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Proteinases as Drug Targets

Author: Ben Dunn

Publisher: Royal Society of Chemistry

Published: 2011-11-22

Total Pages: 292

ISBN-13: 1849733155

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This book provides vital information on a class of enzymes that have emerged as key drug targets in a number of human diseases, including HIV/AIDS, Hypertension, Cancer, and Alzheimer's disease. There is a gap in information due to the lack of recent international meetings on this subject and, thus, no recent summaries of current research have emerged. The book contains up-to-date information, especially with the genomics revolution of recent years, and includes new proteomics techniques. The story of this enzyme family also includes the most significant efforts in computer-aided drug discovery and structure-based drug design. With contributions from experts in the field, the book is edited by the previous President of the International Proteolysis Society, whose academic career in the field has spanned 35 years.

Book Synopsis Proteinases as Drug Targets by : Ben Dunn

Download or read book Proteinases as Drug Targets written by Ben Dunn and published by Royal Society of Chemistry. This book was released on 2011-11-22 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides vital information on a class of enzymes that have emerged as key drug targets in a number of human diseases, including HIV/AIDS, Hypertension, Cancer, and Alzheimer's disease. There is a gap in information due to the lack of recent international meetings on this subject and, thus, no recent summaries of current research have emerged. The book contains up-to-date information, especially with the genomics revolution of recent years, and includes new proteomics techniques. The story of this enzyme family also includes the most significant efforts in computer-aided drug discovery and structure-based drug design. With contributions from experts in the field, the book is edited by the previous President of the International Proteolysis Society, whose academic career in the field has spanned 35 years.

Proteinase and Peptidase Inhibition

Author: H. John Smith

Publisher: CRC Press

Published: 2002-03-28

Total Pages: 440

ISBN-13: 0203219171

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Cellular proteinases and their physiological role in normal and disease states have been the subject of great interest over recent decades. At present, specific protease inhibitors are exploited both as tools in unraveling the role of individual proteinases in particular cellular processes and for the development of chemotherapeutic agents for the

Book Synopsis Proteinase and Peptidase Inhibition by : H. John Smith

Download or read book Proteinase and Peptidase Inhibition written by H. John Smith and published by CRC Press. This book was released on 2002-03-28 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular proteinases and their physiological role in normal and disease states have been the subject of great interest over recent decades. At present, specific protease inhibitors are exploited both as tools in unraveling the role of individual proteinases in particular cellular processes and for the development of chemotherapeutic agents for the

Protein-Protein Interactions as New Drug Targets

Author: Enno Klussmann

Publisher: Springer Science & Business Media

Published: 2008-05-20

Total Pages: 511

ISBN-13: 3540728430

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Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions. This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.

Book Synopsis Protein-Protein Interactions as New Drug Targets by : Enno Klussmann

Download or read book Protein-Protein Interactions as New Drug Targets written by Enno Klussmann and published by Springer Science & Business Media. This book was released on 2008-05-20 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions. This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.

Protein-Protein Interactions as New Drug Targets

Author: Enno Klussmann

Publisher: Springer

Published: 2009-08-29

Total Pages: 512

ISBN-13: 9783540848318

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Book Synopsis Protein-Protein Interactions as New Drug Targets by : Enno Klussmann

Download or read book Protein-Protein Interactions as New Drug Targets written by Enno Klussmann and published by Springer. This book was released on 2009-08-29 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions. This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.

Burger's Medicinal Chemistry, Drug Discovery and Development

Author: Donald J. Abraham

Publisher:

Published: 2021

Total Pages:

ISBN-13: 9781119821519

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"Burger's is a flagship reference source for medicinal chemists and pharmaceutical professionals. This updated and expanded 8th edition has been thoroughly revised and improved to incorporate the concepts of drug hunting along with its existing coverage of the entire process of drug discovery and development. Bringing in a new and expert editorial board, this new edition updates existing chapters and adds 35 new ones, with topics including: opioid addiction treatments, antibody and gene therapy for cancer, blood-brain barrier, HIV treatments, and industrial-academic collaboration structures"--

Book Synopsis Burger's Medicinal Chemistry, Drug Discovery and Development by : Donald J. Abraham

Download or read book Burger's Medicinal Chemistry, Drug Discovery and Development written by Donald J. Abraham and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Burger's is a flagship reference source for medicinal chemists and pharmaceutical professionals. This updated and expanded 8th edition has been thoroughly revised and improved to incorporate the concepts of drug hunting along with its existing coverage of the entire process of drug discovery and development. Bringing in a new and expert editorial board, this new edition updates existing chapters and adds 35 new ones, with topics including: opioid addiction treatments, antibody and gene therapy for cancer, blood-brain barrier, HIV treatments, and industrial-academic collaboration structures"--

Proteases As Drug Targets

Author: Joseph P. Vacca

Publisher: Wiley-VCH

Published: 2010-06-29

Total Pages: 380

ISBN-13: 9783527318124

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Part of a suite of three similarly organized books on proteases, the family of serine proteases is described from a drug developer's perspective. This book also contains numerous case studies from recently developed protease drugs.

Book Synopsis Proteases As Drug Targets by : Joseph P. Vacca

Download or read book Proteases As Drug Targets written by Joseph P. Vacca and published by Wiley-VCH. This book was released on 2010-06-29 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of a suite of three similarly organized books on proteases, the family of serine proteases is described from a drug developer's perspective. This book also contains numerous case studies from recently developed protease drugs.

Proteases as Targets for Therapy

Author: Klaus von der Helm

Publisher: Springer Science & Business Media

Published: 2000

Total Pages: 440

ISBN-13: 9783540661184

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This volume is the first to combine latest information on viral, microbial and cellular proteolytic enzymes as potential targets for human therapeutics. Proteases control a large array of physiological reactions, and are involved in a variety of pathological processes for which effective medications are currently needed and/or being sought after. Although protease inhibitors have been investigated for many years, few have been employed therapeutically. Recent break- through by HIV protease inhibitors as therapeutic drugs has re-encouraged the search for inhibitors of other proteolytic enzymes. Klaus von der Helm, who described the first viral protease has brought leading experts together to discuss not only the success and problems of clinical use and continuing prospects, but to review further potential drug targets. This volume provides detailed information and evaluations of key viral, bacterial, fungal, and cellular proteases as potential future drug candidates.

Book Synopsis Proteases as Targets for Therapy by : Klaus von der Helm

Download or read book Proteases as Targets for Therapy written by Klaus von der Helm and published by Springer Science & Business Media. This book was released on 2000 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the first to combine latest information on viral, microbial and cellular proteolytic enzymes as potential targets for human therapeutics. Proteases control a large array of physiological reactions, and are involved in a variety of pathological processes for which effective medications are currently needed and/or being sought after. Although protease inhibitors have been investigated for many years, few have been employed therapeutically. Recent break- through by HIV protease inhibitors as therapeutic drugs has re-encouraged the search for inhibitors of other proteolytic enzymes. Klaus von der Helm, who described the first viral protease has brought leading experts together to discuss not only the success and problems of clinical use and continuing prospects, but to review further potential drug targets. This volume provides detailed information and evaluations of key viral, bacterial, fungal, and cellular proteases as potential future drug candidates.

Aspartic Acid Proteases as Therapeutic Targets

Author: Arun K. Ghosh

Publisher: John Wiley & Sons

Published: 2011-08-04

Total Pages: 616

ISBN-13: 3527641629

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In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two to five present various case studies of successful protease inhibitor drug design and development, as well as current and potential uses of such inhibitors in pharmaceutical medicine, covering the major therapeutic targets HIV-1 protease, renin, beta-secretase, gamma-secretase,plasmepsins and fungal proteases. A ready reference aimed primarily at professionals in the pharmaceutical industry, as well as for anyone studying proteases and their function.

Book Synopsis Aspartic Acid Proteases as Therapeutic Targets by : Arun K. Ghosh

Download or read book Aspartic Acid Proteases as Therapeutic Targets written by Arun K. Ghosh and published by John Wiley & Sons. This book was released on 2011-08-04 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two to five present various case studies of successful protease inhibitor drug design and development, as well as current and potential uses of such inhibitors in pharmaceutical medicine, covering the major therapeutic targets HIV-1 protease, renin, beta-secretase, gamma-secretase,plasmepsins and fungal proteases. A ready reference aimed primarily at professionals in the pharmaceutical industry, as well as for anyone studying proteases and their function.

Structural Biology in Drug Discovery

Author: Jean-Paul Renaud

Publisher: John Wiley & Sons

Published: 2020-01-09

Total Pages: 1367

ISBN-13: 1118900502

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With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Book Synopsis Structural Biology in Drug Discovery by : Jean-Paul Renaud

Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 1367 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Proteases as Drug Targets

Author: Joseph P. Vacca

Publisher: Wiley-VCH

Published: 2010-06-29

Total Pages: 380

ISBN-13: 9783527318131

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This first-ever guide to protease inhibitor drug design ties together the knowledge gained from numerous recent protease drugs in a single source. Edited by one of the most prominent protease drug developers in the pharmaceutical industry, it describes the family of metalloproteases from a drug developer's perspective.

Book Synopsis Proteases as Drug Targets by : Joseph P. Vacca

Download or read book Proteases as Drug Targets written by Joseph P. Vacca and published by Wiley-VCH. This book was released on 2010-06-29 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first-ever guide to protease inhibitor drug design ties together the knowledge gained from numerous recent protease drugs in a single source. Edited by one of the most prominent protease drug developers in the pharmaceutical industry, it describes the family of metalloproteases from a drug developer's perspective.