Bayesian Designs for Phase I-II Clinical Trials

Bayesian Designs for Phase I-II Clinical Trials

Author: Ying Yuan

Publisher: CRC Press

Published: 2017-12-19

Total Pages: 233

ISBN-13: 1315354225

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Reliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose or schedule may lead to failure in later trials. At the same time, if promising preclinical results do not translate into a real treatment advance, it is important to determine this quickly and terminate the clinical evaluation process to avoid wasting resources. Bayesian Designs for Phase I–II Clinical Trials describes how phase I–II designs can serve as a bridge or protective barrier between preclinical studies and large confirmatory clinical trials. It illustrates many of the severe drawbacks with conventional methods used for early-phase clinical trials and presents numerous Bayesian designs for human clinical trials of new experimental treatment regimes. Written by research leaders from the University of Texas MD Anderson Cancer Center, this book shows how Bayesian designs for early-phase clinical trials can explore, refine, and optimize new experimental treatments. It emphasizes the importance of basing decisions on both efficacy and toxicity.


Book Synopsis Bayesian Designs for Phase I-II Clinical Trials by : Ying Yuan

Download or read book Bayesian Designs for Phase I-II Clinical Trials written by Ying Yuan and published by CRC Press. This book was released on 2017-12-19 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose or schedule may lead to failure in later trials. At the same time, if promising preclinical results do not translate into a real treatment advance, it is important to determine this quickly and terminate the clinical evaluation process to avoid wasting resources. Bayesian Designs for Phase I–II Clinical Trials describes how phase I–II designs can serve as a bridge or protective barrier between preclinical studies and large confirmatory clinical trials. It illustrates many of the severe drawbacks with conventional methods used for early-phase clinical trials and presents numerous Bayesian designs for human clinical trials of new experimental treatment regimes. Written by research leaders from the University of Texas MD Anderson Cancer Center, this book shows how Bayesian designs for early-phase clinical trials can explore, refine, and optimize new experimental treatments. It emphasizes the importance of basing decisions on both efficacy and toxicity.

Embedded SoPC Design with Nios II Processor and VHDL Examples

Embedded SoPC Design with Nios II Processor and VHDL Examples

Author: Pong P. Chu

Publisher: John Wiley & Sons

Published: 2011-08-29

Total Pages: 728

ISBN-13: 111800888X

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The book is divided into four major parts. Part I covers HDL constructs and synthesis of basic digital circuits. Part II provides an overview of embedded software development with the emphasis on low-level I/O access and drivers. Part III demonstrates the design and development of hardware and software for several complex I/O peripherals, including PS2 keyboard and mouse, a graphic video controller, an audio codec, and an SD (secure digital) card. Part IV provides three case studies of the integration of hardware accelerators, including a custom GCD (greatest common divisor) circuit, a Mandelbrot set fractal circuit, and an audio synthesizer based on DDFS (direct digital frequency synthesis) methodology. The book utilizes FPGA devices, Nios II soft-core processor, and development platform from Altera Co., which is one of the two main FPGA manufactures. Altera has a generous university program that provides free software and discounted prototyping boards for educational institutions (details at http://www.altera.com/university). The two main educational prototyping boards are known as DE1 ($99) and DE2 ($269). All experiments can be implemented and tested with these boards. A board combined with this book becomes a “turn-key” solution for the SoPC design experiments and projects. Most HDL and C codes in the book are device independent and can be adapted by other prototyping boards as long as a board has similar I/O configuration.


Book Synopsis Embedded SoPC Design with Nios II Processor and VHDL Examples by : Pong P. Chu

Download or read book Embedded SoPC Design with Nios II Processor and VHDL Examples written by Pong P. Chu and published by John Wiley & Sons. This book was released on 2011-08-29 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is divided into four major parts. Part I covers HDL constructs and synthesis of basic digital circuits. Part II provides an overview of embedded software development with the emphasis on low-level I/O access and drivers. Part III demonstrates the design and development of hardware and software for several complex I/O peripherals, including PS2 keyboard and mouse, a graphic video controller, an audio codec, and an SD (secure digital) card. Part IV provides three case studies of the integration of hardware accelerators, including a custom GCD (greatest common divisor) circuit, a Mandelbrot set fractal circuit, and an audio synthesizer based on DDFS (direct digital frequency synthesis) methodology. The book utilizes FPGA devices, Nios II soft-core processor, and development platform from Altera Co., which is one of the two main FPGA manufactures. Altera has a generous university program that provides free software and discounted prototyping boards for educational institutions (details at http://www.altera.com/university). The two main educational prototyping boards are known as DE1 ($99) and DE2 ($269). All experiments can be implemented and tested with these boards. A board combined with this book becomes a “turn-key” solution for the SoPC design experiments and projects. Most HDL and C codes in the book are device independent and can be adapted by other prototyping boards as long as a board has similar I/O configuration.

Clothing for Women; Selection, Design, Construction

Clothing for Women; Selection, Design, Construction

Author: Laura Irene Baldt

Publisher:

Published: 1916

Total Pages: 490

ISBN-13:

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Book Synopsis Clothing for Women; Selection, Design, Construction by : Laura Irene Baldt

Download or read book Clothing for Women; Selection, Design, Construction written by Laura Irene Baldt and published by . This book was released on 1916 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The American Teacher

The American Teacher

Author:

Publisher:

Published: 1891

Total Pages: 416

ISBN-13:

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Book Synopsis The American Teacher by :

Download or read book The American Teacher written by and published by . This book was released on 1891 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Bulletin

Bulletin

Author: University of Minnesota

Publisher:

Published: 1919

Total Pages: 990

ISBN-13:

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Book Synopsis Bulletin by : University of Minnesota

Download or read book Bulletin written by University of Minnesota and published by . This book was released on 1919 with total page 990 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Practical Pointers for Ceramists - Vol. II

Practical Pointers for Ceramists - Vol. II

Author: Dennis Dinger

Publisher: Lulu.com

Published: 2010-12-07

Total Pages: 332

ISBN-13: 0557871484

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All articles from the Ceramic Processing E-zine are included in this two-volume collection. These newest volumes in the author's "for Ceramists" series contain a tremendous number of practical pointers for practicing ceramic engineers, technicians, students, and managers. Discussions consider suspension rheology and viscosity definitions, measurements, and applications; viscometers and their applications; particle size distribution measurements and applications; particle packing considerations; chemical additives and the how? when? where? and why? of their use; zeta potentials; major processing problems such as syneresis and dilatancy; Predictive Process Control implementation; mixing, HID, deagglomeration, and delamination; gelation tests; firing curve modifications; and much, much more. The complete "for Ceramists" series remains an economical desk reference for all who deal on a daily basis with the control of ceramic process suspensions, bodies, and forming processes.


Book Synopsis Practical Pointers for Ceramists - Vol. II by : Dennis Dinger

Download or read book Practical Pointers for Ceramists - Vol. II written by Dennis Dinger and published by Lulu.com. This book was released on 2010-12-07 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: All articles from the Ceramic Processing E-zine are included in this two-volume collection. These newest volumes in the author's "for Ceramists" series contain a tremendous number of practical pointers for practicing ceramic engineers, technicians, students, and managers. Discussions consider suspension rheology and viscosity definitions, measurements, and applications; viscometers and their applications; particle size distribution measurements and applications; particle packing considerations; chemical additives and the how? when? where? and why? of their use; zeta potentials; major processing problems such as syneresis and dilatancy; Predictive Process Control implementation; mixing, HID, deagglomeration, and delamination; gelation tests; firing curve modifications; and much, much more. The complete "for Ceramists" series remains an economical desk reference for all who deal on a daily basis with the control of ceramic process suspensions, bodies, and forming processes.

Single-Arm Phase II Survival Trial Design

Single-Arm Phase II Survival Trial Design

Author: Jianrong Wu

Publisher: CRC Press

Published: 2021-08-06

Total Pages: 225

ISBN-13: 1000422488

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Single-Arm Phase II Survival Trial Design provides a comprehensive summary to the most commonly- used methods for single-arm phase II trial design with time-to-event endpoints. Single-arm phase II trials are a key component for successfully developing advanced cancer drugs and treatments, particular for target therapy and immunotherapy in which time-to-event endpoints are often the primary endpoints. Most test statistics for single-arm phase II trial design with time-to-event endpoints are not available in commercial software. Key Features: Covers the most frequently used methods for single-arm phase II trial design with time-to-event endpoints in a comprehensive fashion. Provides new material on phase II immunotherapy trial design and phase II trial design with TTP ratio endpoint. Illustrates trial designs by real clinical trial examples Includes R code for all methods proposed in the book, enabling straightforward sample size calculation.


Book Synopsis Single-Arm Phase II Survival Trial Design by : Jianrong Wu

Download or read book Single-Arm Phase II Survival Trial Design written by Jianrong Wu and published by CRC Press. This book was released on 2021-08-06 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Single-Arm Phase II Survival Trial Design provides a comprehensive summary to the most commonly- used methods for single-arm phase II trial design with time-to-event endpoints. Single-arm phase II trials are a key component for successfully developing advanced cancer drugs and treatments, particular for target therapy and immunotherapy in which time-to-event endpoints are often the primary endpoints. Most test statistics for single-arm phase II trial design with time-to-event endpoints are not available in commercial software. Key Features: Covers the most frequently used methods for single-arm phase II trial design with time-to-event endpoints in a comprehensive fashion. Provides new material on phase II immunotherapy trial design and phase II trial design with TTP ratio endpoint. Illustrates trial designs by real clinical trial examples Includes R code for all methods proposed in the book, enabling straightforward sample size calculation.

Circular and Catalogue

Circular and Catalogue

Author: Massachusetts Normal Art School

Publisher:

Published: 1873

Total Pages: 914

ISBN-13:

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Book Synopsis Circular and Catalogue by : Massachusetts Normal Art School

Download or read book Circular and Catalogue written by Massachusetts Normal Art School and published by . This book was released on 1873 with total page 914 pages. Available in PDF, EPUB and Kindle. Book excerpt:

THE HOURNAL OF EDUCATION

THE HOURNAL OF EDUCATION

Author:

Publisher:

Published: 1881

Total Pages: 316

ISBN-13:

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Book Synopsis THE HOURNAL OF EDUCATION by :

Download or read book THE HOURNAL OF EDUCATION written by and published by . This book was released on 1881 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Educational Times

Educational Times

Author:

Publisher:

Published: 1880

Total Pages: 672

ISBN-13:

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Book Synopsis Educational Times by :

Download or read book Educational Times written by and published by . This book was released on 1880 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: