Prostaglandins-Immunopharmacology

Prostaglandins-Immunopharmacology

Author: B. B. Vargaftig

Publisher: Elsevier

Published: 2013-10-22

Total Pages: 236

ISBN-13: 1483156354

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Advances in Pharmacology and Therapeutics, Volume 4: Prostaglandins-Immunopharmacology contains the proceedings of the 7th International Congress of Pharmacology held in Paris, France, in 1978. The papers explore advances in the understanding of prostaglandins, their immunopharmacology, and their therapeutic applications. Topics covered range from the biochemistry of prostaglandins, thromboxanes, and prostacyclin to the pharmacology of blood platelets and pharmacological approaches to enhancement of immunity. This volume is comprised of 23 chapters and opens with a discussion on the discovery of prostaglandins and their possible biological functions, including platelet aggregation and adrenergic neurotransmission. The reader is then introduced to unstable metabolites of arachidonic acid in relation to thrombosis; pharmacological interference in biotransformation of arachidonic acid; participation of prostaglandins in inflammatory pain; and factors affecting the formation and actions of cyclic AMP in blood platelets. The following chapters explore the role of thymosin and the endocrine thymus in the maintenance of immune balance; effects of thymosin fraction 5 in cancer patients; and the immunoregulatory activities of non-toxic synthetic polyribonucleotides. This book will be of interest to practitioners in biosciences, pharmacology, physiology, and medicine.


Book Synopsis Prostaglandins-Immunopharmacology by : B. B. Vargaftig

Download or read book Prostaglandins-Immunopharmacology written by B. B. Vargaftig and published by Elsevier. This book was released on 2013-10-22 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Pharmacology and Therapeutics, Volume 4: Prostaglandins-Immunopharmacology contains the proceedings of the 7th International Congress of Pharmacology held in Paris, France, in 1978. The papers explore advances in the understanding of prostaglandins, their immunopharmacology, and their therapeutic applications. Topics covered range from the biochemistry of prostaglandins, thromboxanes, and prostacyclin to the pharmacology of blood platelets and pharmacological approaches to enhancement of immunity. This volume is comprised of 23 chapters and opens with a discussion on the discovery of prostaglandins and their possible biological functions, including platelet aggregation and adrenergic neurotransmission. The reader is then introduced to unstable metabolites of arachidonic acid in relation to thrombosis; pharmacological interference in biotransformation of arachidonic acid; participation of prostaglandins in inflammatory pain; and factors affecting the formation and actions of cyclic AMP in blood platelets. The following chapters explore the role of thymosin and the endocrine thymus in the maintenance of immune balance; effects of thymosin fraction 5 in cancer patients; and the immunoregulatory activities of non-toxic synthetic polyribonucleotides. This book will be of interest to practitioners in biosciences, pharmacology, physiology, and medicine.

Prostaglandins, Leukotrienes, and the Immune Response

Prostaglandins, Leukotrienes, and the Immune Response

Author: John L. Ninnemann

Publisher: Cambridge University Press

Published: 1988-09-30

Total Pages: 236

ISBN-13: 0521334837

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This study looks at the way the products of arachidonic acid metabolism are active both in normal and abnormal immune responses. While some of the fundamental issues such as whether lymphocytes are capable of producing prostaglandins and leukotrienes are still hotly debated, the evidence is overwhelming that many specific immunological problems and disease states are associated with alterations in the normal balance of arachidonic acid metabolism. This book provides a review of the history and chemistry of the arachidonic acid cascade as well as an exhaustive survey of the literature concerning the interaction of arachidonic acid metabolites with cells of the immune system. The author also presents and discusses the evidence demonstrating prostaglandin and leukotriene participation in response to injury and in malignancy, tissue and organ rejection, rheumatoid arthritis, autoimmunity and allergy.


Book Synopsis Prostaglandins, Leukotrienes, and the Immune Response by : John L. Ninnemann

Download or read book Prostaglandins, Leukotrienes, and the Immune Response written by John L. Ninnemann and published by Cambridge University Press. This book was released on 1988-09-30 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study looks at the way the products of arachidonic acid metabolism are active both in normal and abnormal immune responses. While some of the fundamental issues such as whether lymphocytes are capable of producing prostaglandins and leukotrienes are still hotly debated, the evidence is overwhelming that many specific immunological problems and disease states are associated with alterations in the normal balance of arachidonic acid metabolism. This book provides a review of the history and chemistry of the arachidonic acid cascade as well as an exhaustive survey of the literature concerning the interaction of arachidonic acid metabolites with cells of the immune system. The author also presents and discusses the evidence demonstrating prostaglandin and leukotriene participation in response to injury and in malignancy, tissue and organ rejection, rheumatoid arthritis, autoimmunity and allergy.

Advances in Physiological Sciences

Advances in Physiological Sciences

Author: B. B. Vargaftig

Publisher: Pergamon

Published: 1979-03-01

Total Pages: 230

ISBN-13: 9780080232089

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Book Synopsis Advances in Physiological Sciences by : B. B. Vargaftig

Download or read book Advances in Physiological Sciences written by B. B. Vargaftig and published by Pergamon. This book was released on 1979-03-01 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Prostaglandins in Cellular Biology

Prostaglandins in Cellular Biology

Author: Peter Ramwell

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 527

ISBN-13: 1468428446

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This book represents the first of the ALZA CONFERENCE SERIES which will deal with a wide variety of topics of biomedical interest. These Conferences are planned to cover a range of subjects from the molecular level, such as drug receptor and drug membrane interactions, to the organ and organismal levels and the dynamics of drug therapy. This year's topic is "PROSTAGLANDINS." It is rapidly becoming clear that prosta glandins are of great interest and potential utility in therapeutics. An understanding of the role of prostaglandins in the regulation of cell processes should provide insight into the understanding of a variety of difficult and intransigent fields such as cancer, allergy, and transplant rejection. We hope that this Conference may focus attention on novel approaches to these areas. We wish to thank our distinguished Chairmen and guests for their attendance. The papers and dis cussions were prepared by Yvonne Hendrickson, using an ATS/360 Text-Editing System; we acknowledge with gratitude her skill, patience, and hard work. P.W.R. B.B.P.


Book Synopsis Prostaglandins in Cellular Biology by : Peter Ramwell

Download or read book Prostaglandins in Cellular Biology written by Peter Ramwell and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents the first of the ALZA CONFERENCE SERIES which will deal with a wide variety of topics of biomedical interest. These Conferences are planned to cover a range of subjects from the molecular level, such as drug receptor and drug membrane interactions, to the organ and organismal levels and the dynamics of drug therapy. This year's topic is "PROSTAGLANDINS." It is rapidly becoming clear that prosta glandins are of great interest and potential utility in therapeutics. An understanding of the role of prostaglandins in the regulation of cell processes should provide insight into the understanding of a variety of difficult and intransigent fields such as cancer, allergy, and transplant rejection. We hope that this Conference may focus attention on novel approaches to these areas. We wish to thank our distinguished Chairmen and guests for their attendance. The papers and dis cussions were prepared by Yvonne Hendrickson, using an ATS/360 Text-Editing System; we acknowledge with gratitude her skill, patience, and hard work. P.W.R. B.B.P.

Prostaglandins-immunopharmacology

Prostaglandins-immunopharmacology

Author:

Publisher:

Published: 1979

Total Pages: 0

ISBN-13:

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Book Synopsis Prostaglandins-immunopharmacology by :

Download or read book Prostaglandins-immunopharmacology written by and published by . This book was released on 1979 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in Pharmacology and Therapeutics

Advances in Pharmacology and Therapeutics

Author: Jacques R. Boissier

Publisher:

Published:

Total Pages: 0

ISBN-13: 9780080231945

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Book Synopsis Advances in Pharmacology and Therapeutics by : Jacques R. Boissier

Download or read book Advances in Pharmacology and Therapeutics written by Jacques R. Boissier and published by . This book was released on with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Prostaglandins and Immunity

Prostaglandins and Immunity

Author: James S. Goodwin

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 230

ISBN-13: 1461326036

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Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin E2 (PGE2), prostacyclin (PGI2) and thromboxane A2 (TXA2), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di-and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.


Book Synopsis Prostaglandins and Immunity by : James S. Goodwin

Download or read book Prostaglandins and Immunity written by James S. Goodwin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin E2 (PGE2), prostacyclin (PGI2) and thromboxane A2 (TXA2), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di-and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.

Prostaglandin Inhibitors in Tumor Immunology and Immunotherapy

Prostaglandin Inhibitors in Tumor Immunology and Immunotherapy

Author: Jules E. Harris

Publisher: CRC Press

Published: 1994-03-28

Total Pages: 266

ISBN-13: 9780849369032

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This book provides an updated overview of eicosanoid metabolism. It also presents a timely discussion of eicosanoid metabolism in the process of tumor cell metastasis, in chemoprotection and radioprotection associated with cancer therapy, and in cell differentiation. The book focuses on the role of eicosanoids in the immunology of malignant disease. This includes how various immune cell populations in cancer are affected by the secretion and action of various eicosanoids and metabolites of eicosanoids and how these processes may be affected by various pharmacological manipulations and interventions to augment anti-tumor immunity. Head and neck cancer is covered in great detail to illustrate a cancer in humans where these considerations are particularly relevant. This important volume demonstrates that the principal factor in cancer patient immunologic deficiency is related to excess secretion by monocytes of prostaglandins.


Book Synopsis Prostaglandin Inhibitors in Tumor Immunology and Immunotherapy by : Jules E. Harris

Download or read book Prostaglandin Inhibitors in Tumor Immunology and Immunotherapy written by Jules E. Harris and published by CRC Press. This book was released on 1994-03-28 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an updated overview of eicosanoid metabolism. It also presents a timely discussion of eicosanoid metabolism in the process of tumor cell metastasis, in chemoprotection and radioprotection associated with cancer therapy, and in cell differentiation. The book focuses on the role of eicosanoids in the immunology of malignant disease. This includes how various immune cell populations in cancer are affected by the secretion and action of various eicosanoids and metabolites of eicosanoids and how these processes may be affected by various pharmacological manipulations and interventions to augment anti-tumor immunity. Head and neck cancer is covered in great detail to illustrate a cancer in humans where these considerations are particularly relevant. This important volume demonstrates that the principal factor in cancer patient immunologic deficiency is related to excess secretion by monocytes of prostaglandins.

Immunopharmacology

Immunopharmacology

Author: J. Hadden

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 432

ISBN-13: 1461572495

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Immunopharmacology: A New Discipline of Immense Potential Among the looming triumphs of the biologic revolution is the rapidly developing understanding of the mechanisms of bodily defense. In the short span of 35 years, knowledge of immunologic machinery has progressed from crudest description to major understanding in cellular and molecular terms. Antibodies, immunoglobulins, and the complement system have been almost completely defined in detailed molecular terms. Organs, like thymus, spleen and lymph nodes-so long enigmatic black boxes-are beginning to be understood not only in cellular terms but in molecular, physiologic, and endocrinologic terms. With this surging new information about the immune system comes the possi bility of developing a pharmacology which can modulate and control immunologic functions. Immunopharmacology most broadly conceived must address (1) control of development and function of the cellular components of the immunologic appara tus; (2) facilitation and suppression of function of the immunologically competent cells of the several subclasses, like T helpers, suppressors, and effectors, and B effectors and suppressors; (3) manipulation and repair of the major biologic amplifi cation systems, e. g. , the complement system and kinin-kallikrein system, and (4) utilization, modulation, and inhibition of the galaxy of molecules generated by T lymphocytes, the lymphokines. This new pharmacology must deal with the funda mental effector mechanisms of immunity, namely inflammation, phagocytosis, vascular reactivity, and blood coagulation. Furthermore, immunopharmacology must address and manipulate cell-cell communication and interaction, so vital to control of the immunological apparatus.


Book Synopsis Immunopharmacology by : J. Hadden

Download or read book Immunopharmacology written by J. Hadden and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunopharmacology: A New Discipline of Immense Potential Among the looming triumphs of the biologic revolution is the rapidly developing understanding of the mechanisms of bodily defense. In the short span of 35 years, knowledge of immunologic machinery has progressed from crudest description to major understanding in cellular and molecular terms. Antibodies, immunoglobulins, and the complement system have been almost completely defined in detailed molecular terms. Organs, like thymus, spleen and lymph nodes-so long enigmatic black boxes-are beginning to be understood not only in cellular terms but in molecular, physiologic, and endocrinologic terms. With this surging new information about the immune system comes the possi bility of developing a pharmacology which can modulate and control immunologic functions. Immunopharmacology most broadly conceived must address (1) control of development and function of the cellular components of the immunologic appara tus; (2) facilitation and suppression of function of the immunologically competent cells of the several subclasses, like T helpers, suppressors, and effectors, and B effectors and suppressors; (3) manipulation and repair of the major biologic amplifi cation systems, e. g. , the complement system and kinin-kallikrein system, and (4) utilization, modulation, and inhibition of the galaxy of molecules generated by T lymphocytes, the lymphokines. This new pharmacology must deal with the funda mental effector mechanisms of immunity, namely inflammation, phagocytosis, vascular reactivity, and blood coagulation. Furthermore, immunopharmacology must address and manipulate cell-cell communication and interaction, so vital to control of the immunological apparatus.

Advances in Pharmacology and Therapeutics: Prostaglandins-immunopharmacology

Advances in Pharmacology and Therapeutics: Prostaglandins-immunopharmacology

Author:

Publisher:

Published: 1979

Total Pages: 0

ISBN-13:

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Book Synopsis Advances in Pharmacology and Therapeutics: Prostaglandins-immunopharmacology by :

Download or read book Advances in Pharmacology and Therapeutics: Prostaglandins-immunopharmacology written by and published by . This book was released on 1979 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: