Translational Pain Research: Current status and new trends

Translational Pain Research: Current status and new trends

Author: Jianren Mao

Publisher: Nova Publishers

Published: 2006

Total Pages: 490

ISBN-13: 9781600212062

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Basic science and clinical pain research is particularly challenging for several reasons. First, pain is a subjective experience in response to nociception that follows actual or potential tissue damage. Since the ability to respond to this warning signal is essential for our survival, the nociceptive system that produces and transmits nociceptive signals is remarkably redundant and involves diffuse regions of the central nervous system. Second, unlike other sensory modalities, pain is a multi-dimensional experience including at least cognitive, affective, and sensory-discriminative components. Third, pain experiences can be influenced by psychological, socioeconomic, cultural, and genetic predispositions, making it exceedingly complicated to study pain and pain modulation. In this first volume, the current status and new trends of pain research are selectively discussed in order to take a critical and constructive look at the achievements of basic science research that have made significant differences in clinical pain management as well as the gaps between basic science research and clinical pain management.


Book Synopsis Translational Pain Research: Current status and new trends by : Jianren Mao

Download or read book Translational Pain Research: Current status and new trends written by Jianren Mao and published by Nova Publishers. This book was released on 2006 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic science and clinical pain research is particularly challenging for several reasons. First, pain is a subjective experience in response to nociception that follows actual or potential tissue damage. Since the ability to respond to this warning signal is essential for our survival, the nociceptive system that produces and transmits nociceptive signals is remarkably redundant and involves diffuse regions of the central nervous system. Second, unlike other sensory modalities, pain is a multi-dimensional experience including at least cognitive, affective, and sensory-discriminative components. Third, pain experiences can be influenced by psychological, socioeconomic, cultural, and genetic predispositions, making it exceedingly complicated to study pain and pain modulation. In this first volume, the current status and new trends of pain research are selectively discussed in order to take a critical and constructive look at the achievements of basic science research that have made significant differences in clinical pain management as well as the gaps between basic science research and clinical pain management.

Translational Pain Research: Comparing preclinical studies and clinical pain management. Lost in translation?

Translational Pain Research: Comparing preclinical studies and clinical pain management. Lost in translation?

Author: Jianren Mao

Publisher: Nova Publishers

Published: 2006

Total Pages: 370

ISBN-13: 9781600212055

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Basic science and clinical pain research is particularly challenging for several reasons. First, pain is a subjective experience in response to nociception that follows actual or potential tissue damage. Since the ability to respond to this warning signal is essential for our survival, the nociceptive system that produces and transmits nociceptive signals is remarkably redundant and involves diffuse regions of the central nervous system. Second, unlike other sensory modalities, pain is a multi-dimensional experience including at least cognitive, affective, and sensory-discriminative components. Third, pain experiences can be influenced by psychological, socioeconomic, cultural, and genetic predispositions, making it exceedingly complicated to study pain and pain modulation. The topics covered in this volume are carefully selected and directly related to the daily practice of pain medicine. These topics include 1) central mechanisms of pain and pain modulation (Dickenson, Donovan-Rodriguez, Mattews) and clinical use of ion channel blockers (Chen); 2) spinal glutamatergic mechanisms (Guo, Dubner, Ren) and issues related to glutamate receptor antagonists in pain management (Mao); 3) basic science of opioid analgesics (Gintzler, Chakrabarti) and clinical opioid use (Smith, McCleane); 4) inflammatory cytokines (Samad) and clinical use of anti-inflammatory drugs (Fink, Brenner); 5) role of the sympathetic nervous system in pain mechanisms and its relation to clinical pain management (Sharma, Raja); 6) preclinical studies on tricyclic antidepressants (Gerner, Wang) and clinical use of antidepressants in pain management (Greenberg); 7) developing pain pathways and analgesic mechanisms during the developmental stage (Fitzgerald) and challenges of pediatric pain management (Lebel); 8) basic science mechanisms of serotonin agonists and their use in the clinical management of migraine headache (Biondi); 9) clinical research on gender differences in clinical pain and their implications for clinical pain management (Holdcroft); 10) current modalities of clinical cancer pain management (Popescu, Hord); and 11) preclinical and clinical information on alternative medicine (Chen).


Book Synopsis Translational Pain Research: Comparing preclinical studies and clinical pain management. Lost in translation? by : Jianren Mao

Download or read book Translational Pain Research: Comparing preclinical studies and clinical pain management. Lost in translation? written by Jianren Mao and published by Nova Publishers. This book was released on 2006 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic science and clinical pain research is particularly challenging for several reasons. First, pain is a subjective experience in response to nociception that follows actual or potential tissue damage. Since the ability to respond to this warning signal is essential for our survival, the nociceptive system that produces and transmits nociceptive signals is remarkably redundant and involves diffuse regions of the central nervous system. Second, unlike other sensory modalities, pain is a multi-dimensional experience including at least cognitive, affective, and sensory-discriminative components. Third, pain experiences can be influenced by psychological, socioeconomic, cultural, and genetic predispositions, making it exceedingly complicated to study pain and pain modulation. The topics covered in this volume are carefully selected and directly related to the daily practice of pain medicine. These topics include 1) central mechanisms of pain and pain modulation (Dickenson, Donovan-Rodriguez, Mattews) and clinical use of ion channel blockers (Chen); 2) spinal glutamatergic mechanisms (Guo, Dubner, Ren) and issues related to glutamate receptor antagonists in pain management (Mao); 3) basic science of opioid analgesics (Gintzler, Chakrabarti) and clinical opioid use (Smith, McCleane); 4) inflammatory cytokines (Samad) and clinical use of anti-inflammatory drugs (Fink, Brenner); 5) role of the sympathetic nervous system in pain mechanisms and its relation to clinical pain management (Sharma, Raja); 6) preclinical studies on tricyclic antidepressants (Gerner, Wang) and clinical use of antidepressants in pain management (Greenberg); 7) developing pain pathways and analgesic mechanisms during the developmental stage (Fitzgerald) and challenges of pediatric pain management (Lebel); 8) basic science mechanisms of serotonin agonists and their use in the clinical management of migraine headache (Biondi); 9) clinical research on gender differences in clinical pain and their implications for clinical pain management (Holdcroft); 10) current modalities of clinical cancer pain management (Popescu, Hord); and 11) preclinical and clinical information on alternative medicine (Chen).

Relieving Pain in America

Relieving Pain in America

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2011-10-26

Total Pages: 383

ISBN-13: 030921484X

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Chronic pain costs the nation up to $635 billion each year in medical treatment and lost productivity. The 2010 Patient Protection and Affordable Care Act required the Department of Health and Human Services (HHS) to enlist the Institute of Medicine (IOM) in examining pain as a public health problem. In this report, the IOM offers a blueprint for action in transforming prevention, care, education, and research, with the goal of providing relief for people with pain in America. To reach the vast multitude of people with various types of pain, the nation must adopt a population-level prevention and management strategy. The IOM recommends that HHS develop a comprehensive plan with specific goals, actions, and timeframes. Better data are needed to help shape efforts, especially on the groups of people currently underdiagnosed and undertreated, and the IOM encourages federal and state agencies and private organizations to accelerate the collection of data on pain incidence, prevalence, and treatments. Because pain varies from patient to patient, healthcare providers should increasingly aim at tailoring pain care to each person's experience, and self-management of pain should be promoted. In addition, because there are major gaps in knowledge about pain across health care and society alike, the IOM recommends that federal agencies and other stakeholders redesign education programs to bridge these gaps. Pain is a major driver for visits to physicians, a major reason for taking medications, a major cause of disability, and a key factor in quality of life and productivity. Given the burden of pain in human lives, dollars, and social consequences, relieving pain should be a national priority.


Book Synopsis Relieving Pain in America by : Institute of Medicine

Download or read book Relieving Pain in America written by Institute of Medicine and published by National Academies Press. This book was released on 2011-10-26 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic pain costs the nation up to $635 billion each year in medical treatment and lost productivity. The 2010 Patient Protection and Affordable Care Act required the Department of Health and Human Services (HHS) to enlist the Institute of Medicine (IOM) in examining pain as a public health problem. In this report, the IOM offers a blueprint for action in transforming prevention, care, education, and research, with the goal of providing relief for people with pain in America. To reach the vast multitude of people with various types of pain, the nation must adopt a population-level prevention and management strategy. The IOM recommends that HHS develop a comprehensive plan with specific goals, actions, and timeframes. Better data are needed to help shape efforts, especially on the groups of people currently underdiagnosed and undertreated, and the IOM encourages federal and state agencies and private organizations to accelerate the collection of data on pain incidence, prevalence, and treatments. Because pain varies from patient to patient, healthcare providers should increasingly aim at tailoring pain care to each person's experience, and self-management of pain should be promoted. In addition, because there are major gaps in knowledge about pain across health care and society alike, the IOM recommends that federal agencies and other stakeholders redesign education programs to bridge these gaps. Pain is a major driver for visits to physicians, a major reason for taking medications, a major cause of disability, and a key factor in quality of life and productivity. Given the burden of pain in human lives, dollars, and social consequences, relieving pain should be a national priority.

Pain Models

Pain Models

Author: Hermann Otto Handwerker

Publisher:

Published: 2013

Total Pages: 0

ISBN-13: 9780931092947

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The neurobiology and mechanisms discovered in animals often do not translate to patients with a chronic pain condition. To help researchers and clinicians develop and use models that can help translate data from animals into humans, this book presents experimental animal models, with a focus on how they may translate into humans human experimental pain models, including details about pain induction and assessment human surrogate pain models clinical applications of pain models models that may link mechanisms of pain and pruritus Pain Models contains 29 chapters by internationally recognized experts. It is a comprehensive survey of pain models at different levels, and commentaries by clinicians directly address clinical perspectives. This unique book is unprecedented in its content. It's a quick reminder of the hard work needed to investigate the complex issue of pain perception. With the advent of increasingly sensitive noninvasive investigational tools, the authors want readers to know that basic research is still needed to help develop new drugs. This book will enrich anyone who wishes to know all that goes into conducting pain research with a lab-based pain model. -- Tariq Malik, MD (University of Chicago Pritzker School of Medicine) (c) Copyright Doody's Review Service


Book Synopsis Pain Models by : Hermann Otto Handwerker

Download or read book Pain Models written by Hermann Otto Handwerker and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The neurobiology and mechanisms discovered in animals often do not translate to patients with a chronic pain condition. To help researchers and clinicians develop and use models that can help translate data from animals into humans, this book presents experimental animal models, with a focus on how they may translate into humans human experimental pain models, including details about pain induction and assessment human surrogate pain models clinical applications of pain models models that may link mechanisms of pain and pruritus Pain Models contains 29 chapters by internationally recognized experts. It is a comprehensive survey of pain models at different levels, and commentaries by clinicians directly address clinical perspectives. This unique book is unprecedented in its content. It's a quick reminder of the hard work needed to investigate the complex issue of pain perception. With the advent of increasingly sensitive noninvasive investigational tools, the authors want readers to know that basic research is still needed to help develop new drugs. This book will enrich anyone who wishes to know all that goes into conducting pain research with a lab-based pain model. -- Tariq Malik, MD (University of Chicago Pritzker School of Medicine) (c) Copyright Doody's Review Service

Translational Research in Pain and Itch

Translational Research in Pain and Itch

Author: Chao Ma

Publisher: Springer

Published: 2024-02-03

Total Pages: 0

ISBN-13: 9789819989201

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This book provides a comprehensive review of the latest advances in translational pain and itch research, and presents the cutting-edge developments in the study of our two principal, yet most mysteries sensations. Despite the slow progress in the discovery of effective therapies for chronic pain and pruritus, scientists around the globe now have a better understanding of why and how these conditions occur. Based on these findings, a series of novel treatment strategies are currently under development, and hopefully in a few years, medical practitioners will become more confident and optimistic when facing patients with these annoying and sometimes severe disorders. The contributing authors are world-renowned research scientists, who have made significant discoveries. The book is of interest to neuroscientists, neurologists and pharmacologists in both clinical and basic medical research field. Comparing to the last published version, five existing chapters will be updated. Five new chapters will be added to reflect the lasted developments in the related field of research.


Book Synopsis Translational Research in Pain and Itch by : Chao Ma

Download or read book Translational Research in Pain and Itch written by Chao Ma and published by Springer. This book was released on 2024-02-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive review of the latest advances in translational pain and itch research, and presents the cutting-edge developments in the study of our two principal, yet most mysteries sensations. Despite the slow progress in the discovery of effective therapies for chronic pain and pruritus, scientists around the globe now have a better understanding of why and how these conditions occur. Based on these findings, a series of novel treatment strategies are currently under development, and hopefully in a few years, medical practitioners will become more confident and optimistic when facing patients with these annoying and sometimes severe disorders. The contributing authors are world-renowned research scientists, who have made significant discoveries. The book is of interest to neuroscientists, neurologists and pharmacologists in both clinical and basic medical research field. Comparing to the last published version, five existing chapters will be updated. Five new chapters will be added to reflect the lasted developments in the related field of research.

Translational Pain Research

Translational Pain Research

Author: Lawrence Kruger

Publisher: CRC Press

Published: 2009-11-24

Total Pages: 458

ISBN-13: 1439812101

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One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practical


Book Synopsis Translational Pain Research by : Lawrence Kruger

Download or read book Translational Pain Research written by Lawrence Kruger and published by CRC Press. This book was released on 2009-11-24 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practical

Pain - E-Book

Pain - E-Book

Author: Hubert van Griensven

Publisher: Elsevier Health Sciences

Published: 2022-12-10

Total Pages: 449

ISBN-13: 0323870341

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Pain: A textbook for health professionals provides a comprehensive guide to pain and pain management with a focus on interprofessional practice. Written by internationally acclaimed authors and fully updated to reflect latest evidence and understanding, this book bridges the gap between theoretical underpinning and practice for assessment and management of patients with persistent pain – all in clear and accessible language. Now in its third edition, the text emphasises personal aspects of pain and the therapeutic alliance, as well as social and cultural aspects of pain, pain education for patients, and multidisciplinary and interdisciplinary working. It will provide both students and clinicians with a new lens through which to understand a person’s pain experience, as well as tools for effective management. Comprehensive information about all aspects of pain and pain management Relevant to a wide audience – suitable for physiotherapists, occupational therapists, social workers, nurses and GPs, as well as undergraduate students Factual and informative for clinicians in everyday practice Includes information on acute as well as chronic pain New chapters on communication, the language of pain, pain education for patients, multidisciplinary and interdisciplinary working, and inequities in pain including pain in low- and middle-income countries and amongst indigenous peoples Updated chapters with new information about the psychology of pain Now with full colour artworks and page design


Book Synopsis Pain - E-Book by : Hubert van Griensven

Download or read book Pain - E-Book written by Hubert van Griensven and published by Elsevier Health Sciences. This book was released on 2022-12-10 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain: A textbook for health professionals provides a comprehensive guide to pain and pain management with a focus on interprofessional practice. Written by internationally acclaimed authors and fully updated to reflect latest evidence and understanding, this book bridges the gap between theoretical underpinning and practice for assessment and management of patients with persistent pain – all in clear and accessible language. Now in its third edition, the text emphasises personal aspects of pain and the therapeutic alliance, as well as social and cultural aspects of pain, pain education for patients, and multidisciplinary and interdisciplinary working. It will provide both students and clinicians with a new lens through which to understand a person’s pain experience, as well as tools for effective management. Comprehensive information about all aspects of pain and pain management Relevant to a wide audience – suitable for physiotherapists, occupational therapists, social workers, nurses and GPs, as well as undergraduate students Factual and informative for clinicians in everyday practice Includes information on acute as well as chronic pain New chapters on communication, the language of pain, pain education for patients, multidisciplinary and interdisciplinary working, and inequities in pain including pain in low- and middle-income countries and amongst indigenous peoples Updated chapters with new information about the psychology of pain Now with full colour artworks and page design

Spine Pain Care

Spine Pain Care

Author: Jianren Mao

Publisher: Springer Nature

Published: 2019-11-07

Total Pages: 546

ISBN-13: 3030274470

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This multi-faceted book provides readers with comprehensive guidance to spine pain care. Unique in structure, the contents integrate various specialties involved in spine pain care, thereby bringing in new prospective and expanding readership. This six part reference begins with a review on the epidemiology and economic impacts that present clinical and financial challenges for spine pain care. Part two then brings the reader into a review of the anatomy, pathophysiology, and etiology of spine pain. Subsequent parts then dive into clinical evaluation tactics, unique disease conditions and treatment options. Finally, the book closes with two chapters discussing the challenges of spine pain medicine and the potential future directions of the field. Written by experts in their respective fields, Spine Pain Care - A Comprehensive Clinical Guide is a first-of-its-kind, barrier breaking work designed for all professionals involved in spine pain care, including physicians and nurses, as well as medical students, residents and fellows as a supplementary educational material.


Book Synopsis Spine Pain Care by : Jianren Mao

Download or read book Spine Pain Care written by Jianren Mao and published by Springer Nature. This book was released on 2019-11-07 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: This multi-faceted book provides readers with comprehensive guidance to spine pain care. Unique in structure, the contents integrate various specialties involved in spine pain care, thereby bringing in new prospective and expanding readership. This six part reference begins with a review on the epidemiology and economic impacts that present clinical and financial challenges for spine pain care. Part two then brings the reader into a review of the anatomy, pathophysiology, and etiology of spine pain. Subsequent parts then dive into clinical evaluation tactics, unique disease conditions and treatment options. Finally, the book closes with two chapters discussing the challenges of spine pain medicine and the potential future directions of the field. Written by experts in their respective fields, Spine Pain Care - A Comprehensive Clinical Guide is a first-of-its-kind, barrier breaking work designed for all professionals involved in spine pain care, including physicians and nurses, as well as medical students, residents and fellows as a supplementary educational material.

American Book Publishing Record

American Book Publishing Record

Author:

Publisher:

Published: 2006

Total Pages: 754

ISBN-13:

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Book Synopsis American Book Publishing Record by :

Download or read book American Book Publishing Record written by and published by . This book was released on 2006 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Translational Side of Emerging Invasive and Non-Invasive Stimulation Therapies

Translational Side of Emerging Invasive and Non-Invasive Stimulation Therapies

Author: Jiande Chen

Publisher: Frontiers Media SA

Published: 2022-02-25

Total Pages: 188

ISBN-13: 288974535X

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Book Synopsis Translational Side of Emerging Invasive and Non-Invasive Stimulation Therapies by : Jiande Chen

Download or read book Translational Side of Emerging Invasive and Non-Invasive Stimulation Therapies written by Jiande Chen and published by Frontiers Media SA. This book was released on 2022-02-25 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: