Practical Process Research and Development

Practical Process Research and Development

Author: Neal G. Anderson

Publisher: Academic Press

Published: 2012-05-23

Total Pages: 489

ISBN-13: 0123865387

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Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." Second Edition highlights:• Reflects the current thinking in chemical process R&D for small molecules• Retains similar structure and orientation to the first edition. • Contains approx. 85% new material• Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up)• Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes)• Replaces the first edition, although the first edition contains useful older examples that readers may refer to Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Presents guidelines for implementing and troubleshooting processes


Book Synopsis Practical Process Research and Development by : Neal G. Anderson

Download or read book Practical Process Research and Development written by Neal G. Anderson and published by Academic Press. This book was released on 2012-05-23 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." Second Edition highlights:• Reflects the current thinking in chemical process R&D for small molecules• Retains similar structure and orientation to the first edition. • Contains approx. 85% new material• Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up)• Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes)• Replaces the first edition, although the first edition contains useful older examples that readers may refer to Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Presents guidelines for implementing and troubleshooting processes

Practical Process Research and Development

Practical Process Research and Development

Author: Neal G. Anderson

Publisher: Elsevier

Published: 2000-06-05

Total Pages: 380

ISBN-13: 0080514480

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This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students. Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Includes over 100 tips for rapid process development Presents guidelines for implementing and troubleshooting processes


Book Synopsis Practical Process Research and Development by : Neal G. Anderson

Download or read book Practical Process Research and Development written by Neal G. Anderson and published by Elsevier. This book was released on 2000-06-05 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students. Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Includes over 100 tips for rapid process development Presents guidelines for implementing and troubleshooting processes

Practical Process Research & Development

Practical Process Research & Development

Author: Neal G. Anderson

Publisher: Academic Press

Published: 2000-03

Total Pages: 354

ISBN-13: 9781483299778

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This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students. * Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" * Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more * Includes over 100 tips for rapid process development * Presents guidelines for implementing and troubleshooting processes


Book Synopsis Practical Process Research & Development by : Neal G. Anderson

Download or read book Practical Process Research & Development written by Neal G. Anderson and published by Academic Press. This book was released on 2000-03 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students. * Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" * Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more * Includes over 100 tips for rapid process development * Presents guidelines for implementing and troubleshooting processes

Practical Process Control for Engineers and Technicians

Practical Process Control for Engineers and Technicians

Author: Wolfgang Altmann

Publisher: Elsevier

Published: 2005-05-10

Total Pages: 304

ISBN-13: 008048025X

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This book is aimed at engineers and technicians who need to have a clear, practical understanding of the essentials of process control, loop tuning and how to optimize the operation of their particular plant or process. The reader would typically be involved in the design, implementation and upgrading of industrial control systems. Mathematical theory has been kept to a minimum with the emphasis throughout on practical applications and useful information.This book will enable the reader to:* Specify and design the loop requirements for a plant using PID control* Identify and apply the essential building blocks in automatic control* Apply the procedures for open and closed loop tuning* Tune control loops with significant dead-times* Demonstrate a clear understanding of analog process control and how to tune analog loops* Explain concepts used by major manufacturers who use the most up-to-date technology in the process control field · A practical focus on the optimization of process and plant· Readers develop professional competencies, not just theoretical knowledge· Reduce dead-time with loop tuning techniques


Book Synopsis Practical Process Control for Engineers and Technicians by : Wolfgang Altmann

Download or read book Practical Process Control for Engineers and Technicians written by Wolfgang Altmann and published by Elsevier. This book was released on 2005-05-10 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is aimed at engineers and technicians who need to have a clear, practical understanding of the essentials of process control, loop tuning and how to optimize the operation of their particular plant or process. The reader would typically be involved in the design, implementation and upgrading of industrial control systems. Mathematical theory has been kept to a minimum with the emphasis throughout on practical applications and useful information.This book will enable the reader to:* Specify and design the loop requirements for a plant using PID control* Identify and apply the essential building blocks in automatic control* Apply the procedures for open and closed loop tuning* Tune control loops with significant dead-times* Demonstrate a clear understanding of analog process control and how to tune analog loops* Explain concepts used by major manufacturers who use the most up-to-date technology in the process control field · A practical focus on the optimization of process and plant· Readers develop professional competencies, not just theoretical knowledge· Reduce dead-time with loop tuning techniques

Software Process Improvement and Management: Approaches and Tools for Practical Development

Software Process Improvement and Management: Approaches and Tools for Practical Development

Author: Fauzi, Shukor Sanim Mohd

Publisher: IGI Global

Published: 2011-11-30

Total Pages: 284

ISBN-13: 1613501420

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Over the past decade, there has been an increase in attention and focus on the discipline of software engineering. Software engineering tools and techniques have been developed to gain more predictable quality improvement results. Process standards such as Capability Maturity Model Integration (CMMI), ISO 9000, Software Process Improvement and Capability dEtermination (SPICE), Agile Methodologies, and others have been proposed to assist organizations to achieve more predictable results by incorporating these proven standards and procedures into their software process. Software Process Improvement and Management: Approaches and Tools for Practical Development offers the latest research and case studies on software engineering and development. The production of new process standards assist organizations and software engineers in adding a measure of predictability to the software process. Companies can gain a decisive competitive advantage by applying these new and theoretical methodologies in real-world scenarios. Researchers, scholars, practitioners, students, and anyone interested in the field of software development and design should access this book as a major compendium of the latest research in the field.


Book Synopsis Software Process Improvement and Management: Approaches and Tools for Practical Development by : Fauzi, Shukor Sanim Mohd

Download or read book Software Process Improvement and Management: Approaches and Tools for Practical Development written by Fauzi, Shukor Sanim Mohd and published by IGI Global. This book was released on 2011-11-30 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, there has been an increase in attention and focus on the discipline of software engineering. Software engineering tools and techniques have been developed to gain more predictable quality improvement results. Process standards such as Capability Maturity Model Integration (CMMI), ISO 9000, Software Process Improvement and Capability dEtermination (SPICE), Agile Methodologies, and others have been proposed to assist organizations to achieve more predictable results by incorporating these proven standards and procedures into their software process. Software Process Improvement and Management: Approaches and Tools for Practical Development offers the latest research and case studies on software engineering and development. The production of new process standards assist organizations and software engineers in adding a measure of predictability to the software process. Companies can gain a decisive competitive advantage by applying these new and theoretical methodologies in real-world scenarios. Researchers, scholars, practitioners, students, and anyone interested in the field of software development and design should access this book as a major compendium of the latest research in the field.

Impact Evaluation in Practice, Second Edition

Impact Evaluation in Practice, Second Edition

Author: Paul J. Gertler

Publisher: World Bank Publications

Published: 2016-09-12

Total Pages: 444

ISBN-13: 1464807809

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The second edition of the Impact Evaluation in Practice handbook is a comprehensive and accessible introduction to impact evaluation for policy makers and development practitioners. First published in 2011, it has been used widely across the development and academic communities. The book incorporates real-world examples to present practical guidelines for designing and implementing impact evaluations. Readers will gain an understanding of impact evaluations and the best ways to use them to design evidence-based policies and programs. The updated version covers the newest techniques for evaluating programs and includes state-of-the-art implementation advice, as well as an expanded set of examples and case studies that draw on recent development challenges. It also includes new material on research ethics and partnerships to conduct impact evaluation. The handbook is divided into four sections: Part One discusses what to evaluate and why; Part Two presents the main impact evaluation methods; Part Three addresses how to manage impact evaluations; Part Four reviews impact evaluation sampling and data collection. Case studies illustrate different applications of impact evaluations. The book links to complementary instructional material available online, including an applied case as well as questions and answers. The updated second edition will be a valuable resource for the international development community, universities, and policy makers looking to build better evidence around what works in development.


Book Synopsis Impact Evaluation in Practice, Second Edition by : Paul J. Gertler

Download or read book Impact Evaluation in Practice, Second Edition written by Paul J. Gertler and published by World Bank Publications. This book was released on 2016-09-12 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of the Impact Evaluation in Practice handbook is a comprehensive and accessible introduction to impact evaluation for policy makers and development practitioners. First published in 2011, it has been used widely across the development and academic communities. The book incorporates real-world examples to present practical guidelines for designing and implementing impact evaluations. Readers will gain an understanding of impact evaluations and the best ways to use them to design evidence-based policies and programs. The updated version covers the newest techniques for evaluating programs and includes state-of-the-art implementation advice, as well as an expanded set of examples and case studies that draw on recent development challenges. It also includes new material on research ethics and partnerships to conduct impact evaluation. The handbook is divided into four sections: Part One discusses what to evaluate and why; Part Two presents the main impact evaluation methods; Part Three addresses how to manage impact evaluations; Part Four reviews impact evaluation sampling and data collection. Case studies illustrate different applications of impact evaluations. The book links to complementary instructional material available online, including an applied case as well as questions and answers. The updated second edition will be a valuable resource for the international development community, universities, and policy makers looking to build better evidence around what works in development.

Developing Solid Oral Dosage Forms

Developing Solid Oral Dosage Forms

Author: Yihong Qiu

Publisher: Academic Press

Published: 2009-03-10

Total Pages: 976

ISBN-13: 008093272X

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Developing Solid Oral Dosage Forms is intended for pharmaceutical professionals engaged in research and development of oral dosage forms. It covers essential principles of physical pharmacy, biopharmaceutics and industrial pharmacy as well as various aspects of state-of-the-art techniques and approaches in pharmaceutical sciences and technologies along with examples and/or case studies in product development. The objective of this book is to offer updated (or current) knowledge and skills required for rational oral product design and development. The specific goals are to provide readers with: Basics of modern theories of physical pharmacy, biopharmaceutics and industrial pharmacy and their applications throughout the entire process of research and development of oral dosage forms Tools and approaches of preformulation investigation, formulation/process design, characterization and scale-up in pharmaceutical sciences and technologies New developments, challenges, trends, opportunities, intellectual property issues and regulations in solid product development The first book (ever) that provides comprehensive and in-depth coverage of what's required for developing high quality pharmaceutical products to meet international standards It covers a broad scope of topics that encompass the entire spectrum of solid dosage form development for the global market, including the most updated science and technologies, practice, applications, regulation, intellectual property protection and new development trends with case studies in every chapter A strong team of more than 50 well-established authors/co-authors of diverse background, knowledge, skills and experience from industry, academia and regulatory agencies


Book Synopsis Developing Solid Oral Dosage Forms by : Yihong Qiu

Download or read book Developing Solid Oral Dosage Forms written by Yihong Qiu and published by Academic Press. This book was released on 2009-03-10 with total page 976 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developing Solid Oral Dosage Forms is intended for pharmaceutical professionals engaged in research and development of oral dosage forms. It covers essential principles of physical pharmacy, biopharmaceutics and industrial pharmacy as well as various aspects of state-of-the-art techniques and approaches in pharmaceutical sciences and technologies along with examples and/or case studies in product development. The objective of this book is to offer updated (or current) knowledge and skills required for rational oral product design and development. The specific goals are to provide readers with: Basics of modern theories of physical pharmacy, biopharmaceutics and industrial pharmacy and their applications throughout the entire process of research and development of oral dosage forms Tools and approaches of preformulation investigation, formulation/process design, characterization and scale-up in pharmaceutical sciences and technologies New developments, challenges, trends, opportunities, intellectual property issues and regulations in solid product development The first book (ever) that provides comprehensive and in-depth coverage of what's required for developing high quality pharmaceutical products to meet international standards It covers a broad scope of topics that encompass the entire spectrum of solid dosage form development for the global market, including the most updated science and technologies, practice, applications, regulation, intellectual property protection and new development trends with case studies in every chapter A strong team of more than 50 well-established authors/co-authors of diverse background, knowledge, skills and experience from industry, academia and regulatory agencies

A Practical Guide to Managing Clinical Trials

A Practical Guide to Managing Clinical Trials

Author: JoAnn Pfeiffer

Publisher: CRC Press

Published: 2017-05-18

Total Pages: 292

ISBN-13: 1315299771

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A Practical Guide to Managing Clinical Trials is a basic, comprehensive guide to conducting clinical trials. Designed for individuals working in research site operations, this user-friendly reference guides the reader through each step of the clinical trial process from site selection, to site set-up, subject recruitment, study visits, and to study close-out. Topics include staff roles/responsibilities/training, budget and contract review and management, subject study visits, data and document management, event reporting, research ethics, audits and inspections, consent processes, IRB, FDA regulations, and good clinical practices. Each chapter concludes with a review of key points and knowledge application. Unique to this book is "A View from India," a chapter-by-chapter comparison of clinical trial practices in India versus the U.S. Throughout the book and in Chapter 10, readers will glimpse some of the challenges and opportunities in the emerging and growing market of Indian clinical trials.


Book Synopsis A Practical Guide to Managing Clinical Trials by : JoAnn Pfeiffer

Download or read book A Practical Guide to Managing Clinical Trials written by JoAnn Pfeiffer and published by CRC Press. This book was released on 2017-05-18 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Practical Guide to Managing Clinical Trials is a basic, comprehensive guide to conducting clinical trials. Designed for individuals working in research site operations, this user-friendly reference guides the reader through each step of the clinical trial process from site selection, to site set-up, subject recruitment, study visits, and to study close-out. Topics include staff roles/responsibilities/training, budget and contract review and management, subject study visits, data and document management, event reporting, research ethics, audits and inspections, consent processes, IRB, FDA regulations, and good clinical practices. Each chapter concludes with a review of key points and knowledge application. Unique to this book is "A View from India," a chapter-by-chapter comparison of clinical trial practices in India versus the U.S. Throughout the book and in Chapter 10, readers will glimpse some of the challenges and opportunities in the emerging and growing market of Indian clinical trials.

Mastering Lean Product Development

Mastering Lean Product Development

Author: Ronald Mascitelli

Publisher:

Published: 2011

Total Pages: 0

ISBN-13: 9780966269741

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Book Synopsis Mastering Lean Product Development by : Ronald Mascitelli

Download or read book Mastering Lean Product Development written by Ronald Mascitelli and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Clinical Practice Guidelines We Can Trust

Clinical Practice Guidelines We Can Trust

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2011-06-16

Total Pages: 217

ISBN-13: 030921646X

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Advances in medical, biomedical and health services research have reduced the level of uncertainty in clinical practice. Clinical practice guidelines (CPGs) complement this progress by establishing standards of care backed by strong scientific evidence. CPGs are statements that include recommendations intended to optimize patient care. These statements are informed by a systematic review of evidence and an assessment of the benefits and costs of alternative care options. Clinical Practice Guidelines We Can Trust examines the current state of clinical practice guidelines and how they can be improved to enhance healthcare quality and patient outcomes. Clinical practice guidelines now are ubiquitous in our healthcare system. The Guidelines International Network (GIN) database currently lists more than 3,700 guidelines from 39 countries. Developing guidelines presents a number of challenges including lack of transparent methodological practices, difficulty reconciling conflicting guidelines, and conflicts of interest. Clinical Practice Guidelines We Can Trust explores questions surrounding the quality of CPG development processes and the establishment of standards. It proposes eight standards for developing trustworthy clinical practice guidelines emphasizing transparency; management of conflict of interest ; systematic review-guideline development intersection; establishing evidence foundations for and rating strength of guideline recommendations; articulation of recommendations; external review; and updating. Clinical Practice Guidelines We Can Trust shows how clinical practice guidelines can enhance clinician and patient decision-making by translating complex scientific research findings into recommendations for clinical practice that are relevant to the individual patient encounter, instead of implementing a one size fits all approach to patient care. This book contains information directly related to the work of the Agency for Healthcare Research and Quality (AHRQ), as well as various Congressional staff and policymakers. It is a vital resource for medical specialty societies, disease advocacy groups, health professionals, private and international organizations that develop or use clinical practice guidelines, consumers, clinicians, and payers.


Book Synopsis Clinical Practice Guidelines We Can Trust by : Institute of Medicine

Download or read book Clinical Practice Guidelines We Can Trust written by Institute of Medicine and published by National Academies Press. This book was released on 2011-06-16 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in medical, biomedical and health services research have reduced the level of uncertainty in clinical practice. Clinical practice guidelines (CPGs) complement this progress by establishing standards of care backed by strong scientific evidence. CPGs are statements that include recommendations intended to optimize patient care. These statements are informed by a systematic review of evidence and an assessment of the benefits and costs of alternative care options. Clinical Practice Guidelines We Can Trust examines the current state of clinical practice guidelines and how they can be improved to enhance healthcare quality and patient outcomes. Clinical practice guidelines now are ubiquitous in our healthcare system. The Guidelines International Network (GIN) database currently lists more than 3,700 guidelines from 39 countries. Developing guidelines presents a number of challenges including lack of transparent methodological practices, difficulty reconciling conflicting guidelines, and conflicts of interest. Clinical Practice Guidelines We Can Trust explores questions surrounding the quality of CPG development processes and the establishment of standards. It proposes eight standards for developing trustworthy clinical practice guidelines emphasizing transparency; management of conflict of interest ; systematic review-guideline development intersection; establishing evidence foundations for and rating strength of guideline recommendations; articulation of recommendations; external review; and updating. Clinical Practice Guidelines We Can Trust shows how clinical practice guidelines can enhance clinician and patient decision-making by translating complex scientific research findings into recommendations for clinical practice that are relevant to the individual patient encounter, instead of implementing a one size fits all approach to patient care. This book contains information directly related to the work of the Agency for Healthcare Research and Quality (AHRQ), as well as various Congressional staff and policymakers. It is a vital resource for medical specialty societies, disease advocacy groups, health professionals, private and international organizations that develop or use clinical practice guidelines, consumers, clinicians, and payers.