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This book reviews the current knowledge on tunable hydrogels, including the range of different materials and applications, as well as the existing challenges and limitations in the field. It covers various aspects of the material design, particularly highlighting biological responsiveness, degradability and responsiveness to external stimuli. In this book, readers will discover original research data and state-of-the-art reviews in the area of hydrogel technology, with a specific focus on biotechnology and medicine. Written by leading experts, the contributions outline strategies for designing tunable hydrogels and offer a detailed evaluation of the physical and synthetic methods currently employed to achieve specific hydrogel properties and responsiveness. This highly informative book provides important theoretical and practical insights for scholars and researchers working with hydrogels for biomedical and biotechnological applications.
Book Synopsis Tunable Hydrogels by : Antonina Lavrentieva
Download or read book Tunable Hydrogels written by Antonina Lavrentieva and published by Springer Nature. This book was released on 2021-05-31 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the current knowledge on tunable hydrogels, including the range of different materials and applications, as well as the existing challenges and limitations in the field. It covers various aspects of the material design, particularly highlighting biological responsiveness, degradability and responsiveness to external stimuli. In this book, readers will discover original research data and state-of-the-art reviews in the area of hydrogel technology, with a specific focus on biotechnology and medicine. Written by leading experts, the contributions outline strategies for designing tunable hydrogels and offer a detailed evaluation of the physical and synthetic methods currently employed to achieve specific hydrogel properties and responsiveness. This highly informative book provides important theoretical and practical insights for scholars and researchers working with hydrogels for biomedical and biotechnological applications.
The extracellular matrix is highly influential in regulating cell fate and function in vivo. Biophysical cues from the microenvironment are involved in nearly every cellular phenomenon, from initial embryogenesis to diseases such as atherosclerosis and cancer. This dissertation seeks to develop 3D hydrogel models to more accurately recapitulate the in vivo microenvironment by allowing for temporal modulation of stiffness. A strategy is presented to spatially and temporally tune the mechanical properties of 3D alginate-based hydrogels using a light-triggered mechanism. This approach is demonstrated to be cytocompatible and highly tunable. The system is employed to elucidate the morphological response of fibroblasts to stiffening 3D environments. Additionally, the platform is translated to an in vivo application of transdermal gel modulation. Finally, the phototunable hydrogels are used to evaluate the effect of matrix stiffening on breast epithelial cells in a mechanical environment that mimics tumor stiffening. Changes in the mechanical properties of the gel induce phenotypic changes to MCF10A epithelial cells, including collective cell migration from the mammary acini. This system is broadly applicable to the biomaterials community and could shed light on a number of outstanding biological questions.
Book Synopsis Dynamic Photo-tunable Hydrogels for Temporal Modulation of Matrix Mechanical Properties by : Ryan Scott Stowers
Download or read book Dynamic Photo-tunable Hydrogels for Temporal Modulation of Matrix Mechanical Properties written by Ryan Scott Stowers and published by . This book was released on 2014 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extracellular matrix is highly influential in regulating cell fate and function in vivo. Biophysical cues from the microenvironment are involved in nearly every cellular phenomenon, from initial embryogenesis to diseases such as atherosclerosis and cancer. This dissertation seeks to develop 3D hydrogel models to more accurately recapitulate the in vivo microenvironment by allowing for temporal modulation of stiffness. A strategy is presented to spatially and temporally tune the mechanical properties of 3D alginate-based hydrogels using a light-triggered mechanism. This approach is demonstrated to be cytocompatible and highly tunable. The system is employed to elucidate the morphological response of fibroblasts to stiffening 3D environments. Additionally, the platform is translated to an in vivo application of transdermal gel modulation. Finally, the phototunable hydrogels are used to evaluate the effect of matrix stiffening on breast epithelial cells in a mechanical environment that mimics tumor stiffening. Changes in the mechanical properties of the gel induce phenotypic changes to MCF10A epithelial cells, including collective cell migration from the mammary acini. This system is broadly applicable to the biomaterials community and could shed light on a number of outstanding biological questions.
