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Author: Simone Furini
Publisher: Frontiers Media SA
Published: 2022-12-23
Total Pages: 142
ISBN-13: 2832509541
DOWNLOAD EBOOKDownload or read book Recent advancements in modeling and simulations of ion channels written by Simone Furini and published by Frontiers Media SA. This book was released on 2022-12-23 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author: Deborah Verran
Publisher: Frontiers Media SA
Published: 2022-12-23
Total Pages: 85
ISBN-13: 283250700X
DOWNLOAD EBOOKDownload or read book Recent advancements in modeling and simulations of ion channels written by Deborah Verran and published by Frontiers Media SA. This book was released on 2022-12-23 with total page 85 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author: Francesco L. Gervasio
Publisher: John Wiley & Sons
Published: 2019-04-29
Total Pages: 368
ISBN-13: 3527342656
DOWNLOAD EBOOKA guide to applying the power of modern simulation tools to better drug design Biomolecular Simulations in Structure-based Drug Discovery offers an up-to-date and comprehensive review of modern simulation tools and their applications in real-life drug discovery, for better and quicker results in structure-based drug design. The authors describe common tools used in the biomolecular simulation of drugs and their targets and offer an analysis of the accuracy of the predictions. They also show how to integrate modeling with other experimental data. Filled with numerous case studies from different therapeutic fields, the book helps professionals to quickly adopt these new methods for their current projects. Experts from the pharmaceutical industry and academic institutions present real-life examples for important target classes such as GPCRs, ion channels and amyloids as well as for common challenges in structure-based drug discovery. Biomolecular Simulations in Structure-based Drug Discovery is an important resource that: -Contains a review of the current generation of biomolecular simulation tools that have the robustness and speed that allows them to be used as routine tools by non-specialists -Includes information on the novel methods and strategies for the modeling of drug-target interactions within the framework of real-life drug discovery and development -Offers numerous illustrative case studies from a wide-range of therapeutic fields -Presents an application-oriented reference that is ideal for those working in the various fields Written for medicinal chemists, professionals in the pharmaceutical industry, and pharmaceutical chemists, Biomolecular Simulations in Structure-based Drug Discovery is a comprehensive resource to modern simulation tools that complement and have the potential to complement or replace laboratory assays for better results in drug design.
Download or read book Biomolecular Simulations in Structure-Based Drug Discovery written by Francesco L. Gervasio and published by John Wiley & Sons. This book was released on 2019-04-29 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to applying the power of modern simulation tools to better drug design Biomolecular Simulations in Structure-based Drug Discovery offers an up-to-date and comprehensive review of modern simulation tools and their applications in real-life drug discovery, for better and quicker results in structure-based drug design. The authors describe common tools used in the biomolecular simulation of drugs and their targets and offer an analysis of the accuracy of the predictions. They also show how to integrate modeling with other experimental data. Filled with numerous case studies from different therapeutic fields, the book helps professionals to quickly adopt these new methods for their current projects. Experts from the pharmaceutical industry and academic institutions present real-life examples for important target classes such as GPCRs, ion channels and amyloids as well as for common challenges in structure-based drug discovery. Biomolecular Simulations in Structure-based Drug Discovery is an important resource that: -Contains a review of the current generation of biomolecular simulation tools that have the robustness and speed that allows them to be used as routine tools by non-specialists -Includes information on the novel methods and strategies for the modeling of drug-target interactions within the framework of real-life drug discovery and development -Offers numerous illustrative case studies from a wide-range of therapeutic fields -Presents an application-oriented reference that is ideal for those working in the various fields Written for medicinal chemists, professionals in the pharmaceutical industry, and pharmaceutical chemists, Biomolecular Simulations in Structure-based Drug Discovery is a comprehensive resource to modern simulation tools that complement and have the potential to complement or replace laboratory assays for better results in drug design.
Author: Marcel Verges
Publisher: MDPI
Published: 2021-04-27
Total Pages: 156
ISBN-13: 3039434721
DOWNLOAD EBOOKProtein sorting and trafficking are regulated by well-conserved mechanisms. These allow a distinctive set of resident proteins to be present in the correct subcellular organelle, which is required for proper cell functioning. Voltage-gated ion channels, as responsible for cardiomyocyte action potential, must be properly localized. They participate in cell excitability and electrical coupling, ensuring uninterrupted and rhythmic heart beating. Ion channel complexes comprise one or more pore-forming α subunits, associated β subunits, and additional proteins. Channel localization and function are regulated by the β subunits and associated proteins, such as cytoskeletal elements, cell-adhesion molecules, and adaptors. These influence protein targeting, anchoring, and retention in specific surface domains along the cardiomyocyte sarcolemma, such as intercalated discs, T-tubules, or the lateral membrane. Alterations in ion channel trafficking are the cause of channelopathies associated with inherited arrhythmias leading to sudden death. An outstanding question is how these molecular alterations lead to disease. In this volume, scientists share their vision to understand how cardiac ion channel trafficking is regulated and how it may become altered, leading to channelopathies that often turn into deadly arrhythmias. Data generated can be translated to a clinical context, hopefully turning into approaches to help prevention and treatment, which is of utmost importance, both medically and socially.
