Statistical Physics Of Dna: An Introduction To Melting, Unzipping And Flexibility Of The Double Helix

Statistical Physics Of Dna: An Introduction To Melting, Unzipping And Flexibility Of The Double Helix

Author: Nikos Theodorakopoulos

Publisher: World Scientific

Published: 2019-12-24

Total Pages: 196

ISBN-13: 9811209553

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The stability of the DNA double helix is contingent on fine-tuning a number of physicochemical control parameters. Varying any one of them leads to separation of the two strands, in what constitutes a rare physical example of a thermodynamic phase transition in a one-dimensional system. The present book aims at providing a self-contained account of the statistical physics of cooperative processes in DNA, e.g. thermal and mechanical dissociation, force-induced melting, equilibria of hairpin-like secondary structures. In addition, the book presents some fundamental aspects of DNA elasticity, as observed in key experiments, old and new. The latter include some recently published scattering data on apparently soft, short DNA chains and their interpretation in terms of local structural defects (permanent bends, 'kinky DNA', after the original Crick-Klug hypothesis).The development of mathematical models used (Kratky-Porod polymer chain, Poland-Scheraga and Peyrard-Bishop-Dauxois models of DNA melting) emphasizes the use of realistic parameters and the relevance of practical numerical methods for comparing with experimental data. Accordingly, a large number of specially produced figures has been included.The presentation is at the level of an advanced undergraduate or introductory graduate course. An extra chapter provides the necessary mathematical background on elasticity of model polymer chains.


Book Synopsis Statistical Physics Of Dna: An Introduction To Melting, Unzipping And Flexibility Of The Double Helix by : Nikos Theodorakopoulos

Download or read book Statistical Physics Of Dna: An Introduction To Melting, Unzipping And Flexibility Of The Double Helix written by Nikos Theodorakopoulos and published by World Scientific. This book was released on 2019-12-24 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: The stability of the DNA double helix is contingent on fine-tuning a number of physicochemical control parameters. Varying any one of them leads to separation of the two strands, in what constitutes a rare physical example of a thermodynamic phase transition in a one-dimensional system. The present book aims at providing a self-contained account of the statistical physics of cooperative processes in DNA, e.g. thermal and mechanical dissociation, force-induced melting, equilibria of hairpin-like secondary structures. In addition, the book presents some fundamental aspects of DNA elasticity, as observed in key experiments, old and new. The latter include some recently published scattering data on apparently soft, short DNA chains and their interpretation in terms of local structural defects (permanent bends, 'kinky DNA', after the original Crick-Klug hypothesis).The development of mathematical models used (Kratky-Porod polymer chain, Poland-Scheraga and Peyrard-Bishop-Dauxois models of DNA melting) emphasizes the use of realistic parameters and the relevance of practical numerical methods for comparing with experimental data. Accordingly, a large number of specially produced figures has been included.The presentation is at the level of an advanced undergraduate or introductory graduate course. An extra chapter provides the necessary mathematical background on elasticity of model polymer chains.


Lectures On Statistical Physics And Protein Folding

Lectures On Statistical Physics And Protein Folding

Author: Kerson Huang

Publisher: World Scientific

Published: 2005-05-30

Total Pages: 159

ISBN-13: 9814481068

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This book introduces an approach to protein folding from the point of view of kinetic theory. There is an abundance of data on protein folding, but few proposals are available on the mechanism driving the process. Here, presented for the first time, are suggestions on possible research directions, as developed by the author in collaboration with C C Lin.The first half of this invaluable book contains a concise but relatively complete review of relevant topics in statistical mechanics and kinetic theory. It includes standard topics such as thermodynamics, the Maxwell-Boltzmann distribution, and ensemble theory. Special discussions include the dynamics of phase transitions, and Brownian motion as an illustration of stochastic processes.The second half develops topics in molecular biology and protein structure, with a view to discovering mechanisms underlying protein folding. Attention is focused on the energy flow through the protein in its folded state. A mathematical model, based on the Brownian motion of coupled harmonic oscillators, is worked out in the appendix.


Book Synopsis Lectures On Statistical Physics And Protein Folding by : Kerson Huang

Download or read book Lectures On Statistical Physics And Protein Folding written by Kerson Huang and published by World Scientific. This book was released on 2005-05-30 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces an approach to protein folding from the point of view of kinetic theory. There is an abundance of data on protein folding, but few proposals are available on the mechanism driving the process. Here, presented for the first time, are suggestions on possible research directions, as developed by the author in collaboration with C C Lin.The first half of this invaluable book contains a concise but relatively complete review of relevant topics in statistical mechanics and kinetic theory. It includes standard topics such as thermodynamics, the Maxwell-Boltzmann distribution, and ensemble theory. Special discussions include the dynamics of phase transitions, and Brownian motion as an illustration of stochastic processes.The second half develops topics in molecular biology and protein structure, with a view to discovering mechanisms underlying protein folding. Attention is focused on the energy flow through the protein in its folded state. A mathematical model, based on the Brownian motion of coupled harmonic oscillators, is worked out in the appendix.


Statistical Physics of Macromolecules

Statistical Physics of Macromolecules

Author:

Publisher: Amer Inst of Physics

Published: 1994

Total Pages: 350

ISBN-13: 1563960710

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This text presents an introduction to the field of statistical physics of macromolecules, from the basic concepts to modern achievements. Applications in various fields of polymer physical chemistry and molecular biophysics are also covered, as are: the fundamentals of statistical theory of polymer solutions and melts; classical, sealing and renormalization group approaches; the main ideas of statistical theories of polymer liquid crystals, polymer networks and polyelectrolytes; dynamic viscoelastic behavior of polymer systems; models of house, Zimm and reptation concepts; and specific features of main biopolymers - DNA and proteins. This English edition also includes sections describing the most important recent advances such as: statistical theory of DNA gel-electrophoresis, polymers at interfaces, and dynamics of concentrated solutions of rigid polymers.


Book Synopsis Statistical Physics of Macromolecules by :

Download or read book Statistical Physics of Macromolecules written by and published by Amer Inst of Physics. This book was released on 1994 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text presents an introduction to the field of statistical physics of macromolecules, from the basic concepts to modern achievements. Applications in various fields of polymer physical chemistry and molecular biophysics are also covered, as are: the fundamentals of statistical theory of polymer solutions and melts; classical, sealing and renormalization group approaches; the main ideas of statistical theories of polymer liquid crystals, polymer networks and polyelectrolytes; dynamic viscoelastic behavior of polymer systems; models of house, Zimm and reptation concepts; and specific features of main biopolymers - DNA and proteins. This English edition also includes sections describing the most important recent advances such as: statistical theory of DNA gel-electrophoresis, polymers at interfaces, and dynamics of concentrated solutions of rigid polymers.


Statistical Mechanics

Statistical Mechanics

Author: James Sethna

Publisher: OUP Oxford

Published: 2006-04-07

Total Pages: 374

ISBN-13: 0191566217

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In each generation, scientists must redefine their fields: abstracting, simplifying and distilling the previous standard topics to make room for new advances and methods. Sethna's book takes this step for statistical mechanics - a field rooted in physics and chemistry whose ideas and methods are now central to information theory, complexity, and modern biology. Aimed at advanced undergraduates and early graduate students in all of these fields, Sethna limits his main presentation to the topics that future mathematicians and biologists, as well as physicists and chemists, will find fascinating and central to their work. The amazing breadth of the field is reflected in the author's large supply of carefully crafted exercises, each an introduction to a whole field of study: everything from chaos through information theory to life at the end of the universe.


Book Synopsis Statistical Mechanics by : James Sethna

Download or read book Statistical Mechanics written by James Sethna and published by OUP Oxford. This book was released on 2006-04-07 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: In each generation, scientists must redefine their fields: abstracting, simplifying and distilling the previous standard topics to make room for new advances and methods. Sethna's book takes this step for statistical mechanics - a field rooted in physics and chemistry whose ideas and methods are now central to information theory, complexity, and modern biology. Aimed at advanced undergraduates and early graduate students in all of these fields, Sethna limits his main presentation to the topics that future mathematicians and biologists, as well as physicists and chemists, will find fascinating and central to their work. The amazing breadth of the field is reflected in the author's large supply of carefully crafted exercises, each an introduction to a whole field of study: everything from chaos through information theory to life at the end of the universe.


Computational Biology

Computational Biology

Author: Ralf Blossey

Publisher: CRC Press

Published: 2019-06-11

Total Pages: 285

ISBN-13: 0429994613

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Computational biology has developed rapidly during the last two decades following the genomic revolution which culminated in the sequencing of the human genome. More than ever it has developed into a field which embraces computational methods from different branches of the exact sciences: pure and applied mathematics, computer science, theoretical physics. This Second Edition provides a solid introduction to the techniques of statistical mechanics for graduate students and researchers in computational biology and biophysics. Material has been reorganized to clarify equilbrium and nonequilibrium aspects of biomolecular systems Content has been expanded, in particular in the treatment of the electrostatic interactions of biomolecules and the application of non-equilibrium statistical mechanics to biomolecules New network-based approaches for the study of proteins are presented. All treated topics are put firmly in the context of the current research literature, allowing the reader to easily follow an individual path into a specific research field. Exercises and Tasks accompany the presentations of the topics with the intention of enabling the readers to test their comprehension of the developed basic concepts.


Book Synopsis Computational Biology by : Ralf Blossey

Download or read book Computational Biology written by Ralf Blossey and published by CRC Press. This book was released on 2019-06-11 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational biology has developed rapidly during the last two decades following the genomic revolution which culminated in the sequencing of the human genome. More than ever it has developed into a field which embraces computational methods from different branches of the exact sciences: pure and applied mathematics, computer science, theoretical physics. This Second Edition provides a solid introduction to the techniques of statistical mechanics for graduate students and researchers in computational biology and biophysics. Material has been reorganized to clarify equilbrium and nonequilibrium aspects of biomolecular systems Content has been expanded, in particular in the treatment of the electrostatic interactions of biomolecules and the application of non-equilibrium statistical mechanics to biomolecules New network-based approaches for the study of proteins are presented. All treated topics are put firmly in the context of the current research literature, allowing the reader to easily follow an individual path into a specific research field. Exercises and Tasks accompany the presentations of the topics with the intention of enabling the readers to test their comprehension of the developed basic concepts.


Statistical Mechanics and Stability of Macromolecules

Statistical Mechanics and Stability of Macromolecules

Author: Earl Prohofsky

Publisher: Cambridge University Press

Published: 1995-07-28

Total Pages: 241

ISBN-13: 0521451841

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This book develops a statistical, mechanical analysis of the stability of macromolecules when melting.


Book Synopsis Statistical Mechanics and Stability of Macromolecules by : Earl Prohofsky

Download or read book Statistical Mechanics and Stability of Macromolecules written by Earl Prohofsky and published by Cambridge University Press. This book was released on 1995-07-28 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book develops a statistical, mechanical analysis of the stability of macromolecules when melting.


Statistical Mechanics in Physics and Biology: Volume 463

Statistical Mechanics in Physics and Biology: Volume 463

Author: Denis Wirtz

Publisher:

Published: 1997

Total Pages: 360

ISBN-13:

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Since statistical physics is a tool for the study not only of disordered physical systems, but of biological systems as well, this book from MRS focuses on both. While including physical problems such as fractals, pattern formation at first-order phase transitions, and glassy dynamics, the book also focuses on problems such as the statistical mechanics of DNA and DNA replications, structuring in biological systems, and problems in 'biologically inspired physics'. Topics include: statistical mechanics of proteins; statistical mechanics of DNA; biologically inspired physics; statistical mechanics in biology; micromanipulation in physics and biology; friction and fracture; statistical mechanics in physics and granular media.


Book Synopsis Statistical Mechanics in Physics and Biology: Volume 463 by : Denis Wirtz

Download or read book Statistical Mechanics in Physics and Biology: Volume 463 written by Denis Wirtz and published by . This book was released on 1997 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since statistical physics is a tool for the study not only of disordered physical systems, but of biological systems as well, this book from MRS focuses on both. While including physical problems such as fractals, pattern formation at first-order phase transitions, and glassy dynamics, the book also focuses on problems such as the statistical mechanics of DNA and DNA replications, structuring in biological systems, and problems in 'biologically inspired physics'. Topics include: statistical mechanics of proteins; statistical mechanics of DNA; biologically inspired physics; statistical mechanics in biology; micromanipulation in physics and biology; friction and fracture; statistical mechanics in physics and granular media.


Applications of Statistical Physics

Applications of Statistical Physics

Author: A. Gadomski

Publisher: North Holland

Published: 2000-01-19

Total Pages: 0

ISBN-13: 9780444504098

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The field of statistical physics has undergone a spectacular development in recent years. The fundamentals of the subject have advanced dynamically with multidisciplinary approaches involving physicists, chemists and mathematicians. Equally spectacular has been the development of applications of statistical mechanics to shed light on a wide range of problems, many of them arising in fields quite distant from traditional physics disciplines. Recent applications range from such topics as oil recovery from porous rock to protein folding, DNA structure, morphogenesis and the cooperative behavior of living creatures. Concepts and methods of statistical physics have been applied successfully to "exotic" problems that seem to be far from physics, such as vehicular and pedestrial traffic, or economy and finance. This book presents not only the keynote invited talks, but a number of high quality, interesting, contributed communications from senior scientists and young students active in the field. Topics covered include DNA migration, wetting, chemical waves, granular media, molecular motors, biological pattern formation and motion, as well as practical problems such as heart diagnosis, internet traffic jamming, oil recovery and econophysics.


Book Synopsis Applications of Statistical Physics by : A. Gadomski

Download or read book Applications of Statistical Physics written by A. Gadomski and published by North Holland. This book was released on 2000-01-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of statistical physics has undergone a spectacular development in recent years. The fundamentals of the subject have advanced dynamically with multidisciplinary approaches involving physicists, chemists and mathematicians. Equally spectacular has been the development of applications of statistical mechanics to shed light on a wide range of problems, many of them arising in fields quite distant from traditional physics disciplines. Recent applications range from such topics as oil recovery from porous rock to protein folding, DNA structure, morphogenesis and the cooperative behavior of living creatures. Concepts and methods of statistical physics have been applied successfully to "exotic" problems that seem to be far from physics, such as vehicular and pedestrial traffic, or economy and finance. This book presents not only the keynote invited talks, but a number of high quality, interesting, contributed communications from senior scientists and young students active in the field. Topics covered include DNA migration, wetting, chemical waves, granular media, molecular motors, biological pattern formation and motion, as well as practical problems such as heart diagnosis, internet traffic jamming, oil recovery and econophysics.


Applications of Statistical Physics to Genome Assembly and Protein Folding

Applications of Statistical Physics to Genome Assembly and Protein Folding

Author: Nicholas Helms Putnam

Publisher:

Published: 2004

Total Pages: 296

ISBN-13:

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Book Synopsis Applications of Statistical Physics to Genome Assembly and Protein Folding by : Nicholas Helms Putnam

Download or read book Applications of Statistical Physics to Genome Assembly and Protein Folding written by Nicholas Helms Putnam and published by . This book was released on 2004 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:


Biological Evolution and Statistical Physics

Biological Evolution and Statistical Physics

Author: M. Lässig

Publisher: Springer

Published: 2008-01-11

Total Pages: 340

ISBN-13: 3540456929

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This set of lecture notes gives a first coherent account of a novel aspect of the living world that can be called biological information. The book presents both a pedagogical and state-of-the art roadmap of this rapidly evolving area and covers the whole field, from information which is encoded in the molecular genetic code to the description of large-scale evolution of complex species networks. The book will prove useful for all those who work at the interface of biology, physics and information science.


Book Synopsis Biological Evolution and Statistical Physics by : M. Lässig

Download or read book Biological Evolution and Statistical Physics written by M. Lässig and published by Springer. This book was released on 2008-01-11 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This set of lecture notes gives a first coherent account of a novel aspect of the living world that can be called biological information. The book presents both a pedagogical and state-of-the art roadmap of this rapidly evolving area and covers the whole field, from information which is encoded in the molecular genetic code to the description of large-scale evolution of complex species networks. The book will prove useful for all those who work at the interface of biology, physics and information science.