Free-Radical-Induced DNA Damage and Its Repair

Free-Radical-Induced DNA Damage and Its Repair

Author: Clemens Sonntag

Publisher: Springer Science & Business Media

Published: 2006-03-20

Total Pages: 523

ISBN-13: 3540305920

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The free-radical chemistry of DNA had been discussed in some detail in 1987 in my book The Chemical Basis of Radiation Biology. Obviously, the more recent developments and the concomitant higher level of understanding of mechanistic details are missing. Moreover, in the living cell, free-radical DNA damage is not only induced by ionizing radiation, but free-radical-induced DNA damage is a much more general phenomenon. It was, therefore, felt that it is now timely to review our present knowledge of free-radical-induced DNA damage induced by all conceivable free-radical-generating sources. Originally, it had been thought to include also a very important aspect, the repair of DNA damage by the cell’s various repair enzymes. Kevin Prise (Cancer Campaign, Gray Laboratory, L- don) was so kind to agree to write this part. However, an adequate description of this strongly expanding area would have exceeded the allocated space by much, and this section had to be omitted. The directors of the Max-Planck-Institut für Strahlenchemie (now MPI für Bioanorganische Chemie), Karl Wieghardt and Wolfgang Lubitz, kindly allowed me to continue to use its facilities after my retirement in 2001. Notably, our - brarian, Mrs. Jutta Theurich, and her right-hand help, Mrs. Rosemarie Schr- er, were most helpful in getting hold of the literature. I thank them very much. Without their constant help, this would have been very difficult indeed.


Book Synopsis Free-Radical-Induced DNA Damage and Its Repair by : Clemens Sonntag

Download or read book Free-Radical-Induced DNA Damage and Its Repair written by Clemens Sonntag and published by Springer Science & Business Media. This book was released on 2006-03-20 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: The free-radical chemistry of DNA had been discussed in some detail in 1987 in my book The Chemical Basis of Radiation Biology. Obviously, the more recent developments and the concomitant higher level of understanding of mechanistic details are missing. Moreover, in the living cell, free-radical DNA damage is not only induced by ionizing radiation, but free-radical-induced DNA damage is a much more general phenomenon. It was, therefore, felt that it is now timely to review our present knowledge of free-radical-induced DNA damage induced by all conceivable free-radical-generating sources. Originally, it had been thought to include also a very important aspect, the repair of DNA damage by the cell’s various repair enzymes. Kevin Prise (Cancer Campaign, Gray Laboratory, L- don) was so kind to agree to write this part. However, an adequate description of this strongly expanding area would have exceeded the allocated space by much, and this section had to be omitted. The directors of the Max-Planck-Institut für Strahlenchemie (now MPI für Bioanorganische Chemie), Karl Wieghardt and Wolfgang Lubitz, kindly allowed me to continue to use its facilities after my retirement in 2001. Notably, our - brarian, Mrs. Jutta Theurich, and her right-hand help, Mrs. Rosemarie Schr- er, were most helpful in getting hold of the literature. I thank them very much. Without their constant help, this would have been very difficult indeed.


Radical Heroes

Radical Heroes

Author: Diana Coben

Publisher: Routledge

Published: 2013-10-08

Total Pages: 275

ISBN-13: 1135586462

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First Published in 1998. This book examines the ideas of two of the most controversial radical heroes of adult education, Antonio Gramsci and Paulo Freire, gauging their significance for the development of a radical politics of adult education in the post-Soviet, post-apartheid new world order. Gramsci offers a noble vision of the role of adult education in the creation of revolutionary Marxist hegemony; but the cause he lived and died for has all but collapsed. Nevertheless, his distinction between common sense and good sense, his theory of the intellectual and his concept of hegemony bear scrutiny today. In Freire's pedagogy of the oppressed, the relationship between leader and followed, teacher and student, is problematic and this book questions whether his pedagogy has the liberating potential he envisioned. The author considers and rejects the linkage of Gramsci's and Freire's ideas in the adult education literature. Nonetheless, Gramsci and Freire have huge symbolic importance as radical heroes in an under-theorized and marginalised field. The study highlights a problem with the radical hero phenomenon: when individuals become icons, their ideas cease to be open, and new insights do not emerge as challenge becomes inadmissible and debate dies. While neither Gramsci nor Freire can provide us with answers, Gramsci helps us address the difficult questions of purpose and content in the politics of adult education.


Book Synopsis Radical Heroes by : Diana Coben

Download or read book Radical Heroes written by Diana Coben and published by Routledge. This book was released on 2013-10-08 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: First Published in 1998. This book examines the ideas of two of the most controversial radical heroes of adult education, Antonio Gramsci and Paulo Freire, gauging their significance for the development of a radical politics of adult education in the post-Soviet, post-apartheid new world order. Gramsci offers a noble vision of the role of adult education in the creation of revolutionary Marxist hegemony; but the cause he lived and died for has all but collapsed. Nevertheless, his distinction between common sense and good sense, his theory of the intellectual and his concept of hegemony bear scrutiny today. In Freire's pedagogy of the oppressed, the relationship between leader and followed, teacher and student, is problematic and this book questions whether his pedagogy has the liberating potential he envisioned. The author considers and rejects the linkage of Gramsci's and Freire's ideas in the adult education literature. Nonetheless, Gramsci and Freire have huge symbolic importance as radical heroes in an under-theorized and marginalised field. The study highlights a problem with the radical hero phenomenon: when individuals become icons, their ideas cease to be open, and new insights do not emerge as challenge becomes inadmissible and debate dies. While neither Gramsci nor Freire can provide us with answers, Gramsci helps us address the difficult questions of purpose and content in the politics of adult education.


Radical Puritans in England 1550 - 1660

Radical Puritans in England 1550 - 1660

Author: R.J. Acheson

Publisher: Routledge

Published: 2014-07-15

Total Pages: 121

ISBN-13: 1317880706

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This study of religious tensions in Early Modern England explores the different religious separatist movements between 1550-1660. It describes the development of radical sectarianism during the reign of Charles I and explores why the unity of radical cause was shattered following the restoration of the monarchy in 1660.


Book Synopsis Radical Puritans in England 1550 - 1660 by : R.J. Acheson

Download or read book Radical Puritans in England 1550 - 1660 written by R.J. Acheson and published by Routledge. This book was released on 2014-07-15 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study of religious tensions in Early Modern England explores the different religious separatist movements between 1550-1660. It describes the development of radical sectarianism during the reign of Charles I and explores why the unity of radical cause was shattered following the restoration of the monarchy in 1660.


Radical Polymerization Kinetics in Aqueos Solution and in Systems with Secondary and Tertiary Radicals Studied by Novel Pulsed-laser Techniques

Radical Polymerization Kinetics in Aqueos Solution and in Systems with Secondary and Tertiary Radicals Studied by Novel Pulsed-laser Techniques

Author: Pascal Hesse

Publisher: Cuvillier Verlag

Published: 2008

Total Pages: 325

ISBN-13: 386727682X

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Book Synopsis Radical Polymerization Kinetics in Aqueos Solution and in Systems with Secondary and Tertiary Radicals Studied by Novel Pulsed-laser Techniques by : Pascal Hesse

Download or read book Radical Polymerization Kinetics in Aqueos Solution and in Systems with Secondary and Tertiary Radicals Studied by Novel Pulsed-laser Techniques written by Pascal Hesse and published by Cuvillier Verlag. This book was released on 2008 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt:


Unrespectable Radicals?

Unrespectable Radicals?

Author: Michael T. Davis

Publisher: Ashgate Publishing, Ltd.

Published: 2008

Total Pages: 240

ISBN-13: 9780754656197

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This book brings together an international team of experienced scholars to honour Iain McCalman for his contribution to the field of British studies and to further explore the concepts and subjects he pioneered. Each of the contributors has been invited to take part in this volume and has submitted an original essay on the assigned topic, ensuring that the entire volume presents a focused and coherent review of popular politics, from the meeting rooms of a reform society and the theatre stage, to the forum of the courtroom and the depths of prison.


Book Synopsis Unrespectable Radicals? by : Michael T. Davis

Download or read book Unrespectable Radicals? written by Michael T. Davis and published by Ashgate Publishing, Ltd.. This book was released on 2008 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together an international team of experienced scholars to honour Iain McCalman for his contribution to the field of British studies and to further explore the concepts and subjects he pioneered. Each of the contributors has been invited to take part in this volume and has submitted an original essay on the assigned topic, ensuring that the entire volume presents a focused and coherent review of popular politics, from the meeting rooms of a reform society and the theatre stage, to the forum of the courtroom and the depths of prison.


The Chemical Dynamics and Kinetics of Small Radicals

The Chemical Dynamics and Kinetics of Small Radicals

Author: Kopin Liu

Publisher: World Scientific

Published: 1996

Total Pages: 484

ISBN-13: 9814317187

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This book highlights recent progress in the chemistry of radicals. Developments include the growing use of lasers to generate radicals, the application of lasers to provide state, angular, polarization, energy and real-time resolution in kinetics and dynamics experiments, the development of theories for handling the reactions of radicals, and the simulation of the reaction dynamics of increasingly larger systems for direct comparison to experimental results. The book emphasizes the increasing interaction between experimental dynamics, kinetics and theory. It is appropriate for chemistry graduate students and researchers about to enter the field. However, the discussions of some topics progress to a more advanced level so that even an expert will find the book useful.


Book Synopsis The Chemical Dynamics and Kinetics of Small Radicals by : Kopin Liu

Download or read book The Chemical Dynamics and Kinetics of Small Radicals written by Kopin Liu and published by World Scientific. This book was released on 1996 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights recent progress in the chemistry of radicals. Developments include the growing use of lasers to generate radicals, the application of lasers to provide state, angular, polarization, energy and real-time resolution in kinetics and dynamics experiments, the development of theories for handling the reactions of radicals, and the simulation of the reaction dynamics of increasingly larger systems for direct comparison to experimental results. The book emphasizes the increasing interaction between experimental dynamics, kinetics and theory. It is appropriate for chemistry graduate students and researchers about to enter the field. However, the discussions of some topics progress to a more advanced level so that even an expert will find the book useful.


Reactions of Hydroxyl Radicals with Oxygenated Hydrocarbons in the Gas Phase: A Laser Photolysis/Laser-Induced Fluorescence Study

Reactions of Hydroxyl Radicals with Oxygenated Hydrocarbons in the Gas Phase: A Laser Photolysis/Laser-Induced Fluorescence Study

Author: Cornelie Bänsch

Publisher: Logos Verlag Berlin GmbH

Published: 2017-12-21

Total Pages: 173

ISBN-13: 3832546324

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Hydroxyl radicals (OH) play a key role in ignition processes and in the atmosphere. Thus, the detailed knowledge of the kinetics of OH reactions is crucial in combustion and atmospheric research. In this work, an experimental approach for time-resolved studies of OH radical reactions at high pressures with pulsed laser photolysis/laser-induced fluorescence was revised and the reactions of dimethyl ether, diethyl ether, and dimethoxymethane with OH radicals were investigated in detail. The results reveal a deeper insight into the reaction processes of ether compounds with OH in general, contributing to a better understanding of the combustion of different biofuels and fuel additives.


Book Synopsis Reactions of Hydroxyl Radicals with Oxygenated Hydrocarbons in the Gas Phase: A Laser Photolysis/Laser-Induced Fluorescence Study by : Cornelie Bänsch

Download or read book Reactions of Hydroxyl Radicals with Oxygenated Hydrocarbons in the Gas Phase: A Laser Photolysis/Laser-Induced Fluorescence Study written by Cornelie Bänsch and published by Logos Verlag Berlin GmbH. This book was released on 2017-12-21 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hydroxyl radicals (OH) play a key role in ignition processes and in the atmosphere. Thus, the detailed knowledge of the kinetics of OH reactions is crucial in combustion and atmospheric research. In this work, an experimental approach for time-resolved studies of OH radical reactions at high pressures with pulsed laser photolysis/laser-induced fluorescence was revised and the reactions of dimethyl ether, diethyl ether, and dimethoxymethane with OH radicals were investigated in detail. The results reveal a deeper insight into the reaction processes of ether compounds with OH in general, contributing to a better understanding of the combustion of different biofuels and fuel additives.


Social Work for Lazy Radicals

Social Work for Lazy Radicals

Author: Jane Fenton

Publisher: Bloomsbury Publishing

Published: 2019-04-12

Total Pages: 199

ISBN-13: 1352002469

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Be proud to be a lazy radical! This textbook makes the case for a radical approach to social work that can be embraced by everyone. It's an approach based on real empathy and an understanding of oppression, of managerialism, of the moral heart of social work, of humanism and of the effects of neoliberal hegemony. Jane Fenton provides a model of radical practice for students and social workers who are committed to 'doing the right thing', and who want to develop their own framework for practice. This book will appeal to students who are activists, but want to frame their individual-level practice in a meaningful way, and to those who are non-activist and non-political but simply want to be good social workers. It will give a political and moral understanding of social work practice and lead to confident, value-based and enjoyable social work.


Book Synopsis Social Work for Lazy Radicals by : Jane Fenton

Download or read book Social Work for Lazy Radicals written by Jane Fenton and published by Bloomsbury Publishing. This book was released on 2019-04-12 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: Be proud to be a lazy radical! This textbook makes the case for a radical approach to social work that can be embraced by everyone. It's an approach based on real empathy and an understanding of oppression, of managerialism, of the moral heart of social work, of humanism and of the effects of neoliberal hegemony. Jane Fenton provides a model of radical practice for students and social workers who are committed to 'doing the right thing', and who want to develop their own framework for practice. This book will appeal to students who are activists, but want to frame their individual-level practice in a meaningful way, and to those who are non-activist and non-political but simply want to be good social workers. It will give a political and moral understanding of social work practice and lead to confident, value-based and enjoyable social work.


Oxidative Stress and Oxygen Radicals

Oxidative Stress and Oxygen Radicals

Author: Michael Breitenbach

Publisher: MDPI

Published: 2018-09-27

Total Pages: 542

ISBN-13: 3038421731

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This book is a printed edition of the Special Issue "Oxidative Stress and Oxygen Radicals" that was published in Biomolecules


Book Synopsis Oxidative Stress and Oxygen Radicals by : Michael Breitenbach

Download or read book Oxidative Stress and Oxygen Radicals written by Michael Breitenbach and published by MDPI. This book was released on 2018-09-27 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Oxidative Stress and Oxygen Radicals" that was published in Biomolecules


Transatlantic Radicals and the Early American Republic

Transatlantic Radicals and the Early American Republic

Author: Michael Durey

Publisher:

Published: 1997

Total Pages: 448

ISBN-13:

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In the transatlantic world of the late eighteenth century, easterly winds blew radical thought to America. Thomas Paine had already arrived on these shores in 1774 and made his mark as a radical pamphleteer during the Revolution. In his wake followed more than 200 other radical exiles—English Dissenters, Whigs, and Painites; Scottish "lads o'parts"; and Irish patriots—who became influential newspaper writers and editors and helped change the nature of political discourse in a young nation. Michael Durey has written the first full-scale analysis of these radicals, evaluating the long-term influence their ideas have had on American political thought. Transatlantic Radicals uncovers the roots of their radicalism in the Old World and tells the story of how these men came to be exiled, how they emigrated, and how they participated in the politics of their adopted country. Nearly all of these radicals looked to Paine as their spiritual leader and to Thomas Jefferson as their political champion. They held egalitarian, anti-federalist values and promoted an extreme form of participatory democracy that found a niche in the radical wing of Jefferson's Republican Party. Their divided views on slavery, however, reveal that democratic republicanism was unable to cope with the realities of that institution. As political activists during the 1790s, they proved crucial to Jefferson's 1800 presidential victory; then, after his views moderated and their influence waned, many repatriated, others drifted into anonymity, and a few managed to find success in the New World. Although many of these men are known to us through other histories, their influence as a group has never before been so closely examined. Durey persuasively demonstrates that the intellectual ferment in Britain did indeed have tremendous influence on American politics. His account of that influence sheds considerable light on transatlantic political history and differences in religious, political, and economic freedoms. Skillfully balancing a large cast of characters, Transatlantic Radicals depicts the diversity of their experiences and shows how crucial these reluctant émigrés were to shaping our republic in its formative years.


Book Synopsis Transatlantic Radicals and the Early American Republic by : Michael Durey

Download or read book Transatlantic Radicals and the Early American Republic written by Michael Durey and published by . This book was released on 1997 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the transatlantic world of the late eighteenth century, easterly winds blew radical thought to America. Thomas Paine had already arrived on these shores in 1774 and made his mark as a radical pamphleteer during the Revolution. In his wake followed more than 200 other radical exiles—English Dissenters, Whigs, and Painites; Scottish "lads o'parts"; and Irish patriots—who became influential newspaper writers and editors and helped change the nature of political discourse in a young nation. Michael Durey has written the first full-scale analysis of these radicals, evaluating the long-term influence their ideas have had on American political thought. Transatlantic Radicals uncovers the roots of their radicalism in the Old World and tells the story of how these men came to be exiled, how they emigrated, and how they participated in the politics of their adopted country. Nearly all of these radicals looked to Paine as their spiritual leader and to Thomas Jefferson as their political champion. They held egalitarian, anti-federalist values and promoted an extreme form of participatory democracy that found a niche in the radical wing of Jefferson's Republican Party. Their divided views on slavery, however, reveal that democratic republicanism was unable to cope with the realities of that institution. As political activists during the 1790s, they proved crucial to Jefferson's 1800 presidential victory; then, after his views moderated and their influence waned, many repatriated, others drifted into anonymity, and a few managed to find success in the New World. Although many of these men are known to us through other histories, their influence as a group has never before been so closely examined. Durey persuasively demonstrates that the intellectual ferment in Britain did indeed have tremendous influence on American politics. His account of that influence sheds considerable light on transatlantic political history and differences in religious, political, and economic freedoms. Skillfully balancing a large cast of characters, Transatlantic Radicals depicts the diversity of their experiences and shows how crucial these reluctant émigrés were to shaping our republic in its formative years.