Toxoplasma Gondii Co-opts Host Immune Signaling by Secretion of a Polymorphic Tyrosine Kinase, ROP16

Toxoplasma Gondii Co-opts Host Immune Signaling by Secretion of a Polymorphic Tyrosine Kinase, ROP16

Author: Yi-Ching Ong

Publisher: Stanford University

Published: 2010

Total Pages: 154

ISBN-13:

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Toxoplasma gondii is an obligate, intracellular parasite of the Apicomplexan phylum that is able to infect nearly all warm-blooded vertebrates. This capability for survival in a variety of host niches is reflected in the diversification of Toxoplasma strains. Strains differ dramatically in their interaction with hosts, and a fruitful approach towards understanding the molecular underpinnings of disease has been to identify and characterize drivers of strain-specific differences in host response. Chapter 1 provides a general introduction to Toxoplasma gondii and its ability to modulate host immunity, with special attention given to what is known about the mechanisms behind strain-specific phenotypes and the role of one particular player, ROP16. Chapter 2 describes experiments demonstrating that Toxoplasma secretes a polymorphic tyrosine kinase, ROP16, that can directly phosphorylate host STAT6. These experiments made use of a targeted disruption of the ROP16 locus in Type I parasites to identify ROP16-dependent signaling pathways, and used biochemical approaches to dissect the mechanism by which ROP16 is able to induce rapid STAT6 activation. Chapter 3 describes work demonstrating that ROP16 activation of STAT6 directs murine macrophage polarization towards an alternatively activated (M2) phenotype. In Chapter 4, the avian host response to Toxoplasma is examined to determine whether strain-specific differences in host response might be inverted in non-mammalian hosts. We show that strain-specific transcriptional host response, as well as transcriptional host response modulated by ROP16, appears very similar in chickens as in mice and humans. This suggests that variance between mammalian and avian host species in general may not be the source of selective pressure for the success of these common strains, or of ROP16's variability. Chapter 5 concludes with a discussion of future directions for further characterization of ROP16's role in modulating host response. We show that ROP16 interacts with host chromatin and suggest that investigation of ROP16's function in the host nucleus might yield further molecular insights as to how Toxoplasma is able to co-opt host cells and influence the course of infection.


Book Synopsis Toxoplasma Gondii Co-opts Host Immune Signaling by Secretion of a Polymorphic Tyrosine Kinase, ROP16 by : Yi-Ching Ong

Download or read book Toxoplasma Gondii Co-opts Host Immune Signaling by Secretion of a Polymorphic Tyrosine Kinase, ROP16 written by Yi-Ching Ong and published by Stanford University. This book was released on 2010 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxoplasma gondii is an obligate, intracellular parasite of the Apicomplexan phylum that is able to infect nearly all warm-blooded vertebrates. This capability for survival in a variety of host niches is reflected in the diversification of Toxoplasma strains. Strains differ dramatically in their interaction with hosts, and a fruitful approach towards understanding the molecular underpinnings of disease has been to identify and characterize drivers of strain-specific differences in host response. Chapter 1 provides a general introduction to Toxoplasma gondii and its ability to modulate host immunity, with special attention given to what is known about the mechanisms behind strain-specific phenotypes and the role of one particular player, ROP16. Chapter 2 describes experiments demonstrating that Toxoplasma secretes a polymorphic tyrosine kinase, ROP16, that can directly phosphorylate host STAT6. These experiments made use of a targeted disruption of the ROP16 locus in Type I parasites to identify ROP16-dependent signaling pathways, and used biochemical approaches to dissect the mechanism by which ROP16 is able to induce rapid STAT6 activation. Chapter 3 describes work demonstrating that ROP16 activation of STAT6 directs murine macrophage polarization towards an alternatively activated (M2) phenotype. In Chapter 4, the avian host response to Toxoplasma is examined to determine whether strain-specific differences in host response might be inverted in non-mammalian hosts. We show that strain-specific transcriptional host response, as well as transcriptional host response modulated by ROP16, appears very similar in chickens as in mice and humans. This suggests that variance between mammalian and avian host species in general may not be the source of selective pressure for the success of these common strains, or of ROP16's variability. Chapter 5 concludes with a discussion of future directions for further characterization of ROP16's role in modulating host response. We show that ROP16 interacts with host chromatin and suggest that investigation of ROP16's function in the host nucleus might yield further molecular insights as to how Toxoplasma is able to co-opt host cells and influence the course of infection.

Toxoplasma Gondii Co-opts Host Immune Signaling by Secretion of a Polymorphic Tyrosine Kinase, ROP16

Toxoplasma Gondii Co-opts Host Immune Signaling by Secretion of a Polymorphic Tyrosine Kinase, ROP16

Author: Yi-Ching Ong

Publisher:

Published: 2010

Total Pages:

ISBN-13:

DOWNLOAD EBOOK

Toxoplasma gondii is an obligate, intracellular parasite of the Apicomplexan phylum that is able to infect nearly all warm-blooded vertebrates. This capability for survival in a variety of host niches is reflected in the diversification of Toxoplasma strains. Strains differ dramatically in their interaction with hosts, and a fruitful approach towards understanding the molecular underpinnings of disease has been to identify and characterize drivers of strain-specific differences in host response. Chapter 1 provides a general introduction to Toxoplasma gondii and its ability to modulate host immunity, with special attention given to what is known about the mechanisms behind strain-specific phenotypes and the role of one particular player, ROP16. Chapter 2 describes experiments demonstrating that Toxoplasma secretes a polymorphic tyrosine kinase, ROP16, that can directly phosphorylate host STAT6. These experiments made use of a targeted disruption of the ROP16 locus in Type I parasites to identify ROP16-dependent signaling pathways, and used biochemical approaches to dissect the mechanism by which ROP16 is able to induce rapid STAT6 activation. Chapter 3 describes work demonstrating that ROP16 activation of STAT6 directs murine macrophage polarization towards an alternatively activated (M2) phenotype. In Chapter 4, the avian host response to Toxoplasma is examined to determine whether strain-specific differences in host response might be inverted in non-mammalian hosts. We show that strain-specific transcriptional host response, as well as transcriptional host response modulated by ROP16, appears very similar in chickens as in mice and humans. This suggests that variance between mammalian and avian host species in general may not be the source of selective pressure for the success of these common strains, or of ROP16's variability. Chapter 5 concludes with a discussion of future directions for further characterization of ROP16's role in modulating host response. We show that ROP16 interacts with host chromatin and suggest that investigation of ROP16's function in the host nucleus might yield further molecular insights as to how Toxoplasma is able to co-opt host cells and influence the course of infection.


Book Synopsis Toxoplasma Gondii Co-opts Host Immune Signaling by Secretion of a Polymorphic Tyrosine Kinase, ROP16 by : Yi-Ching Ong

Download or read book Toxoplasma Gondii Co-opts Host Immune Signaling by Secretion of a Polymorphic Tyrosine Kinase, ROP16 written by Yi-Ching Ong and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxoplasma gondii is an obligate, intracellular parasite of the Apicomplexan phylum that is able to infect nearly all warm-blooded vertebrates. This capability for survival in a variety of host niches is reflected in the diversification of Toxoplasma strains. Strains differ dramatically in their interaction with hosts, and a fruitful approach towards understanding the molecular underpinnings of disease has been to identify and characterize drivers of strain-specific differences in host response. Chapter 1 provides a general introduction to Toxoplasma gondii and its ability to modulate host immunity, with special attention given to what is known about the mechanisms behind strain-specific phenotypes and the role of one particular player, ROP16. Chapter 2 describes experiments demonstrating that Toxoplasma secretes a polymorphic tyrosine kinase, ROP16, that can directly phosphorylate host STAT6. These experiments made use of a targeted disruption of the ROP16 locus in Type I parasites to identify ROP16-dependent signaling pathways, and used biochemical approaches to dissect the mechanism by which ROP16 is able to induce rapid STAT6 activation. Chapter 3 describes work demonstrating that ROP16 activation of STAT6 directs murine macrophage polarization towards an alternatively activated (M2) phenotype. In Chapter 4, the avian host response to Toxoplasma is examined to determine whether strain-specific differences in host response might be inverted in non-mammalian hosts. We show that strain-specific transcriptional host response, as well as transcriptional host response modulated by ROP16, appears very similar in chickens as in mice and humans. This suggests that variance between mammalian and avian host species in general may not be the source of selective pressure for the success of these common strains, or of ROP16's variability. Chapter 5 concludes with a discussion of future directions for further characterization of ROP16's role in modulating host response. We show that ROP16 interacts with host chromatin and suggest that investigation of ROP16's function in the host nucleus might yield further molecular insights as to how Toxoplasma is able to co-opt host cells and influence the course of infection.

Encyclopedia of Immunobiology

Encyclopedia of Immunobiology

Author:

Publisher: Academic Press

Published: 2016-04-27

Total Pages: 3161

ISBN-13: 0080921523

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Encyclopedia of Immunobiology, Five Volume Set provides the largest integrated source of immunological knowledge currently available. It consists of broad ranging, validated summaries on all of the major topics in the field as written by a team of leading experts. The large number of topics covered is relevant to a wide range of scientists working on experimental and clinical immunology, microbiology, biochemistry, genetics, veterinary science, physiology, and hematology. The book is built in thematic sections that allow readers to rapidly navigate around related content. Specific sections focus on basic, applied, and clinical immunology. The structure of each section helps readers from a range of backgrounds gain important understanding of the subject. Contains tables, pictures, and multimedia features that enhance the learning process In-depth coverage allows readers from a range of backgrounds to benefit from the material Provides handy cross-referencing between articles to improve readability, including easy access from portable devices


Book Synopsis Encyclopedia of Immunobiology by :

Download or read book Encyclopedia of Immunobiology written by and published by Academic Press. This book was released on 2016-04-27 with total page 3161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Immunobiology, Five Volume Set provides the largest integrated source of immunological knowledge currently available. It consists of broad ranging, validated summaries on all of the major topics in the field as written by a team of leading experts. The large number of topics covered is relevant to a wide range of scientists working on experimental and clinical immunology, microbiology, biochemistry, genetics, veterinary science, physiology, and hematology. The book is built in thematic sections that allow readers to rapidly navigate around related content. Specific sections focus on basic, applied, and clinical immunology. The structure of each section helps readers from a range of backgrounds gain important understanding of the subject. Contains tables, pictures, and multimedia features that enhance the learning process In-depth coverage allows readers from a range of backgrounds to benefit from the material Provides handy cross-referencing between articles to improve readability, including easy access from portable devices

Toxoplasma Gondii

Toxoplasma Gondii

Author: Louis M. Weiss

Publisher: Academic Press

Published: 2013-08-10

Total Pages: 1109

ISBN-13: 0123965365

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This 2e of Toxoplasma gondii reflects the significant advances in the field in the last 5 years, including new information on the genomics, epigenomics and proteomics of T. gondii as well as a new understanding of the population biology and genetic diversity of this organism. T. gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists. Toxoplasmosis is caused by a one-celled protozoan parasite known as T. gondii. The infection produces a wide range of clinical syndromes in humans, land and sea mammals, and various bird species. Most humans contract toxoplasmosis by eating contaminated, raw or undercooked meat (particularly pork), vegetables, or milk products; by coming into contact with the T. gondii eggs from cat feces; or by drinking contaminated water. The parasite damages the ocular and central nervous systems, causing behavioral and personality alterations as well as fatal necrotizing encephalitis. It is especially dangerous for the fetus of an infected pregnant woman and for individuals with compromised immune systems, such as HIV-infected patients. Completely updated, the 2e presents recent advances driven by new information on the genetics and genomics of the pathogen Provides the latest information concerning the epidemiology, diagnosis, treatment and prevention of toxoplasmosis Offers a single-source reference for a wide range of scientists and physicians working with this pathogen, including parasitologists, cell and molecular biologists, veterinarians, neuroscientists, physicians, and food scientists


Book Synopsis Toxoplasma Gondii by : Louis M. Weiss

Download or read book Toxoplasma Gondii written by Louis M. Weiss and published by Academic Press. This book was released on 2013-08-10 with total page 1109 pages. Available in PDF, EPUB and Kindle. Book excerpt: This 2e of Toxoplasma gondii reflects the significant advances in the field in the last 5 years, including new information on the genomics, epigenomics and proteomics of T. gondii as well as a new understanding of the population biology and genetic diversity of this organism. T. gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists. Toxoplasmosis is caused by a one-celled protozoan parasite known as T. gondii. The infection produces a wide range of clinical syndromes in humans, land and sea mammals, and various bird species. Most humans contract toxoplasmosis by eating contaminated, raw or undercooked meat (particularly pork), vegetables, or milk products; by coming into contact with the T. gondii eggs from cat feces; or by drinking contaminated water. The parasite damages the ocular and central nervous systems, causing behavioral and personality alterations as well as fatal necrotizing encephalitis. It is especially dangerous for the fetus of an infected pregnant woman and for individuals with compromised immune systems, such as HIV-infected patients. Completely updated, the 2e presents recent advances driven by new information on the genetics and genomics of the pathogen Provides the latest information concerning the epidemiology, diagnosis, treatment and prevention of toxoplasmosis Offers a single-source reference for a wide range of scientists and physicians working with this pathogen, including parasitologists, cell and molecular biologists, veterinarians, neuroscientists, physicians, and food scientists

Insights in Toxoplasma Biology and Infection - 15th biennial meeting on Toxoplasma Biology and Toxoplasmosis

Insights in Toxoplasma Biology and Infection - 15th biennial meeting on Toxoplasma Biology and Toxoplasmosis

Author: Jorge Enrique Gómez Marín

Publisher: Frontiers Media SA

Published: 2021-04-29

Total Pages: 155

ISBN-13: 2889667219

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Book Synopsis Insights in Toxoplasma Biology and Infection - 15th biennial meeting on Toxoplasma Biology and Toxoplasmosis by : Jorge Enrique Gómez Marín

Download or read book Insights in Toxoplasma Biology and Infection - 15th biennial meeting on Toxoplasma Biology and Toxoplasmosis written by Jorge Enrique Gómez Marín and published by Frontiers Media SA. This book was released on 2021-04-29 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology

Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology

Author: Nancy Guillen

Publisher: Springer Nature

Published: 2020-06-01

Total Pages: 368

ISBN-13: 3030448266

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Multiple demographic or economic parameters contribute to the origin of emerging infections, for example: poverty, urbanization, climate change, conflicts and population migrations. All these factors are a challenge to assess the impact (present and future) of parasitic diseases on public health. The intestine is a major target of these infections; it is a nutrient-rich environment harbouring a complex and dynamic population of 100 trillion microbes: the microbiome. Most researches on the microbiome focus on bacteria, which share the gut ecosystem with a population of uni- and multi cellular eukaryotic organisms that may prey on them. Our interest focuses on the families of eukaryotic microbes inhabiting the intestine, called “intestinal eukaryome”, that include fungi, protists and helminths. Knowledge on the reciprocal influence between the microbiome and the eukaryome, and on their combined impact on homeostasis and intestinal diseases is scanty and can be considered as an important emerging field. Furthermore, the factors that differentiate pathogenic eukaryotes from commensals are still unknown. This book presents an overview of the science presented and discussed in the First Eukaryome Congress held from October 16th to 18th, 2019 at the Pasteur Institute in Paris. This book covers the following topics: Phylogenetic, prevalence, and diversity of intestinal eukaryotic microbes; and their (still enigmatic) historical evolution and potential contributions to mucosal immune homeostasis. Integrative biology to study the molecular cell biology of parasite-host interactions and the multiple parameters underlining the infectious process. The exploitation of tissue engineering and microfluidics to establish three-dimensional (3D) systems that help to understand homeostasis and pathological processes in the human intestine.


Book Synopsis Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology by : Nancy Guillen

Download or read book Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology written by Nancy Guillen and published by Springer Nature. This book was released on 2020-06-01 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple demographic or economic parameters contribute to the origin of emerging infections, for example: poverty, urbanization, climate change, conflicts and population migrations. All these factors are a challenge to assess the impact (present and future) of parasitic diseases on public health. The intestine is a major target of these infections; it is a nutrient-rich environment harbouring a complex and dynamic population of 100 trillion microbes: the microbiome. Most researches on the microbiome focus on bacteria, which share the gut ecosystem with a population of uni- and multi cellular eukaryotic organisms that may prey on them. Our interest focuses on the families of eukaryotic microbes inhabiting the intestine, called “intestinal eukaryome”, that include fungi, protists and helminths. Knowledge on the reciprocal influence between the microbiome and the eukaryome, and on their combined impact on homeostasis and intestinal diseases is scanty and can be considered as an important emerging field. Furthermore, the factors that differentiate pathogenic eukaryotes from commensals are still unknown. This book presents an overview of the science presented and discussed in the First Eukaryome Congress held from October 16th to 18th, 2019 at the Pasteur Institute in Paris. This book covers the following topics: Phylogenetic, prevalence, and diversity of intestinal eukaryotic microbes; and their (still enigmatic) historical evolution and potential contributions to mucosal immune homeostasis. Integrative biology to study the molecular cell biology of parasite-host interactions and the multiple parameters underlining the infectious process. The exploitation of tissue engineering and microfluidics to establish three-dimensional (3D) systems that help to understand homeostasis and pathological processes in the human intestine.

Prospects of Plant-Based Vaccines in Veterinary Medicine

Prospects of Plant-Based Vaccines in Veterinary Medicine

Author: Jacqueline MacDonald

Publisher: Springer

Published: 2018-07-03

Total Pages: 367

ISBN-13: 3319901370

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This book provides an in-depth explanation of the advantages and current limitations of recombinant plant-made vaccines for use in veterinary medicine, including for livestock, pets, and wild animals. Written by top scientists in the field, it discusses the background to and latest scientific advances in plant-made vaccines for the most commonly targeted veterinary infections. With the recent high-profile research into recombinant plant-made therapeutics for Ebola and Zika viruses, it is likely that the products will be commercialized and widely used in the future. Plant-made therapeutics have a variety of advantages over those made in traditional systems; however, their most fruitful application may be in veterinary medicine, due to less stringent regulations and a greater need for low-cost products.


Book Synopsis Prospects of Plant-Based Vaccines in Veterinary Medicine by : Jacqueline MacDonald

Download or read book Prospects of Plant-Based Vaccines in Veterinary Medicine written by Jacqueline MacDonald and published by Springer. This book was released on 2018-07-03 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an in-depth explanation of the advantages and current limitations of recombinant plant-made vaccines for use in veterinary medicine, including for livestock, pets, and wild animals. Written by top scientists in the field, it discusses the background to and latest scientific advances in plant-made vaccines for the most commonly targeted veterinary infections. With the recent high-profile research into recombinant plant-made therapeutics for Ebola and Zika viruses, it is likely that the products will be commercialized and widely used in the future. Plant-made therapeutics have a variety of advantages over those made in traditional systems; however, their most fruitful application may be in veterinary medicine, due to less stringent regulations and a greater need for low-cost products.

Animal Parasites

Animal Parasites

Author: Heinz Mehlhorn

Publisher: Springer

Published: 2016-12-01

Total Pages: 730

ISBN-13: 3319464035

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This textbook focuses on the most important parasites affecting dogs, cats, ruminants, horses, pigs, rabbits, rodents, birds, fishes, reptiles and bees. For each parasite, the book offers a concise summary including its distribution, epidemiology, lifecycle, morphology, clinical manifestations, diagnosis, prophylaxis and therapeutic measures. Numerous informative tables and more than 500 color micrographs and schemes present the most important aspects of the parasites, their induced diseases and the latest information on suitable prevention and control measures. 100 questions at the end of the book offer readers the chance to test their comprehension. The book is well suited as both a textbook and a reference guide for veterinarians, students of the veterinary and life sciences, veterinarian nurses, laboratory staff, and pet and livestock owners.


Book Synopsis Animal Parasites by : Heinz Mehlhorn

Download or read book Animal Parasites written by Heinz Mehlhorn and published by Springer. This book was released on 2016-12-01 with total page 730 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook focuses on the most important parasites affecting dogs, cats, ruminants, horses, pigs, rabbits, rodents, birds, fishes, reptiles and bees. For each parasite, the book offers a concise summary including its distribution, epidemiology, lifecycle, morphology, clinical manifestations, diagnosis, prophylaxis and therapeutic measures. Numerous informative tables and more than 500 color micrographs and schemes present the most important aspects of the parasites, their induced diseases and the latest information on suitable prevention and control measures. 100 questions at the end of the book offer readers the chance to test their comprehension. The book is well suited as both a textbook and a reference guide for veterinarians, students of the veterinary and life sciences, veterinarian nurses, laboratory staff, and pet and livestock owners.

Toxoplasmosis of Animals and Humans

Toxoplasmosis of Animals and Humans

Author: J. P. Dubey

Publisher: CRC Press

Published: 2016-04-19

Total Pages: 336

ISBN-13: 1420092375

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Found worldwide from Alaska to Australasia, Toxoplasma gondii knows no geographic boundaries. The protozoan is the source of one of the most common parasitic infections in humans, livestock, companion animals, and wildlife, and has gained notoriety with its inclusion on the list of potential bioterrorism microbes. In the two decades since the publi


Book Synopsis Toxoplasmosis of Animals and Humans by : J. P. Dubey

Download or read book Toxoplasmosis of Animals and Humans written by J. P. Dubey and published by CRC Press. This book was released on 2016-04-19 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Found worldwide from Alaska to Australasia, Toxoplasma gondii knows no geographic boundaries. The protozoan is the source of one of the most common parasitic infections in humans, livestock, companion animals, and wildlife, and has gained notoriety with its inclusion on the list of potential bioterrorism microbes. In the two decades since the publi

Neosporosis in Animals

Neosporosis in Animals

Author: J.P. Dubey

Publisher: CRC Press

Published: 2017-07-12

Total Pages: 512

ISBN-13: 1351648608

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Key features: Written by the scientist who named this parasite and was the first to set up proper diagnostic techniques Serves as the first ever book to provide information on the parasite structure, biology, pathogenesis, clinical signs, epidemiology, prevention, and control of neosporosis Covers both approaches toward preventing & controlling this disease: Developing an efficacious vaccine and sound cattle management practices Contains a wealth of illustrations, including many of the author's original photographs of the parasite Provides basic information on immunologic and molecular aspects of the disease Abortion is a worldwide problem in the livestock industry accounting for annual economic losses of billions of dollars, and N. caninum is a major cause of it. Neosporosis is a newly recognized disease of animals. Until 1988 it was misdiagnosed as toxoplasmosis. Considerable progress in understanding the biology of neosporosis has been made in the last 30 years, resulting in more than 2,000 scientific publications. The economic importance of abortion in cattle, and the availability of knowledge, reagents, and technology used to study toxoplasmosis, have contributed to the rapid progress in understanding the biology of neosporosis. Written by pioneers in this field, Neosporosis in Animals presents a comprehensive summary of the biology of neosporosis, starting with chapter 1 on the historical background of the discovery of the disease. Subsequent chapters deal with general aspects of the biology of N. caninum (chapter 2), techniques (chapter 3), and the disease caused by this parasite in cattle (chapter 4), dogs (chapter 5), and all other animals including sheep, pigs, primates and humans (chapters 6-18). This book provides, for the first time in a single authoritative source, a complete account of the structure, biology, clinical disease, diagnosis, epidemiology, treatment, attempts at immunoprophylaxis, and control in all hosts. There are 175 illustrations and tables devoted to the life cycle, structure of parasitic stages, and lesions. More than 2100 references are cited, allowing the reader to locate additional information on specific topics in an efficient way. This book will be useful to a broad range of researchers in biology and veterinarians.


Book Synopsis Neosporosis in Animals by : J.P. Dubey

Download or read book Neosporosis in Animals written by J.P. Dubey and published by CRC Press. This book was released on 2017-07-12 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Key features: Written by the scientist who named this parasite and was the first to set up proper diagnostic techniques Serves as the first ever book to provide information on the parasite structure, biology, pathogenesis, clinical signs, epidemiology, prevention, and control of neosporosis Covers both approaches toward preventing & controlling this disease: Developing an efficacious vaccine and sound cattle management practices Contains a wealth of illustrations, including many of the author's original photographs of the parasite Provides basic information on immunologic and molecular aspects of the disease Abortion is a worldwide problem in the livestock industry accounting for annual economic losses of billions of dollars, and N. caninum is a major cause of it. Neosporosis is a newly recognized disease of animals. Until 1988 it was misdiagnosed as toxoplasmosis. Considerable progress in understanding the biology of neosporosis has been made in the last 30 years, resulting in more than 2,000 scientific publications. The economic importance of abortion in cattle, and the availability of knowledge, reagents, and technology used to study toxoplasmosis, have contributed to the rapid progress in understanding the biology of neosporosis. Written by pioneers in this field, Neosporosis in Animals presents a comprehensive summary of the biology of neosporosis, starting with chapter 1 on the historical background of the discovery of the disease. Subsequent chapters deal with general aspects of the biology of N. caninum (chapter 2), techniques (chapter 3), and the disease caused by this parasite in cattle (chapter 4), dogs (chapter 5), and all other animals including sheep, pigs, primates and humans (chapters 6-18). This book provides, for the first time in a single authoritative source, a complete account of the structure, biology, clinical disease, diagnosis, epidemiology, treatment, attempts at immunoprophylaxis, and control in all hosts. There are 175 illustrations and tables devoted to the life cycle, structure of parasitic stages, and lesions. More than 2100 references are cited, allowing the reader to locate additional information on specific topics in an efficient way. This book will be useful to a broad range of researchers in biology and veterinarians.