Ultra-high Field Magnetic Resonance Imaging: Mri Instrumentation And Clinical Implementation

Ultra-high Field Magnetic Resonance Imaging: Mri Instrumentation And Clinical Implementation

Author: Shaileshkumar B. Raval, Ph.D.

Publisher: Index of Sciences Ltd

Published: 2021-04-06

Total Pages: 340

ISBN-13: 1838088849

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Magnetic Resonance Imaging“Magnetic Resonance Imaging” (MRI) is the most widely clinically used diagnostic tool for soft tissue imaging. This advanced technology and its applications are under continuous research and development, ranging from lower fields to ultra-high fields to the highest possible fields for preclinical (animal) and human imaging. Formerly known as Nuclear Magnetic Resonance Imaging (NMR), with the rising demands of clinical diagnosis requirements, it is under constant development and innovation in hospitals for populations around the world because of constant desire to go to higher fields that lead to unique research and clinical applications that aren’t achievable with other commercially and or research technologies. The basics of MRIThe human body is rich in hydrogen, when a human body is subjected to a large magnetic field, many of the free hydrogen nuclei align themselves with the direction of the magnetic field. MRI works on the principle of the directional magnetic field associated with charged particles in motion. MRI is also known as nuclear magnetic resonance imaging, a technique used to create images of parts of the human body based on the resonance of nuclei in motion under the effect of a magnetic field. Overview of the bookThis book’s lucid style makes it an easy read. It is written in a simple and comprehensible way, making it easy to followand readfor a large audience ranging from students to researchers. The areas covered include an overview of the theories and practical aspects of High-Field MRIwith each chapter Introduction, Challenges, Objectives, Methods(Materials), Results, Discussion, FutureWworks,including basic concepts, along with research-oriented and clinical concepts, technologies that are researched and developed, and implemented clinically, and published nationally and internationally recognized conferences, and publications with global awards recognition from ISMRM, TTS, and many other academic and industry organizationsthat are recognized worldwide. In this book, unexplored research theories are described along with a list of products, project developments, and completion of major and unattempted theories, which are considered to be challenging in high-field MRI. These unexplored research theories are further delved into to emerge with practical and translational products, as described in various chapters. These products are deemed to be of potential research and clinical use if implemented in clinical and hospital settings, to help thus could the patients as well as healthy populations to improve the standard of their lives. Advances in extremities and musculoskeletal imaging in patients undergoing transplants, including first-ever(never been implemented)technologies such as Ultra high field upper extremity RF coils, research publications, and intellectual properties have been explored in detail. Another major advancement discussed in this book is the Whole-body MRI RF high density transmit coil and receiver array designs(first evevr application of antenna design), published in national and international journals as intellectual properties. Various other aspects of these 4intellectual properties have been discussed such as instrumentation developed, design procedures, Electromagnetic Simulations (simulated versions), Novel whole head(Brain) MRI RF array, Innovative Visualization Techniques, Neuro and vascular flow imaging, Segmentation methods. Regenerative Imaging, Pre and post-operative (surgical) imaging, clinical implementations, pulse sequence developments and optimizations, imaging resultswith 3D volume Texture and Visualizations, also peer research and references from around the world, plus future works, and more have been entailed. This is a rather different book in terms of depth and detail in which the subject is dealt with in this book. The data is well represented with tables, equations, and nearly three hundred figures. Combining technologies, research, and clinical applications of innovations in the field of MRI, it is one of a kind and a treat for curious minds. The content is mainly focused on whole head imaging, whole-body imaging, and extremity imaging, describing their clinical applications and their implementation for high risk and high demand patient populations, healthy populations for enhanced human anatomical, biological, functional and physiological performances in a detailed manner. The research has been utilized by peers in their studies, research, publications, and learning as part of the research and clinical developments, and implementations. This book presents the author’s original research works and their applications in the real world to offer advanced innovations to the healthcare sector and improve quality and standard of life for the masses around the world and beyond as future goals as there are many aviations,Biomedical Applications and projects are in demand. The author’s research works have been publishedand awarded in various nationalllyand internationallyrecognized journals and presented in numerous conferences as well. The chapters of this book are each one of the many research publications by the author


Book Synopsis Ultra-high Field Magnetic Resonance Imaging: Mri Instrumentation And Clinical Implementation by : Shaileshkumar B. Raval, Ph.D.

Download or read book Ultra-high Field Magnetic Resonance Imaging: Mri Instrumentation And Clinical Implementation written by Shaileshkumar B. Raval, Ph.D. and published by Index of Sciences Ltd. This book was released on 2021-04-06 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic Resonance Imaging“Magnetic Resonance Imaging” (MRI) is the most widely clinically used diagnostic tool for soft tissue imaging. This advanced technology and its applications are under continuous research and development, ranging from lower fields to ultra-high fields to the highest possible fields for preclinical (animal) and human imaging. Formerly known as Nuclear Magnetic Resonance Imaging (NMR), with the rising demands of clinical diagnosis requirements, it is under constant development and innovation in hospitals for populations around the world because of constant desire to go to higher fields that lead to unique research and clinical applications that aren’t achievable with other commercially and or research technologies. The basics of MRIThe human body is rich in hydrogen, when a human body is subjected to a large magnetic field, many of the free hydrogen nuclei align themselves with the direction of the magnetic field. MRI works on the principle of the directional magnetic field associated with charged particles in motion. MRI is also known as nuclear magnetic resonance imaging, a technique used to create images of parts of the human body based on the resonance of nuclei in motion under the effect of a magnetic field. Overview of the bookThis book’s lucid style makes it an easy read. It is written in a simple and comprehensible way, making it easy to followand readfor a large audience ranging from students to researchers. The areas covered include an overview of the theories and practical aspects of High-Field MRIwith each chapter Introduction, Challenges, Objectives, Methods(Materials), Results, Discussion, FutureWworks,including basic concepts, along with research-oriented and clinical concepts, technologies that are researched and developed, and implemented clinically, and published nationally and internationally recognized conferences, and publications with global awards recognition from ISMRM, TTS, and many other academic and industry organizationsthat are recognized worldwide. In this book, unexplored research theories are described along with a list of products, project developments, and completion of major and unattempted theories, which are considered to be challenging in high-field MRI. These unexplored research theories are further delved into to emerge with practical and translational products, as described in various chapters. These products are deemed to be of potential research and clinical use if implemented in clinical and hospital settings, to help thus could the patients as well as healthy populations to improve the standard of their lives. Advances in extremities and musculoskeletal imaging in patients undergoing transplants, including first-ever(never been implemented)technologies such as Ultra high field upper extremity RF coils, research publications, and intellectual properties have been explored in detail. Another major advancement discussed in this book is the Whole-body MRI RF high density transmit coil and receiver array designs(first evevr application of antenna design), published in national and international journals as intellectual properties. Various other aspects of these 4intellectual properties have been discussed such as instrumentation developed, design procedures, Electromagnetic Simulations (simulated versions), Novel whole head(Brain) MRI RF array, Innovative Visualization Techniques, Neuro and vascular flow imaging, Segmentation methods. Regenerative Imaging, Pre and post-operative (surgical) imaging, clinical implementations, pulse sequence developments and optimizations, imaging resultswith 3D volume Texture and Visualizations, also peer research and references from around the world, plus future works, and more have been entailed. This is a rather different book in terms of depth and detail in which the subject is dealt with in this book. The data is well represented with tables, equations, and nearly three hundred figures. Combining technologies, research, and clinical applications of innovations in the field of MRI, it is one of a kind and a treat for curious minds. The content is mainly focused on whole head imaging, whole-body imaging, and extremity imaging, describing their clinical applications and their implementation for high risk and high demand patient populations, healthy populations for enhanced human anatomical, biological, functional and physiological performances in a detailed manner. The research has been utilized by peers in their studies, research, publications, and learning as part of the research and clinical developments, and implementations. This book presents the author’s original research works and their applications in the real world to offer advanced innovations to the healthcare sector and improve quality and standard of life for the masses around the world and beyond as future goals as there are many aviations,Biomedical Applications and projects are in demand. The author’s research works have been publishedand awarded in various nationalllyand internationallyrecognized journals and presented in numerous conferences as well. The chapters of this book are each one of the many research publications by the author

Ultra High Field Magnetic Resonance Imaging

Ultra High Field Magnetic Resonance Imaging

Author: Pierre-Marie Robitaille

Publisher: Springer

Published: 2014-10-20

Total Pages: 0

ISBN-13: 9781489973375

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The foundation for understanding the function and dynamics of biological systems is not only knowledge of their structure, but the new methodologies and applications used to determine that structure. This volume in Biological Magnetic Resonance emphasizes the methods that involve Ultra High Field Magnetic Resonance Imaging. It will interest researchers working in the field of imaging.


Book Synopsis Ultra High Field Magnetic Resonance Imaging by : Pierre-Marie Robitaille

Download or read book Ultra High Field Magnetic Resonance Imaging written by Pierre-Marie Robitaille and published by Springer. This book was released on 2014-10-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The foundation for understanding the function and dynamics of biological systems is not only knowledge of their structure, but the new methodologies and applications used to determine that structure. This volume in Biological Magnetic Resonance emphasizes the methods that involve Ultra High Field Magnetic Resonance Imaging. It will interest researchers working in the field of imaging.

Mathematics and Physics of Emerging Biomedical Imaging

Mathematics and Physics of Emerging Biomedical Imaging

Author: Committee on the Mathematics and Physics of Emerging Dynamic Biomedical Imaging

Publisher: National Academies Press

Published: 1996-03-13

Total Pages: 261

ISBN-13: 0309552923

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This cross-disciplinary book documents the key research challenges in the mathematical sciences and physics that could enable the economical development of novel biomedical imaging devices. It is hoped that the infusion of new insights from mathematical scientists and physicists will accelerate progress in imaging. Incorporating input from dozens of biomedical researchers who described what they perceived as key open problems of imaging that are amenable to attack by mathematical scientists and physicists, this book introduces the frontiers of biomedical imaging, especially the imaging of dynamic physiological functions, to the educated nonspecialist. Ten imaging modalities are covered, from the well-established (e.g., CAT scanning, MRI) to the more speculative (e.g., electrical and magnetic source imaging). For each modality, mathematics and physics research challenges are identified and a short list of suggested reading offered. Two additional chapters offer visions of the next generation of surgical and interventional techniques and of image processing. A final chapter provides an overview of mathematical issues that cut across the various modalities.


Book Synopsis Mathematics and Physics of Emerging Biomedical Imaging by : Committee on the Mathematics and Physics of Emerging Dynamic Biomedical Imaging

Download or read book Mathematics and Physics of Emerging Biomedical Imaging written by Committee on the Mathematics and Physics of Emerging Dynamic Biomedical Imaging and published by National Academies Press. This book was released on 1996-03-13 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This cross-disciplinary book documents the key research challenges in the mathematical sciences and physics that could enable the economical development of novel biomedical imaging devices. It is hoped that the infusion of new insights from mathematical scientists and physicists will accelerate progress in imaging. Incorporating input from dozens of biomedical researchers who described what they perceived as key open problems of imaging that are amenable to attack by mathematical scientists and physicists, this book introduces the frontiers of biomedical imaging, especially the imaging of dynamic physiological functions, to the educated nonspecialist. Ten imaging modalities are covered, from the well-established (e.g., CAT scanning, MRI) to the more speculative (e.g., electrical and magnetic source imaging). For each modality, mathematics and physics research challenges are identified and a short list of suggested reading offered. Two additional chapters offer visions of the next generation of surgical and interventional techniques and of image processing. A final chapter provides an overview of mathematical issues that cut across the various modalities.

Ultra-High Field Neuro MRI

Ultra-High Field Neuro MRI

Author: Karin Markenroth Bloch

Publisher: Elsevier

Published: 2023-08-21

Total Pages: 628

ISBN-13: 0323999530

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Ultra-High Field Neuro MRI is a comprehensive reference and educational resource on the current state of neuroimaging at ultra-high field (UHF), with an emphasis on 7T. Sections cover the MR physics aspects of UHF, including the technical challenges and practical solutions that have enabled the rapid growth of 7T MRI. Individual chapters are dedicated to the different techniques that most strongly benefit from UHF, as well as chapters with a focus on different application areas in anatomical, functional and metabolic imaging. Finally, several chapters highlight the neurological and psychiatric applications for which 7T has shown benefits. The book is aimed at scientists who develop MR technologies and support clinical and neuroscience research, as well as users who want to benefit from UHF neuro MR techniques in their work. It also provides a comprehensive introduction to the field. Presents the opportunities and technical challenges presented by MRI at ultra-high field Describes advanced ultra-high field neuro MR techniques for clinical and neuroscience applications Enables the reader to critically assess the specific UHF advantages over currently available techniques at clinical field strengths


Book Synopsis Ultra-High Field Neuro MRI by : Karin Markenroth Bloch

Download or read book Ultra-High Field Neuro MRI written by Karin Markenroth Bloch and published by Elsevier. This book was released on 2023-08-21 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ultra-High Field Neuro MRI is a comprehensive reference and educational resource on the current state of neuroimaging at ultra-high field (UHF), with an emphasis on 7T. Sections cover the MR physics aspects of UHF, including the technical challenges and practical solutions that have enabled the rapid growth of 7T MRI. Individual chapters are dedicated to the different techniques that most strongly benefit from UHF, as well as chapters with a focus on different application areas in anatomical, functional and metabolic imaging. Finally, several chapters highlight the neurological and psychiatric applications for which 7T has shown benefits. The book is aimed at scientists who develop MR technologies and support clinical and neuroscience research, as well as users who want to benefit from UHF neuro MR techniques in their work. It also provides a comprehensive introduction to the field. Presents the opportunities and technical challenges presented by MRI at ultra-high field Describes advanced ultra-high field neuro MR techniques for clinical and neuroscience applications Enables the reader to critically assess the specific UHF advantages over currently available techniques at clinical field strengths

Principles of Magnetic Resonance Imaging

Principles of Magnetic Resonance Imaging

Author: Zhi-Pei Liang

Publisher: Wiley-IEEE Press

Published: 2000

Total Pages: 442

ISBN-13:

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In 1971 Dr. Paul C. Lauterbur pioneered spatial information encoding principles that made image formation possible by using magnetic resonance signals. Now Lauterbur, "father of the MRI", and Dr. Zhi-Pei Liang have co-authored the first engineering textbook on magnetic resonance imaging. This long-awaited, definitive text will help undergraduate and graduate students of biomedical engineering, biomedical imaging scientists, radiologists, and electrical engineers gain an in-depth understanding of MRI principles. The authors use a signal processing approach to describe the fundamentals of magnetic resonance imaging. You will find a clear and rigorous discussion of these carefully selected essential topics: Mathematical fundamentals Signal generation and detection principles Signal characteristics Signal localization principles Image reconstruction techniques Image contrast mechanisms Image resolution, noise, and artifacts Fast-scan imaging Constrained reconstruction Complete with a comprehensive set of examples and homework problems, Principles of Magnetic Resonance Imaging is the must-read book to improve your knowledge of this revolutionary technique.


Book Synopsis Principles of Magnetic Resonance Imaging by : Zhi-Pei Liang

Download or read book Principles of Magnetic Resonance Imaging written by Zhi-Pei Liang and published by Wiley-IEEE Press. This book was released on 2000 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1971 Dr. Paul C. Lauterbur pioneered spatial information encoding principles that made image formation possible by using magnetic resonance signals. Now Lauterbur, "father of the MRI", and Dr. Zhi-Pei Liang have co-authored the first engineering textbook on magnetic resonance imaging. This long-awaited, definitive text will help undergraduate and graduate students of biomedical engineering, biomedical imaging scientists, radiologists, and electrical engineers gain an in-depth understanding of MRI principles. The authors use a signal processing approach to describe the fundamentals of magnetic resonance imaging. You will find a clear and rigorous discussion of these carefully selected essential topics: Mathematical fundamentals Signal generation and detection principles Signal characteristics Signal localization principles Image reconstruction techniques Image contrast mechanisms Image resolution, noise, and artifacts Fast-scan imaging Constrained reconstruction Complete with a comprehensive set of examples and homework problems, Principles of Magnetic Resonance Imaging is the must-read book to improve your knowledge of this revolutionary technique.

Ultra-Low Field Nuclear Magnetic Resonance

Ultra-Low Field Nuclear Magnetic Resonance

Author: Robert Kraus Jr.

Publisher: Oxford University Press

Published: 2014-02-26

Total Pages: 266

ISBN-13: 0199796513

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This book is designed to introduce the reader to the field of NMR/MRI at very low magnetic fields, from milli-Tesla to micro-Tesla, the ultra-low field (ULF) regime. The book is focused on applications to imaging the human brain, and hardware methods primarily based upon pre-polarization methods and SQUID-based detection. The goal of the text is to provide insight and tools for the reader to better understand what applications are best served by ULF NMR/MRI approaches. A discussion of the hardware challenges, such as shielding, operation of SQUID sensors in a dynamic field environment, and pulsed magnetic field generation are presented. One goal of the text is to provide the reader a framework of understanding the approaches to estimation and mitigation of low signal-to-noise and long imaging time, which are the main challenges. Special attention is paid to the combination of MEG and ULF MRI, and the benefits and challenges presented by trying to accomplish both with the same hardware. The book discusses the origin of unique relaxation contrast at ULF, and special considerations for image artifacts and how to correct them (i.e. concomitant gradients, ghost artifacts). A general discussion of MRI, with special consideration to the challenges of imaging at ULF and unique opportunities in pulse sequences, is presented. The book also presents an overview of some of the primary applications of ULF NMR/MRI being pursued.


Book Synopsis Ultra-Low Field Nuclear Magnetic Resonance by : Robert Kraus Jr.

Download or read book Ultra-Low Field Nuclear Magnetic Resonance written by Robert Kraus Jr. and published by Oxford University Press. This book was released on 2014-02-26 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed to introduce the reader to the field of NMR/MRI at very low magnetic fields, from milli-Tesla to micro-Tesla, the ultra-low field (ULF) regime. The book is focused on applications to imaging the human brain, and hardware methods primarily based upon pre-polarization methods and SQUID-based detection. The goal of the text is to provide insight and tools for the reader to better understand what applications are best served by ULF NMR/MRI approaches. A discussion of the hardware challenges, such as shielding, operation of SQUID sensors in a dynamic field environment, and pulsed magnetic field generation are presented. One goal of the text is to provide the reader a framework of understanding the approaches to estimation and mitigation of low signal-to-noise and long imaging time, which are the main challenges. Special attention is paid to the combination of MEG and ULF MRI, and the benefits and challenges presented by trying to accomplish both with the same hardware. The book discusses the origin of unique relaxation contrast at ULF, and special considerations for image artifacts and how to correct them (i.e. concomitant gradients, ghost artifacts). A general discussion of MRI, with special consideration to the challenges of imaging at ULF and unique opportunities in pulse sequences, is presented. The book also presents an overview of some of the primary applications of ULF NMR/MRI being pursued.

Quantitative Magnetic Resonance Imaging

Quantitative Magnetic Resonance Imaging

Author: Nicole Seiberlich

Publisher: Academic Press

Published: 2020-11-18

Total Pages: 1094

ISBN-13: 0128170581

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Quantitative Magnetic Resonance Imaging is a ‘go-to’ reference for methods and applications of quantitative magnetic resonance imaging, with specific sections on Relaxometry, Perfusion, and Diffusion. Each section will start with an explanation of the basic techniques for mapping the tissue property in question, including a description of the challenges that arise when using these basic approaches. For properties which can be measured in multiple ways, each of these basic methods will be described in separate chapters. Following the basics, a chapter in each section presents more advanced and recently proposed techniques for quantitative tissue property mapping, with a concluding chapter on clinical applications. The reader will learn: The basic physics behind tissue property mapping How to implement basic pulse sequences for the quantitative measurement of tissue properties The strengths and limitations to the basic and more rapid methods for mapping the magnetic relaxation properties T1, T2, and T2* The pros and cons for different approaches to mapping perfusion The methods of Diffusion-weighted imaging and how this approach can be used to generate diffusion tensor maps and more complex representations of diffusion How flow, magneto-electric tissue property, fat fraction, exchange, elastography, and temperature mapping are performed How fast imaging approaches including parallel imaging, compressed sensing, and Magnetic Resonance Fingerprinting can be used to accelerate or improve tissue property mapping schemes How tissue property mapping is used clinically in different organs Structured to cater for MRI researchers and graduate students with a wide variety of backgrounds Explains basic methods for quantitatively measuring tissue properties with MRI - including T1, T2, perfusion, diffusion, fat and iron fraction, elastography, flow, susceptibility - enabling the implementation of pulse sequences to perform measurements Shows the limitations of the techniques and explains the challenges to the clinical adoption of these traditional methods, presenting the latest research in rapid quantitative imaging which has the possibility to tackle these challenges Each section contains a chapter explaining the basics of novel ideas for quantitative mapping, such as compressed sensing and Magnetic Resonance Fingerprinting-based approaches


Book Synopsis Quantitative Magnetic Resonance Imaging by : Nicole Seiberlich

Download or read book Quantitative Magnetic Resonance Imaging written by Nicole Seiberlich and published by Academic Press. This book was released on 2020-11-18 with total page 1094 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative Magnetic Resonance Imaging is a ‘go-to’ reference for methods and applications of quantitative magnetic resonance imaging, with specific sections on Relaxometry, Perfusion, and Diffusion. Each section will start with an explanation of the basic techniques for mapping the tissue property in question, including a description of the challenges that arise when using these basic approaches. For properties which can be measured in multiple ways, each of these basic methods will be described in separate chapters. Following the basics, a chapter in each section presents more advanced and recently proposed techniques for quantitative tissue property mapping, with a concluding chapter on clinical applications. The reader will learn: The basic physics behind tissue property mapping How to implement basic pulse sequences for the quantitative measurement of tissue properties The strengths and limitations to the basic and more rapid methods for mapping the magnetic relaxation properties T1, T2, and T2* The pros and cons for different approaches to mapping perfusion The methods of Diffusion-weighted imaging and how this approach can be used to generate diffusion tensor maps and more complex representations of diffusion How flow, magneto-electric tissue property, fat fraction, exchange, elastography, and temperature mapping are performed How fast imaging approaches including parallel imaging, compressed sensing, and Magnetic Resonance Fingerprinting can be used to accelerate or improve tissue property mapping schemes How tissue property mapping is used clinically in different organs Structured to cater for MRI researchers and graduate students with a wide variety of backgrounds Explains basic methods for quantitatively measuring tissue properties with MRI - including T1, T2, perfusion, diffusion, fat and iron fraction, elastography, flow, susceptibility - enabling the implementation of pulse sequences to perform measurements Shows the limitations of the techniques and explains the challenges to the clinical adoption of these traditional methods, presenting the latest research in rapid quantitative imaging which has the possibility to tackle these challenges Each section contains a chapter explaining the basics of novel ideas for quantitative mapping, such as compressed sensing and Magnetic Resonance Fingerprinting-based approaches

Ultra High Field Magnetic Resonance Imaging

Ultra High Field Magnetic Resonance Imaging

Author: Pierre-Marie Robitaille

Publisher: Springer

Published: 2006-10-12

Total Pages: 508

ISBN-13: 9780387342313

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The foundation for understanding the function and dynamics of biological systems is not only knowledge of their structure, but the new methodologies and applications used to determine that structure. This volume in Biological Magnetic Resonance emphasizes the methods that involve Ultra High Field Magnetic Resonance Imaging. It will interest researchers working in the field of imaging.


Book Synopsis Ultra High Field Magnetic Resonance Imaging by : Pierre-Marie Robitaille

Download or read book Ultra High Field Magnetic Resonance Imaging written by Pierre-Marie Robitaille and published by Springer. This book was released on 2006-10-12 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: The foundation for understanding the function and dynamics of biological systems is not only knowledge of their structure, but the new methodologies and applications used to determine that structure. This volume in Biological Magnetic Resonance emphasizes the methods that involve Ultra High Field Magnetic Resonance Imaging. It will interest researchers working in the field of imaging.

Ultrafast MRI

Ultrafast MRI

Author: Jörg F. Debatin

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 364

ISBN-13: 3642803849

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The imaging potential of the MR experiment continues to evolve. In recent years, an increasing number of fast and ultrafast imaging strategies has been described. In this evolu tion the definition of the terms fast and ultrafast has been blurred. Hence they are frequently used interchangeably. The evolution of these methods has been based on two related, yet separate developments: an increasingly thorough understand ing of the complexities inherent to pulse sequence design and the increasing availability of stronger and faster gradient sys tems. The combination of these two factors has laid the foun dation for vast reductions of MRI data acquisition times. Min utes have been replaced by seconds. Beyond shortening MR examination times and thereby increasing patient throughput, a most significant consequence has been the ability to acquire complex MR image sets within the time confines of a single breath-hold. The constraints placed by the presence of respi ratory motion have thus been effectively eliminated. Ultrafast breath-held data acquisition strategies already represent the backbone of many abdominal, thoracic and even pelvic imaging protocols. The enhanced image quality permits full exploitation of the unsurpassed soft tissue contrast inherent to the MR experiment. Beyond improving the quality of ex isting applications, the implementation of ultrafast imaging techniques has permitted the exploration of new imaging in dications, particularly in the area of perfusion and diffusion as well as ultrafast 3D imaging.


Book Synopsis Ultrafast MRI by : Jörg F. Debatin

Download or read book Ultrafast MRI written by Jörg F. Debatin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: The imaging potential of the MR experiment continues to evolve. In recent years, an increasing number of fast and ultrafast imaging strategies has been described. In this evolu tion the definition of the terms fast and ultrafast has been blurred. Hence they are frequently used interchangeably. The evolution of these methods has been based on two related, yet separate developments: an increasingly thorough understand ing of the complexities inherent to pulse sequence design and the increasing availability of stronger and faster gradient sys tems. The combination of these two factors has laid the foun dation for vast reductions of MRI data acquisition times. Min utes have been replaced by seconds. Beyond shortening MR examination times and thereby increasing patient throughput, a most significant consequence has been the ability to acquire complex MR image sets within the time confines of a single breath-hold. The constraints placed by the presence of respi ratory motion have thus been effectively eliminated. Ultrafast breath-held data acquisition strategies already represent the backbone of many abdominal, thoracic and even pelvic imaging protocols. The enhanced image quality permits full exploitation of the unsurpassed soft tissue contrast inherent to the MR experiment. Beyond improving the quality of ex isting applications, the implementation of ultrafast imaging techniques has permitted the exploration of new imaging in dications, particularly in the area of perfusion and diffusion as well as ultrafast 3D imaging.

Applications of Ultra-high-field Magnetic Resonance Imaging (MRI) and Proton Magnetic Resonance Spectroscopy (1H-MRS) in Preclinical Research

Applications of Ultra-high-field Magnetic Resonance Imaging (MRI) and Proton Magnetic Resonance Spectroscopy (1H-MRS) in Preclinical Research

Author: Ivina Mali

Publisher:

Published: 2022

Total Pages: 0

ISBN-13:

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Magnetic resonance imaging (MRI) is widely used to non-invasively evaluate anatomical and physiological properties of tissues in both clinical and preclinical studies making it the gold standard in medical imaging. The protocols and workflows for MRI are well established; such is not the case for Magnetic Resonance Spectroscopy (MRS). In contrast to MRI or as a complement, MRS provides biochemical composition and quantitative information of the tissue being analyzed. Modern MRI scanners can be used for MRS without any hardware modifications. MR scanners used in the clinic are of low field strength (1.5 Tesla (T) or 3 T) and require contrast agents to improve the visibility of tissue structures. On the other hand, small animal imaging requires scanners of high field strength to acquire higher resolutions to visualize similar structures and produce clinically translatable results. In this study, we use an ultra-high-field scanner of 14.1 T and optimized pulse sequences to obtain MRI and image-guided-MRS data of high spatial and spectral resolution, respectively. This work focuses on small animal models of solid tumors and neurological disorders. We monitored the growth of pancreatic ductal adenocarcinomas (PDAC) on C57BL/6 mice using a RARE (Rapid Acquisition with Relaxation Enhancement) pulse sequence after tumor implantation. MRI-guided thermal treatments were applied to mouse models of PDACs and aldosterone-producing adenoma in vivo. To evaluate the tissues before and after treatment, T1 mapping techniques were used. Another objective of this study was to use single voxel 1H-MRS (Proton MRS) techniques to study metabolite levels in cell lines and tissues ex vivo. We used a PRESS (Point RESolved Spectroscopy) sequence to acquire spectral information from five different cell lines (four cancer and one non-cancer) and solid tumors excised from mouse models and human subjects. Short, intermediate, and long echo times (TEs) were explored where short TE was found effective in resolving major metabolites compared to conventional long TE scans. Spectra with high SNR (signal-to-noise ratio) were acquired from voxel sizes up to 2 x 2 x 2 mm3. The current work also uses the valproic acid (VPA) model of autism spectrum disorder (ASD) in rodents. We collected 3D MRI scans to measure gray matter volumes in cerebellar and frontal regions of VPA-treated and control rat brains ex vivo. High-resolution MRI data allowed accurate segmentation across different regions of the rat brains. Altogether, we demonstrate diverse applications of MRI and image-guided 1H-MRS in preclinical studies using an ultra-high-field scanner.


Book Synopsis Applications of Ultra-high-field Magnetic Resonance Imaging (MRI) and Proton Magnetic Resonance Spectroscopy (1H-MRS) in Preclinical Research by : Ivina Mali

Download or read book Applications of Ultra-high-field Magnetic Resonance Imaging (MRI) and Proton Magnetic Resonance Spectroscopy (1H-MRS) in Preclinical Research written by Ivina Mali and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic resonance imaging (MRI) is widely used to non-invasively evaluate anatomical and physiological properties of tissues in both clinical and preclinical studies making it the gold standard in medical imaging. The protocols and workflows for MRI are well established; such is not the case for Magnetic Resonance Spectroscopy (MRS). In contrast to MRI or as a complement, MRS provides biochemical composition and quantitative information of the tissue being analyzed. Modern MRI scanners can be used for MRS without any hardware modifications. MR scanners used in the clinic are of low field strength (1.5 Tesla (T) or 3 T) and require contrast agents to improve the visibility of tissue structures. On the other hand, small animal imaging requires scanners of high field strength to acquire higher resolutions to visualize similar structures and produce clinically translatable results. In this study, we use an ultra-high-field scanner of 14.1 T and optimized pulse sequences to obtain MRI and image-guided-MRS data of high spatial and spectral resolution, respectively. This work focuses on small animal models of solid tumors and neurological disorders. We monitored the growth of pancreatic ductal adenocarcinomas (PDAC) on C57BL/6 mice using a RARE (Rapid Acquisition with Relaxation Enhancement) pulse sequence after tumor implantation. MRI-guided thermal treatments were applied to mouse models of PDACs and aldosterone-producing adenoma in vivo. To evaluate the tissues before and after treatment, T1 mapping techniques were used. Another objective of this study was to use single voxel 1H-MRS (Proton MRS) techniques to study metabolite levels in cell lines and tissues ex vivo. We used a PRESS (Point RESolved Spectroscopy) sequence to acquire spectral information from five different cell lines (four cancer and one non-cancer) and solid tumors excised from mouse models and human subjects. Short, intermediate, and long echo times (TEs) were explored where short TE was found effective in resolving major metabolites compared to conventional long TE scans. Spectra with high SNR (signal-to-noise ratio) were acquired from voxel sizes up to 2 x 2 x 2 mm3. The current work also uses the valproic acid (VPA) model of autism spectrum disorder (ASD) in rodents. We collected 3D MRI scans to measure gray matter volumes in cerebellar and frontal regions of VPA-treated and control rat brains ex vivo. High-resolution MRI data allowed accurate segmentation across different regions of the rat brains. Altogether, we demonstrate diverse applications of MRI and image-guided 1H-MRS in preclinical studies using an ultra-high-field scanner.