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Two Decades of Adult T-cell Leukemia and HTLV-I Research

Author: Kazuo Sugamura

Publisher: S. Karger AG (Switzerland)

Published: 2003

Total Pages: 394

ISBN-13:

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In April 2001, the Japanese Cancer Association was privileged to host a symposium in Kyoto to commemorate the twentieth anniversary of the discovery of the viral pathogenesis of adult T-cell leukemia (ATL). In this monograph, the editors have selected not only papers presented at the symposium but also eminent papers of several individuals from around the world who have extensively researched human T-cell-leukemia virus type I (HTLV-I), the etiological virus of ATL, over the years. During the last two decades, HTLV-I was molecularly characterized as harboring a variety of oncogenic properties in its Tax protein. Epidemiological studies not only revealed the existence of HTLV-I-endemic areas in the world, but also disclosed the routes of transmission. Despite these great strides, the mechanisms of ATL development have not yet been fully clarified, and viable therapeutic measures are still to be established. This monograph contains recent exciting achievements in molecular virology, epidemiology, immunology and therapeutic trials as well as historical profiles of HTLV-I and HTLV-I-associated diseases.

Book Synopsis Two Decades of Adult T-cell Leukemia and HTLV-I Research by : Kazuo Sugamura

Download or read book Two Decades of Adult T-cell Leukemia and HTLV-I Research written by Kazuo Sugamura and published by S. Karger AG (Switzerland). This book was released on 2003 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: In April 2001, the Japanese Cancer Association was privileged to host a symposium in Kyoto to commemorate the twentieth anniversary of the discovery of the viral pathogenesis of adult T-cell leukemia (ATL). In this monograph, the editors have selected not only papers presented at the symposium but also eminent papers of several individuals from around the world who have extensively researched human T-cell-leukemia virus type I (HTLV-I), the etiological virus of ATL, over the years. During the last two decades, HTLV-I was molecularly characterized as harboring a variety of oncogenic properties in its Tax protein. Epidemiological studies not only revealed the existence of HTLV-I-endemic areas in the world, but also disclosed the routes of transmission. Despite these great strides, the mechanisms of ATL development have not yet been fully clarified, and viable therapeutic measures are still to be established. This monograph contains recent exciting achievements in molecular virology, epidemiology, immunology and therapeutic trials as well as historical profiles of HTLV-I and HTLV-I-associated diseases.

Adult T-cell Leukaemia

Author: Kiyoshi Takatsuki

Publisher: Oxford University Press, USA

Published: 1994

Total Pages: 346

ISBN-13:

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Advances made so far in the worldwide study of AIDS and HIV owe much to our knowledge of T-cell leukaemia, which is the first human cancer known to be caused by a retrovirus. This book records the state-of-the-art findings on ATL and related diseases, and reviews the information which has been accumalated over the past two decades. Contributions from leading experts cover haematology, neurology, virology, epidemiology, pathophysiology, animal models, and treatment of ATL. The major contribution of ATL research to the understanding of AIDS, another retrovirus-caused disease, is clearly highlighted in this book. Contents include: ATL and HTLV-I-related diseases; regulation of HTLV-I-gene expression and its roles in ATL development; epidemiology of HTLV-I and HTLV-II infection; ethnoepidemiology of ATL in Japan, with special reference to mongoloid dispersal; ATL of Caribbean origin; molecular epidemiology of HTLV-I and HTLV-II; HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP); pathophysiology of ATL cells; cell growth characteristics; animal models of HTLV-1 infection; chemotherapy of ATL, and new approaches to the treatmant of ATL.

Book Synopsis Adult T-cell Leukaemia by : Kiyoshi Takatsuki

Download or read book Adult T-cell Leukaemia written by Kiyoshi Takatsuki and published by Oxford University Press, USA. This book was released on 1994 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances made so far in the worldwide study of AIDS and HIV owe much to our knowledge of T-cell leukaemia, which is the first human cancer known to be caused by a retrovirus. This book records the state-of-the-art findings on ATL and related diseases, and reviews the information which has been accumalated over the past two decades. Contributions from leading experts cover haematology, neurology, virology, epidemiology, pathophysiology, animal models, and treatment of ATL. The major contribution of ATL research to the understanding of AIDS, another retrovirus-caused disease, is clearly highlighted in this book. Contents include: ATL and HTLV-I-related diseases; regulation of HTLV-I-gene expression and its roles in ATL development; epidemiology of HTLV-I and HTLV-II infection; ethnoepidemiology of ATL in Japan, with special reference to mongoloid dispersal; ATL of Caribbean origin; molecular epidemiology of HTLV-I and HTLV-II; HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP); pathophysiology of ATL cells; cell growth characteristics; animal models of HTLV-1 infection; chemotherapy of ATL, and new approaches to the treatmant of ATL.

Adult T-cell Leukemia/Lymphoma

Author: Toshiki Watanabe

Publisher: Springer

Published: 2017-04-27

Total Pages: 170

ISBN-13: 443156523X

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This book provides essential information on the epidemiology, molecular and genetic features, anti-CCR4 antibody therapy and a nationwide study of transplantation on human T-leukemia virus type-I (HTLV-1) and adult T-cell leukemia/lymphoma (ATL). This rare but important disease has restricted endemic areas and distinct clinical features such as a high frequency of hypercalcemia, strong predisposition to infection and poor response to chemotherapy, aspects which set ATL apart from other types of non-Hodgkin lymphoma. Given the small number of patients, enrollment in clinical trials has not been feasible, and establishing treatment standard has been difficult but new evidence, such as results of nationwide studies on transplantation, have shown new insights and potential treatments. Based on recent evidence, the book presents new treatment methods for ATL and infection prevention of HTLV-1, enabling clinicians, researchers and post-docs specializing in hematology and virology to gain a valuable overview of the disease.

Book Synopsis Adult T-cell Leukemia/Lymphoma by : Toshiki Watanabe

Download or read book Adult T-cell Leukemia/Lymphoma written by Toshiki Watanabe and published by Springer. This book was released on 2017-04-27 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides essential information on the epidemiology, molecular and genetic features, anti-CCR4 antibody therapy and a nationwide study of transplantation on human T-leukemia virus type-I (HTLV-1) and adult T-cell leukemia/lymphoma (ATL). This rare but important disease has restricted endemic areas and distinct clinical features such as a high frequency of hypercalcemia, strong predisposition to infection and poor response to chemotherapy, aspects which set ATL apart from other types of non-Hodgkin lymphoma. Given the small number of patients, enrollment in clinical trials has not been feasible, and establishing treatment standard has been difficult but new evidence, such as results of nationwide studies on transplantation, have shown new insights and potential treatments. Based on recent evidence, the book presents new treatment methods for ATL and infection prevention of HTLV-1, enabling clinicians, researchers and post-docs specializing in hematology and virology to gain a valuable overview of the disease.

Allogeneic Stem Cell Transplantation

Author: Hillard M. Lazarus

Publisher: Springer Science & Business Media

Published: 2010-03-02

Total Pages: 885

ISBN-13: 1597454788

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Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.

Book Synopsis Allogeneic Stem Cell Transplantation by : Hillard M. Lazarus

Download or read book Allogeneic Stem Cell Transplantation written by Hillard M. Lazarus and published by Springer Science & Business Media. This book was released on 2010-03-02 with total page 885 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.

Advances in Adult T-cell Leukemia and HTLV-I Research

Author: Kiyoshi Takatsuki

Publisher: CRC PressI Llc

Published: 1992

Total Pages: 261

ISBN-13: 9780849377464

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Provides an examination of the epidemiology, molecular biology, immunology, pathology and genetics of the HTLV-1 virus. The text reflects the advances in research conducted in Japan over the last 10 years and includes information on the molecular mechanisms of viral replication and leukemogenesis.

Book Synopsis Advances in Adult T-cell Leukemia and HTLV-I Research by : Kiyoshi Takatsuki

Download or read book Advances in Adult T-cell Leukemia and HTLV-I Research written by Kiyoshi Takatsuki and published by CRC PressI Llc. This book was released on 1992 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides an examination of the epidemiology, molecular biology, immunology, pathology and genetics of the HTLV-1 virus. The text reflects the advances in research conducted in Japan over the last 10 years and includes information on the molecular mechanisms of viral replication and leukemogenesis.

HTLV-1 and Adult T-cell Leukemia

Author: Kuan-Teh Jeang

Publisher:

Published: 2005

Total Pages: 146

ISBN-13:

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Book Synopsis HTLV-1 and Adult T-cell Leukemia by : Kuan-Teh Jeang

Download or read book HTLV-1 and Adult T-cell Leukemia written by Kuan-Teh Jeang and published by . This book was released on 2005 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:

HTLV-1 and Adult T-cell Leukemia: 25 Years of Research on the First Human Retrovirus

Author: Kuan-Teh Jeang

Publisher:

Published: 2005

Total Pages: 142

ISBN-13:

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Book Synopsis HTLV-1 and Adult T-cell Leukemia: 25 Years of Research on the First Human Retrovirus by : Kuan-Teh Jeang

Download or read book HTLV-1 and Adult T-cell Leukemia: 25 Years of Research on the First Human Retrovirus written by Kuan-Teh Jeang and published by . This book was released on 2005 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Adult T-Cell Leukemia-Lymphoma: New Insights for the Healthcare Professional: 2011 Edition

Author:

Publisher: ScholarlyEditions

Published: 2012-01-09

Total Pages: 25

ISBN-13: 1464914699

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Adult T-Cell Leukemia-Lymphoma: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Adult T-Cell Leukemia-Lymphoma in a compact format. The editors have built Adult T-Cell Leukemia-Lymphoma: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Adult T-Cell Leukemia-Lymphoma in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Adult T-Cell Leukemia-Lymphoma: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Book Synopsis Adult T-Cell Leukemia-Lymphoma: New Insights for the Healthcare Professional: 2011 Edition by :

Download or read book Adult T-Cell Leukemia-Lymphoma: New Insights for the Healthcare Professional: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 25 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adult T-Cell Leukemia-Lymphoma: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Adult T-Cell Leukemia-Lymphoma in a compact format. The editors have built Adult T-Cell Leukemia-Lymphoma: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Adult T-Cell Leukemia-Lymphoma in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Adult T-Cell Leukemia-Lymphoma: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Adult T Cell Leukemia and Related Diseases

Author: Takashi Uchiyama

Publisher: Springer

Published: 1995

Total Pages: 158

ISBN-13:

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Reviews research in adult T cell leukemia (ATL), one of the central disorders related to infections caused by the retrovirus human T lymphotrophic virus (HTLV-1), for researchers and clinicians. Describes clinical features of ATL and other related diseases and biological properties of cells, explains the IL-2/IL-2 receptor system in ATL and redox regulation and ATL-derived factor, and compares the relationship between AIDS and HIV to ATL and HTLV-1. Includes bandw diagrams and photos. Annotation copyright by Book News, Inc., Portland, OR

Book Synopsis Adult T Cell Leukemia and Related Diseases by : Takashi Uchiyama

Download or read book Adult T Cell Leukemia and Related Diseases written by Takashi Uchiyama and published by Springer. This book was released on 1995 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews research in adult T cell leukemia (ATL), one of the central disorders related to infections caused by the retrovirus human T lymphotrophic virus (HTLV-1), for researchers and clinicians. Describes clinical features of ATL and other related diseases and biological properties of cells, explains the IL-2/IL-2 receptor system in ATL and redox regulation and ATL-derived factor, and compares the relationship between AIDS and HIV to ATL and HTLV-1. Includes bandw diagrams and photos. Annotation copyright by Book News, Inc., Portland, OR

Recent Advances in HTLV Research 2015

Author:

Publisher: Mdpi AG

Published: 2017-02-24

Total Pages: 308

ISBN-13: 9783038423768

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The human T-cell leukemia virus types 1 and 2 (HTLV-1 and HTLV-2) were both discovered over three decades ago and infect millions people worldwide. HTLV-1 is associated with the adult T-cell leukemia/lymphoma (ATLL) in about 2% of individuals infected, and another 2 to 3% of individuals develop a neurologic disorder called HTLV-associated myelopathy (HAM). HTLV-2 causes HAM in approximately 1 to 2% of infected individuals, but does not cause ATLL. HTLV-1 and HTLV-2 have served as excellent models for the study of the epidemiology and pathogenesis of virus-associated cancers as well as autoimmune conditions such as multiple sclerosis. Recently, two new members--HTLV-3 and HTLV-4--have been discovered in bushmeat hunters from central Africa, which emphasizes the urgent need for continual surveillance for new human retroviruses and their capacity to cause disease. Important public health issues remain open issues to be addressed in spite of the basic epidemiology of HTLV-1 and HTLV-2 being reasonably well defined. Clinical research is needed in developing potential HTLV-1 and HTLV-2 vaccines, as well as development of treatment options for ATLL and HAM. This 'Recent Advances Issue' contains both reviews and updates on research that encompasses these areas.

Book Synopsis Recent Advances in HTLV Research 2015 by :

Download or read book Recent Advances in HTLV Research 2015 written by and published by Mdpi AG. This book was released on 2017-02-24 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human T-cell leukemia virus types 1 and 2 (HTLV-1 and HTLV-2) were both discovered over three decades ago and infect millions people worldwide. HTLV-1 is associated with the adult T-cell leukemia/lymphoma (ATLL) in about 2% of individuals infected, and another 2 to 3% of individuals develop a neurologic disorder called HTLV-associated myelopathy (HAM). HTLV-2 causes HAM in approximately 1 to 2% of infected individuals, but does not cause ATLL. HTLV-1 and HTLV-2 have served as excellent models for the study of the epidemiology and pathogenesis of virus-associated cancers as well as autoimmune conditions such as multiple sclerosis. Recently, two new members--HTLV-3 and HTLV-4--have been discovered in bushmeat hunters from central Africa, which emphasizes the urgent need for continual surveillance for new human retroviruses and their capacity to cause disease. Important public health issues remain open issues to be addressed in spite of the basic epidemiology of HTLV-1 and HTLV-2 being reasonably well defined. Clinical research is needed in developing potential HTLV-1 and HTLV-2 vaccines, as well as development of treatment options for ATLL and HAM. This 'Recent Advances Issue' contains both reviews and updates on research that encompasses these areas.