Evolutionary Quantitative Genetics

Evolutionary Quantitative Genetics

Author: Derek A. Roff

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 503

ISBN-13: 1461540801

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The impetus for this book arose out of my previous book, The Evolution of Life Histories (Roff, 1992). In that book I presented a single chapter on quanti tative genetic theory. However, as the book was concerned with the evolution of life histories and traits connected to this, the presence of quantitative genetic variation was an underlying theme throughout. Much of the focus was placed on optimality theory, for it is this approach that has proven to be extremely successful in the analysis of life history variation. But quantitative genetics cannot be ig nored, because there are some questions for which optimality approaches are inappropriate; for example, although optimality modeling can address the ques tion of the maintenance of phenotypic variation, it cannot say anything about genetic variation, on which further evolution clearly depends. The present book is, thus, a natural extension of the first. I have approached the problem not from the point of view of an animal or plant breeder but from that of one interested in understanding the evolution of quantitative traits in wild populations. The subject is large with a considerable body of theory: I generally present the assumptions underlying the analysis and the results, giving the relevant references for those interested in the intervening mathematics. My interest is in what quantitative genetics tells me about evolutionary processes; therefore, I have concentrated on areas of research most relevant to field studies.


Book Synopsis Evolutionary Quantitative Genetics by : Derek A. Roff

Download or read book Evolutionary Quantitative Genetics written by Derek A. Roff and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: The impetus for this book arose out of my previous book, The Evolution of Life Histories (Roff, 1992). In that book I presented a single chapter on quanti tative genetic theory. However, as the book was concerned with the evolution of life histories and traits connected to this, the presence of quantitative genetic variation was an underlying theme throughout. Much of the focus was placed on optimality theory, for it is this approach that has proven to be extremely successful in the analysis of life history variation. But quantitative genetics cannot be ig nored, because there are some questions for which optimality approaches are inappropriate; for example, although optimality modeling can address the ques tion of the maintenance of phenotypic variation, it cannot say anything about genetic variation, on which further evolution clearly depends. The present book is, thus, a natural extension of the first. I have approached the problem not from the point of view of an animal or plant breeder but from that of one interested in understanding the evolution of quantitative traits in wild populations. The subject is large with a considerable body of theory: I generally present the assumptions underlying the analysis and the results, giving the relevant references for those interested in the intervening mathematics. My interest is in what quantitative genetics tells me about evolutionary processes; therefore, I have concentrated on areas of research most relevant to field studies.

Genetics and Analysis of Quantitative Traits

Genetics and Analysis of Quantitative Traits

Author: Michael Lynch

Publisher: Sinauer Associates Incorporated

Published: 1998-01

Total Pages: 980

ISBN-13: 9780878934812

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Professors Lynch and Walsh bring together the diverse array of theoretical and empirical applications of quantitative genetics in a work that is comprehensive and accessible to anyone with a rudimentary understanding of statistics and genetics.


Book Synopsis Genetics and Analysis of Quantitative Traits by : Michael Lynch

Download or read book Genetics and Analysis of Quantitative Traits written by Michael Lynch and published by Sinauer Associates Incorporated. This book was released on 1998-01 with total page 980 pages. Available in PDF, EPUB and Kindle. Book excerpt: Professors Lynch and Walsh bring together the diverse array of theoretical and empirical applications of quantitative genetics in a work that is comprehensive and accessible to anyone with a rudimentary understanding of statistics and genetics.

Quantitative genetic variation

Quantitative genetic variation

Author: James N. Jr. Thompson

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 327

ISBN-13: 0323156029

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Quantitative Genetic Variation describes some of the experimental approaches to quantitative genetic variation, along with their potential applications and limitations. It considers one of the most widely applicable tools, i.e., biometrical analysis, as well as individual polygenic effects, specific components of a quantitative genetic trait, and artificial selection, and it shows how selection experiments can address specific developmental and genetic questions. Organized into four sections encompassing 17 chapters, this volume begins with a historical overview of the study of quantitative genetic variation, along with genetic variation in fungi and Drosophila. It then discusses the biometrical approach to quantitative variation, selection theory and analysis, uses and limitations of polygene mapping, and computer simulation of the breeding program for polygene location. The reader is also introduced to genes affecting quantitative aspects of physiology in rodents, as well as cytological markers and quantitative variation in wheat. This book will be extremely useful to students, researchers, and geneticists.


Book Synopsis Quantitative genetic variation by : James N. Jr. Thompson

Download or read book Quantitative genetic variation written by James N. Jr. Thompson and published by Elsevier. This book was released on 2012-12-02 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative Genetic Variation describes some of the experimental approaches to quantitative genetic variation, along with their potential applications and limitations. It considers one of the most widely applicable tools, i.e., biometrical analysis, as well as individual polygenic effects, specific components of a quantitative genetic trait, and artificial selection, and it shows how selection experiments can address specific developmental and genetic questions. Organized into four sections encompassing 17 chapters, this volume begins with a historical overview of the study of quantitative genetic variation, along with genetic variation in fungi and Drosophila. It then discusses the biometrical approach to quantitative variation, selection theory and analysis, uses and limitations of polygene mapping, and computer simulation of the breeding program for polygene location. The reader is also introduced to genes affecting quantitative aspects of physiology in rodents, as well as cytological markers and quantitative variation in wheat. This book will be extremely useful to students, researchers, and geneticists.

Evolution and Selection of Quantitative Traits

Evolution and Selection of Quantitative Traits

Author: Bruce Walsh

Publisher: Oxford University Press

Published: 2018-06-21

Total Pages: 1504

ISBN-13: 0192566644

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Quantitative traits-be they morphological or physiological characters, aspects of behavior, or genome-level features such as the amount of RNA or protein expression for a specific gene-usually show considerable variation within and among populations. Quantitative genetics, also referred to as the genetics of complex traits, is the study of such characters and is based on mathematical models of evolution in which many genes influence the trait and in which non-genetic factors may also be important. Evolution and Selection of Quantitative Traits presents a holistic treatment of the subject, showing the interplay between theory and data with extensive discussions on statistical issues relating to the estimation of the biologically relevant parameters for these models. Quantitative genetics is viewed as the bridge between complex mathematical models of trait evolution and real-world data, and the authors have clearly framed their treatment as such. This is the second volume in a planned trilogy that summarizes the modern field of quantitative genetics, informed by empirical observations from wide-ranging fields (agriculture, evolution, ecology, and human biology) as well as population genetics, statistical theory, mathematical modeling, genetics, and genomics. Whilst volume 1 (1998) dealt with the genetics of such traits, the main focus of volume 2 is on their evolution, with a special emphasis on detecting selection (ranging from the use of genomic and historical data through to ecological field data) and examining its consequences.


Book Synopsis Evolution and Selection of Quantitative Traits by : Bruce Walsh

Download or read book Evolution and Selection of Quantitative Traits written by Bruce Walsh and published by Oxford University Press. This book was released on 2018-06-21 with total page 1504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative traits-be they morphological or physiological characters, aspects of behavior, or genome-level features such as the amount of RNA or protein expression for a specific gene-usually show considerable variation within and among populations. Quantitative genetics, also referred to as the genetics of complex traits, is the study of such characters and is based on mathematical models of evolution in which many genes influence the trait and in which non-genetic factors may also be important. Evolution and Selection of Quantitative Traits presents a holistic treatment of the subject, showing the interplay between theory and data with extensive discussions on statistical issues relating to the estimation of the biologically relevant parameters for these models. Quantitative genetics is viewed as the bridge between complex mathematical models of trait evolution and real-world data, and the authors have clearly framed their treatment as such. This is the second volume in a planned trilogy that summarizes the modern field of quantitative genetics, informed by empirical observations from wide-ranging fields (agriculture, evolution, ecology, and human biology) as well as population genetics, statistical theory, mathematical modeling, genetics, and genomics. Whilst volume 1 (1998) dealt with the genetics of such traits, the main focus of volume 2 is on their evolution, with a special emphasis on detecting selection (ranging from the use of genomic and historical data through to ecological field data) and examining its consequences.

Statistical Genetics of Quantitative Traits

Statistical Genetics of Quantitative Traits

Author: Rongling Wu

Publisher: Springer Science & Business Media

Published: 2007-07-17

Total Pages: 371

ISBN-13: 038768154X

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This book introduces the basic concepts and methods that are useful in the statistical analysis and modeling of the DNA-based marker and phenotypic data that arise in agriculture, forestry, experimental biology, and other fields. It concentrates on the linkage analysis of markers, map construction and quantitative trait locus (QTL) mapping, and assumes a background in regression analysis and maximum likelihood approaches. The strength of this book lies in the construction of general models and algorithms for linkage analysis, as well as in QTL mapping in any kind of crossed pedigrees initiated with inbred lines of crops.


Book Synopsis Statistical Genetics of Quantitative Traits by : Rongling Wu

Download or read book Statistical Genetics of Quantitative Traits written by Rongling Wu and published by Springer Science & Business Media. This book was released on 2007-07-17 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the basic concepts and methods that are useful in the statistical analysis and modeling of the DNA-based marker and phenotypic data that arise in agriculture, forestry, experimental biology, and other fields. It concentrates on the linkage analysis of markers, map construction and quantitative trait locus (QTL) mapping, and assumes a background in regression analysis and maximum likelihood approaches. The strength of this book lies in the construction of general models and algorithms for linkage analysis, as well as in QTL mapping in any kind of crossed pedigrees initiated with inbred lines of crops.

Quantitative Genetic Studies of Behavioral Evolution

Quantitative Genetic Studies of Behavioral Evolution

Author: Christine R. B. Boake

Publisher: University of Chicago Press

Published: 1994-08-15

Total Pages: 400

ISBN-13: 0226062163

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Taken together, these studies document both the benefits and pitfalls of quantitative genetics.


Book Synopsis Quantitative Genetic Studies of Behavioral Evolution by : Christine R. B. Boake

Download or read book Quantitative Genetic Studies of Behavioral Evolution written by Christine R. B. Boake and published by University of Chicago Press. This book was released on 1994-08-15 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Taken together, these studies document both the benefits and pitfalls of quantitative genetics.

Next Steps for Functional Genomics

Next Steps for Functional Genomics

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

Published: 2020-12-18

Total Pages: 201

ISBN-13: 0309676738

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One of the holy grails in biology is the ability to predict functional characteristics from an organism's genetic sequence. Despite decades of research since the first sequencing of an organism in 1995, scientists still do not understand exactly how the information in genes is converted into an organism's phenotype, its physical characteristics. Functional genomics attempts to make use of the vast wealth of data from "-omics" screens and projects to describe gene and protein functions and interactions. A February 2020 workshop was held to determine research needs to advance the field of functional genomics over the next 10-20 years. Speakers and participants discussed goals, strategies, and technical needs to allow functional genomics to contribute to the advancement of basic knowledge and its applications that would benefit society. This publication summarizes the presentations and discussions from the workshop.


Book Synopsis Next Steps for Functional Genomics by : National Academies of Sciences, Engineering, and Medicine

Download or read book Next Steps for Functional Genomics written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-12-18 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the holy grails in biology is the ability to predict functional characteristics from an organism's genetic sequence. Despite decades of research since the first sequencing of an organism in 1995, scientists still do not understand exactly how the information in genes is converted into an organism's phenotype, its physical characteristics. Functional genomics attempts to make use of the vast wealth of data from "-omics" screens and projects to describe gene and protein functions and interactions. A February 2020 workshop was held to determine research needs to advance the field of functional genomics over the next 10-20 years. Speakers and participants discussed goals, strategies, and technical needs to allow functional genomics to contribute to the advancement of basic knowledge and its applications that would benefit society. This publication summarizes the presentations and discussions from the workshop.

Genetical Analysis of Quantitative Traits

Genetical Analysis of Quantitative Traits

Author: Dr M Kearsey

Publisher: Garland Science

Published: 2020-10-29

Total Pages: 396

ISBN-13: 1000144178

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This text provides a guide to the experimental and analytical methodologies available to study quantitative traits, a review of the genetic control of quantitative traits, and a discussion of how this knowledge can be applied to breeding problems and evolution.


Book Synopsis Genetical Analysis of Quantitative Traits by : Dr M Kearsey

Download or read book Genetical Analysis of Quantitative Traits written by Dr M Kearsey and published by Garland Science. This book was released on 2020-10-29 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides a guide to the experimental and analytical methodologies available to study quantitative traits, a review of the genetic control of quantitative traits, and a discussion of how this knowledge can be applied to breeding problems and evolution.

Quantitative Genetics in the Wild

Quantitative Genetics in the Wild

Author: Anne Charmantier

Publisher: Oxford University Press

Published: 2014

Total Pages: 293

ISBN-13: 019967423X

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This book gathers the expertise of 30 evolutionary biologists from around the globe to highlight how applying the field of quantitative genetics - the analysis of the genetic basis of complex traits - aids in the study of wild populations.


Book Synopsis Quantitative Genetics in the Wild by : Anne Charmantier

Download or read book Quantitative Genetics in the Wild written by Anne Charmantier and published by Oxford University Press. This book was released on 2014 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gathers the expertise of 30 evolutionary biologists from around the globe to highlight how applying the field of quantitative genetics - the analysis of the genetic basis of complex traits - aids in the study of wild populations.

Handbook of Statistical Genomics

Handbook of Statistical Genomics

Author: David J. Balding

Publisher: John Wiley & Sons

Published: 2019-07-09

Total Pages: 1828

ISBN-13: 1119429250

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A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and epigenetics, as well as metabolomics. It also examines population genetics and evolutionary models and inference, with new chapters on the multi-species coalescent, admixture and ancient DNA, as well as genetic association studies including causal analyses and variant interpretation. The Handbook of Statistical Genomics focuses on explaining the main ideas, analysis methods and algorithms, citing key recent and historic literature for further details and references. It also includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between chapters, tying the different areas together. With heavy use of up-to-date examples and references to web-based resources, this continues to be a must-have reference in a vital area of research. Provides much-needed, timely coverage of new developments in this expanding area of study Numerous, brand new chapters, for example covering bacterial genomics, microbiome and metagenomics Detailed coverage of application areas, with chapters on plant breeding, conservation and forensic genetics Extensive coverage of human genetic epidemiology, including ethical aspects Edited by one of the leading experts in the field along with rising stars as his co-editors Chapter authors are world-renowned experts in the field, and newly emerging leaders. The Handbook of Statistical Genomics is an excellent introductory text for advanced graduate students and early-career researchers involved in statistical genetics.


Book Synopsis Handbook of Statistical Genomics by : David J. Balding

Download or read book Handbook of Statistical Genomics written by David J. Balding and published by John Wiley & Sons. This book was released on 2019-07-09 with total page 1828 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and epigenetics, as well as metabolomics. It also examines population genetics and evolutionary models and inference, with new chapters on the multi-species coalescent, admixture and ancient DNA, as well as genetic association studies including causal analyses and variant interpretation. The Handbook of Statistical Genomics focuses on explaining the main ideas, analysis methods and algorithms, citing key recent and historic literature for further details and references. It also includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between chapters, tying the different areas together. With heavy use of up-to-date examples and references to web-based resources, this continues to be a must-have reference in a vital area of research. Provides much-needed, timely coverage of new developments in this expanding area of study Numerous, brand new chapters, for example covering bacterial genomics, microbiome and metagenomics Detailed coverage of application areas, with chapters on plant breeding, conservation and forensic genetics Extensive coverage of human genetic epidemiology, including ethical aspects Edited by one of the leading experts in the field along with rising stars as his co-editors Chapter authors are world-renowned experts in the field, and newly emerging leaders. The Handbook of Statistical Genomics is an excellent introductory text for advanced graduate students and early-career researchers involved in statistical genetics.