Download or read book Trafficking of Cardiac Ion Channels written by Marcel Verges and published by MDPI. This book was released on 2021-04-27 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein sorting and trafficking are regulated by well-conserved mechanisms. These allow a distinctive set of resident proteins to be present in the correct subcellular organelle, which is required for proper cell functioning. Voltage-gated ion channels, as responsible for cardiomyocyte action potential, must be properly localized. They participate in cell excitability and electrical coupling, ensuring uninterrupted and rhythmic heart beating. Ion channel complexes comprise one or more pore-forming α subunits, associated β subunits, and additional proteins. Channel localization and function are regulated by the β subunits and associated proteins, such as cytoskeletal elements, cell-adhesion molecules, and adaptors. These influence protein targeting, anchoring, and retention in specific surface domains along the cardiomyocyte sarcolemma, such as intercalated discs, T-tubules, or the lateral membrane. Alterations in ion channel trafficking are the cause of channelopathies associated with inherited arrhythmias leading to sudden death. An outstanding question is how these molecular alterations lead to disease. In this volume, scientists share their vision to understand how cardiac ion channel trafficking is regulated and how it may become altered, leading to channelopathies that often turn into deadly arrhythmias. Data generated can be translated to a clinical context, hopefully turning into approaches to help prevention and treatment, which is of utmost importance, both medically and socially.
Author: Georg Pabst
Publisher: CRC Press
Published: 2014-03-04
Total Pages: 470
ISBN-13: 146650711X
DOWNLOAD EBOOKAs a result of their unique physical properties, biological membrane mimetics, such as liposomes, are used in a broad range of scientific and technological applications. Liposomes, Lipid Bilayers and Model Membranes: From Basic Research to Application describes state-of-the-art research and future directions in the field of membranes, which has evo
Download or read book Liposomes, Lipid Bilayers and Model Membranes written by Georg Pabst and published by CRC Press. This book was released on 2014-03-04 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a result of their unique physical properties, biological membrane mimetics, such as liposomes, are used in a broad range of scientific and technological applications. Liposomes, Lipid Bilayers and Model Membranes: From Basic Research to Application describes state-of-the-art research and future directions in the field of membranes, which has evo
Author:
Publisher: ScholarlyEditions
Published: 2012-12-26
Total Pages: 459
ISBN-13: 1464993408
DOWNLOAD EBOOKIon Channels—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Ion Channels. The editors have built Ion Channels—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Ion Channels in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Ion Channels—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Ion Channels—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion Channels—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Ion Channels. The editors have built Ion Channels—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Ion Channels in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Ion Channels—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: Tamer M. A. Mohamed
Publisher: Frontiers Media SA
Published: 2022-01-05
Total Pages: 142
ISBN-13: 2889719545
DOWNLOAD EBOOKDownload or read book Recent Advances in Cardiotoxicity Testing written by Tamer M. A. Mohamed and published by Frontiers Media SA. This book was released on 2022-01-05 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author: A. Ottova-Leitmannova
Publisher: Gulf Professional Publishing
Published: 2005-09
Total Pages: 348
ISBN-13: 9780123694539
DOWNLOAD EBOOKThe lipid bilayer is central to life, as all living organisms possess a lipid bilayer structure, thereby underlying the lipid bilayer principle of biomembranes. The lipid bilayer principle and its applications are the main theme of this new book series. This new series on bilayer lipid membranes (BLMs and liposomes) include invited chapters on a broad range of topics, from theoretical investigations, specific studies, experimental methods, to practical applications. Written for newcomers, experienced scientists, and those who are not familiar with these specific research areas, the Series covers all aspects of lipid bilayer investigations, both fundamental and applied. * Covers a broad range of topics ranging from theoretical research, specific studies, experimental methods, to practical applications * Authoritative timely reviews by experts in this field * Indispensable source of information for new scientists
Download or read book Advances in Planar Lipid Bilayers and Liposomes written by A. Ottova-Leitmannova and published by Gulf Professional Publishing. This book was released on 2005-09 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: The lipid bilayer is central to life, as all living organisms possess a lipid bilayer structure, thereby underlying the lipid bilayer principle of biomembranes. The lipid bilayer principle and its applications are the main theme of this new book series. This new series on bilayer lipid membranes (BLMs and liposomes) include invited chapters on a broad range of topics, from theoretical investigations, specific studies, experimental methods, to practical applications. Written for newcomers, experienced scientists, and those who are not familiar with these specific research areas, the Series covers all aspects of lipid bilayer investigations, both fundamental and applied. * Covers a broad range of topics ranging from theoretical research, specific studies, experimental methods, to practical applications * Authoritative timely reviews by experts in this field * Indispensable source of information for new scientists
Author: Tamar Schlick
Publisher: Springer Science & Business Media
Published: 2010-08-03
Total Pages: 757
ISBN-13: 1441963510
DOWNLOAD EBOOKVery broad overview of the field intended for an interdisciplinary audience; Lively discussion of current challenges written in a colloquial style; Author is a rising star in this discipline; Suitably accessible for beginners and suitably rigorous for experts; Features extensive four-color illustrations; Appendices featuring homework assignments and reading lists complement the material in the main text
Download or read book Molecular Modeling and Simulation: An Interdisciplinary Guide written by Tamar Schlick and published by Springer Science & Business Media. This book was released on 2010-08-03 with total page 757 pages. Available in PDF, EPUB and Kindle. Book excerpt: Very broad overview of the field intended for an interdisciplinary audience; Lively discussion of current challenges written in a colloquial style; Author is a rising star in this discipline; Suitably accessible for beginners and suitably rigorous for experts; Features extensive four-color illustrations; Appendices featuring homework assignments and reading lists complement the material in the main text
Author:
Publisher: ScholarlyEditions
Published: 2012-12-26
Total Pages: 248
ISBN-13: 1464996571
DOWNLOAD EBOOKMembrane Glycoproteins—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Membrane Glycoproteins. The editors have built Membrane Glycoproteins—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Membrane Glycoproteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Membrane Glycoproteins—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Membrane Glycoproteins—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Membrane Glycoproteins—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Membrane Glycoproteins. The editors have built Membrane Glycoproteins—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Membrane Glycoproteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Membrane Glycoproteins—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
