Prostaglandins: Chemical and Biochemical Aspects

Prostaglandins: Chemical and Biochemical Aspects

Author: S. M. M. Karim

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 239

ISBN-13: 9401196486

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This is the second in a series of three books on advances in prostaglandin research. In recent years there has been an unparalleled interest in these compounds and as a result a vast amount of research data has accumulated since the publication of my earlier book in 1972. At that time it was possible to present a fairly comprehensive review of the various aspects of prosta glandin research in one volume. This is no longer possible and the contents are divided into three volumes; the first one dealing with prostaglandins and reproduction was published in October 1975; the present volume dealing with chemical and biochemical aspects of prostaglandin research, to be published in April 1976 and the third book dealing with physiological, pharmacological and pathological aspects of prostaglandin research wiII be published in May 1976. The authorship represents international scientists consisting of physiolo-. gists, pharmacologists, chemists, biochemists, veterinary scientists and obstetrician gynaecologists actively engaged in different areas of prosta glandin research. An attempt has been made to provide a total coverage of advances relating to prostaglandins. For the sake of completeness and continuity, material covered in the 1972 book is either briefly summarised or reference made to that edition. In recent years there have been notable advances in the chemical and biochemical aspects of prostaglandin research and these are discussed by various authorities in the chapters that follow.


Book Synopsis Prostaglandins: Chemical and Biochemical Aspects by : S. M. M. Karim

Download or read book Prostaglandins: Chemical and Biochemical Aspects written by S. M. M. Karim and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second in a series of three books on advances in prostaglandin research. In recent years there has been an unparalleled interest in these compounds and as a result a vast amount of research data has accumulated since the publication of my earlier book in 1972. At that time it was possible to present a fairly comprehensive review of the various aspects of prosta glandin research in one volume. This is no longer possible and the contents are divided into three volumes; the first one dealing with prostaglandins and reproduction was published in October 1975; the present volume dealing with chemical and biochemical aspects of prostaglandin research, to be published in April 1976 and the third book dealing with physiological, pharmacological and pathological aspects of prostaglandin research wiII be published in May 1976. The authorship represents international scientists consisting of physiolo-. gists, pharmacologists, chemists, biochemists, veterinary scientists and obstetrician gynaecologists actively engaged in different areas of prosta glandin research. An attempt has been made to provide a total coverage of advances relating to prostaglandins. For the sake of completeness and continuity, material covered in the 1972 book is either briefly summarised or reference made to that edition. In recent years there have been notable advances in the chemical and biochemical aspects of prostaglandin research and these are discussed by various authorities in the chapters that follow.

Prostaglandins

Prostaglandins

Author: Gillian M. Goodwin

Publisher: Nova Science Publishers

Published: 2010

Total Pages: 0

ISBN-13: 9781616682729

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A prostaglandin is any member of a group of lipid compounds that are derived enzymatically from fatty acids and have important functions in the animal body. Every prostaglandin contains 20 carbon atoms, including a 5-carbon ring. They are mediators that participate in the regulation of multiple biological processes, both in health and disease. Prostaglandins contribute to the regulation of vascular tone, platelet function, and fertility. They also play key roles as inflammatory mediators and modulators of tumor biology. Although they are technically hormones, they are rarely classified as such. This book examines the biological role of prostaglandins in drug discovery, and on immune cells; the prostaglandin interchange; and the roles of prostaglandin E2 in inflammation-related cardiovascular disease as well as other related topics of import.


Book Synopsis Prostaglandins by : Gillian M. Goodwin

Download or read book Prostaglandins written by Gillian M. Goodwin and published by Nova Science Publishers. This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A prostaglandin is any member of a group of lipid compounds that are derived enzymatically from fatty acids and have important functions in the animal body. Every prostaglandin contains 20 carbon atoms, including a 5-carbon ring. They are mediators that participate in the regulation of multiple biological processes, both in health and disease. Prostaglandins contribute to the regulation of vascular tone, platelet function, and fertility. They also play key roles as inflammatory mediators and modulators of tumor biology. Although they are technically hormones, they are rarely classified as such. This book examines the biological role of prostaglandins in drug discovery, and on immune cells; the prostaglandin interchange; and the roles of prostaglandin E2 in inflammation-related cardiovascular disease as well as other related topics of import.

Prostaglandins and Related Substances

Prostaglandins and Related Substances

Author:

Publisher: Elsevier

Published: 1983-01-01

Total Pages: 228

ISBN-13: 9780080860633

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Prostaglandins and Related Substances


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Download or read book Prostaglandins and Related Substances written by and published by Elsevier. This book was released on 1983-01-01 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostaglandins and Related Substances

Prostaglandins and Thromboxanes

Prostaglandins and Thromboxanes

Author: Roger F. Newton

Publisher: Butterworth-Heinemann

Published: 2016-01-21

Total Pages: 157

ISBN-13: 1483161099

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Prostaglandins and Thromboxanes explores the two members of the prostanoid class of fatty acid. This book attempts to thoroughly discuss the topic after collecting enough information through research in physical and biological sciences. As the title suggests, the book revolves around prostaglandins and thromboxanes. The book's first chapter contains a discussion on the subject's history, stating the year of discovery and crediting the scientist who coined the names. The chapter ends talking about the possible uses of prostaglandins and thromboxanes in the clinic. The chapters that follow discuss the two lipids' basic and advanced synthesis, pharmacology, biosynthesis, biological activity, chemical interconversions, and metabolism, along with its subtopics. The book will serve as an excellent reference for undergraduate and graduate students in the related field.


Book Synopsis Prostaglandins and Thromboxanes by : Roger F. Newton

Download or read book Prostaglandins and Thromboxanes written by Roger F. Newton and published by Butterworth-Heinemann. This book was released on 2016-01-21 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostaglandins and Thromboxanes explores the two members of the prostanoid class of fatty acid. This book attempts to thoroughly discuss the topic after collecting enough information through research in physical and biological sciences. As the title suggests, the book revolves around prostaglandins and thromboxanes. The book's first chapter contains a discussion on the subject's history, stating the year of discovery and crediting the scientist who coined the names. The chapter ends talking about the possible uses of prostaglandins and thromboxanes in the clinic. The chapters that follow discuss the two lipids' basic and advanced synthesis, pharmacology, biosynthesis, biological activity, chemical interconversions, and metabolism, along with its subtopics. The book will serve as an excellent reference for undergraduate and graduate students in the related field.

Angiogenesis in Health, Disease and Malignancy

Angiogenesis in Health, Disease and Malignancy

Author: Ali Salajegheh

Publisher: Springer

Published: 2016-03-10

Total Pages: 423

ISBN-13: 3319281402

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This book is about “Angiogenesis”. A process in which new vasculature is formed from pre-existing capillaries. Angiogenesis process is associated with the proliferation and growth of both physiologically normal and neoplastic tissues, through the formation of vascular supply, essential for delivering growth requirements such as oxygen and nutrients. The book describes more than 100 genes and their key regulatory functions in the context of normal healthy condition, disease and malignancy, cancer proliferation and progression. New insights into the role of angiogenesis and the therapeutic inhibition of its regulators are investigated, due to the great potential for exploitation in the development of a novel treatment for cancer. New scientists, junior researchers and biomedical science students will find this book an invaluable introductory reference to their insight about angiogenesis and angiogenic role of more than 100 angiogenes and their role in healthy, disease and malignant conditions.


Book Synopsis Angiogenesis in Health, Disease and Malignancy by : Ali Salajegheh

Download or read book Angiogenesis in Health, Disease and Malignancy written by Ali Salajegheh and published by Springer. This book was released on 2016-03-10 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about “Angiogenesis”. A process in which new vasculature is formed from pre-existing capillaries. Angiogenesis process is associated with the proliferation and growth of both physiologically normal and neoplastic tissues, through the formation of vascular supply, essential for delivering growth requirements such as oxygen and nutrients. The book describes more than 100 genes and their key regulatory functions in the context of normal healthy condition, disease and malignancy, cancer proliferation and progression. New insights into the role of angiogenesis and the therapeutic inhibition of its regulators are investigated, due to the great potential for exploitation in the development of a novel treatment for cancer. New scientists, junior researchers and biomedical science students will find this book an invaluable introductory reference to their insight about angiogenesis and angiogenic role of more than 100 angiogenes and their role in healthy, disease and malignant conditions.

Prostaglandins in Abortion and Reproductive Physiology

Prostaglandins in Abortion and Reproductive Physiology

Author: Geraldine D. Nowak

Publisher:

Published: 1973

Total Pages: 20

ISBN-13:

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Book Synopsis Prostaglandins in Abortion and Reproductive Physiology by : Geraldine D. Nowak

Download or read book Prostaglandins in Abortion and Reproductive Physiology written by Geraldine D. Nowak and published by . This book was released on 1973 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Prostaglandins

The Prostaglandins

Author: M. F. Cuthbert

Publisher: Elsevier

Published: 2016-01-26

Total Pages: 345

ISBN-13: 1483192806

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The Prostaglandins: Pharmacological and Therapeutic Advances provides a concise account of the more important theoretical developments and areas in which the prostaglandins are being introduced into clinical practice or have potential clinical application. Chapters I to IV of this book deal with the chemistry and classification, distribution and metabolism, general pharmacology, and mechanism of action. The rest of the chapters discuss the relationship of the prostaglandins to the reproductive, cardiovascular, respiratory, and gastro-intestinal systems with an emphasis on the human pharmacology and potential therapeutic applications. This text also includes the speculations and suggestions of contributors regarding the possible and further use of the prostaglandins. This publication is a good reference for biochemists and medical students concerned with the potential of prostaglandins.


Book Synopsis The Prostaglandins by : M. F. Cuthbert

Download or read book The Prostaglandins written by M. F. Cuthbert and published by Elsevier. This book was released on 2016-01-26 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Prostaglandins: Pharmacological and Therapeutic Advances provides a concise account of the more important theoretical developments and areas in which the prostaglandins are being introduced into clinical practice or have potential clinical application. Chapters I to IV of this book deal with the chemistry and classification, distribution and metabolism, general pharmacology, and mechanism of action. The rest of the chapters discuss the relationship of the prostaglandins to the reproductive, cardiovascular, respiratory, and gastro-intestinal systems with an emphasis on the human pharmacology and potential therapeutic applications. This text also includes the speculations and suggestions of contributors regarding the possible and further use of the prostaglandins. This publication is a good reference for biochemists and medical students concerned with the potential of prostaglandins.

The Prostaglandins

The Prostaglandins

Author: Peter Ramwell

Publisher: Springer Science & Business Media

Published: 2013-11-11

Total Pages: 356

ISBN-13: 1461345448

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There is much evidence to suggest that prostaglandins may have a physiological role to play in the control of thyroid gland metabolism, although the precise nature of this role remains to be defined. Prostaglandins have been found in normal thyroid tissue, and there is evidence of increased levels in some, but not all, cases of medullary carcinoma of the thyroid. which may account for the associated diarrhea. Exogenous prostaglandins, like TSH, bind to thyroid plasma mem branes, stimulate the adenylate cyclase-cyclic AMP system, thyroid hormone secretion, iodide organification, colloid droplet formation, glucose oxidation, and 32p incorporation into phospholipids. Prosta glandins of the E series are the most potent, although their maximal effects are generally less than the maximal effects of TSH. The interrelationships existing between TSH and prostaglandins have been the subject of intensive investigation, but as yet no one uni fying concept has emerged. TSH and prostaglandins have been shown to occupy different receptors on the thyroid plasma membrane. Al though TSH can increase intracellular prostaglandin levels, probably as a result of increased synthesis, prostaglandins do not appear to be essential intermediates in TSH action on adenylate cyclase. The pos sibility that prostaglandins are part of a negative feedback system con trolling TSH action is, as yet, a tentative hypothesis, and further work will be required to unravel the interrelationships between these sub stances that now appear to be far more complex than has been envisaged thus far.


Book Synopsis The Prostaglandins by : Peter Ramwell

Download or read book The Prostaglandins written by Peter Ramwell and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is much evidence to suggest that prostaglandins may have a physiological role to play in the control of thyroid gland metabolism, although the precise nature of this role remains to be defined. Prostaglandins have been found in normal thyroid tissue, and there is evidence of increased levels in some, but not all, cases of medullary carcinoma of the thyroid. which may account for the associated diarrhea. Exogenous prostaglandins, like TSH, bind to thyroid plasma mem branes, stimulate the adenylate cyclase-cyclic AMP system, thyroid hormone secretion, iodide organification, colloid droplet formation, glucose oxidation, and 32p incorporation into phospholipids. Prosta glandins of the E series are the most potent, although their maximal effects are generally less than the maximal effects of TSH. The interrelationships existing between TSH and prostaglandins have been the subject of intensive investigation, but as yet no one uni fying concept has emerged. TSH and prostaglandins have been shown to occupy different receptors on the thyroid plasma membrane. Al though TSH can increase intracellular prostaglandin levels, probably as a result of increased synthesis, prostaglandins do not appear to be essential intermediates in TSH action on adenylate cyclase. The pos sibility that prostaglandins are part of a negative feedback system con trolling TSH action is, as yet, a tentative hypothesis, and further work will be required to unravel the interrelationships between these sub stances that now appear to be far more complex than has been envisaged thus far.

Prostaglandins and Fertility Regulation

Prostaglandins and Fertility Regulation

Author: M. Toppozada

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 158

ISBN-13: 9400956002

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The role of prostaglandins in physiological events and pathological disorders related to human reproduction has been most actively investigated in the past decade. Their clinical use for fertility regulation, extensively evaluated, represents the most common clinical indication for the administration of these remarkable compounds. Thus, it is most appropriate to update the available information related to the use of prostaglandins in the regulation of human fertility to provide a background document for the benefit of clinicians and scientists. Invited experts of international reputation from various parts of the world have contributed, each in his own area of interest, to offer this book, which we hope will fill an existing gap. M. T. M. B. E. S. E. H. ix 1 Potential for prostaglandin use in controlling human reproduction K. T. KIRTON and F. A. KIMBALL BACKGROUND It was observed in 1930 that seminal plasma of a number of species contained very large amounts of substance(s) capable of altering uterine motility. These substances were subsequently demonstrated to be prostaglandins (PGs); this began the early and continued association of this group of compounds with reproduction. The activity was found to be associated with a fraction containing lipid-soluble acids, derived from prostanoic acid. Restrictions imposed by obscure sources and small amounts of material available for testing were initially impediments to their study.


Book Synopsis Prostaglandins and Fertility Regulation by : M. Toppozada

Download or read book Prostaglandins and Fertility Regulation written by M. Toppozada and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: The role of prostaglandins in physiological events and pathological disorders related to human reproduction has been most actively investigated in the past decade. Their clinical use for fertility regulation, extensively evaluated, represents the most common clinical indication for the administration of these remarkable compounds. Thus, it is most appropriate to update the available information related to the use of prostaglandins in the regulation of human fertility to provide a background document for the benefit of clinicians and scientists. Invited experts of international reputation from various parts of the world have contributed, each in his own area of interest, to offer this book, which we hope will fill an existing gap. M. T. M. B. E. S. E. H. ix 1 Potential for prostaglandin use in controlling human reproduction K. T. KIRTON and F. A. KIMBALL BACKGROUND It was observed in 1930 that seminal plasma of a number of species contained very large amounts of substance(s) capable of altering uterine motility. These substances were subsequently demonstrated to be prostaglandins (PGs); this began the early and continued association of this group of compounds with reproduction. The activity was found to be associated with a fraction containing lipid-soluble acids, derived from prostanoic acid. Restrictions imposed by obscure sources and small amounts of material available for testing were initially impediments to their study.

Practical Applications of Prostaglandins and their Synthesis Inhibitors

Practical Applications of Prostaglandins and their Synthesis Inhibitors

Author: Sultan M.M. Karim

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 459

ISBN-13: 9401178437

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This is the fourth in a series of books on Advances in Prostaglandin Research published by MTP Press. From laboratory and animal studies a large number of practical applications of prostaglandins have been identified. In some areas clinical trials have also been carried out. There is usually a long time interval between identifying practical applications of new drugs and clinical trials. Most of the information on practical applications of prostaglandins is scattered in different journals. Although a number of books dealing with prostaglandin research have been published (including some on practical applications in specific areas, e.g. reproduction) there is no single volume dealing with all areas of practical applications of these substances. This book aims at filling this gap and should be of interest to clinicians as well as to medical and basic scientists in academic institutions and in the pharmaceutical industry. In some areas, exciting potential applications of prostaglandins have been identified from basic research but clinical trials have so far not been carried out. Such areas of practical applications are covered in a separate intro ductory chapter. All contributors to the volume are scientists and clinicians actively engaged in prostaglandin research and most are recognized authorities in specific areas. The need for rapid publication in a fast-expanding field is obvious.


Book Synopsis Practical Applications of Prostaglandins and their Synthesis Inhibitors by : Sultan M.M. Karim

Download or read book Practical Applications of Prostaglandins and their Synthesis Inhibitors written by Sultan M.M. Karim and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the fourth in a series of books on Advances in Prostaglandin Research published by MTP Press. From laboratory and animal studies a large number of practical applications of prostaglandins have been identified. In some areas clinical trials have also been carried out. There is usually a long time interval between identifying practical applications of new drugs and clinical trials. Most of the information on practical applications of prostaglandins is scattered in different journals. Although a number of books dealing with prostaglandin research have been published (including some on practical applications in specific areas, e.g. reproduction) there is no single volume dealing with all areas of practical applications of these substances. This book aims at filling this gap and should be of interest to clinicians as well as to medical and basic scientists in academic institutions and in the pharmaceutical industry. In some areas, exciting potential applications of prostaglandins have been identified from basic research but clinical trials have so far not been carried out. Such areas of practical applications are covered in a separate intro ductory chapter. All contributors to the volume are scientists and clinicians actively engaged in prostaglandin research and most are recognized authorities in specific areas. The need for rapid publication in a fast-expanding field is obvious.