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The Role of Sphingolipids in Cancer Development and Therapy

Author:

Publisher: Academic Press

Published: 2012-12-31

Total Pages: 313

ISBN-13: 0123944139

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Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This thematic volume looks at "The Role of Sphingolipids in Cancer Development and Therapy" Provides invaluable information on the exciting and fast-moving field of cancer research This thematic volume looks at "The Role of Sphingolipids in Cancer Development and Therapy" Outstanding and original reviews

Book Synopsis The Role of Sphingolipids in Cancer Development and Therapy by :

Download or read book The Role of Sphingolipids in Cancer Development and Therapy written by and published by Academic Press. This book was released on 2012-12-31 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This thematic volume looks at "The Role of Sphingolipids in Cancer Development and Therapy" Provides invaluable information on the exciting and fast-moving field of cancer research This thematic volume looks at "The Role of Sphingolipids in Cancer Development and Therapy" Outstanding and original reviews

Bioactive Sphingolipids in Cancer Biology and Therapy

Author: Yusuf A. Hannun

Publisher: Springer

Published: 2015-08-28

Total Pages: 491

ISBN-13: 3319207504

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This volume presents information on both the basic and clinical aspects of sphingolipid-metabolizing enzymes in various cancers. The volume also includes discussions of the innovative techniques and approaches for quantitative analysis and imaging that could significantly impact the general understanding of this topic, and the potential benefit of targeting sphingolipid enzymes to develop novel cancer therapeutics. As well, the volume includes a critical examination of the specific pathways and pathobiologies associated with the altered regulation of sphingolipid metabolism as a contributor to the development and/or maintenance of pathological conditions such as cancer.

Book Synopsis Bioactive Sphingolipids in Cancer Biology and Therapy by : Yusuf A. Hannun

Download or read book Bioactive Sphingolipids in Cancer Biology and Therapy written by Yusuf A. Hannun and published by Springer. This book was released on 2015-08-28 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents information on both the basic and clinical aspects of sphingolipid-metabolizing enzymes in various cancers. The volume also includes discussions of the innovative techniques and approaches for quantitative analysis and imaging that could significantly impact the general understanding of this topic, and the potential benefit of targeting sphingolipid enzymes to develop novel cancer therapeutics. As well, the volume includes a critical examination of the specific pathways and pathobiologies associated with the altered regulation of sphingolipid metabolism as a contributor to the development and/or maintenance of pathological conditions such as cancer.

Sphingolipids in Cancer

Author:

Publisher: Academic Press

Published: 2018-07-27

Total Pages: 410

ISBN-13: 0128142243

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Sphingolipids in Cancer, Volume 140, the latest release in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Topics discussed in this updated volume include Mechanisms of ceramide-dependent cancer cell death, Sphingolipids as regulators of autophagy and endocytic trafficking, The role and function of sphingomyelin biosynthesis in the development of cancer, Neutral sphingomyelinases in cancer: Friend or foe?, Sphingolipid rendezvous at the crossroad of NAFLD and senescence, Ceramide signaling and p53 pathways, Sphingolipid regulation of RNA Biology in cancer phenotypes, The role of ceramide-1-phosphate in tumor cell survival and dissemination, and more. Provides information on cancer research, with this release focusing on sphingolipids Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike

Book Synopsis Sphingolipids in Cancer by :

Download or read book Sphingolipids in Cancer written by and published by Academic Press. This book was released on 2018-07-27 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sphingolipids in Cancer, Volume 140, the latest release in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Topics discussed in this updated volume include Mechanisms of ceramide-dependent cancer cell death, Sphingolipids as regulators of autophagy and endocytic trafficking, The role and function of sphingomyelin biosynthesis in the development of cancer, Neutral sphingomyelinases in cancer: Friend or foe?, Sphingolipid rendezvous at the crossroad of NAFLD and senescence, Ceramide signaling and p53 pathways, Sphingolipid regulation of RNA Biology in cancer phenotypes, The role of ceramide-1-phosphate in tumor cell survival and dissemination, and more. Provides information on cancer research, with this release focusing on sphingolipids Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike

Exploring the Roles of Sphingolipid Metabolites on Breast Cancer

Author:

Publisher:

Published: 2013

Total Pages: 38

ISBN-13:

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Breast cancer is the most common cancer in women worldwide despite recent progress in breast cancer diagnosis and therapy. Thus, it remains crucial to explore novel approaches for its management. Sphingolipids have emerged as important regulators of cancer cell fate: ceramide has been shown to be pro-apoptotic, while sphingosine-1 phosphate (S1P) induces cell growth and survival. This research explores the roles of sphingolipid metabolites by evaluating five Drosophila melanogaster mutants with altered endogenous levels of ceramide, S1P, sphingosine and sphingadiene. Isolating, purifying and measuring lipid extracts from Drosophila allows the assessment of how different levels of sphingolipids can affect the growth of breast cancer cells by measuring their cytotoxicity, ability to generate ROS, and their effect on cell proliferation. The results indicate that the Sply, SK-1 and SK-2 lipid extracts were cytotoxic to breast cancer cells and stimulated ROS production in vitro. These results confirm the importance of investigating sphingolipid metabolites for chemotherapeutic development.

Book Synopsis Exploring the Roles of Sphingolipid Metabolites on Breast Cancer by :

Download or read book Exploring the Roles of Sphingolipid Metabolites on Breast Cancer written by and published by . This book was released on 2013 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancer is the most common cancer in women worldwide despite recent progress in breast cancer diagnosis and therapy. Thus, it remains crucial to explore novel approaches for its management. Sphingolipids have emerged as important regulators of cancer cell fate: ceramide has been shown to be pro-apoptotic, while sphingosine-1 phosphate (S1P) induces cell growth and survival. This research explores the roles of sphingolipid metabolites by evaluating five Drosophila melanogaster mutants with altered endogenous levels of ceramide, S1P, sphingosine and sphingadiene. Isolating, purifying and measuring lipid extracts from Drosophila allows the assessment of how different levels of sphingolipids can affect the growth of breast cancer cells by measuring their cytotoxicity, ability to generate ROS, and their effect on cell proliferation. The results indicate that the Sply, SK-1 and SK-2 lipid extracts were cytotoxic to breast cancer cells and stimulated ROS production in vitro. These results confirm the importance of investigating sphingolipid metabolites for chemotherapeutic development.

Advances in Lipid Metabolism

Author: Rodrigo Valenzuela Baez

Publisher: BoD – Books on Demand

Published: 2020-06-03

Total Pages: 100

ISBN-13: 1789844584

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This edited volume is a collection of reviewed and relevant research chapters concerning developments within the field of lipid metabolism. It includes scholarly contributions from experts in the field that cover such topics as roles of lipids in cancer, analytical tools for lipid assessment in biological assays, plant lipid metabolism, the effect of nanoparticles on lipid peroxidation in plants, and fatty acid compositions in fermented fish products. This book provides a thorough overview of the latest research efforts by international authors on lipid metabolism, and opens new possible research paths for further novel developments.

Book Synopsis Advances in Lipid Metabolism by : Rodrigo Valenzuela Baez

Download or read book Advances in Lipid Metabolism written by Rodrigo Valenzuela Baez and published by BoD – Books on Demand. This book was released on 2020-06-03 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume is a collection of reviewed and relevant research chapters concerning developments within the field of lipid metabolism. It includes scholarly contributions from experts in the field that cover such topics as roles of lipids in cancer, analytical tools for lipid assessment in biological assays, plant lipid metabolism, the effect of nanoparticles on lipid peroxidation in plants, and fatty acid compositions in fermented fish products. This book provides a thorough overview of the latest research efforts by international authors on lipid metabolism, and opens new possible research paths for further novel developments.

The Role of Sphingolipids in Cancer Development and Therapy

Author:

Publisher: Academic Press

Published: 2013-01-28

Total Pages: 312

ISBN-13: 9780123942746

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Book Synopsis The Role of Sphingolipids in Cancer Development and Therapy by :

Download or read book The Role of Sphingolipids in Cancer Development and Therapy written by and published by Academic Press. This book was released on 2013-01-28 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This thematic volume looks at "The Role of Sphingolipids in Cancer Development and Therapy" Provides invaluable information on the exciting and fast-moving field of cancer research This thematic volume looks at "The Role of Sphingolipids in Cancer Development and Therapy" Outstanding and original reviews

The Heterogeneity of Cancer Metabolism

Author: Anne Le

Publisher: Springer

Published: 2018-06-26

Total Pages: 186

ISBN-13: 331977736X

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Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le

Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Sphingolipid Biology

Author: Y. Hirabayashi

Publisher: Springer Science & Business Media

Published: 2007-12-31

Total Pages: 528

ISBN-13: 4431342001

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Sphingolipids are fundamental to the structures of cell membranes, lipoproteins, and the stratum cornea of the skin. Many complex sphingolipids, as well as simpler sphingoid bases and derivatives, are highly bioactive as extra- and intracellular regulators of growth, differentiation, migration, survival, senescence, and numerous cellular responses to stress. This book reviews exciting new developments in sphingolipid biology/sphingolipidology that challenge our understanding of how multicellular organisms grow, develop, function, age, and die.

Book Synopsis Sphingolipid Biology by : Y. Hirabayashi

Download or read book Sphingolipid Biology written by Y. Hirabayashi and published by Springer Science & Business Media. This book was released on 2007-12-31 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sphingolipids are fundamental to the structures of cell membranes, lipoproteins, and the stratum cornea of the skin. Many complex sphingolipids, as well as simpler sphingoid bases and derivatives, are highly bioactive as extra- and intracellular regulators of growth, differentiation, migration, survival, senescence, and numerous cellular responses to stress. This book reviews exciting new developments in sphingolipid biology/sphingolipidology that challenge our understanding of how multicellular organisms grow, develop, function, age, and die.

Trends in Stem Cell Proliferation and Cancer Research

Author: Rodrigo R. Resende

Publisher: Springer Science & Business Media

Published: 2013-08-13

Total Pages: 663

ISBN-13: 9400762119

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The book will discuss the molecular mechanisms of cancer diseases, stem cell proliferation and transformation into cancer cells beyond the physiological processes that occur in normal stem cell biology. Some of the key oncogenic events in cancer and their signaling pathways that regulate cell division cycle progression will be described considering prospects for using such knowledge in advanced cancer therapy. Each chapter shall provide an invaluable resource for information on the most current advances in the field, with discussion of controversial issues and areas of emerging importance

Book Synopsis Trends in Stem Cell Proliferation and Cancer Research by : Rodrigo R. Resende

Download or read book Trends in Stem Cell Proliferation and Cancer Research written by Rodrigo R. Resende and published by Springer Science & Business Media. This book was released on 2013-08-13 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book will discuss the molecular mechanisms of cancer diseases, stem cell proliferation and transformation into cancer cells beyond the physiological processes that occur in normal stem cell biology. Some of the key oncogenic events in cancer and their signaling pathways that regulate cell division cycle progression will be described considering prospects for using such knowledge in advanced cancer therapy. Each chapter shall provide an invaluable resource for information on the most current advances in the field, with discussion of controversial issues and areas of emerging importance

The Role of Bioactive Lipids in Cancer, Inflammation and Related Diseases

Author: Kenneth V. Honn

Publisher: Springer Nature

Published: 2019-09-27

Total Pages: 256

ISBN-13: 3030217353

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The Organizing Committee of the 15th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases compiled a group of junior investigators to provide reviews on the topics they presented at the Puerto Vallarta Bioactive Lipids conference, as part of the book series, Advances in Experimental Medicine and Biology (AEMB). The book in this series will be titled Bioactive Lipids in Cancer, Inflammation and Related Diseases. Topics range from all classes of lipids including prostaglandins, resolvins, spingolipids, P450-derived lipids, endocannabanoids and phospholipids. The focus includes physiology, cell biology, and structural studies in organisms from bacteria to humans and how these studies addressed the role of lipids in various disease i.e. cancer, inflammation, diabetes, obesity, cardiovascular disease and others.

Book Synopsis The Role of Bioactive Lipids in Cancer, Inflammation and Related Diseases by : Kenneth V. Honn

Download or read book The Role of Bioactive Lipids in Cancer, Inflammation and Related Diseases written by Kenneth V. Honn and published by Springer Nature. This book was released on 2019-09-27 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Organizing Committee of the 15th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases compiled a group of junior investigators to provide reviews on the topics they presented at the Puerto Vallarta Bioactive Lipids conference, as part of the book series, Advances in Experimental Medicine and Biology (AEMB). The book in this series will be titled Bioactive Lipids in Cancer, Inflammation and Related Diseases. Topics range from all classes of lipids including prostaglandins, resolvins, spingolipids, P450-derived lipids, endocannabanoids and phospholipids. The focus includes physiology, cell biology, and structural studies in organisms from bacteria to humans and how these studies addressed the role of lipids in various disease i.e. cancer, inflammation, diabetes, obesity, cardiovascular disease and others.