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Sphingolipids: Basic Science and Drug Development

Author: Erich Gulbins

Publisher: Springer Science & Business Media

Published: 2013-04-11

Total Pages: 264

ISBN-13: 3709113687

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Sphingolipids are lipid components of the plasma membrane in eukaryotic cells. They have an important function in signaling mechanisms in the cell. This book on sphingolipids provides insights into the basics of sphingolipid biology and drug development, with a particular emphasis on the sphingolipid derivative ceramide. In the first part basic functions of sphingolipids are described, as well as the genetics of important enzymes, sphingolipid metabolism and synthesis. The second part of this first volume focuses on drug development and pharmacology. The book is intended for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians working in pharmacology, oncology, cardiology, neurology and infectious disease. Together with Volume 216 by the same editors, the collection represents a unique, comprehensive work on sphingolipids, providing information on both sphingolipids’ basic biology (including synthesis, metabolism and cell biology) and their important function in a (patho-)physiological context.

Book Synopsis Sphingolipids: Basic Science and Drug Development by : Erich Gulbins

Download or read book Sphingolipids: Basic Science and Drug Development written by Erich Gulbins and published by Springer Science & Business Media. This book was released on 2013-04-11 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sphingolipids are lipid components of the plasma membrane in eukaryotic cells. They have an important function in signaling mechanisms in the cell. This book on sphingolipids provides insights into the basics of sphingolipid biology and drug development, with a particular emphasis on the sphingolipid derivative ceramide. In the first part basic functions of sphingolipids are described, as well as the genetics of important enzymes, sphingolipid metabolism and synthesis. The second part of this first volume focuses on drug development and pharmacology. The book is intended for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians working in pharmacology, oncology, cardiology, neurology and infectious disease. Together with Volume 216 by the same editors, the collection represents a unique, comprehensive work on sphingolipids, providing information on both sphingolipids’ basic biology (including synthesis, metabolism and cell biology) and their important function in a (patho-)physiological context.

Sphingolipids

Author: Angel Catalá

Publisher: Nova Science Publishers

Published: 2015

Total Pages: 0

ISBN-13: 9781634830195

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This book presents an overview of sphingolipids: biology, synthesis and functions. The topics analysed in this book cover a broad spectrum of functions played by sphingolipids including: the role of sphingomyelin in the regulation of membrane physical state; tricyclic antidepressants as modulators of sphingolipid turnover and cell sensitivity to insulin action; sphingolipid diversity, biosynthesis and regulation; metabolism of glycolipids at the cell's surface: modulation and functional implications; the specific role of sphingomyelins in cell physiology; the role of sphingosine-based lipids using sphingolipidomics; sphingolipids and ceramides of aqueous humor and trabecular meshwork; the effect of membrane microdomains containing sphingolipids on lipid peroxidation; and roles of sphingolipids in skeletal development and homeostasis.

Book Synopsis Sphingolipids by : Angel Catalá

Download or read book Sphingolipids written by Angel Catalá and published by Nova Science Publishers. This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an overview of sphingolipids: biology, synthesis and functions. The topics analysed in this book cover a broad spectrum of functions played by sphingolipids including: the role of sphingomyelin in the regulation of membrane physical state; tricyclic antidepressants as modulators of sphingolipid turnover and cell sensitivity to insulin action; sphingolipid diversity, biosynthesis and regulation; metabolism of glycolipids at the cell's surface: modulation and functional implications; the specific role of sphingomyelins in cell physiology; the role of sphingosine-based lipids using sphingolipidomics; sphingolipids and ceramides of aqueous humor and trabecular meshwork; the effect of membrane microdomains containing sphingolipids on lipid peroxidation; and roles of sphingolipids in skeletal development and homeostasis.

Bioactive Ceramides in Health and Disease

Author: Johnny Stiban

Publisher: Springer Nature

Published: 2019-09-09

Total Pages: 153

ISBN-13: 3030211622

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This book is about the various roles of bioactive ceramides and other sphingolipids in cellular biology. The enigmatic biophysical and biochemical properties of ceramides and their propensity to influence membranes whether as rafts or protein-permeable channels are heavily discussed. Metabolism of ceramides and their metabolites is also focused with ceramide synthase family of proteins being a target of extensive review. Ceramide 1-phosphate and other sphingolipids are also presented in cellular physiology and pathophysiology. Prokaryotic origins of mitochondria at the level of membranes and the occurrence of apoptosis in bacteria are presented. Many aspects of ceramide and sphingolipid biology are addressed in this book. Its focus is the metabolism of ceramide in normal and diseased states and the biophysical and biochemical mechanisms governing the bioactivity of these molecules. Sphingolipid research has surged over the past thirty years and this book gathers the recent findings of various aspects of sphingolipid biochemistry. World-renowned scientists from the field of lipid biology, specifically sphingolipid biochemistry, were gathered to write this book. Scholars from most continents of the globe committed to write diligently about their expertise and the newest findings in the relevant fields. This book came to fruition after almost a year and a half of laborious preparation and diligent writings. This book is targeted to the experienced reader who is looking to read about the various aspects of bioactive ceramide signaling, as well as to the newcomer into the field, as the topics are explained in concise yet very informative manner. The authors and editor wish all readers a pleasant time reading this volume, and are adamant that this book will meet all expectations.

Book Synopsis Bioactive Ceramides in Health and Disease by : Johnny Stiban

Download or read book Bioactive Ceramides in Health and Disease written by Johnny Stiban and published by Springer Nature. This book was released on 2019-09-09 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about the various roles of bioactive ceramides and other sphingolipids in cellular biology. The enigmatic biophysical and biochemical properties of ceramides and their propensity to influence membranes whether as rafts or protein-permeable channels are heavily discussed. Metabolism of ceramides and their metabolites is also focused with ceramide synthase family of proteins being a target of extensive review. Ceramide 1-phosphate and other sphingolipids are also presented in cellular physiology and pathophysiology. Prokaryotic origins of mitochondria at the level of membranes and the occurrence of apoptosis in bacteria are presented. Many aspects of ceramide and sphingolipid biology are addressed in this book. Its focus is the metabolism of ceramide in normal and diseased states and the biophysical and biochemical mechanisms governing the bioactivity of these molecules. Sphingolipid research has surged over the past thirty years and this book gathers the recent findings of various aspects of sphingolipid biochemistry. World-renowned scientists from the field of lipid biology, specifically sphingolipid biochemistry, were gathered to write this book. Scholars from most continents of the globe committed to write diligently about their expertise and the newest findings in the relevant fields. This book came to fruition after almost a year and a half of laborious preparation and diligent writings. This book is targeted to the experienced reader who is looking to read about the various aspects of bioactive ceramide signaling, as well as to the newcomer into the field, as the topics are explained in concise yet very informative manner. The authors and editor wish all readers a pleasant time reading this volume, and are adamant that this book will meet all expectations.

Bioactive Sphingolipids in Cancer Biology and Therapy

Author: Yusuf A. Hannun

Publisher: Springer

Published: 2015-08-28

Total Pages: 490

ISBN-13: 3319207504

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This volume presents information on both the basic and clinical aspects of sphingolipid-metabolizing enzymes in various cancers. The volume also includes discussions of the innovative techniques and approaches for quantitative analysis and imaging that could significantly impact the general understanding of this topic, and the potential benefit of targeting sphingolipid enzymes to develop novel cancer therapeutics. As well, the volume includes a critical examination of the specific pathways and pathobiologies associated with the altered regulation of sphingolipid metabolism as a contributor to the development and/or maintenance of pathological conditions such as cancer.

Book Synopsis Bioactive Sphingolipids in Cancer Biology and Therapy by : Yusuf A. Hannun

Download or read book Bioactive Sphingolipids in Cancer Biology and Therapy written by Yusuf A. Hannun and published by Springer. This book was released on 2015-08-28 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents information on both the basic and clinical aspects of sphingolipid-metabolizing enzymes in various cancers. The volume also includes discussions of the innovative techniques and approaches for quantitative analysis and imaging that could significantly impact the general understanding of this topic, and the potential benefit of targeting sphingolipid enzymes to develop novel cancer therapeutics. As well, the volume includes a critical examination of the specific pathways and pathobiologies associated with the altered regulation of sphingolipid metabolism as a contributor to the development and/or maintenance of pathological conditions such as cancer.

Inborn Disorders of Sphingolipid Metabolism

Author: Stanley M. Aronson

Publisher: Elsevier

Published: 2017-01-31

Total Pages: 530

ISBN-13: 1483223582

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Inborn Disorders of Sphingolipid Metabolism is a collection of papers presented at the Third International Symposium on the Cerebral Sphingolipidoses and Allied Diseases, held at the Isaac Albert Research Institute of the Jewish Chronic Disease Hospital and at the State University of New York, Downstate Medical Center, on October 25 and 26, 1965. This book is organized into three parts encompassing 35 chapters. Part I deals first with electron microscopic, histochemical, and morphological investigations of certain sphingolipid metabolism disorders. This part also examines several case reports on the features and symptoms of spongy degeneration of the central nervous system, familial leukodystrophy, adrenal insufficiency, and cutaneous melanosis. Part II surveys the metabolism, biosynthesis, and structure of gangliosides and sialic acids. This part also considers the nature of the lipophilic portions of the brain gangliosides. This part particularly looks into the features and clinical manifestation of Tay-Sachs disease. The third part covers the genetic and clinical aspects of the Tay-Sachs disease. This part also evaluates the genetics of the Hurler-Hunter syndrome, Batten-Spielmeyer-Vogt disease, and lipogranulomatosis syndrome. This book is of value to biochemists, histochemists, geneticists, and researchers in the allied fields of lipidosis.

Book Synopsis Inborn Disorders of Sphingolipid Metabolism by : Stanley M. Aronson

Download or read book Inborn Disorders of Sphingolipid Metabolism written by Stanley M. Aronson and published by Elsevier. This book was released on 2017-01-31 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inborn Disorders of Sphingolipid Metabolism is a collection of papers presented at the Third International Symposium on the Cerebral Sphingolipidoses and Allied Diseases, held at the Isaac Albert Research Institute of the Jewish Chronic Disease Hospital and at the State University of New York, Downstate Medical Center, on October 25 and 26, 1965. This book is organized into three parts encompassing 35 chapters. Part I deals first with electron microscopic, histochemical, and morphological investigations of certain sphingolipid metabolism disorders. This part also examines several case reports on the features and symptoms of spongy degeneration of the central nervous system, familial leukodystrophy, adrenal insufficiency, and cutaneous melanosis. Part II surveys the metabolism, biosynthesis, and structure of gangliosides and sialic acids. This part also considers the nature of the lipophilic portions of the brain gangliosides. This part particularly looks into the features and clinical manifestation of Tay-Sachs disease. The third part covers the genetic and clinical aspects of the Tay-Sachs disease. This part also evaluates the genetics of the Hurler-Hunter syndrome, Batten-Spielmeyer-Vogt disease, and lipogranulomatosis syndrome. This book is of value to biochemists, histochemists, geneticists, and researchers in the allied fields of lipidosis.

Biochemistry of Lipids, Lipoproteins and Membranes

Author: Neale Ridgway

Publisher: Elsevier

Published: 2015-07-24

Total Pages: 625

ISBN-13: 0444634495

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Biochemistry of Lipids: Lipoproteins and Membranes, Volume Six, contains concise chapters that cover a wide spectrum of topics in the field of lipid biochemistry and cell biology. It provides an important bridge between broad-based biochemistry textbooks and more technical research publications, offering cohesive, foundational information. It is a valuable tool for advanced graduate students and researchers who are interested in exploring lipid biology in more detail, and includes overviews of lipid biology in both prokaryotes and eukaryotes, while also providing fundamental background on the subsequent descriptions of fatty acid synthesis, desaturation and elongation, and the pathways that lead the synthesis of complex phospholipids, sphingolipids, and their structural variants. Also covered are sections on how bioactive lipids are involved in cell signaling with an emphasis on disease implications and pathological consequences. Serves as a general reference book for scientists studying lipids, lipoproteins and membranes and as an advanced and up-to-date textbook for teachers and students who are familiar with the basic concepts of lipid biochemistry References from current literature will be included in each chapter to facilitate more in-depth study Key concepts are supported by figures and models to improve reader understanding Chapters provide historical perspective and current analysis of each topic

Book Synopsis Biochemistry of Lipids, Lipoproteins and Membranes by : Neale Ridgway

Download or read book Biochemistry of Lipids, Lipoproteins and Membranes written by Neale Ridgway and published by Elsevier. This book was released on 2015-07-24 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemistry of Lipids: Lipoproteins and Membranes, Volume Six, contains concise chapters that cover a wide spectrum of topics in the field of lipid biochemistry and cell biology. It provides an important bridge between broad-based biochemistry textbooks and more technical research publications, offering cohesive, foundational information. It is a valuable tool for advanced graduate students and researchers who are interested in exploring lipid biology in more detail, and includes overviews of lipid biology in both prokaryotes and eukaryotes, while also providing fundamental background on the subsequent descriptions of fatty acid synthesis, desaturation and elongation, and the pathways that lead the synthesis of complex phospholipids, sphingolipids, and their structural variants. Also covered are sections on how bioactive lipids are involved in cell signaling with an emphasis on disease implications and pathological consequences. Serves as a general reference book for scientists studying lipids, lipoproteins and membranes and as an advanced and up-to-date textbook for teachers and students who are familiar with the basic concepts of lipid biochemistry References from current literature will be included in each chapter to facilitate more in-depth study Key concepts are supported by figures and models to improve reader understanding Chapters provide historical perspective and current analysis of each topic

Sphingolipid Biology

Author: Y. Hirabayashi

Publisher: Springer Science & Business Media

Published: 2007-12-31

Total Pages: 528

ISBN-13: 4431342001

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Sphingolipids are fundamental to the structures of cell membranes, lipoproteins, and the stratum cornea of the skin. Many complex sphingolipids, as well as simpler sphingoid bases and derivatives, are highly bioactive as extra- and intracellular regulators of growth, differentiation, migration, survival, senescence, and numerous cellular responses to stress. This book reviews exciting new developments in sphingolipid biology/sphingolipidology that challenge our understanding of how multicellular organisms grow, develop, function, age, and die.

Book Synopsis Sphingolipid Biology by : Y. Hirabayashi

Download or read book Sphingolipid Biology written by Y. Hirabayashi and published by Springer Science & Business Media. This book was released on 2007-12-31 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sphingolipids are fundamental to the structures of cell membranes, lipoproteins, and the stratum cornea of the skin. Many complex sphingolipids, as well as simpler sphingoid bases and derivatives, are highly bioactive as extra- and intracellular regulators of growth, differentiation, migration, survival, senescence, and numerous cellular responses to stress. This book reviews exciting new developments in sphingolipid biology/sphingolipidology that challenge our understanding of how multicellular organisms grow, develop, function, age, and die.

Sphingolipids as Signaling and Regulatory Molecules

Author: Charles Chalfant

Publisher: Springer Science & Business Media

Published: 2011-01-12

Total Pages: 311

ISBN-13: 1441967419

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This book attempts to analyze the latest discoveries in sphingolipid biology and how the alteration of their metabolism leads to altered signaling events and to the development of pathobiological disorders, such as cancer, cardiovascular diseases, asthma, diabetes, inflammation and infectious diseases.

Book Synopsis Sphingolipids as Signaling and Regulatory Molecules by : Charles Chalfant

Download or read book Sphingolipids as Signaling and Regulatory Molecules written by Charles Chalfant and published by Springer Science & Business Media. This book was released on 2011-01-12 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book attempts to analyze the latest discoveries in sphingolipid biology and how the alteration of their metabolism leads to altered signaling events and to the development of pathobiological disorders, such as cancer, cardiovascular diseases, asthma, diabetes, inflammation and infectious diseases.

Sphingolipids and Metabolic Disease

Author: L. Ashley Cowart

Publisher: Springer Science & Business Media

Published: 2011-09-15

Total Pages: 163

ISBN-13: 1461406501

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Current thinking holds that obesity derives primarily from overnutrition (though compelling arguments for other mechanisms, like endocrine disruption by environmental pollutants, also gain support from the literature). In animals, overnutrition is initially handled by adipose tissue expansion; however, exhaustion of this route of lipid sequestering results in oversupply of lipid to other tissues including skeletal muscle, heart, liver, and others. Failure of these tissues to clear excess lipids through either metabolism or sequestration into putatively inert triacylglycerols results in perturbation of bioactive lipid metabolism in cells. In particular, aberrant generation of bioactive sphingolipids is implicated in a multitude of pathological outcomes of metabolic disease including insulin resistance, inflammation, cardiomyopathy, and others. This volume addresses not only the fundamentals of sphingolipid metabolism and analysis, but also the roles of sphingolipids in these disease processes.

Book Synopsis Sphingolipids and Metabolic Disease by : L. Ashley Cowart

Download or read book Sphingolipids and Metabolic Disease written by L. Ashley Cowart and published by Springer Science & Business Media. This book was released on 2011-09-15 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current thinking holds that obesity derives primarily from overnutrition (though compelling arguments for other mechanisms, like endocrine disruption by environmental pollutants, also gain support from the literature). In animals, overnutrition is initially handled by adipose tissue expansion; however, exhaustion of this route of lipid sequestering results in oversupply of lipid to other tissues including skeletal muscle, heart, liver, and others. Failure of these tissues to clear excess lipids through either metabolism or sequestration into putatively inert triacylglycerols results in perturbation of bioactive lipid metabolism in cells. In particular, aberrant generation of bioactive sphingolipids is implicated in a multitude of pathological outcomes of metabolic disease including insulin resistance, inflammation, cardiomyopathy, and others. This volume addresses not only the fundamentals of sphingolipid metabolism and analysis, but also the roles of sphingolipids in these disease processes.

Sphingolipids in Disease

Author: Erich Gulbins

Publisher: Springer Science & Business Media

Published: 2013-04-06

Total Pages: 474

ISBN-13: 3709115116

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Sphingolipids are lipid components of the plasma membrane of eukaryotic cells with an important function in signaling mechanisms in the cell. This book provides insight into the physiological and pathophysiological role of sphingolipids and in particular its derivative ceramide. The function of Sphingolipids in cell signaling with regard to infectious and lung diseases, cancer, cardiovascular diseases and neuropsychiatric disorders are described and treated in distinct parts. Together with Volume 215 from the same Editors, the collection represents a unique, comprehensive work on Sphingolipids, providing information on both: Sphingolipid basic biology as well as its important function in a (patho)physiological context. The book is written for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians in pharmacology, oncology, cardiology, neurology and infectious disease.

Book Synopsis Sphingolipids in Disease by : Erich Gulbins

Download or read book Sphingolipids in Disease written by Erich Gulbins and published by Springer Science & Business Media. This book was released on 2013-04-06 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sphingolipids are lipid components of the plasma membrane of eukaryotic cells with an important function in signaling mechanisms in the cell. This book provides insight into the physiological and pathophysiological role of sphingolipids and in particular its derivative ceramide. The function of Sphingolipids in cell signaling with regard to infectious and lung diseases, cancer, cardiovascular diseases and neuropsychiatric disorders are described and treated in distinct parts. Together with Volume 215 from the same Editors, the collection represents a unique, comprehensive work on Sphingolipids, providing information on both: Sphingolipid basic biology as well as its important function in a (patho)physiological context. The book is written for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians in pharmacology, oncology, cardiology, neurology and infectious disease.