UPSTREAM AND DOWNSTREAM PROCESSING OF BIOPRODUCTS

UPSTREAM AND DOWNSTREAM PROCESSING OF BIOPRODUCTS

Author: R. Puvanakrishnan

Publisher: MJP Publisher

Published: 2019-06-20

Total Pages: 241

ISBN-13:

DOWNLOAD EBOOK

Microorganisms have been exploited for many centuries for the production of fermented foods and beverages and for bread-making. The production of alcoholic beverages using microbes was the first major industrialized process. The technology developed for large-scale brewing was adapted for other anaerobic processes such as acetone and butanol in the early 1900s. With the discovery of penicillins, rapid developments were made in the technology of submerged culture fermentation of aerobic microorganisms under controlled conditions. The advancements in microbiology and process biochemistry improved our ability to harness the potential of microorganisms through improved bioprocessing methods to manufacture new products with economic viability. Microbial derived bioproducts have been gaining importance in the food, pharmaceutical, textile, leather, cosmetic and chemical industries, and most important among them are therapeutic proteins and peptides, enzymes, antigens, vaccines, antibiotics, drugs, etc.Not all microbial production processes involve culture of the organism in liquid medium. Instead, the organism can be grown on the surface of a solid substrate. Solid substrate (or solid state) fermentation (SSF) is an established traditional technology in many countries, producing edible mushrooms, fungal- fermented foods and soy sauce. Before the development of processes in liquid culture, citric acid and some microbial enzymes were produced by SSF. Carbon composting is also a form of SSF.


Book Synopsis UPSTREAM AND DOWNSTREAM PROCESSING OF BIOPRODUCTS by : R. Puvanakrishnan

Download or read book UPSTREAM AND DOWNSTREAM PROCESSING OF BIOPRODUCTS written by R. Puvanakrishnan and published by MJP Publisher. This book was released on 2019-06-20 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microorganisms have been exploited for many centuries for the production of fermented foods and beverages and for bread-making. The production of alcoholic beverages using microbes was the first major industrialized process. The technology developed for large-scale brewing was adapted for other anaerobic processes such as acetone and butanol in the early 1900s. With the discovery of penicillins, rapid developments were made in the technology of submerged culture fermentation of aerobic microorganisms under controlled conditions. The advancements in microbiology and process biochemistry improved our ability to harness the potential of microorganisms through improved bioprocessing methods to manufacture new products with economic viability. Microbial derived bioproducts have been gaining importance in the food, pharmaceutical, textile, leather, cosmetic and chemical industries, and most important among them are therapeutic proteins and peptides, enzymes, antigens, vaccines, antibiotics, drugs, etc.Not all microbial production processes involve culture of the organism in liquid medium. Instead, the organism can be grown on the surface of a solid substrate. Solid substrate (or solid state) fermentation (SSF) is an established traditional technology in many countries, producing edible mushrooms, fungal- fermented foods and soy sauce. Before the development of processes in liquid culture, citric acid and some microbial enzymes were produced by SSF. Carbon composting is also a form of SSF.


Bioprocess Engineering

Bioprocess Engineering

Author: Pau Loke Show

Publisher: CRC Press

Published: 2019-06-13

Total Pages: 186

ISBN-13: 0429882513

DOWNLOAD EBOOK

Bioprocess Engineering: Downstream Processing is the first book to present the principles of bioprocess engineering, focusing on downstream bioprocessing. It aims to provide the latest bioprocess technology and explain process analysis from an engineering point of view, using worked examples related to biological systems. This book introduces the commonly used technologies for downstream processing of biobased products. The covered topics include centrifugation, filtration, membrane separation, reverse osmosis, chromatography, biosorption, liquid-liquid separation, and drying. The basic principles and mechanism of separation are covered in each of the topics, wherein the engineering concept and design are emphasized. This book is aimed at bioprocess engineers and professionals who wish to perform downstream processing for their feedstock, as well as students.


Book Synopsis Bioprocess Engineering by : Pau Loke Show

Download or read book Bioprocess Engineering written by Pau Loke Show and published by CRC Press. This book was released on 2019-06-13 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioprocess Engineering: Downstream Processing is the first book to present the principles of bioprocess engineering, focusing on downstream bioprocessing. It aims to provide the latest bioprocess technology and explain process analysis from an engineering point of view, using worked examples related to biological systems. This book introduces the commonly used technologies for downstream processing of biobased products. The covered topics include centrifugation, filtration, membrane separation, reverse osmosis, chromatography, biosorption, liquid-liquid separation, and drying. The basic principles and mechanism of separation are covered in each of the topics, wherein the engineering concept and design are emphasized. This book is aimed at bioprocess engineers and professionals who wish to perform downstream processing for their feedstock, as well as students.


Downstream Processing in Biotechnology. Recovery and Purification of Bioproducts and Recovery of Bioproducts

Downstream Processing in Biotechnology. Recovery and Purification of Bioproducts and Recovery of Bioproducts

Author: G. Schmidt-Kastner

Publisher:

Published: 1987

Total Pages: 125

ISBN-13:

DOWNLOAD EBOOK


Book Synopsis Downstream Processing in Biotechnology. Recovery and Purification of Bioproducts and Recovery of Bioproducts by : G. Schmidt-Kastner

Download or read book Downstream Processing in Biotechnology. Recovery and Purification of Bioproducts and Recovery of Bioproducts written by G. Schmidt-Kastner and published by . This book was released on 1987 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt:


Downstream Processing in Biotechnology

Downstream Processing in Biotechnology

Author:

Publisher:

Published: 1987

Total Pages: 126

ISBN-13:

DOWNLOAD EBOOK


Book Synopsis Downstream Processing in Biotechnology by :

Download or read book Downstream Processing in Biotechnology written by and published by . This book was released on 1987 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt:


Downstream Processing in Biotechnology

Downstream Processing in Biotechnology

Author: Venko N. Beschkov

Publisher: Walter de Gruyter GmbH & Co KG

Published: 2021-06-21

Total Pages: 211

ISBN-13: 3110574004

DOWNLOAD EBOOK

The current book gives an excellent insight into downstream processing technology and explains how to establish a successful strategy for an efficient recovery, isolation and purification of biosynthetic products. In addition to the overview of purification steps and unit operations, the authors provide practical information on capital and operating costs related to downstream processing.


Book Synopsis Downstream Processing in Biotechnology by : Venko N. Beschkov

Download or read book Downstream Processing in Biotechnology written by Venko N. Beschkov and published by Walter de Gruyter GmbH & Co KG. This book was released on 2021-06-21 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: The current book gives an excellent insight into downstream processing technology and explains how to establish a successful strategy for an efficient recovery, isolation and purification of biosynthetic products. In addition to the overview of purification steps and unit operations, the authors provide practical information on capital and operating costs related to downstream processing.


Recovery of Bioproducts

Recovery of Bioproducts

Author: G. Schmidt-Kastner

Publisher:

Published: 1993-01-01

Total Pages: 130

ISBN-13: 9780901001795

DOWNLOAD EBOOK


Book Synopsis Recovery of Bioproducts by : G. Schmidt-Kastner

Download or read book Recovery of Bioproducts written by G. Schmidt-Kastner and published by . This book was released on 1993-01-01 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:


Downstream Industrial Biotechnology

Downstream Industrial Biotechnology

Author: Michael C. Flickinger

Publisher: John Wiley & Sons

Published: 2013-07-17

Total Pages: 884

ISBN-13: 111861898X

DOWNLOAD EBOOK

DOWNSTREAM INDUSTRIAL BIOTECHNOLOGY An affordable, easily accessible desk reference on biomanufacturing, focused on downstream recovery and purification Advances in the fundamental knowledge surrounding biotechnology, novel materials, and advanced engineering approaches continue to be translated into bioprocesses that bring new products to market at a significantly faster pace than most other industries. Industrial scale biotechnology and new manufacturing methods are revolutionizing medicine, environmental monitoring and remediation, consumer products, food production, agriculture, and forestry, and continue to be a major area of research. The downstream stage in industrial biotechnology refers to recovery, isolation, and purification of the microbial products from cell debris, processing medium and contaminating biomolecules from the upstream process into a finished product such as biopharmaceuticals and vaccines. Downstream process design has the greatest impact on overall biomanufacturing cost because not only does the biochemistry of different products ( e.g., peptides, proteins, hormones, antibiotics, and complex antigens) dictate different methods for the isolation and purification of these products, but contaminating byproducts can also reduce overall process yield, and may have serious consequences on clinical safety and efficacy. Therefore downstream separation scientists and engineers are continually seeking to eliminate, or combine, unit operations to minimize the number of process steps in order to maximize product recovery at a specified concentration and purity. Based on Wiley’s Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology, this volume features fifty articles that provide information on down- stream recovery of cells and protein capture; process development and facility design; equipment; PAT in downstream processes; downstream cGMP operations; and regulatory compliance. It covers: Cell wall disruption and lysis Cell recovery by centrifugation and filtration Large-scale protein chromatography Scale down of biopharmaceutical purification operations Lipopolysaccharide removal Porous media in biotechnology Equipment used in industrial protein purification Affinity chromatography Antibody purification, monoclonal and polyclonal Protein aggregation, precipitation and crystallization Freeze-drying of biopharmaceuticals Biopharmaceutical facility design and validation Pharmaceutical bioburden testing Regulatory requirements Ideal for graduate and advanced undergraduate courses on biomanufacturing, biochemical engineering, biopharmaceutical facility design, biochemistry, industrial microbiology, gene expression technology, and cell culture technology, Downstream Industrial Biotechnology is also a highly recommended resource for industry professionals and libraries.


Book Synopsis Downstream Industrial Biotechnology by : Michael C. Flickinger

Download or read book Downstream Industrial Biotechnology written by Michael C. Flickinger and published by John Wiley & Sons. This book was released on 2013-07-17 with total page 884 pages. Available in PDF, EPUB and Kindle. Book excerpt: DOWNSTREAM INDUSTRIAL BIOTECHNOLOGY An affordable, easily accessible desk reference on biomanufacturing, focused on downstream recovery and purification Advances in the fundamental knowledge surrounding biotechnology, novel materials, and advanced engineering approaches continue to be translated into bioprocesses that bring new products to market at a significantly faster pace than most other industries. Industrial scale biotechnology and new manufacturing methods are revolutionizing medicine, environmental monitoring and remediation, consumer products, food production, agriculture, and forestry, and continue to be a major area of research. The downstream stage in industrial biotechnology refers to recovery, isolation, and purification of the microbial products from cell debris, processing medium and contaminating biomolecules from the upstream process into a finished product such as biopharmaceuticals and vaccines. Downstream process design has the greatest impact on overall biomanufacturing cost because not only does the biochemistry of different products ( e.g., peptides, proteins, hormones, antibiotics, and complex antigens) dictate different methods for the isolation and purification of these products, but contaminating byproducts can also reduce overall process yield, and may have serious consequences on clinical safety and efficacy. Therefore downstream separation scientists and engineers are continually seeking to eliminate, or combine, unit operations to minimize the number of process steps in order to maximize product recovery at a specified concentration and purity. Based on Wiley’s Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology, this volume features fifty articles that provide information on down- stream recovery of cells and protein capture; process development and facility design; equipment; PAT in downstream processes; downstream cGMP operations; and regulatory compliance. It covers: Cell wall disruption and lysis Cell recovery by centrifugation and filtration Large-scale protein chromatography Scale down of biopharmaceutical purification operations Lipopolysaccharide removal Porous media in biotechnology Equipment used in industrial protein purification Affinity chromatography Antibody purification, monoclonal and polyclonal Protein aggregation, precipitation and crystallization Freeze-drying of biopharmaceuticals Biopharmaceutical facility design and validation Pharmaceutical bioburden testing Regulatory requirements Ideal for graduate and advanced undergraduate courses on biomanufacturing, biochemical engineering, biopharmaceutical facility design, biochemistry, industrial microbiology, gene expression technology, and cell culture technology, Downstream Industrial Biotechnology is also a highly recommended resource for industry professionals and libraries.


Bioprocess Engineering, Downstream Processing and Recovery of Bioproducts, Safety in Biotechnology, Regulations in Biotechnology: Bioprocess engineering; Downstream processing and recovery of bioproducts; Safety in biotechnology; Regulations in biotechnology

Bioprocess Engineering, Downstream Processing and Recovery of Bioproducts, Safety in Biotechnology, Regulations in Biotechnology: Bioprocess engineering; Downstream processing and recovery of bioproducts; Safety in biotechnology; Regulations in biotechnology

Author: Dieter Behrens

Publisher:

Published: 1990

Total Pages: 548

ISBN-13: 9780895739247

DOWNLOAD EBOOK


Book Synopsis Bioprocess Engineering, Downstream Processing and Recovery of Bioproducts, Safety in Biotechnology, Regulations in Biotechnology: Bioprocess engineering; Downstream processing and recovery of bioproducts; Safety in biotechnology; Regulations in biotechnology by : Dieter Behrens

Download or read book Bioprocess Engineering, Downstream Processing and Recovery of Bioproducts, Safety in Biotechnology, Regulations in Biotechnology: Bioprocess engineering; Downstream processing and recovery of bioproducts; Safety in biotechnology; Regulations in biotechnology written by Dieter Behrens and published by . This book was released on 1990 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt:


Pharmaceuticals from Microbes

Pharmaceuticals from Microbes

Author: Divya Arora

Publisher: Springer

Published: 2019-01-09

Total Pages: 212

ISBN-13: 3030018814

DOWNLOAD EBOOK

This book has been assembled with the hope of being an authoritative, comprehensive, conceptually sound and highly informative compilation of recent advances describing the concepts of bioengineering in the field of microbiology. It comprises of seven chapters written by eminent authors in their respective fields. Topics included deal with the significant advancement of microbial technology with emphasis on drug delivery strategies for healthcare products, vaccine delivery, biotransformation approaches to generate new molecules, upstream/downstream processing of biopharmaceuticals. It serves as excellent reference material for researchers, students and academicians in the fields of biotechnology, microbiology and pharmaceutical sciences.


Book Synopsis Pharmaceuticals from Microbes by : Divya Arora

Download or read book Pharmaceuticals from Microbes written by Divya Arora and published by Springer. This book was released on 2019-01-09 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has been assembled with the hope of being an authoritative, comprehensive, conceptually sound and highly informative compilation of recent advances describing the concepts of bioengineering in the field of microbiology. It comprises of seven chapters written by eminent authors in their respective fields. Topics included deal with the significant advancement of microbial technology with emphasis on drug delivery strategies for healthcare products, vaccine delivery, biotransformation approaches to generate new molecules, upstream/downstream processing of biopharmaceuticals. It serves as excellent reference material for researchers, students and academicians in the fields of biotechnology, microbiology and pharmaceutical sciences.


Continuous Biomanufacturing

Continuous Biomanufacturing

Author: Ganapathy Subramanian

Publisher: John Wiley & Sons

Published: 2017-12-26

Total Pages: 628

ISBN-13: 3527340637

DOWNLOAD EBOOK

This is the most comprehensive treatise of this topic available, providing invaluable information on the technological and economic benefits to be gained from implementing continuous processes in the biopharmaceutical industry. Top experts from industry and academia cover the latest technical developments in the field, describing the use of single-use technologies alongside perfusion production platforms and downstream operations. Special emphasis is given to process control and monitoring, including such topics as 'quality by design' and automation. The book is supplemented by case studies that highlight the enormous potential of continuous manufacturing for biopharmaceutical production facilities.


Book Synopsis Continuous Biomanufacturing by : Ganapathy Subramanian

Download or read book Continuous Biomanufacturing written by Ganapathy Subramanian and published by John Wiley & Sons. This book was released on 2017-12-26 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the most comprehensive treatise of this topic available, providing invaluable information on the technological and economic benefits to be gained from implementing continuous processes in the biopharmaceutical industry. Top experts from industry and academia cover the latest technical developments in the field, describing the use of single-use technologies alongside perfusion production platforms and downstream operations. Special emphasis is given to process control and monitoring, including such topics as 'quality by design' and automation. The book is supplemented by case studies that highlight the enormous potential of continuous manufacturing for biopharmaceutical production facilities.