioneers in their respective fields, this book: Describes x-ray spectral imaging detectors based on cadmium zinc telluride (CdZnTe) and cadmium telluride (CdTe) materials Presents novel computed tomography (CT) and x-ray clinical applications of photon-counting detectors Considers the future use of CT scanners as both an anatomical and a functional modality in areas typically reserved for nuclear medicine techniques Addresses pulse pileup, incomplete charge collection, and other phenomena that can degrade the spectral response of photon-counting detectors Examines silicon photomultipliers used in single-photon emission computed tomography (SPECT) and positron emission tomography (PET) systems Radiation Detectors for Medical Imaging explores cutting-edge technologies that play a vital role in the detection, diagnosis, and treatment of major human diseases, including heart disease and cancer—the top killers in developed countries.

Electronics for Radiation Detection

Electronics for Radiation Detection

Author: Krzysztof Iniewski

Publisher: CRC Press

Published: 2018-09-03

Total Pages: 384

ISBN-13: 1439858845

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There is a growing need to understand and combat potential radiation damage problems in semiconductor devices and circuits. Assessing the billion-dollar market for detection equipment in the context of medical imaging using ionizing radiation, Electronics for Radiation Detection presents valuable information that will help integrated circuit (IC) designers and other electronics professionals take full advantage of the tremendous developments and opportunities associated with this burgeoning field. Assembling contributions from industrial and academic experts, this book— Addresses the state of the art in the design of semiconductor detectors, integrated circuits, and other electronics used in radiation detection Analyzes the main effects of radiation in semiconductor devices and circuits, paying special attention to degradation observed in MOS devices and circuits when they are irradiated Explains how circuits are built to deal with radiation, focusing on practical information about how they are being used, rather than mathematical details Radiation detection is critical in space applications, nuclear physics, semiconductor processing, and medical imaging, as well as security, drug development, and modern silicon processing techniques. The authors discuss new opportunities in these fields and address emerging detector technologies, circuit design techniques, new materials, and innovative system approaches. Aimed at postgraduate researchers and practicing engineers, this book is a must for those serious about improving their understanding of electronics used in radiation detection. The information presented here can help you make optimal use of electronic detection equipment and stimulate further interest in its development, use, and benefits.


Book Synopsis Electronics for Radiation Detection by : Krzysztof Iniewski

Download or read book Electronics for Radiation Detection written by Krzysztof Iniewski and published by CRC Press. This book was released on 2018-09-03 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a growing need to understand and combat potential radiation damage problems in semiconductor devices and circuits. Assessing the billion-dollar market for detection equipment in the context of medical imaging using ionizing radiation, Electronics for Radiation Detection presents valuable information that will help integrated circuit (IC) designers and other electronics professionals take full advantage of the tremendous developments and opportunities associated with this burgeoning field. Assembling contributions from industrial and academic experts, this book— Addresses the state of the art in the design of semiconductor detectors, integrated circuits, and other electronics used in radiation detection Analyzes the main effects of radiation in semiconductor devices and circuits, paying special attention to degradation observed in MOS devices and circuits when they are irradiated Explains how circuits are built to deal with radiation, focusing on practical information about how they are being used, rather than mathematical details Radiation detection is critical in space applications, nuclear physics, semiconductor processing, and medical imaging, as well as security, drug development, and modern silicon processing techniques. The authors discuss new opportunities in these fields and address emerging detector technologies, circuit design techniques, new materials, and innovative system approaches. Aimed at postgraduate researchers and practicing engineers, this book is a must for those serious about improving their understanding of electronics used in radiation detection. The information presented here can help you make optimal use of electronic detection equipment and stimulate further interest in its development, use, and benefits.

Photon Counting Computed Tomography

Photon Counting Computed Tomography

Author: Scott Hsieh

Publisher: Springer Nature

Published: 2023-05-27

Total Pages: 271

ISBN-13: 3031260627

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This book will provide readers with a good overview of some of most recent advances in the field of Photon Counting CT technology for X-ray medical imaging, especially as it pertains to new detectors. There will be a good mixture of general chapters in both technology and applications in CT medical imaging. The book will have an in-depth review of the research topics from world-leading specialists in the field. The conversion of the X-ray signal into analogue/digital value will be covered in some chapters. The authors also provide a review of CMOS chips for X-ray image sensors, methods of material discrimination and image reconstruction techniques. Covers a broad range of topics, including an introduction to novel spectral Computed Tomography; Includes in-depth analysis on how to optimize X-ray detection; Discusses analysis of electronics for X-ray detection.


Book Synopsis Photon Counting Computed Tomography by : Scott Hsieh

Download or read book Photon Counting Computed Tomography written by Scott Hsieh and published by Springer Nature. This book was released on 2023-05-27 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will provide readers with a good overview of some of most recent advances in the field of Photon Counting CT technology for X-ray medical imaging, especially as it pertains to new detectors. There will be a good mixture of general chapters in both technology and applications in CT medical imaging. The book will have an in-depth review of the research topics from world-leading specialists in the field. The conversion of the X-ray signal into analogue/digital value will be covered in some chapters. The authors also provide a review of CMOS chips for X-ray image sensors, methods of material discrimination and image reconstruction techniques. Covers a broad range of topics, including an introduction to novel spectral Computed Tomography; Includes in-depth analysis on how to optimize X-ray detection; Discusses analysis of electronics for X-ray detection.