The first comprehensive survey of state-of-the-art tunable micro-optics, covering advances in materials, components and systems.
Book Synopsis Tunable Micro-optics by : Hans P. Zappe
Download or read book Tunable Micro-optics written by Hans P. Zappe and published by Cambridge University Press. This book was released on 2016 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first comprehensive survey of state-of-the-art tunable micro-optics, covering advances in materials, components and systems.
This book introduces readers to the latest advances in hydrogel biomaterials, mainly focusing on the emerging areas of synthetic and biopolymer hydrogels formed through specially designed chemical or physical crosslinking, and the cyclodextrin-based host-guest supramolecular self-assembly, for cell encapsulation, cell expansion, cell differentiation and tissue repair, stem cell culture, and cellular therapy and drug delivery applications. The book was written by experts at the forefront of these interdisciplinary areas and is intended for all researchers working in the fields of biomaterials and biomedical engineering, as well as medical professions. Jun Li is a Professor at the Department of Biomedical Engineering, National University of Singapore, Singapore. Yoshihito Osada is a Professor at RIKEN Advanced Science Institute, Japan. Justin Cooper-White is a Professor at the Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Australia.
Book Synopsis Functional Hydrogels as Biomaterials by : Jun Li
Download or read book Functional Hydrogels as Biomaterials written by Jun Li and published by Springer. This book was released on 2018-07-17 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces readers to the latest advances in hydrogel biomaterials, mainly focusing on the emerging areas of synthetic and biopolymer hydrogels formed through specially designed chemical or physical crosslinking, and the cyclodextrin-based host-guest supramolecular self-assembly, for cell encapsulation, cell expansion, cell differentiation and tissue repair, stem cell culture, and cellular therapy and drug delivery applications. The book was written by experts at the forefront of these interdisciplinary areas and is intended for all researchers working in the fields of biomaterials and biomedical engineering, as well as medical professions. Jun Li is a Professor at the Department of Biomedical Engineering, National University of Singapore, Singapore. Yoshihito Osada is a Professor at RIKEN Advanced Science Institute, Japan. Justin Cooper-White is a Professor at the Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Australia.
Polymeric Gels: Characterization, Properties and Biomedical Applications covers the fundamentals and applications of polymeric gels. Particular emphasis is given to their synthesis, properties and characteristics, with topics such as natural, synthetic, and smart polymeric gels, medical applications, and advancements in conductive and magnetic gels presented. The book covers the basics and applications of hydrogels, providing readers with a comprehensive guide on the types of polymeric gels used in the field of biomedical engineering. Provides guidance for decisions on the suitability and appropriateness of a synthetic route and characterization technique for particular polymeric networks Analyzes and compares experimental data Presents in-depth information on the physical properties of polymeric gels using mathematical models Uses an interdisciplinary approach to discuss potential new applications for both established polymeric gels and recent advances
Book Synopsis Polymeric Gels by : Kunal Pal
Download or read book Polymeric Gels written by Kunal Pal and published by Woodhead Publishing. This book was released on 2018-06-15 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymeric Gels: Characterization, Properties and Biomedical Applications covers the fundamentals and applications of polymeric gels. Particular emphasis is given to their synthesis, properties and characteristics, with topics such as natural, synthetic, and smart polymeric gels, medical applications, and advancements in conductive and magnetic gels presented. The book covers the basics and applications of hydrogels, providing readers with a comprehensive guide on the types of polymeric gels used in the field of biomedical engineering. Provides guidance for decisions on the suitability and appropriateness of a synthetic route and characterization technique for particular polymeric networks Analyzes and compares experimental data Presents in-depth information on the physical properties of polymeric gels using mathematical models Uses an interdisciplinary approach to discuss potential new applications for both established polymeric gels and recent advances
Full-thickness skin equivalents used as grafts for the replacement of damaged skin or for the establishment of in vitro skin models are composed of an epidermal layer seeded on top of a dermal compartment. While collagen is principally used as matrix to form the dermal equivalent, materials from animal sources still elicit an ethical dilemma, have weak mechanical properties, batch-to-batch variability and present risk of pathogen transfer. The use of synthetic materials as scaffolds could overcome these disadvantages. Poly(ethylene glycol) (PEG) hydrogels have been extensively used in tissue engineering applications, owing to their biocompatibility and tunable mechanical properties. However, their bio-inert properties require them to be associated with other functional moieties. We propose here to reticulate PEG molecules with poly-L-lysine dendrigrafts (DGL) that, beside serving as multifunctional crosslinkers, could provide inherent biological properties such as cell adhesion to PEG-based hydrogels. To judge the hydrogel's potential as a substrate for biological applications, the cellular response to the material surface, in relation to its composition, was determined. Subsequently, particulate leaching was evaluated as a simple fabrication technique to render the hydrogels porous and allow cell infiltration and colonization in three-dimensions, in view of forming a dermal equivalent. The resulting tissues were investigated in the context of full-thickness skin equivalents. Furthermore, a synthetic elastin-like polypeptide was incorporated to the hydrogels to increase their bioactivity and elastic properties. Finally, in vivo biocompatibility was assessed by subcutaneous implantation in mice.
Book Synopsis Development of a Novel Tunable Hydrogel to Support Tissue Formation in the Context of Full-thickness Skin Equivalents by : Mariana Carranca Palomo
Download or read book Development of a Novel Tunable Hydrogel to Support Tissue Formation in the Context of Full-thickness Skin Equivalents written by Mariana Carranca Palomo and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Full-thickness skin equivalents used as grafts for the replacement of damaged skin or for the establishment of in vitro skin models are composed of an epidermal layer seeded on top of a dermal compartment. While collagen is principally used as matrix to form the dermal equivalent, materials from animal sources still elicit an ethical dilemma, have weak mechanical properties, batch-to-batch variability and present risk of pathogen transfer. The use of synthetic materials as scaffolds could overcome these disadvantages. Poly(ethylene glycol) (PEG) hydrogels have been extensively used in tissue engineering applications, owing to their biocompatibility and tunable mechanical properties. However, their bio-inert properties require them to be associated with other functional moieties. We propose here to reticulate PEG molecules with poly-L-lysine dendrigrafts (DGL) that, beside serving as multifunctional crosslinkers, could provide inherent biological properties such as cell adhesion to PEG-based hydrogels. To judge the hydrogel's potential as a substrate for biological applications, the cellular response to the material surface, in relation to its composition, was determined. Subsequently, particulate leaching was evaluated as a simple fabrication technique to render the hydrogels porous and allow cell infiltration and colonization in three-dimensions, in view of forming a dermal equivalent. The resulting tissues were investigated in the context of full-thickness skin equivalents. Furthermore, a synthetic elastin-like polypeptide was incorporated to the hydrogels to increase their bioactivity and elastic properties. Finally, in vivo biocompatibility was assessed by subcutaneous implantation in mice.
Multifunctional Hydrogels for Biomedical Applications Comprehensive resource presenting a thorough overview of the biomedical applications of hydrogels This book provides an overview of the development and applications of the clinically relevant hydrogels that are used particularly in tissue engineering, regenerative medicine, and drug delivery. Taking a multidisciplinary approach, it goes through the material from chemistry, materials science, biology, medicine, nanotechnology, and bioengineering points of view. Sample topics covered by the three well-qualified editors include: The design, functions, and developments of hydrogels Proteins and polysaccharides that mimic extracellular matrix Generation and applications of supramolecular hydrogels Design and functions of cell encapsulation systems Multifunctional Hydrogels for Biomedical Applications is a useful all-in-one reference work for materials scientists, polymer chemists, and bioengineers which provides a comprehensive, contemporary understanding of hydrogels and their applications targeting a wide variety of pathologies.
Book Synopsis Multifunctional Hydrogels for Biomedical Applications by : Ricardo A. Pires
Download or read book Multifunctional Hydrogels for Biomedical Applications written by Ricardo A. Pires and published by John Wiley & Sons. This book was released on 2022-05-31 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multifunctional Hydrogels for Biomedical Applications Comprehensive resource presenting a thorough overview of the biomedical applications of hydrogels This book provides an overview of the development and applications of the clinically relevant hydrogels that are used particularly in tissue engineering, regenerative medicine, and drug delivery. Taking a multidisciplinary approach, it goes through the material from chemistry, materials science, biology, medicine, nanotechnology, and bioengineering points of view. Sample topics covered by the three well-qualified editors include: The design, functions, and developments of hydrogels Proteins and polysaccharides that mimic extracellular matrix Generation and applications of supramolecular hydrogels Design and functions of cell encapsulation systems Multifunctional Hydrogels for Biomedical Applications is a useful all-in-one reference work for materials scientists, polymer chemists, and bioengineers which provides a comprehensive, contemporary understanding of hydrogels and their applications targeting a wide variety of pathologies.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Book Synopsis Synthesis of Novel Hydrogels with Unique Mechanical Properties by : Yi Cao
Download or read book Synthesis of Novel Hydrogels with Unique Mechanical Properties written by Yi Cao and published by Frontiers Media SA. This book was released on 2020-12-23 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
This book covers a broad area of engineering research in translational medicine. Leaders in academic institutions around the world contributed focused chapters on a broad array of topics such as: cell and tissue engineering (6 chapters), genetic and protein engineering (10 chapters), nanoengineering (10 chapters), biomedical instrumentation (4 chapters), and theranostics and other novel approaches (4 chapters). Each chapter is a stand-alone review that summarizes the state-of-the-art of the specific research area. Engineering in Translational Medicine gives readers a comprehensive and in-depth overview of a broad array of related research areas, making this an excellent reference book for scientists and students both new to engineering/translational medicine and currently working in this area. The ability for engineering approaches to change biomedical research are increasing and having significant impact. Development of basic assays and their numerous applications are allowing for many new discoveries and should eventually impact human health. This book brings together many diverse yet related topics to give the reader a solid overview of many important areas that are not found together elsewhere. Dr. Weibo Cai has taken great care to select key research leaders of many sub-disciplines who have put together very detailed chapters that are easy to read yet highly rich in content. _______________ This book brings together many diverse yet related topics to give the reader a solid overview of many important areas that are not found together elsewhere. Dr. Weibo Cai has taken great care to select key research leaders of many sub-disciplines who have put together very detailed chapters that are easy to read yet highly rich in content. It is very exciting to see such a great set of chapters all together to allow one to have a key understanding of many different areas including cell, gene, protein, and nano engineering as well as the emerging field of theranostics. I am sure the readers will find this collection of important chapters helpful in their own research and understanding of how engineering has and will continue to play a critical role in biomedical research and clinical translation. Sanjiv Sam Gambhir M.D., Ph.D. Stanford University, USA Engineering in Translational Medicine is a landmark book bridging the fields of engineering and medicine with a focus on translational technologies and methods. In a single, well-coordinated volume, this book brings together contributions from a strong and international scientific cast, broadly covering the topics. The book captures the tremendous opportunities made possible by recent developments in bioengineering, and highlights the potential impact of these advances across a broad spectrum of pressing health care needs. The book can equally serve as a text for graduate level courses, a reference source, a book to be dipped into for pleasure by those working within the field, or a cover-to-cover read for those wanting a comprehensive, yet readable introduction to the current state of engineering advances and how they are impacting translational medicine. Simon R. Cherry, Ph.D. University of California, Davis, USA
Book Synopsis Engineering in Translational Medicine by : Weibo Cai
Download or read book Engineering in Translational Medicine written by Weibo Cai and published by Springer Science & Business Media. This book was released on 2013-12-19 with total page 997 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers a broad area of engineering research in translational medicine. Leaders in academic institutions around the world contributed focused chapters on a broad array of topics such as: cell and tissue engineering (6 chapters), genetic and protein engineering (10 chapters), nanoengineering (10 chapters), biomedical instrumentation (4 chapters), and theranostics and other novel approaches (4 chapters). Each chapter is a stand-alone review that summarizes the state-of-the-art of the specific research area. Engineering in Translational Medicine gives readers a comprehensive and in-depth overview of a broad array of related research areas, making this an excellent reference book for scientists and students both new to engineering/translational medicine and currently working in this area. The ability for engineering approaches to change biomedical research are increasing and having significant impact. Development of basic assays and their numerous applications are allowing for many new discoveries and should eventually impact human health. This book brings together many diverse yet related topics to give the reader a solid overview of many important areas that are not found together elsewhere. Dr. Weibo Cai has taken great care to select key research leaders of many sub-disciplines who have put together very detailed chapters that are easy to read yet highly rich in content. _______________ This book brings together many diverse yet related topics to give the reader a solid overview of many important areas that are not found together elsewhere. Dr. Weibo Cai has taken great care to select key research leaders of many sub-disciplines who have put together very detailed chapters that are easy to read yet highly rich in content. It is very exciting to see such a great set of chapters all together to allow one to have a key understanding of many different areas including cell, gene, protein, and nano engineering as well as the emerging field of theranostics. I am sure the readers will find this collection of important chapters helpful in their own research and understanding of how engineering has and will continue to play a critical role in biomedical research and clinical translation. Sanjiv Sam Gambhir M.D., Ph.D. Stanford University, USA Engineering in Translational Medicine is a landmark book bridging the fields of engineering and medicine with a focus on translational technologies and methods. In a single, well-coordinated volume, this book brings together contributions from a strong and international scientific cast, broadly covering the topics. The book captures the tremendous opportunities made possible by recent developments in bioengineering, and highlights the potential impact of these advances across a broad spectrum of pressing health care needs. The book can equally serve as a text for graduate level courses, a reference source, a book to be dipped into for pleasure by those working within the field, or a cover-to-cover read for those wanting a comprehensive, yet readable introduction to the current state of engineering advances and how they are impacting translational medicine. Simon R. Cherry, Ph.D. University of California, Davis, USA
This book is the second of two volumes that together offer a comprehensive account of cutting-edge advances in the development of biomaterials for use within tissue engineering and regenerative medicine. In this volume, which is devoted to biomimetic biomaterials, the opening section discusses bone regeneration by means of duck’s feet-derived collagen scaffold and the use of decellularized extracellular matrices. The role of various novel biomimetic hydrogels in regenerative medicine is then considered in detail. The third section focuses on the control of stem cell fate by biomimetic biomaterials, covering exosome-integrated biomaterials for bone regeneration, cellular responses to materials for biomedical engineering, and the regulation of stem cell functions by micropatterned structures. Finally, the use of nano-intelligent biocomposites in regenerative medicine is addressed, with discussion of, for example, recent advances in biphasic calcium phosphate bioceramics and blood-contacting polymeric biomaterials. The authors are recognized experts in the interdisciplinary field of regenerative medicine and the book will be of value for all with an interest in regenerative medicine based on biomaterials.
Book Synopsis Biomimicked Biomaterials by : Heung Jae Chun
Download or read book Biomimicked Biomaterials written by Heung Jae Chun and published by Springer Nature. This book was released on 2020-06-29 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the second of two volumes that together offer a comprehensive account of cutting-edge advances in the development of biomaterials for use within tissue engineering and regenerative medicine. In this volume, which is devoted to biomimetic biomaterials, the opening section discusses bone regeneration by means of duck’s feet-derived collagen scaffold and the use of decellularized extracellular matrices. The role of various novel biomimetic hydrogels in regenerative medicine is then considered in detail. The third section focuses on the control of stem cell fate by biomimetic biomaterials, covering exosome-integrated biomaterials for bone regeneration, cellular responses to materials for biomedical engineering, and the regulation of stem cell functions by micropatterned structures. Finally, the use of nano-intelligent biocomposites in regenerative medicine is addressed, with discussion of, for example, recent advances in biphasic calcium phosphate bioceramics and blood-contacting polymeric biomaterials. The authors are recognized experts in the interdisciplinary field of regenerative medicine and the book will be of value for all with an interest in regenerative medicine based on biomaterials.
