Stroke Genomics

Stroke Genomics

Author: Simon J. Read

Publisher: Springer Science & Business Media

Published: 2008-02-01

Total Pages: 352

ISBN-13: 1592598366

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With sequencing of the human genome now complete, deciphering the role of gene function in human neurological pathophysiology is a promise that has yet to be realized. More than most diseases, stroke has been keenly studied from a genomic perspective. Studies are numerous and incorporate data on stroke inheritance, chromosomal loci of risk, preclinical models of stroke, and differential gene expression of brain injury, repair, and recovery. The problem is no longer a lack of information but one of interpretation and prioritization of what we do know. The aims of Stroke Genomics: Methods and Reviews are twofold. First, it aims to provide the reader with cutting-edge reviews of clinical and preclinical genomics, written by leading experts in the field. In particular, the authors of certain chapters relate gene expression changes to physiological end points, such as functional imaging paradigms. Thus, a more holistic approach to gene expression is described, one in which molecular biology goes hand in hand with stroke pathophysiology. Second, detailed methods for study of the molecular biology of stroke are TM also included. Following the format of the Methods in Molecular Medicine series, these chapters will enable the reader to employ each technique without recourse to other methods texts. In its entirety, this book should provide the reader with the knowledge needed to design, execute, and interpret preclinical and clinical studies of stroke genomics.


Book Synopsis Stroke Genomics by : Simon J. Read

Download or read book Stroke Genomics written by Simon J. Read and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: With sequencing of the human genome now complete, deciphering the role of gene function in human neurological pathophysiology is a promise that has yet to be realized. More than most diseases, stroke has been keenly studied from a genomic perspective. Studies are numerous and incorporate data on stroke inheritance, chromosomal loci of risk, preclinical models of stroke, and differential gene expression of brain injury, repair, and recovery. The problem is no longer a lack of information but one of interpretation and prioritization of what we do know. The aims of Stroke Genomics: Methods and Reviews are twofold. First, it aims to provide the reader with cutting-edge reviews of clinical and preclinical genomics, written by leading experts in the field. In particular, the authors of certain chapters relate gene expression changes to physiological end points, such as functional imaging paradigms. Thus, a more holistic approach to gene expression is described, one in which molecular biology goes hand in hand with stroke pathophysiology. Second, detailed methods for study of the molecular biology of stroke are TM also included. Following the format of the Methods in Molecular Medicine series, these chapters will enable the reader to employ each technique without recourse to other methods texts. In its entirety, this book should provide the reader with the knowledge needed to design, execute, and interpret preclinical and clinical studies of stroke genomics.

Stroke Genetics

Stroke Genetics

Author: Pankaj Sharma

Publisher: Springer

Published: 2017-06-12

Total Pages: 431

ISBN-13: 331956210X

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This revised, expanded second edition updates the reader on this fast moving field as well providing an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genomewide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed. Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics.


Book Synopsis Stroke Genetics by : Pankaj Sharma

Download or read book Stroke Genetics written by Pankaj Sharma and published by Springer. This book was released on 2017-06-12 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised, expanded second edition updates the reader on this fast moving field as well providing an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genomewide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed. Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics.

Molecular Genetics of Stroke

Molecular Genetics of Stroke

Author: Yoshiji Yamada

Publisher: Morgan & Claypool Publishers

Published: 2012-04

Total Pages: 95

ISBN-13: 1615043705

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Stroke is an important clinical problem because of its large contribution to mortality. The main causal and treatable risk factors for stroke include hypertension, diabetes mellitus, dyslipidemia, and smoking. In addition to these risk factors, recent studies have shown the importance of genetic factors and interactions between multiple genes and environmental factors. Genetic linkage analyses of families and sib-pairs as well as candidate gene association studies have implicated several loci and many candidate genes in predisposition to ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage. Recent genome-wide association studies identified various loci and genes that confer susceptibility to ischemic stroke or intracranial aneurysm. Such studies may provide insight into the function of implicated genes as well as into the role of genetic factors in the development of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage. Table of Contents: Introduction / Genetics of Stroke / Single-Gene Disorders Associated with Stroke / Genetics of Common Forms of Stroke / Clinical Implications / Conclusion / References / Titles of Related Interest


Book Synopsis Molecular Genetics of Stroke by : Yoshiji Yamada

Download or read book Molecular Genetics of Stroke written by Yoshiji Yamada and published by Morgan & Claypool Publishers. This book was released on 2012-04 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stroke is an important clinical problem because of its large contribution to mortality. The main causal and treatable risk factors for stroke include hypertension, diabetes mellitus, dyslipidemia, and smoking. In addition to these risk factors, recent studies have shown the importance of genetic factors and interactions between multiple genes and environmental factors. Genetic linkage analyses of families and sib-pairs as well as candidate gene association studies have implicated several loci and many candidate genes in predisposition to ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage. Recent genome-wide association studies identified various loci and genes that confer susceptibility to ischemic stroke or intracranial aneurysm. Such studies may provide insight into the function of implicated genes as well as into the role of genetic factors in the development of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage. Table of Contents: Introduction / Genetics of Stroke / Single-Gene Disorders Associated with Stroke / Genetics of Common Forms of Stroke / Clinical Implications / Conclusion / References / Titles of Related Interest

Stroke Genetics

Stroke Genetics

Author: Pankaj Sharma

Publisher: Springer

Published: 2012-08-27

Total Pages: 0

ISBN-13: 9780857292087

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Over the last decade there has been a substantial increase in our understanding of the genetic basis of common disorders such as stroke. Stroke Genetics is designed to give the reader an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genome-wide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed. Stroke Genetics benefits from the contribution of renowned experts from throughout the world who have been intimately involved in unraveling the genetic etiology of stroke. Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics.


Book Synopsis Stroke Genetics by : Pankaj Sharma

Download or read book Stroke Genetics written by Pankaj Sharma and published by Springer. This book was released on 2012-08-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade there has been a substantial increase in our understanding of the genetic basis of common disorders such as stroke. Stroke Genetics is designed to give the reader an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genome-wide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed. Stroke Genetics benefits from the contribution of renowned experts from throughout the world who have been intimately involved in unraveling the genetic etiology of stroke. Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics.

Stroke Genetics

Stroke Genetics

Author: Hugh S. Markus

Publisher: Oxford Medical Publications

Published: 2003

Total Pages: 362

ISBN-13: 0198515863

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Stroke is a major cause of death and the major cause of adult neurological disability in most of the world. Despite its importance on a population basis, research into the genetics of stroke has lagged behind that of many other disorders. However, the situation is now changing. Anincreasing number of single gene disorders causing stroke are being described, and there is growing evidence that polygenic factors are important in the risk of apparently "sporadic" stroke.Stroke Genetics provides an up-to-date review of the area, suitable for clinicians treating stroke patients, and both clinical and non-clinical researchers in the field of cerebrovascular disease. The full range of monogenic stroke disorders causing cerebrovascular disease, including ischaemicstroke, intracerebral haemorrhage, aneurysms and arteriovenous malformations, are covered. For each, clinical features, diagnosis, and genetics are described. Increasing evidence suggest that genetic factors are also important for the much more common multifactorial stroke; this evidence isreviewed along with the results of genetic studies in this area. Optimal and novel strategies for investigating multifactorial stroke, including the use of intermediate phenotypes such as intima-media thickness and MRI detected small vessel disease are reviewed. The book concludes by describing apractical approach to investigating patients with stroke for underlying genetic disorders. Also included is a list of useful websites.


Book Synopsis Stroke Genetics by : Hugh S. Markus

Download or read book Stroke Genetics written by Hugh S. Markus and published by Oxford Medical Publications. This book was released on 2003 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stroke is a major cause of death and the major cause of adult neurological disability in most of the world. Despite its importance on a population basis, research into the genetics of stroke has lagged behind that of many other disorders. However, the situation is now changing. Anincreasing number of single gene disorders causing stroke are being described, and there is growing evidence that polygenic factors are important in the risk of apparently "sporadic" stroke.Stroke Genetics provides an up-to-date review of the area, suitable for clinicians treating stroke patients, and both clinical and non-clinical researchers in the field of cerebrovascular disease. The full range of monogenic stroke disorders causing cerebrovascular disease, including ischaemicstroke, intracerebral haemorrhage, aneurysms and arteriovenous malformations, are covered. For each, clinical features, diagnosis, and genetics are described. Increasing evidence suggest that genetic factors are also important for the much more common multifactorial stroke; this evidence isreviewed along with the results of genetic studies in this area. Optimal and novel strategies for investigating multifactorial stroke, including the use of intermediate phenotypes such as intima-media thickness and MRI detected small vessel disease are reviewed. The book concludes by describing apractical approach to investigating patients with stroke for underlying genetic disorders. Also included is a list of useful websites.

Acute Stroke Nursing

Acute Stroke Nursing

Author: Jane Williams

Publisher: John Wiley & Sons

Published: 2013-05-07

Total Pages: 367

ISBN-13: 1118699629

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Stroke is a medical emergency that requires immediate medical attention. With active and efficient nursing management in the initial hours after stroke onset and throughout subsequent care, effective recovery and rehabilitation is increased. Acute Stroke Nursing provides an evidence-based, practical text facilitating the provision of optimal stroke care during the primary prevention, acute and continuing care phases. This timely and comprehensive text is structured to follow the acute stroke pathway experienced by patients. It explores the causes, symptoms and effects of stroke, and provides guidance on issues such as nutrition, continence, positioning, mobility and carer support. The text also considers rehabilitation, discharge planning, palliative care and the role of the nurse within the multi-professional team. Acute Stroke Nursing is the definitive reference on acute stroke for all nurses and healthcare professionals wishing to extend their knowledge of stroke nursing. Evidence-based and practical in style, with case studies and practice examples throughout Edited and authored by recognised stroke nursing experts, clinicians and leaders in the field of nursing practice, research and education The first text to explore stroke management from UK and international perspectives, and with a nursing focus


Book Synopsis Acute Stroke Nursing by : Jane Williams

Download or read book Acute Stroke Nursing written by Jane Williams and published by John Wiley & Sons. This book was released on 2013-05-07 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stroke is a medical emergency that requires immediate medical attention. With active and efficient nursing management in the initial hours after stroke onset and throughout subsequent care, effective recovery and rehabilitation is increased. Acute Stroke Nursing provides an evidence-based, practical text facilitating the provision of optimal stroke care during the primary prevention, acute and continuing care phases. This timely and comprehensive text is structured to follow the acute stroke pathway experienced by patients. It explores the causes, symptoms and effects of stroke, and provides guidance on issues such as nutrition, continence, positioning, mobility and carer support. The text also considers rehabilitation, discharge planning, palliative care and the role of the nurse within the multi-professional team. Acute Stroke Nursing is the definitive reference on acute stroke for all nurses and healthcare professionals wishing to extend their knowledge of stroke nursing. Evidence-based and practical in style, with case studies and practice examples throughout Edited and authored by recognised stroke nursing experts, clinicians and leaders in the field of nursing practice, research and education The first text to explore stroke management from UK and international perspectives, and with a nursing focus

Genetics of Cerebrovascular Disease

Genetics of Cerebrovascular Disease

Author: Mark Alberts

Publisher: Blackwell Publishing

Published: 1999-03-12

Total Pages: 386

ISBN-13: 9780879935849

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This is the first book that focuses on genetics and stroke, an area of ever growing clinical and research importance. It integrates laboratory, applied and clinical research, with an emphasis on molecular genetic and genetic epidemiologic aspects of cerebrovascular disease. Beginning with an overview of the key risk factors for stroke, most of the major stroke types and syndromes are detailed, as well as the key genetic advances for several stroke mechanisms and etiologies. The text also provides expert guidance for evaluating patients' genetic stroke profile. Extensive bibliographies for each chapter further guide the reader to topics of particular interest. As the pioneering text on this topic, Genetics of Cerebrovascular Disease should be of considerable interest and value to both clinicians and researchers in this area.


Book Synopsis Genetics of Cerebrovascular Disease by : Mark Alberts

Download or read book Genetics of Cerebrovascular Disease written by Mark Alberts and published by Blackwell Publishing. This book was released on 1999-03-12 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book that focuses on genetics and stroke, an area of ever growing clinical and research importance. It integrates laboratory, applied and clinical research, with an emphasis on molecular genetic and genetic epidemiologic aspects of cerebrovascular disease. Beginning with an overview of the key risk factors for stroke, most of the major stroke types and syndromes are detailed, as well as the key genetic advances for several stroke mechanisms and etiologies. The text also provides expert guidance for evaluating patients' genetic stroke profile. Extensive bibliographies for each chapter further guide the reader to topics of particular interest. As the pioneering text on this topic, Genetics of Cerebrovascular Disease should be of considerable interest and value to both clinicians and researchers in this area.

Stroke Genetics

Stroke Genetics

Author: Hugh S. Markus

Publisher: Oxford University Press

Published: 2003-05-01

Total Pages:

ISBN-13: 0191500070

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Stroke is a major cause of death and the major cause of adult neurological disability in most of the world. Despite its importance on a population basis, research into the genetics of stroke has lagged behind that of many other disorders. However, the situation is now changing. An increasing number of single gene disorders causing stroke are being described, and there is growing evidence that polygenic factors are important in the risk of apparently "sporadic" stroke. Stroke Genetics provides an up-to-date review of the area, suitable for clinicians treating stroke patients, and both clinical and non-clinical researchers in the field of cerebrovascular disease. The full range of monogenic stroke disorders causing cerebrovascular disease, including ischaemic stroke, intracerebral haemorrhage, aneurysms and arteriovenous malformations, are covered. For each, clinical features, diagnosis, and genetics are described. Increasing evidence suggest that genetic factors are also important for the much more common multifactorial stroke; this evidence is reviewed along with the results of genetic studies in this area. Optimal and novel strategies for investigating multifactorial stroke, including the use of intermediate phenotypes such as intima-media thickness and MRI detected small vessel disease are reviewed. The book concludes by describing a practical approach to investigating patients with stroke for underlying genetic disorders. Also included is a list of useful websites.


Book Synopsis Stroke Genetics by : Hugh S. Markus

Download or read book Stroke Genetics written by Hugh S. Markus and published by Oxford University Press. This book was released on 2003-05-01 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Stroke is a major cause of death and the major cause of adult neurological disability in most of the world. Despite its importance on a population basis, research into the genetics of stroke has lagged behind that of many other disorders. However, the situation is now changing. An increasing number of single gene disorders causing stroke are being described, and there is growing evidence that polygenic factors are important in the risk of apparently "sporadic" stroke. Stroke Genetics provides an up-to-date review of the area, suitable for clinicians treating stroke patients, and both clinical and non-clinical researchers in the field of cerebrovascular disease. The full range of monogenic stroke disorders causing cerebrovascular disease, including ischaemic stroke, intracerebral haemorrhage, aneurysms and arteriovenous malformations, are covered. For each, clinical features, diagnosis, and genetics are described. Increasing evidence suggest that genetic factors are also important for the much more common multifactorial stroke; this evidence is reviewed along with the results of genetic studies in this area. Optimal and novel strategies for investigating multifactorial stroke, including the use of intermediate phenotypes such as intima-media thickness and MRI detected small vessel disease are reviewed. The book concludes by describing a practical approach to investigating patients with stroke for underlying genetic disorders. Also included is a list of useful websites.

Molecular, Genetic, And Cellular Advances In Cerebrovascular Diseases

Molecular, Genetic, And Cellular Advances In Cerebrovascular Diseases

Author: Su Hua

Publisher: World Scientific

Published: 2017-12-26

Total Pages: 320

ISBN-13: 9814723312

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This book will cover recent advances in genetics and molecular biology of cerebrovascular diseases, including ischemic stroke, brain arteriovenous malformation, brain aneurysms, and cavernous malformation. Developments in diagnostics, imaging and treatment will also be discussed. Much progress has been made in recent years in these fields, but not been summarized in one comprehensive text. This volume fills the gap in the literature by compiling them in one convenient, handy volume for neuroscience researchers and medical professionals. Contents: Imaging in Cerebrovascular Disease (Christopher P Hess)Cell Mechanisms and Clinical Targets in Stroke (Jing Lan, Elga Esposito, MingMing Ning, Xunming Ji, and Eng H Lo)Neural Repair for Cerebrovascular Diseases (Steven C Cramer)Brain AVM: Current Treatments and Challenges (W Caleb Rutledge and Michael T Lawton)Animal Models and Prospective Therapeutic Targets for Brain Arteriovenous Malformation (Wan Zhu, Rui Zhang, Li Ma, and Hua Su)Biology of Brain Aneurysms (W Caleb Rutledge and Tomoki Hashimoto)Intracranial Aneurysms: Imaging, Hemodynamics, and Remodeling (David Saloner)Recent Advances in CADASIL Research (Suning Ping and Li-Ru Zhao)Dural Fistula (Daniel L Cooke, Matthew R Amans, and Van V Halbach)Interventional Therapies for Cerebrovascular Diseases (Fabio Settecase and Steven W Hetts)Stem Cell-mediated Biobridge: Crossing the Great Divide Between Bench and Clinic in Translating Cell Therapy for Stroke (Trenton Lippert, Marci Crowley, M Grant Liska, and Cesar V Borlongan) Readership: Neurologists, neurobiologists, neuroscientists. Keywords: Ischemic Stroke;Brain Arteriovenous Malformation;Brain Aneurism;Cerebral Cavernous Malformation;Dural Fistula;Brain ImageReview:0


Book Synopsis Molecular, Genetic, And Cellular Advances In Cerebrovascular Diseases by : Su Hua

Download or read book Molecular, Genetic, And Cellular Advances In Cerebrovascular Diseases written by Su Hua and published by World Scientific. This book was released on 2017-12-26 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will cover recent advances in genetics and molecular biology of cerebrovascular diseases, including ischemic stroke, brain arteriovenous malformation, brain aneurysms, and cavernous malformation. Developments in diagnostics, imaging and treatment will also be discussed. Much progress has been made in recent years in these fields, but not been summarized in one comprehensive text. This volume fills the gap in the literature by compiling them in one convenient, handy volume for neuroscience researchers and medical professionals. Contents: Imaging in Cerebrovascular Disease (Christopher P Hess)Cell Mechanisms and Clinical Targets in Stroke (Jing Lan, Elga Esposito, MingMing Ning, Xunming Ji, and Eng H Lo)Neural Repair for Cerebrovascular Diseases (Steven C Cramer)Brain AVM: Current Treatments and Challenges (W Caleb Rutledge and Michael T Lawton)Animal Models and Prospective Therapeutic Targets for Brain Arteriovenous Malformation (Wan Zhu, Rui Zhang, Li Ma, and Hua Su)Biology of Brain Aneurysms (W Caleb Rutledge and Tomoki Hashimoto)Intracranial Aneurysms: Imaging, Hemodynamics, and Remodeling (David Saloner)Recent Advances in CADASIL Research (Suning Ping and Li-Ru Zhao)Dural Fistula (Daniel L Cooke, Matthew R Amans, and Van V Halbach)Interventional Therapies for Cerebrovascular Diseases (Fabio Settecase and Steven W Hetts)Stem Cell-mediated Biobridge: Crossing the Great Divide Between Bench and Clinic in Translating Cell Therapy for Stroke (Trenton Lippert, Marci Crowley, M Grant Liska, and Cesar V Borlongan) Readership: Neurologists, neurobiologists, neuroscientists. Keywords: Ischemic Stroke;Brain Arteriovenous Malformation;Brain Aneurism;Cerebral Cavernous Malformation;Dural Fistula;Brain ImageReview:0

Stroke Genetics

Stroke Genetics

Author: Pankaj Sharma

Publisher: Springer Science & Business Media

Published: 2012-08-27

Total Pages: 333

ISBN-13: 0857292099

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Over the last decade there has been a substantial increase in our understanding of the genetic basis of common disorders such as stroke. Stroke Genetics is designed to give the reader an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genome-wide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed. Stroke Genetics benefits from the contribution of renowned experts from throughout the world who have been intimately involved in unraveling the genetic etiology of stroke. Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics.


Book Synopsis Stroke Genetics by : Pankaj Sharma

Download or read book Stroke Genetics written by Pankaj Sharma and published by Springer Science & Business Media. This book was released on 2012-08-27 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade there has been a substantial increase in our understanding of the genetic basis of common disorders such as stroke. Stroke Genetics is designed to give the reader an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genome-wide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed. Stroke Genetics benefits from the contribution of renowned experts from throughout the world who have been intimately involved in unraveling the genetic etiology of stroke. Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics.