Quantification, Validation and Uncertainty in Analytical Sciences

Quantification, Validation and Uncertainty in Analytical Sciences

Author: Max Feinberg

Publisher: John Wiley & Sons

Published: 2024-02-16

Total Pages: 341

ISBN-13: 3527845267

DOWNLOAD EBOOK

Quantification, Validation and Uncertainty in Analytical Sciences Companion guide explaining all processes in measuring uncertainty in quantitative analytical results Quantification, Validation and Uncertainty in Analytical Sciences provides basic and expert knowledge by building on the sequence of operations starting from the quantification in analytical sciences by defining the analyte and linking it to the calibration function. Proposing a comprehensive approach to MU (Measurement Uncertainty) estimation, it empowers the reader to apply Method Accuracy Profile (MAP) efficiently as a statistical tool in measuring uncertainty. The text elucidates several examples and template worksheets explaining the theoretical aspects of the procedure and includes novel method validation procedures that can accurately estimate the data obtained in measurements. It also enables the reader to provide practical insights to improve decision making by accurately evaluating and comparing different analytical methods. Brings together an interdisciplinary approach with statistical tools and algorithms applied in analytical chemistry and written by two international experts with long-standing experience in the field of Analytical measurements and Uncertainty, Quantification, Validation and Uncertainty in Analytical Sciences includes information on: The know-how of methods in an analytical laboratory, effective usage of a spurious measurement and methods to estimate errors. Quantification, calibration, precision, trueness, MAP addons, estimating MU for analytical sciences, and uncertainty functions Employing measurement uncertainty, sampling uncertainty, quantification limits, and sample conformity assessment Decision making, uncertainty and standard addition method, and accuracy profile for method comparison Quantification, Validation and Uncertainty in Analytical Sciences is an ideal resource for every individual quantifying or studying analytes. With several chapters dedicated to MU’s practical use in decision making demonstrating its advantages, the book is primarily intended for professional analysts, although researchers and students will also find it of interest.


Book Synopsis Quantification, Validation and Uncertainty in Analytical Sciences by : Max Feinberg

Download or read book Quantification, Validation and Uncertainty in Analytical Sciences written by Max Feinberg and published by John Wiley & Sons. This book was released on 2024-02-16 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantification, Validation and Uncertainty in Analytical Sciences Companion guide explaining all processes in measuring uncertainty in quantitative analytical results Quantification, Validation and Uncertainty in Analytical Sciences provides basic and expert knowledge by building on the sequence of operations starting from the quantification in analytical sciences by defining the analyte and linking it to the calibration function. Proposing a comprehensive approach to MU (Measurement Uncertainty) estimation, it empowers the reader to apply Method Accuracy Profile (MAP) efficiently as a statistical tool in measuring uncertainty. The text elucidates several examples and template worksheets explaining the theoretical aspects of the procedure and includes novel method validation procedures that can accurately estimate the data obtained in measurements. It also enables the reader to provide practical insights to improve decision making by accurately evaluating and comparing different analytical methods. Brings together an interdisciplinary approach with statistical tools and algorithms applied in analytical chemistry and written by two international experts with long-standing experience in the field of Analytical measurements and Uncertainty, Quantification, Validation and Uncertainty in Analytical Sciences includes information on: The know-how of methods in an analytical laboratory, effective usage of a spurious measurement and methods to estimate errors. Quantification, calibration, precision, trueness, MAP addons, estimating MU for analytical sciences, and uncertainty functions Employing measurement uncertainty, sampling uncertainty, quantification limits, and sample conformity assessment Decision making, uncertainty and standard addition method, and accuracy profile for method comparison Quantification, Validation and Uncertainty in Analytical Sciences is an ideal resource for every individual quantifying or studying analytes. With several chapters dedicated to MU’s practical use in decision making demonstrating its advantages, the book is primarily intended for professional analysts, although researchers and students will also find it of interest.


Traceability, Validation and Measurement Uncertainty in Chemistry: Vol. 3

Traceability, Validation and Measurement Uncertainty in Chemistry: Vol. 3

Author: Nineta Hrastelj

Publisher: Springer

Published: 2019-08-13

Total Pages: 129

ISBN-13: 3030203476

DOWNLOAD EBOOK

This book presents worked examples of five analytical procedures. These practical examples address traceability, validation and measurement uncertainty aspects in a systematic and consistent way, and cover applications in the analysis of water, food, as well as ores and minerals. This concept is based on the experiences of the TrainMiCc program, in which more than 9000 laboratory professionals all over Europe have participated.


Book Synopsis Traceability, Validation and Measurement Uncertainty in Chemistry: Vol. 3 by : Nineta Hrastelj

Download or read book Traceability, Validation and Measurement Uncertainty in Chemistry: Vol. 3 written by Nineta Hrastelj and published by Springer. This book was released on 2019-08-13 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents worked examples of five analytical procedures. These practical examples address traceability, validation and measurement uncertainty aspects in a systematic and consistent way, and cover applications in the analysis of water, food, as well as ores and minerals. This concept is based on the experiences of the TrainMiCc program, in which more than 9000 laboratory professionals all over Europe have participated.


Quantifying Uncertainty in Analytical Measurement

Quantifying Uncertainty in Analytical Measurement

Author: Eurachem/CITAC Working Group

Publisher:

Published: 2000-01-01

Total Pages: 120

ISBN-13: 9780948926150

DOWNLOAD EBOOK


Book Synopsis Quantifying Uncertainty in Analytical Measurement by : Eurachem/CITAC Working Group

Download or read book Quantifying Uncertainty in Analytical Measurement written by Eurachem/CITAC Working Group and published by . This book was released on 2000-01-01 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:


Measurement Uncertainty in Chemical Analysis

Measurement Uncertainty in Chemical Analysis

Author: Paul De Bièvre

Publisher: Springer Science & Business Media

Published: 2013-06-29

Total Pages: 294

ISBN-13: 3662051737

DOWNLOAD EBOOK

It is now becoming recognized in the measurement community that it is as important to communicate the uncertainty related to a specific measurement as it is to report the measurement itself. Without knowing the uncertainty, it is impossible for the users of the result to know what confidence can be placed in it; it is also impossible to assess the comparability of different measurements of the same parameter. This volume collects 20 outstanding papers on the topic, mostly published from 1999-2002 in the journal "Accreditation and Quality Assurance." They provide the rationale for why it is important to evaluate and report the uncertainty of a result in a consistent manner. They also describe the concept of uncertainty, the methodology for evaluating uncertainty, and the advantages of using suitable reference materials. Finally, the benefits to both the analytical laboratory and the user of the results are considered.


Book Synopsis Measurement Uncertainty in Chemical Analysis by : Paul De Bièvre

Download or read book Measurement Uncertainty in Chemical Analysis written by Paul De Bièvre and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is now becoming recognized in the measurement community that it is as important to communicate the uncertainty related to a specific measurement as it is to report the measurement itself. Without knowing the uncertainty, it is impossible for the users of the result to know what confidence can be placed in it; it is also impossible to assess the comparability of different measurements of the same parameter. This volume collects 20 outstanding papers on the topic, mostly published from 1999-2002 in the journal "Accreditation and Quality Assurance." They provide the rationale for why it is important to evaluate and report the uncertainty of a result in a consistent manner. They also describe the concept of uncertainty, the methodology for evaluating uncertainty, and the advantages of using suitable reference materials. Finally, the benefits to both the analytical laboratory and the user of the results are considered.


Validation in Chemical Measurement

Validation in Chemical Measurement

Author: Paul De Bièvre

Publisher: Springer Science & Business Media

Published: 2005-01-12

Total Pages: 190

ISBN-13: 9783540207887

DOWNLOAD EBOOK

The validation of analytical methods is based on the characterisation of a measurement procedure (selectivity, sensitivity, repeatability, reproducibility). This volume collects 31 outstanding papers on the topic, mostly published in the period 2000-2003 in the journal "Accreditation and Quality Assurance". They provide the latest understanding, and possibly the rationale why it is important to integrate the concept of validation into the standard procedures of every analytical laboratory. In addition, this anthology considers the benefits to both: the analytical laboratory and the user of the measurement results.


Book Synopsis Validation in Chemical Measurement by : Paul De Bièvre

Download or read book Validation in Chemical Measurement written by Paul De Bièvre and published by Springer Science & Business Media. This book was released on 2005-01-12 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: The validation of analytical methods is based on the characterisation of a measurement procedure (selectivity, sensitivity, repeatability, reproducibility). This volume collects 31 outstanding papers on the topic, mostly published in the period 2000-2003 in the journal "Accreditation and Quality Assurance". They provide the latest understanding, and possibly the rationale why it is important to integrate the concept of validation into the standard procedures of every analytical laboratory. In addition, this anthology considers the benefits to both: the analytical laboratory and the user of the measurement results.


Quality Assurance in Analytical Chemistry

Quality Assurance in Analytical Chemistry

Author: Elizabeth Prichard

Publisher: John Wiley & Sons

Published: 2007-09-27

Total Pages: 316

ISBN-13: 9780470517765

DOWNLOAD EBOOK

The issue of quality assurance in the analytical chemistry laboratory has become of great importance in recent years. Quality Assurance in Analytical Chemistry introduces the reader to the whole concept of quality assurance. It discusses how all aspects of chemical analysis, from sampling and method selection to choice of equipment and the taking and reporting of measurements affect the quality of analytical data. Finally, the implementation and use of quality systems are covered.


Book Synopsis Quality Assurance in Analytical Chemistry by : Elizabeth Prichard

Download or read book Quality Assurance in Analytical Chemistry written by Elizabeth Prichard and published by John Wiley & Sons. This book was released on 2007-09-27 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: The issue of quality assurance in the analytical chemistry laboratory has become of great importance in recent years. Quality Assurance in Analytical Chemistry introduces the reader to the whole concept of quality assurance. It discusses how all aspects of chemical analysis, from sampling and method selection to choice of equipment and the taking and reporting of measurements affect the quality of analytical data. Finally, the implementation and use of quality systems are covered.


Calibration and Validation of Analytical Methods

Calibration and Validation of Analytical Methods

Author: Mark Stauffer

Publisher: BoD – Books on Demand

Published: 2018-04-25

Total Pages: 176

ISBN-13: 1789230845

DOWNLOAD EBOOK

This book seeks to introduce the reader to current methodologies in analytical calibration and validation. This collection of contributed research articles and reviews addresses current developments in the calibration of analytical methods and techniques and their subsequent validation. Section 1, "Introduction," contains the Introductory Chapter, a broad overview of analytical calibration and validation, and a brief synopsis of the following chapters. Section 2 "Calibration Approaches" presents five chapters covering calibration schemes for some modern analytical methods and techniques. The last chapter in this section provides a segue into Section 3, "Validation Approaches," which contains two chapters on validation procedures and parameters. This book is a valuable source of scientific information for anyone interested in analytical calibration and validation.


Book Synopsis Calibration and Validation of Analytical Methods by : Mark Stauffer

Download or read book Calibration and Validation of Analytical Methods written by Mark Stauffer and published by BoD – Books on Demand. This book was released on 2018-04-25 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book seeks to introduce the reader to current methodologies in analytical calibration and validation. This collection of contributed research articles and reviews addresses current developments in the calibration of analytical methods and techniques and their subsequent validation. Section 1, "Introduction," contains the Introductory Chapter, a broad overview of analytical calibration and validation, and a brief synopsis of the following chapters. Section 2 "Calibration Approaches" presents five chapters covering calibration schemes for some modern analytical methods and techniques. The last chapter in this section provides a segue into Section 3, "Validation Approaches," which contains two chapters on validation procedures and parameters. This book is a valuable source of scientific information for anyone interested in analytical calibration and validation.


Analytical Method Validation and Instrument Performance Verification

Analytical Method Validation and Instrument Performance Verification

Author: Chung Chow Chan

Publisher: John Wiley & Sons

Published: 2004-04-23

Total Pages: 320

ISBN-13: 047146371X

DOWNLOAD EBOOK

Validation describes the procedures used to analyze pharmaceutical products so that the data generated will comply with the requirements of regulatory bodies of the US, Canada, Europe and Japan. Calibration of Instruments describes the process of fixing, checking or correcting the graduations of instruments so that they comply with those regulatory bodies. This book provides a thorough explanation of both the fundamental and practical aspects of biopharmaceutical and bioanalytical methods validation. It teaches the proper procedures for using the tools and analysis methods in a regulated lab setting. Readers will learn the appropriate procedures for calibration of laboratory instrumentation and validation of analytical methods of analysis. These procedures must be executed properly in all regulated laboratories, including pharmaceutical and biopharmaceutical laboratories, clinical testing laboratories (hospitals, medical offices) and in food and cosmetic testing laboratories.


Book Synopsis Analytical Method Validation and Instrument Performance Verification by : Chung Chow Chan

Download or read book Analytical Method Validation and Instrument Performance Verification written by Chung Chow Chan and published by John Wiley & Sons. This book was released on 2004-04-23 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Validation describes the procedures used to analyze pharmaceutical products so that the data generated will comply with the requirements of regulatory bodies of the US, Canada, Europe and Japan. Calibration of Instruments describes the process of fixing, checking or correcting the graduations of instruments so that they comply with those regulatory bodies. This book provides a thorough explanation of both the fundamental and practical aspects of biopharmaceutical and bioanalytical methods validation. It teaches the proper procedures for using the tools and analysis methods in a regulated lab setting. Readers will learn the appropriate procedures for calibration of laboratory instrumentation and validation of analytical methods of analysis. These procedures must be executed properly in all regulated laboratories, including pharmaceutical and biopharmaceutical laboratories, clinical testing laboratories (hospitals, medical offices) and in food and cosmetic testing laboratories.


Assessing the Reliability of Complex Models

Assessing the Reliability of Complex Models

Author: National Research Council

Publisher: National Academies Press

Published: 2012-07-26

Total Pages: 144

ISBN-13: 0309256348

DOWNLOAD EBOOK

Advances in computing hardware and algorithms have dramatically improved the ability to simulate complex processes computationally. Today's simulation capabilities offer the prospect of addressing questions that in the past could be addressed only by resource-intensive experimentation, if at all. Assessing the Reliability of Complex Models recognizes the ubiquity of uncertainty in computational estimates of reality and the necessity for its quantification. As computational science and engineering have matured, the process of quantifying or bounding uncertainties in a computational estimate of a physical quality of interest has evolved into a small set of interdependent tasks: verification, validation, and uncertainty of quantification (VVUQ). In recognition of the increasing importance of computational simulation and the increasing need to assess uncertainties in computational results, the National Research Council was asked to study the mathematical foundations of VVUQ and to recommend steps that will ultimately lead to improved processes. Assessing the Reliability of Complex Models discusses changes in education of professionals and dissemination of information that should enhance the ability of future VVUQ practitioners to improve and properly apply VVUQ methodologies to difficult problems, enhance the ability of VVUQ customers to understand VVUQ results and use them to make informed decisions, and enhance the ability of all VVUQ stakeholders to communicate with each other. This report is an essential resource for all decision and policy makers in the field, students, stakeholders, UQ experts, and VVUQ educators and practitioners.


Book Synopsis Assessing the Reliability of Complex Models by : National Research Council

Download or read book Assessing the Reliability of Complex Models written by National Research Council and published by National Academies Press. This book was released on 2012-07-26 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in computing hardware and algorithms have dramatically improved the ability to simulate complex processes computationally. Today's simulation capabilities offer the prospect of addressing questions that in the past could be addressed only by resource-intensive experimentation, if at all. Assessing the Reliability of Complex Models recognizes the ubiquity of uncertainty in computational estimates of reality and the necessity for its quantification. As computational science and engineering have matured, the process of quantifying or bounding uncertainties in a computational estimate of a physical quality of interest has evolved into a small set of interdependent tasks: verification, validation, and uncertainty of quantification (VVUQ). In recognition of the increasing importance of computational simulation and the increasing need to assess uncertainties in computational results, the National Research Council was asked to study the mathematical foundations of VVUQ and to recommend steps that will ultimately lead to improved processes. Assessing the Reliability of Complex Models discusses changes in education of professionals and dissemination of information that should enhance the ability of future VVUQ practitioners to improve and properly apply VVUQ methodologies to difficult problems, enhance the ability of VVUQ customers to understand VVUQ results and use them to make informed decisions, and enhance the ability of all VVUQ stakeholders to communicate with each other. This report is an essential resource for all decision and policy makers in the field, students, stakeholders, UQ experts, and VVUQ educators and practitioners.


Method Validation in Pharmaceutical Analysis

Method Validation in Pharmaceutical Analysis

Author: Joachim Ermer

Publisher: John Wiley & Sons

Published: 2014-11-10

Total Pages: 451

ISBN-13: 3527335633

DOWNLOAD EBOOK

This second edition of a global bestseller has been completely redesigned and extensively rewritten to take into account the new Quality by Design (QbD) and lifecycle concepts in pharmaceutical manufacturing. As in the first edition, the fundamental requirements for analytical method validation are covered, but the second edition describes how these are applied systematically throughout the entire analytical lifecycle. QbD principles require adoption of a systematic approach to development and validation that begin with predefined objectives. For analytical methods these predefined objectives are established as an Analytical Target Profile (ATP). The book chapters are aligned with recently introduced standards and guidelines for manufacturing processes validation and follow the three stages of the analytical lifecycle: Method Design, Method Performance Qualification, and Continued Method Performance Verification. Case studies and examples from the pharmaceutical industry illustrate the concepts and guidelines presented, and the standards and regulations from the US (FDA), European (EMA) and global (ICH) regulatory authorities are considered throughout. The undisputed gold standard in the field.


Book Synopsis Method Validation in Pharmaceutical Analysis by : Joachim Ermer

Download or read book Method Validation in Pharmaceutical Analysis written by Joachim Ermer and published by John Wiley & Sons. This book was released on 2014-11-10 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of a global bestseller has been completely redesigned and extensively rewritten to take into account the new Quality by Design (QbD) and lifecycle concepts in pharmaceutical manufacturing. As in the first edition, the fundamental requirements for analytical method validation are covered, but the second edition describes how these are applied systematically throughout the entire analytical lifecycle. QbD principles require adoption of a systematic approach to development and validation that begin with predefined objectives. For analytical methods these predefined objectives are established as an Analytical Target Profile (ATP). The book chapters are aligned with recently introduced standards and guidelines for manufacturing processes validation and follow the three stages of the analytical lifecycle: Method Design, Method Performance Qualification, and Continued Method Performance Verification. Case studies and examples from the pharmaceutical industry illustrate the concepts and guidelines presented, and the standards and regulations from the US (FDA), European (EMA) and global (ICH) regulatory authorities are considered throughout. The undisputed gold standard in the field.